Combination bacteriolytic therapy for the treatment of experimental tumors.

Abstract:

:Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here systematically assessed anaerobic bacteria for their capacity to grow expansively within avascular compartments of transplanted tumors. Among 26 different strains tested, one (Clostridium novyi) appeared particularly promising. We created a strain of C. novyi devoid of its lethal toxin (C. novyi-NT) and showed that intravenously injected C. novyi-NT spores germinated within the avascular regions of tumors in mice and destroyed surrounding viable tumor cells. When C. novyi-NT spores were administered together with conventional chemotherapeutic drugs, extensive hemorrhagic necrosis of tumors often developed within 24 h, resulting in significant and prolonged antitumor effects. This strategy, called combination bacteriolytic therapy (COBALT), has the potential to add a new dimension to the treatment of cancer.

authors

Dang LH,Bettegowda C,Huso DL,Kinzler KW,Vogelstein B

doi

10.1073/pnas.251543698

keywords:

subject

Has Abstract

pub_date

2001-12-18 00:00:00

pages

15155-60

issue

26

eissn

0027-8424

issn

1091-6490

pii

251543698

journal_volume

98

pub_type

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