Abstract:
:Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here systematically assessed anaerobic bacteria for their capacity to grow expansively within avascular compartments of transplanted tumors. Among 26 different strains tested, one (Clostridium novyi) appeared particularly promising. We created a strain of C. novyi devoid of its lethal toxin (C. novyi-NT) and showed that intravenously injected C. novyi-NT spores germinated within the avascular regions of tumors in mice and destroyed surrounding viable tumor cells. When C. novyi-NT spores were administered together with conventional chemotherapeutic drugs, extensive hemorrhagic necrosis of tumors often developed within 24 h, resulting in significant and prolonged antitumor effects. This strategy, called combination bacteriolytic therapy (COBALT), has the potential to add a new dimension to the treatment of cancer.
journal_name
Proc Natl Acad Sci U S Aauthors
Dang LH,Bettegowda C,Huso DL,Kinzler KW,Vogelstein Bdoi
10.1073/pnas.251543698keywords:
subject
Has Abstractpub_date
2001-12-18 00:00:00pages
15155-60issue
26eissn
0027-8424issn
1091-6490pii
251543698journal_volume
98pub_type
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