A structural framework for unidirectional transport by a bacterial ABC exporter.

abstract：:Binding of carbon monoxide and oxygen to sterically protected heme model compounds (basket-handle porphyrins) was investigated in liquid toluene at temperatures from 180 to 300 K by laser flash photolysis. Only a single exponential rebinding process from the solvent could be seen in the time range of 20 nsec to millis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tetreau C,Lavalette D,Momenteau M,Lhoste JM

更新日期：1987-04-01 00:00:00

abstract：:Herpesvirus entry into cells requires the coordinated action of multiple virus envelope glycoproteins, including gH, gL, and gB. For EBV, the gp42 protein assembles into complexes with gHgL heterodimers and binds HLA class II to activate gB-mediated membrane fusion with B cells. EBV tropism is dictated by gp42 levels ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sathiyamoorthy K,Jiang J,Möhl BS,Chen J,Zhou ZH,Longnecker R,Jardetzky TS

更新日期：2017-10-10 00:00:00

abstract：:Mutations in copper/zinc superoxide dismutase (SOD1) are causative for dominantly inherited amyotrophic lateral sclerosis (ALS). Despite high variability in biochemical properties among the disease-causing mutants, a proportion of both dismutase-active and -inactive mutants are stably bound to spinal cord mitochondria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vande Velde C,Miller TM,Cashman NR,Cleveland DW

更新日期：2008-03-11 00:00:00

abstract：:Gamma-band synchronization adjusts the timing of excitatory and inhibitory inputs to a neuron. Neurons in the visual cortex are selective for stimulus orientation because of dynamic interactions between excitatory and inhibitory inputs. We hypothesized that these interactions and hence also orientation selectivity var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Womelsdorf T,Lima B,Vinck M,Oostenveld R,Singer W,Neuenschwander S,Fries P

更新日期：2012-03-13 00:00:00

abstract：:Insect molting and metamorphosis are induced by steroid hormones named ecdysteroids, whose production is regulated by various neuropeptides. We cloned the gene and analyzed the expression of the prothoracicostatic peptide, a unique neuropeptide shown to suppress the production of ecdysteroids in the prothoracic gland ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamanaka N,Hua YJ,Roller L,Spalovská-Valachová I,Mizoguchi A,Kataoka H,Tanaka Y

更新日期：2010-02-02 00:00:00

abstract：:Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are IP(3)-gated Ca(2+) channels that are located on intracellular Ca(2+) stores. We previously identified an IP(3)R binding protein, termed IP(3)R binding protein released with IP(3) (IRBIT). Because IRBIT is released from IP(3)R by physiological concentrations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shirakabe K,Priori G,Yamada H,Ando H,Horita S,Fujita T,Fujimoto I,Mizutani A,Seki G,Mikoshiba K

更新日期：2006-06-20 00:00:00

abstract：:Selective culling in populations of most organisms is rank-order: individuals of low rank on a scale of potential fitnesses tend to be eliminated during early development, whereas surviving adults (whose number reflects the carrying capacity of the environment) are generally drawn from the distribution's upper end. Ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallace B

更新日期：1989-03-01 00:00:00

abstract：:The type specimen for Australopithecus africanus (Taung) includes a natural endocast that reproduces most of the external morphology of the right cerebral hemisphere and a fragment of fossilized face that articulates with the endocast. Despite the fact that Taung died between 3 and 4 y of age, the endocast reproduces ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falk D,Zollikofer CP,Morimoto N,Ponce de León MS

更新日期：2012-05-29 00:00:00

abstract：:The extracellular matrix (ECM) is an intricate network composed of an array of macromolecules capable of regulating the functional responsiveness of cells. Its composition greatly varies among different types of tissue, and dysregulation of its metabolism may contribute to vascular remodeling during the pathogenesis o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth M,Eickelberg O,Kohler E,Erne P,Block LH

更新日期：1996-05-28 00:00:00

abstract：:Neuroblastoma-glioma hybrid cells (NG108-15) in suspension accumulate the permeant lipophilic cation [(3)H]tetraphenylphosphonium (TPP(+)) against a concentration gradient. The steady-state level of TPP(+) accumulation is about twice as great in physiological media of low K(+) concentration (i.e., 5 mM K(+)/135 mM Na(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lichtshtein D,Kaback HR,Blume AJ

更新日期：1979-02-01 00:00:00

abstract：:The voltage-gated potassium (Kv) channel Kv1.5 mediates the I(Kur) repolarizing current in human atrial myocytes and regulates vascular tone in multiple peripheral vascular beds. Understanding the complex regulation of Kv1.5 function is of substantial interest because it represents a promising pharmacological target f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benson MD,Li QJ,Kieckhafer K,Dudek D,Whorton MR,Sunahara RK,Iñiguez-Lluhí JA,Martens JR

更新日期：2007-02-06 00:00:00

abstract：:We present a comparative study of calorimetrically derived thermodynamic profiles for the binding of a series of drugs with selected DNA host duplexes. We use these data to demonstrate that comparisons between complete thermodynamic profiles (delta G zero, delta H zero, delta S zero, delta Cp) are required before drug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breslauer KJ,Remeta DP,Chou WY,Ferrante R,Curry J,Zaunczkowski D,Snyder JG,Marky LA

更新日期：1987-12-01 00:00:00

abstract：:We studied the effect of gangliosides GD1a and GM1 on the lamellar-to-hexagonal II phase transition of mixtures of dioleoylphosphatidylethanolamine/dioleoylphosphatidyl choline, 3:1, and of transphosphatidylated phosphatidylethanolamine with dioleoylglycerol by high-sensitivity differential scanning calorimetry, 31P-N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perillo MA,Scarsdale NJ,Yu RK,Maggio B

更新日期：1994-10-11 00:00:00

abstract：:To understand the pathogenesis that may be induced by human adenovirus type 12 (Ad12), we have generated transgenic mice carrying the Ad12 early region 1 under control of the mouse mammary tumor virus long terminal repeat. Eleven of 11 male founder mice, but only 2 of 12 females, died between 3 to 4 mo of age. Death w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koike K,Hinrichs SH,Isselbacher KJ,Jay G

更新日期：1989-07-01 00:00:00

abstract：:The folding, stability, and oligomerization of helical membrane proteins depend in part on a precise set of packing interactions between transmembrane helices. To understand the energetic principles of these helix-helix interactions, we have used alanine-scanning mutagenesis and sedimentation equilibrium analytical ul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleming KG,Engelman DM

更新日期：2001-12-04 00:00:00

abstract：:Before they even speak, infants become attuned to the sounds of the language(s) they hear, processing native phonetic contrasts more easily than nonnative ones. For example, between 6 to 8 mo and 10 to 12 mo, infants learning American English get better at distinguishing English and [l], as in "rock" vs. "lock," relat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schatz T,Feldman NH,Goldwater S,Cao XN,Dupoux E

更新日期：2021-02-09 00:00:00

abstract：:MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. However, Mnk1/2 double knockout (Mnk-DKO) mice show normal cell growth and development despite an absence of eI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueda T,Sasaki M,Elia AJ,Chio II,Hamada K,Fukunaga R,Mak TW

更新日期：2010-08-10 00:00:00

abstract：:An inductive interaction between the sevenless (sev) transmembrane tyrosine kinase receptor and the bride of sevenless (boss) transmembrane ligand is required for the development of the R7 photoreceptor neuron in the compound eye of Drosophila melanogaster. The boss protein is proposed to contain a large N-terminal ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hart AC,Harrison SD,Van Vactor DL Jr,Rubin GM,Zipursky SL

更新日期：1993-06-01 00:00:00

abstract：:Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER

更新日期：2017-11-28 00:00:00

abstract：:Recombinant DNA techniques have been combined with somatic cell genetic methods to identify, isolate, and amplify fragments of human DNA localized at specific regions of human chromosome 11 selected as a model system. A library of genomic DNA segments has been constructed, in lambda Charon 4A bacteriophage, from the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gusella JF,Keys C,VarsanyiBreiner A,Kao FT,Jones C,Puck TT,Housman D

更新日期：1980-05-01 00:00:00

abstract：:A series of HIV integrase (HIV-1 IN) inhibitors were synthesized to evaluate the role of the metal-binding group (MBG) in this class of metalloenzyme inhibitors. A total of 21 different raltegravir-chelator derivative (RCD) compounds were prepared that differed only in the nature of the MBG. These IN strand-transfer i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal A,DeSoto J,Fullagar JL,Maddali K,Rostami S,Richman DD,Pommier Y,Cohen SM

更新日期：2012-02-14 00:00:00

abstract：:In an fMRI experiment, participants were exposed to narratives based on true stories designed to evoke admiration and compassion in 4 distinct categories: admiration for virtue (AV), admiration for skill (AS), compassion for social/psychological pain (CSP), and compassion for physical pain (CPP). The goal was to test ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Immordino-Yang MH,McColl A,Damasio H,Damasio A

更新日期：2009-05-12 00:00:00

abstract：:Targeting and innervation of the cerebral cortex by thalamic afferents is a key event in the specification of cortical areas. The molecular targets of thalamic regulation, however, have remained elusive. We now demonstrate that thalamic afferents regulate the expression of gamma-aminobutyric acid type A (GABAA) recept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paysan J,Kossel A,Bolz J,Fritschy JM

更新日期：1997-06-24 00:00:00

abstract：:A bone-resorbing factor, comparable to the osteoclast-activating factor (OAF) produced from peripheral blood leukocytes, is shown to be produced by murine spleen cells activated with the T-cell mitogen Con A. Murine OAF is demonstrated here as being a product of the interaction between thymus-derived T lymphocytes and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horowitz M,Vignery A,Gershon RK,Baron R

更新日期：1984-04-01 00:00:00

abstract：:There is currently no consensus on the importance of climate change in Mesoamerican prehistory. Some invoke drought as a causal factor in major cultural transitions, including the abandonment of many sites at 900 CE, while others conclude that cultural factors were more important. This lack of agreement reflects the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharya T,Byrne R,Böhnel H,Wogau K,Kienel U,Ingram BL,Zimmerman S

更新日期：2015-02-10 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases are central components of signal transduction pathways for cell proliferation, stress responses, and differentiation. Signaling efficiency and specificity are modulated in large part by docking interactions between individual MAP kinase and the kinase interaction motif (KIM), (R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Sun JP,Zhou B,Zhang ZY

更新日期：2006-04-04 00:00:00

abstract：:There is now abundant evidence to substantiate an important role of hepatitis C virus (HCV) core protein in cellular gene expression as well as in the viral cycle. Thus the subcellular localization of this protein has important implications. However, several studies have shown controversial results: the HCV core has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barba G,Harper F,Harada T,Kohara M,Goulinet S,Matsuura Y,Eder G,Schaff Z,Chapman MJ,Miyamura T,Bréchot C

更新日期：1997-02-18 00:00:00

abstract：:Ultraviolet (UV)-stimulated nonconservative DNA synthesis has been observed in E. coli rendered permeable to nucleoside triphosphates by exposure to toluene. This synthesis is detected in toluenized cells in which the background of UV-independent DNA synthesis is reduced by use of dnaB mutants temperature-sensitive fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masker WE,Hanawalt PC

更新日期：1973-01-01 00:00:00

abstract：:The absorption spectrum of an activesite specific chromophoric acyl enzyme, sturgeon beta-(2-furyl)-acryloyl-glyceraldehyde-3-phosphate dehydrogenase, is reported. This acyl enzyme undergoes all of the catalyzed reactions characteristic of the intermediate of the physiological acyl enzyme, 3-phospho-D-glyceroyl-glycer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malhotra OP,Bernhard SA

更新日期：1973-07-01 00:00:00

abstract：:The lack of genetic means has been a serious limitation in studying mosquito immunity. We generated Relish-mediated immune deficiency (RMID) by transforming Aedes aegypti with the Delta Rel transgene driven by the vitellogenin (Vg) promoter using the pBac[3xP3-EGFP, afm] vector. A stable transformed line had a single ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shin SW,Kokoza V,Lobkov I,Raikhel AS

更新日期：2003-03-04 00:00:00