Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system.

abstract：:A flexible finite difference method is described that gives approximate solutions of linear elliptic partial differential equations, Lu = G, subject to general linear boundary conditions. The method gives high-order accuracy. The values of the unknown approximation function U are determined at mesh points by solving a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynch RE,Rice JR

更新日期：1978-06-01 00:00:00

abstract：:We report the identification and cloning of a 28-kDa polypeptide (p28) in Tetrahymena macronuclei that shares several features with the well studied heterochromatin-associated protein HP1 from Drosophila. Notably, like HP1, p28 contains both a chromodomain and a chromoshadow domain. p28 also shares features with linke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang H,Wiley EA,Lending CR,Allis CD

更新日期：1998-11-10 00:00:00

abstract：:Chronic and adult-onset GM2 gangliosidoses are neurological disorders caused by marked deficiency of the A isoenzyme of beta-hexosaminidase; they occur in the Ashkenazi Jewish population, though less frequently than classic (infantile) Tay-Sachs disease. Earlier biosynthetic studies had identified a defective alpha-su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paw BH,Kaback MM,Neufeld EF

更新日期：1989-04-01 00:00:00

abstract：:Zooxanthellae are unicellular algae that occur as endosymbionts in many hundreds of common marine invertebrates. The issue of zooxanthella diversity has been difficult to address. Most zooxanthellae have been placed in the dinoflagellate genus Symbiodinium as one or several species that are not easily distinguished. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowan R,Powers DA

更新日期：1992-04-15 00:00:00

abstract：:Are animals conscious? If so, when did consciousness evolve? We address these long-standing and essential questions using a modern neuroscientific approach that draws on diverse fields such as consciousness studies, evolutionary neurobiology, animal psychology, and anesthesiology. We propose that the stepwise emergenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mashour GA,Alkire MT

更新日期：2013-06-18 00:00:00

abstract：:The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capital...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spence MM,Rubin SM,Dimitrov IE,Ruiz EJ,Wemmer DE,Pines A,Yao SQ,Tian F,Schultz PG

更新日期：2001-09-11 00:00:00

abstract：:In the preceding paper we described an experiment that determined the in vivo forward mutation rate in a single replication cycle for spleen necrosis virus. In addition to substitutions, frameshifts, and hypermutations, the mutated proviruses contained two classes of deletions. One class of deletions contained short d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pathak VK,Temin HM

更新日期：1990-08-01 00:00:00

abstract：:Lead pollution in Arctic ice reflects large-scale historical changes in midlatitude industrial activities such as ancient lead/silver production and recent fossil fuel burning. Here we used measurements in a broad array of 13 accurately dated ice cores from Greenland and Severnaya Zemlya to document spatial and tempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McConnell JR,Chellman NJ,Wilson AI,Stohl A,Arienzo MM,Eckhardt S,Fritzsche D,Kipfstuhl S,Opel T,Place PF,Steffensen JP

更新日期：2019-07-23 00:00:00

abstract：:Chromophore-assisted light inactivation (CALI) offers the only method capable of modulating specific protein activities in localized regions and at particular times. Here, we generalize CALI so that it can be applied to a wider range of tasks. Specifically, we show that CALI can work with a genetically inserted epitop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Surrey T,Elowitz MB,Wolf PE,Yang F,Nédélec F,Shokat K,Leibler S

更新日期：1998-04-14 00:00:00

abstract：:A strong mutator effect has been observed in Escherichia coli K-12 strains mutated in the bglY gene (27 min). The frequency of point mutations is not modified in bglY mutant strains. In contrast, a strong increase in spontaneous generation of large deletions has been observed in these strains, both for chromosomal mar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lejeune P,Danchin A

更新日期：1990-01-01 00:00:00

abstract：:Gap junctions are specialized membrane regions that seem to mediate intercellular communication. They appear to contain closely packed arrays of equally sized particles all of which, upon freeze-cleaving, remain attached to one membrane leaflet and not to the other. One gap junction cleavage face, therefore, always ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Staehelin LA

更新日期：1972-05-01 00:00:00

abstract：:Vertebrate hematopoietic stem cells are derived from vental mesoderm, which is postulated to migrate to both extra- and intraembryonic positions during gastrula and neurula stages. Extraembryonic migration has previously been documented, but the origin and migration of intraembryonic hematopoietic cells have not been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Detrich HW 3rd,Kieran MW,Chan FY,Barone LM,Yee K,Rundstadler JA,Pratt S,Ransom D,Zon LI

更新日期：1995-11-07 00:00:00

abstract：:Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are associated with dysbiosis of the gut microbiome. Emerging evidence suggests that small-molecule metabolites derived from bacterial breakdown of a variety of dietary nutrients confer a wide array of host benefits, including amelio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scott SA,Fu J,Chang PV

更新日期：2020-08-11 00:00:00

abstract：:Autophagy, a conserved pathway that delivers intracellular materials into lysosomes for degradation, is involved in development, aging, and a variety of diseases. Accumulating evidence demonstrates that autophagy plays a protective role against infectious diseases by diminishing intracellular pathogens, including bact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zou CG,Ma YC,Dai LL,Zhang KQ

更新日期：2014-08-26 00:00:00

abstract：:The location of renin (EC 3.4.99.19) in rat pituitary was determined by the peroxidase-antiperoxidase immunohistochemical technique. By using antisera prepared with purified rat renal renin, an immunoreactive substance was localized within ovoid cells scattered throughout the anterior pituitary. These cells were shown...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naruse K,Takii Y,Inagami T

更新日期：1981-12-01 00:00:00

abstract：:This paper presents a computational model for color coding that provides a functional explanation of how humans perceive colors in a homogeneous color space. Beginning with known properties of human cone photoreceptors, the model estimates the locations of the reflectance spectra of Munsell color chips in perceptual c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romney AK,Chiao CC

更新日期：2009-06-23 00:00:00

abstract：:In recent years, the field of psychology has begun to conduct replication tests on a large scale. Here, we show that "replicator degrees of freedom" make it far too easy to obtain and publish false-negative replication results, even while appearing to adhere to strict methodological standards. Specifically, using data...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryan CJ,Yeager DS,O'Brien JM

更新日期：2019-12-17 00:00:00

abstract：:Two chlorophyll-protein complexes associated with photosystem II (PSII) of the cyanobacterium Anacystis nidulans R2 have been detected. The larger of the two complexes, CPVI-1, contained a 71-kDa and a 42-kDa protein. The 71-kDa protein was determined to be the anchor protein of the phycobilisomes (the light-harvestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pakrasi HB,Riethman HC,Sherman LA

更新日期：1985-10-01 00:00:00

abstract：:Evidence indicates that the modulatory effects of the adrenergic stress hormone epinephrine as well as several other neuromodulatory systems on memory storage are mediated by activation of beta-adrenergic mechanisms in the amygdala. In view of our recent findings indicating that the amygdala is involved in mediating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quirarte GL,Roozendaal B,McGaugh JL

更新日期：1997-12-09 00:00:00

abstract：:Hox genes encode transcription factors that control spatial patterning during embryogenesis. To date, downstream targets of Hox genes have proven difficult to identify. Here, we describe studies designed to identify target genes under the control of the murine transcription factor Hoxc8. We used a mouse 16,463 gene ol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lei H,Wang H,Juan AH,Ruddle FH

更新日期：2005-02-15 00:00:00

abstract：:The regulatory mechanisms underlying the uptake and utilization of multiple types of carbohydrates in actinomycetes remain poorly understood. In this study, we show that GlnR (central regulator of nitrogen metabolism) serves as a universal regulator of nitrogen metabolism and plays an important, previously unknown rol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao CH,Yao L,Xu Y,Liu WB,Zhou Y,Ye BC

更新日期：2015-12-22 00:00:00

abstract：:By using a simplified model of small open liquid-like clusters with surface effects, in the gas phase, it is shown how the statistical thermodynamics of small systems can be extended to include metastable supersaturated gaseous states not too far from the gas-liquid equilibrium transition point. To accomplish this, on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL,Chamberlin RV

更新日期：1998-10-27 00:00:00

abstract：:Bloom syndrome is a disorder of profound and early cancer predisposition in which cells become hypermutable, exhibit high frequency of sister chromatid exchanges, and show increased micronuclei. BLM, the gene mutated in Bloom syndrome, has been cloned previously, and the BLM protein is a member of the RecQ family of D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imamura O,Campbell JL

更新日期：2003-07-08 00:00:00

abstract：:The ability to dynamically organize functional nanoparticles (NPs) via the use of environmental triggers (temperature, pH, light, or solvent polarity) opens up important perspectives for rapid and convenient construction of a rich variety of complex assemblies and materials with new structures and functionalities. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Wang Z,He Y,Yoon YJ,Jung J,Zhang G,Lin Z

更新日期：2018-02-13 00:00:00

abstract：:The two nitrile groups at the wings of the nonnucleoside HIV-1 reverse transcriptase (RT) inhibitor TMC278 are both identified in high-sensitivity 2D IR spectroscopy experiments of the HIV-1 RT/TMC278 complex. The vibrational spectra indicate that the two arms of the inhibitor sense quite different environments within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang C,Bauman JD,Das K,Remorino A,Arnold E,Hochstrasser RM

更新日期：2008-02-05 00:00:00

abstract：:Microtubules (MTs) are hollow cytoskeletal filaments assembled from αβ-tubulin heterodimers. Tau, an unstructured protein found in neuronal axons, binds to MTs and regulates their dynamics. Aberrant Tau behavior is associated with neurodegenerative dementias, including Alzheimer's. Here, we report on a direct force me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung PJ,Choi MC,Miller HP,Feinstein HE,Raviv U,Li Y,Wilson L,Feinstein SC,Safinya CR

更新日期：2015-11-24 00:00:00

abstract：:The SCF ubiquitin ligase complex of budding yeast triggers DNA replication by catalyzing ubiquitination of the S phase cyclin-dependent kinase inhibitor SIC1. SCF is composed of three proteins-ySKP1, CDC53 (Cullin), and the F-box protein CDC4-that are conserved from yeast to humans. As part of an effort to identify co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyapina SA,Correll CC,Kipreos ET,Deshaies RJ

更新日期：1998-06-23 00:00:00

abstract：:In Escherichia coli, acetyl phosphate can be formed from acetyl-CoA via the phosphotransacetylase (phosphate acetyltransferase; acetyl-CoA:orthophosphate acetyltransferase, EC 2.3.1.8) reaction and from acetate (plus ATP) via the acetate kinase (ATP:acetate phosphotransferase, EC 2.7.2.1) reaction. By restricting acet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong JS,Hunt AG,Masters PS,Lieberman MA

更新日期：1979-03-01 00:00:00

abstract：:Two human B-cell differentiation antigens, Bp35 and Bp50, apparently play distinct roles as signal receptors in B-cell activation. Monoclonal antibodies (mAbs) to either Bp35 or Bp50 deliver positive signals to B cells that stimulate their transition through the cell cycle. mAb to Bp35, like anti-immunoglobulin antibo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark EA,Ledbetter JA

更新日期：1986-06-01 00:00:00

abstract：:Amplitude-modulated phosphorescence/microwave double-resonance (AM-PMDR) spectra are reported for complexes of methylmercury(II) cation, designated CH3Hg(II), with tryptophan and glyceraldehyde-3-phosphate dehydrogenase (GPDHase; from rabbit muscle). Wavelength shifts are observed in the AM-PMDR spectra of CH3Hg(II)-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JM,Maki AH

更新日期：1982-07-01 00:00:00