Oxytocin, the peptide that bonds the sexes also divides them.

abstract：:Myasthenia gravis (MG) is a T cell-regulated, antibody-mediated autoimmune disease. Two peptides representing sequences of the human acetylcholine receptor alpha-subunit, p195-212 and p259-271, were previously shown to stimulate peripheral blood lymphocytes of patients with MG and were found to be immunodominant T cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katz-Levy Y,Paas-Rozner M,Kirshner S,Dayan M,Zisman E,Fridkin M,Wirguin I,Sela M,Mozes E

更新日期：1997-04-01 00:00:00

abstract：:Prothoracicotropic hormone (PTTH) is the central cerebral neurohormone in insect development. Its release has been believed for decades to be confined to one (or two) critical moments early in each developmental stage at which time it triggers prolonged activation of the prothoracic glands to synthesize and release th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vafopoulou X,Steel CG

更新日期：1996-04-16 00:00:00

abstract：:Immunoprecipitation of proteins extracted from metabolically labeled human glioblastoma and fibrosarcoma cells with antiserum to platelet-derived growth factor (PDGF) showed that these cells express and secrete proteins that are recognized specifically by the antiserum. The molecular masses of immunoprecipitated prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pantazis P,Pelicci PG,Dalla-Favera R,Antoniades HN

更新日期：1985-04-01 00:00:00

abstract：:In contrast to mechanisms mediating uptake of intracellular bacterial pathogens, bacterial egress and cell-to-cell transmission are poorly understood. Previously, we showed that the transmission of pathogenic mycobacteria between phagocytic cells also depends on nonlytic ejection through an F-actin based structure, ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerstenmaier L,Pilla R,Herrmann L,Herrmann H,Prado M,Villafano GJ,Kolonko M,Reimer R,Soldati T,King JS,Hagedorn M

更新日期：2015-02-17 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is strongly associated with obesity in most, but not all, ethnic groups, suggesting important ethnic differences in disease susceptibility. Although it is clear that insulin resistance plays a major role in the pathogenesis of T2DM and that insulin resistance is strongly associated with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petersen KF,Dufour S,Feng J,Befroy D,Dziura J,Dalla Man C,Cobelli C,Shulman GI

更新日期：2006-11-28 00:00:00

abstract：:The nucleus accumbens is considered a critical target of the action of drugs of abuse. In this nucleus a "shell" and a "core" have been distinguished on the basis of anatomical and histochemical criteria. The present study investigated the effect in freely moving rats of intravenous cocaine, amphetamine, and morphine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pontieri FE,Tanda G,Di Chiara G

更新日期：1995-12-19 00:00:00

abstract：:Inducible cAMP early repressor (ICER) is a transcriptional repressor, which, because of alternate promoter use, is generated from the 3' region of the cAMP response modulator (Crem) gene. Its expression and nuclear occurrence are elevated by high cAMP levels in naturally occurring regulatory T cells (nTregs). Using tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaeth M,Gogishvili T,Bopp T,Klein M,Berberich-Siebelt F,Gattenloehner S,Avots A,Sparwasser T,Grebe N,Schmitt E,Hünig T,Serfling E,Bodor J

更新日期：2011-02-08 00:00:00

abstract：:The gene encoding the receptor for hyaluronan-mediated motility (RHAMM) is overexpressed in many human cancers. However, it is unclear whether RHAMM plays a causal role in tumor initiation or progression. Using somatic gene transfer in a mouse model of islet cell tumorigenesis, we demonstrate that RHAMM isoform B (RHA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du YC,Chou CK,Klimstra DS,Varmus H

更新日期：2011-10-04 00:00:00

abstract：:Characterization and functional annotation of the large number of proteins predicted from genome sequencing projects poses a major scientific challenge. Whereas several proteomics techniques have been developed to quantify the abundance of proteins, these methods provide little information regarding protein function. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okerberg ES,Wu J,Zhang B,Samii B,Blackford K,Winn DT,Shreder KR,Burbaum JJ,Patricelli MP

更新日期：2005-04-05 00:00:00

abstract：:Glycosylation is one of the most common posttranslational modifications to occur in protein biosynthesis, yet its effect on the thermodynamics and kinetics of proteins is poorly understood. A minimalist model based on the native protein topology, in which each amino acid and sugar ring was represented by a single bead...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shental-Bechor D,Levy Y

更新日期：2008-06-17 00:00:00

abstract：:A previously undescribed toothless flying reptile from northeastern China, Nemicolopterus crypticus gen. et sp. nov., was discovered in the lacustrine sediments of the Early Cretaceous Jiufotang Formation, western Liaoning, China. The specimen consists of an almost complete articulated skeleton (IVPP V14377) and, desp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Kellner AW,Zhou Z,Campos Dde A

更新日期：2008-02-12 00:00:00

abstract：:Anthrax toxin is an intracellularly acting toxin in which sufficient information is available regarding the structure of its transmembrane channel, allowing for detailed investigation of models of translocation. Anthrax toxin, comprising three proteins-protective antigen (PA), lethal factor (LF), and edema factor-tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das D,Krantz BA

更新日期：2016-08-23 00:00:00

abstract：:Myosin-binding protein C (MyBP-C) is an accessory protein of striated muscle thick filaments and a modulator of cardiac muscle contraction. Defects in the cardiac isoform, cMyBP-C, cause heart disease. cMyBP-C includes 11 Ig- and fibronectin-like domains and a cMyBP-C-specific motif. In vitro studies show that in addi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mun JY,Previs MJ,Yu HY,Gulick J,Tobacman LS,Beck Previs S,Robbins J,Warshaw DM,Craig R

更新日期：2014-02-11 00:00:00

abstract：:Organelles in the axoplasm from the squid giant axon move along exogenous actin filaments toward their barbed ends. An approximately 235-kDa protein, the only band recognized by a pan-myosin antibody in Western blots of isolated axoplasmic organelles, has been previously proposed to be a motor for these movements. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bearer EL,DeGiorgis JA,Jaffe H,Medeiros NA,Reese TS

更新日期：1996-06-11 00:00:00

abstract：:Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base. The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 down-regulated genes; ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown DD,Wang Z,Furlow JD,Kanamori A,Schwartzman RA,Remo BF,Pinder A

更新日期：1996-03-05 00:00:00

abstract：:Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional elongation, chromatin conformation, as well as the regulation of specific histone H3 methylations. Herein, we report a strategy for the site-specific chemical attachment of ubiquitin to preassembled nucleosomes. This allowed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holt MT,David Y,Pollock S,Tang Z,Jeon J,Kim J,Roeder RG,Muir TW

更新日期：2015-08-18 00:00:00

abstract：:The recently characterized corticosteroid receptor on amphibian neuronal membranes appears to mediate rapid, stress-induced changes in male reproductive behaviors. Because the transduction mechanisms associated with this receptor are unknown, we performed radioligand binding studies to determine whether this steroid r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orchinik M,Murray TF,Franklin PH,Moore FL

更新日期：1992-05-01 00:00:00

abstract：:Cyclic electron flow (CEF) around photosystem I is thought to balance the ATP/NADPH energy budget of photosynthesis, requiring that its rate be finely regulated. The mechanisms of this regulation are not well understood. We observed that mutants that exhibited constitutively high rates of CEF also showed elevated prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strand DD,Livingston AK,Satoh-Cruz M,Froehlich JE,Maurino VG,Kramer DM

更新日期：2015-04-28 00:00:00

abstract：:We have found that phagocytic leukocytes exposed to the tumor-promoting agent, 12-O-tetradecanoyl phorbol-13-acetate, efficiently release carbon-1 of 2-deoxyglucose in the form of CO2 with concurrent intracellular accumulation of a phosphorylated 5-carbon intermediate. In the absence of 12-O-tetradecanoyl phorbol-13-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zabos P,Kyner D,Mendelsohn N,Schreiber C,Waxman S,Christman J,Acs G

更新日期：1978-11-01 00:00:00

abstract：:Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to immune-dependent and conventional therapeutic modalities. As a hallmark of glioblastoma (GBM), TAMCs are massively recruited to reach up to 50% of the brain tumor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang P,Miska J,Lee-Chang C,Rashidi A,Panek WK,An S,Zannikou M,Lopez-Rosas A,Han Y,Xiao T,Pituch KC,Kanojia D,Balyasnikova IV,Lesniak MS

更新日期：2019-11-19 00:00:00

abstract：:Several significant steps have been completed toward a general method for the site-specific incorporation of unnatural amino acids into proteins in vivo. An "orthogonal" suppressor tRNA was derived from Saccharomyces cerevisiae tRNA2Gln. This yeast orthogonal tRNA is not a substrate in vitro or in vivo for any Escheri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu DR,Schultz PG

更新日期：1999-04-27 00:00:00

abstract：:P elements have been cloned and sequenced from Drosophila nebulosa. Their sequences have diverged less than 6% from P elements of Drosophila melanogaster. However D. nebulosa P elements have nucleotide changes that close all four open reading frames found in the D. melanogaster P element. Microinjection experiments sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansman RA,Shade RO,Grigliatti TA,Brock HW

更新日期：1987-09-01 00:00:00

abstract：:The ecology of microbes in the gut has been shown to play important roles in the health of the host. To better understand microbial growth and population dynamics in the proximal colon, the primary region of bacterial growth in the gut, we built and applied a fluidic channel that we call the "minigut." This is a chann...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cremer J,Segota I,Yang CY,Arnoldini M,Sauls JT,Zhang Z,Gutierrez E,Groisman A,Hwa T

更新日期：2016-10-11 00:00:00

abstract：:We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG) for contrast enhancement. The optical examination was performed concurrently with a magnetic resonance imaging (MRI) exam ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ntziachristos V,Yodh AG,Schnall M,Chance B

更新日期：2000-03-14 00:00:00

abstract：:Two-component signal transduction systems are most often found in prokaryotic organisms where they are responsible for mediating the cellular responses to many environmental stimuli. These systems are composed of an autophosphorylating histidine kinase and a response regulator. We have found evidence for the existence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alex LA,Borkovich KA,Simon MI

更新日期：1996-04-16 00:00:00

abstract：:The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietzschold B,Kao M,Zheng YM,Chen ZY,Maul G,Fu ZF,Rupprecht CE,Koprowski H

更新日期：1992-08-01 00:00:00

abstract：:Mice with a targeted deletion of beta3 integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of beta3+/+ mice by 14 days. In contrast, only 4% of beta3-/- mice developed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bakewell SJ,Nestor P,Prasad S,Tomasson MH,Dowland N,Mehrotra M,Scarborough R,Kanter J,Abe K,Phillips D,Weilbaecher KN

更新日期：2003-11-25 00:00:00

abstract：:Knowledge of how insects are actually affected by sex pheromones deployed throughout a crop so as to disrupt mating has lacked a mechanistic framework sufficient for guiding optimization of this environmentally friendly pest-control tactic. Major hypotheses are competitive attraction, desensitization, and camouflage. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller JR,McGhee PS,Siegert PY,Adams CG,Huang J,Grieshop MJ,Gut LJ

更新日期：2010-01-05 00:00:00

abstract：:The human retinoic acid receptor (hRAR) is a member of the nuclear receptor superfamily that regulates the transcription of target genes in a ligand-dependent manner. The three hRAR isotypes are targets for retinoids that are used in the treatment of various diseases, including breast cancer and skin diseases. Drug ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klaholz BP,Mitschler A,Belema M,Zusi C,Moras D

更新日期：2000-06-06 00:00:00

abstract：:Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular structures and metabolic pathways. The finding that patients with mutations in mitochondrial rRNA are hypersusceptible to aminoglycoside-induced hearing loss has indicated a possible role for mitochondrial protein synthesis. To stud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie SN,Akshay S,Kalapala SK,Bruell CM,Shcherbakov D,Böttger EC

更新日期：2008-12-30 00:00:00