Modulation by gangliosides of the lamellar-inverted micelle (hexagonal II) phase transition in mixtures containing phosphatidylethanolamine and dioleoylglycerol.

abstract：:Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive state. It was recently reported that Mos, an integral component of CSF, acts in part by promoting the Rsk-mediated phosphorylation of the APC inhibitor Emi2/Erp1....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu JQ,Hansen DV,Guo Y,Wang MZ,Tang W,Freel CD,Tung JJ,Jackson PK,Kornbluth S

更新日期：2007-10-16 00:00:00

abstract：:Meiotic mutant (2n) gametes formed by first-division restitution without crossover (FDR-NCO) are expected to be superior to FDR with crossover (FDR-CO) because they transmit to the progeny, without disruption by recombination, almost 100% of the parental genotype. FDR-CO transfers approximately 80% of the parental het...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buso JA,Boiteux LS,Tai GC,Peloquin SJ

更新日期：1999-02-16 00:00:00

abstract：:Tau is a highly soluble protein, yet it aggregates abnormally in Alzheimer's disease. Here, we address the question of proteolytic processing of tau and the nucleation of aggregates by tau fragments. We show in neuronal cell models that fragments of the repeat domain of tau containing mutations of FTDP17 (frontotempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang YP,Biernat J,Pickhardt M,Mandelkow E,Mandelkow EM

更新日期：2007-06-12 00:00:00

abstract：:The management of harmful species, including invasive species, pests, parasites, and diseases, is a major global challenge. Harmful species cause severe damage to ecosystems, biodiversity, agriculture, and human health. In particular, managing harmful species often requires cooperation among multiple agents, such as l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampert A

更新日期：2020-05-12 00:00:00

abstract：:Anatoxin-a, a bicyclic amine isolated from blue-green alga, binds to the nicotinic acetylcholine receptor of Torpedo electric tissue, thereby inducing conformational changes in the postsynaptic receptor--ion channel complex as evidenced by alterations in the binding of radiolabeled ligands to the complex. Anatoxin-a b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aronstam RS,Witkop B

更新日期：1981-07-01 00:00:00

abstract：:Bacteriophage N4 minivirion RNA polymerase (mini-vRNAP), the RNA polymerase (RNAP) domain of vRNAP, is a member of the T7-like RNAP family. Mini-vRNAP recognizes promoters that comprise conserved sequences and a 3-base loop-5-base pair (bp) stem DNA hairpin structure on single-stranded templates. Here, we defined the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davydova EK,Santangelo TJ,Rothman-Denes LB

更新日期：2007-04-24 00:00:00

abstract：:Previous studies have shown that binding of interleukin 1 (IL-1) to its receptor and intracellular processing of the IL-1/IL-1 receptor complex appear to be different in B- and T-lymphocyte cell lines. In this study we used a B-lymphoid cell line, 70Z/3, and T-lymphoid cell line, EL-4 6.1 C10, to explore further the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bomsztyk K,Sims JE,Stanton TH,Slack J,McMahan CJ,Valentine MA,Dower SK

更新日期：1989-10-01 00:00:00

abstract：:We have utilized a recombinant vector system designed to study gene control elements by fusing them to the Escherichia coli galactokinase gene (galK) to examine the effects of gene expression that result from introducing changes into the 5' noncoding leader region of the galK transcription unit. We varied the length o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johansen H,Schümperli D,Rosenberg M

更新日期：1984-12-01 00:00:00

abstract：:Nitric oxide-releasing compounds were shown to activate an ADP-ribosyltransferase activity in the cytosol of Dictyostelium discoideum. The enzyme ADP-ribosylated a cytosolic protein of approximately 41 kDa, p41. Neither cGMP nor GTP and its analogues affected this ADP-ribosylation. p41 differs from other substrates AD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao Y,Howlett A,Klein C

更新日期：1992-07-01 00:00:00

abstract：:Molecular oxygen (O(2)) began to accumulate in the atmosphere and surface ocean ca. 2,400 million years ago (Ma), but the persistent oxygenation of water masses throughout the oceans developed much later, perhaps beginning as recently as 580-550 Ma. For much of the intervening interval, moderately oxic surface waters ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnston DT,Wolfe-Simon F,Pearson A,Knoll AH

更新日期：2009-10-06 00:00:00

abstract：:Inelastic electron tunneling spectra of nucleosides and nucleotides are presented which show that detailed information on the vibrational spectra of these molecules can be obtained from a few micrograms of material. A series of studies on adenine derivatives demonstrates that unambiguous identification of a large numb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark JM,Coleman RV

更新日期：1976-05-01 00:00:00

abstract：:The semaphorins comprise a large family of membrane-bound and secreted proteins, some of which have been shown to function in axon guidance. We have cloned a transmembrane semaphorin, Sema W, that belongs to the class IV subgroup of the semaphorin family. The mouse and rat forms of Sema W show 97% amino acid sequence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Encinas JA,Kikuchi K,Chedotal A,de Castro F,Goodman CS,Kimura T

更新日期：1999-03-02 00:00:00

abstract：:alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors undergo constitutive and ligand-induced internalization that requires dynamin and the clathrin adaptor complex AP-2. We report here that an atypical basic motif within the cytoplasmic tails of AMPA-type glutamate receptors directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kastning K,Kukhtina V,Kittler JT,Chen G,Pechstein A,Enders S,Lee SH,Sheng M,Yan Z,Haucke V

更新日期：2007-02-20 00:00:00

abstract：:In the troposphere, methanol (CH3OH) is present ubiquitously and second in abundance among organic gases after methane. In the surface ocean, methanol represents a supply of energy and carbon for marine microbes. Here we report direct measurements of air-sea methanol transfer along a ∼10,000-km north-south transect of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang M,Nightingale PD,Beale R,Liss PS,Blomquist B,Fairall C

更新日期：2013-12-10 00:00:00

abstract：:S-nitrosylation, the selective modification of cysteine residues in proteins to form S-nitrosocysteine, is a major emerging mechanism by which nitric oxide acts as a signaling molecule. Even though nitric oxide is intimately involved in the regulation of vascular smooth muscle cell functions, the potential protein tar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greco TM,Hodara R,Parastatidis I,Heijnen HF,Dennehy MK,Liebler DC,Ischiropoulos H

更新日期：2006-05-09 00:00:00

abstract：:The synthesis of cytoplasmic proteins from quiescent and serum-stimulated Swiss 3T3 cells was compared by two-dimensional polyacrylamide gel electrophoresis. Four new proteins of Mrs 26,000, 28,000, 45,000, and 47,000 designated N26, N28, N45, and N47, which were not detectable in quiescent cells, appeared 60 min afte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas G,Thomas G,Luther H

更新日期：1981-09-01 00:00:00

abstract：:Site-specific heritable mutations in maize genes were engineered by introducing chimeric RNA/DNA oligonucleotides. Two independent targets within the endogenous maize acetohydroxyacid synthase gene sequence were modified in a site-specific fashion, thereby conferring resistance to either imidazolinone or sulfonylurea ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu T,Peterson DJ,Tagliani L,St Clair G,Baszczynski CL,Bowen B

更新日期：1999-07-20 00:00:00

abstract：:Familial multiple system tauopathy with presenile dementia (MSTD) is a neurodegenerative disease with an abundant filamentous tau protein pathology. It belongs to the group of familial frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17), a major class of inherited dementing disorders whose gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Murrell JR,Goedert M,Farlow MR,Klug A,Ghetti B

更新日期：1998-06-23 00:00:00

abstract：:Aggression is a universal social behavior important for the acquisition of food, mates, territory, and social status. Aggression in Drosophila is context-dependent and can thus be expected to involve inputs from multiple sensory modalities. Here, we use mechanical disruption and genetic approaches in Drosophila melano...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Versteven M,Vanden Broeck L,Geurten B,Zwarts L,Decraecker L,Beelen M,Göpfert MC,Heinrich R,Callaerts P

更新日期：2017-02-21 00:00:00

abstract：:Understanding the detailed mechanism of the activation of voltage-gated ion channels has been a problem of great current interest. Reliable molecular simulations of voltage effects present a major challenge because meaningful converging microscopic simulations are not yet available and macroscopic treatments involve m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dryga A,Chakrabarty S,Vicatos S,Warshel A

更新日期：2012-02-28 00:00:00

abstract：:Neutrophils are immune cells that bind to, engulf, and destroy bacterial and fungal pathogens in infected tissue, and their clearance by apoptosis is essential for the resolution of inflammation. Killing involves both oxidative and nonoxidative processes, the oxidative pathway requiring electrogenic production of supe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fay AJ,Qian X,Jan YN,Jan LY

更新日期：2006-11-14 00:00:00

abstract：:Facilitation of social attraction and bonding by the evolutionarily conserved neuropeptide oxytocin is well-established in female mammals. However, accumulating behavioral evidence suggests that oxytocin may have evolved sex-specific functional roles in the domain of human social cognition. A critical question is how ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao S,Becker B,Luo L,Geng Y,Zhao W,Yin Y,Hu J,Gao Z,Gong Q,Hurlemann R,Yao D,Kendrick KM

更新日期：2016-07-05 00:00:00

abstract：:The ability to track cells and their patterns of gene expression in living organisms can increase our understanding of tissue development and disease. Gene reporters for bioluminescence, fluorescence, radionuclide, and magnetic resonance imaging (MRI) have been described but these suffer variously from limited depth p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patrick PS,Hammersley J,Loizou L,Kettunen MI,Rodrigues TB,Hu DE,Tee SS,Hesketh R,Lyons SK,Soloviev D,Lewis DY,Aime S,Fulton SM,Brindle KM

更新日期：2014-01-07 00:00:00

abstract：:The partial amino acid sequences of human T-cell growth factors (TCGFs) isolated from normal peripheral blood lymphocytes and from a leukemia T-cell line (Jurkat) show that the amino-terminal sequences of the two proteins (15 residues) are identical. Oligonucleotides based on the published Jurkat TCGF DNA sequence wer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark SC,Arya SK,Wong-Staal F,Matsumoto-Kobayashi M,Kay RM,Kaufman RJ,Brown EL,Shoemaker C,Copeland T,Oroszlan S

更新日期：1984-04-01 00:00:00

abstract：:A methionine-rich low complexity (LC) domain is found within a C-terminal region of the TDP43 RNA-binding protein. Self-association of this domain leads to the formation of labile cross-β polymers and liquid-like droplets. Treatment with H2O2 caused phenomena of methionine oxidation and droplet melting that were rever...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Y,Zhou X,Kato M,Liu D,Ghaemmaghami S,Tu BP,McKnight SL

更新日期：2020-11-17 00:00:00

abstract：:The effects of calcium ion on the Na+ activation gate were studied in squid giant axons. Saxitoxin (STX) was used to block ion entry into Na+ channels without hindering access to the membrane surface, making it possible to distinguish surface effects of calcium from pore-occupancy effects. In the presence of STX, gati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armstrong CM

更新日期：1999-03-30 00:00:00

abstract：:Bacterial proteins often localize to distinct sites within the cell, but the primary cues that dictate localization are largely unknown. Recent evidence has shown that positive membrane curvature can serve as a cue for localization of a peripheral membrane protein. Here we report that localization of the peripheral me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramamurthi KS,Losick R

更新日期：2009-08-11 00:00:00

abstract：:Established T cell dysfunction is a barrier to antitumor responses, and checkpoint blockade presumably reverses this. Many patients fail to respond to treatment and/or develop autoimmune adverse events. The underlying reason for T cell responsiveness remains elusive. Here, we show that susceptibility to checkpoint blo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson CE,Mills LJ,McCurtain JL,Thompson EA,Seelig DM,Bhela S,Quarnstrom CF,Fife BT,Vezys V

更新日期：2019-02-12 00:00:00

abstract：:Molybdate- and ATP-dependent in vitro synthesis of the iron-molybdenum cofactor (FeMo-co) of nitrogenase requires the protein products of at least the nifB, nifN, and nifE genes. Extracts of FeMo-co-negative mutants of Klebsiella pneumoniae and Azotobacter vinelandii with lesions in different genes can be complemented...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah VK,Imperial J,Ugalde RA,Ludden PW,Brill WJ

更新日期：1986-03-01 00:00:00

abstract：:The stability of an immunogen against enzymatic degradation is considered an important factor for the design of synthetic vaccines. For our studies, we have selected an epitope from the tandem-repeat unit of the high-molecular-weight MUC2 mucin glycoprotein, which can be underglycosylated in case of colon cancer. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tugyi R,Uray K,Iván D,Fellinger E,Perkins A,Hudecz F

更新日期：2005-01-11 00:00:00