Immunohistochemical localization of renin in luteinizing hormone-producing cells of rat pituitary.

abstract：:We present a model to explain how the neurosecretory system of aquatic mollusks generates their diversity of shell structures and pigmentation patterns. The anatomical and physiological basis of this model sets it apart from other models used to explain shape and pattern. The model reproduces most known shell shapes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boettiger A,Ermentrout B,Oster G

更新日期：2009-04-21 00:00:00

abstract：:Previously we reported that proteasome inhibitors were able to overcome Bcl-2-mediated protection from apoptosis. Here we show that inhibition of the proteasome activity in Bcl-2-overexpressing cells accumulates the proapoptotic Bax protein to mitochondria/cytoplasm, where it interacts to Bcl-2 protein. This event was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li B,Dou QP

更新日期：2000-04-11 00:00:00

abstract：:One of the earliest detectable events during plant-pathogen interaction is a rapid increase in ethylene biosynthesis. This gaseous plant stress hormone may be a signal for plants to activate defense mechanisms against invading pathogens such as bacteria, fungi, and viruses. The effect of ethylene on four plant genes i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ecker JR,Davis RW

更新日期：1987-08-01 00:00:00

abstract：:We previously found that a minor fraction of single-stranded DNA (ss-DNA) isolated from native nuclear DNA of normal chicken embryonic cells and cells of other species hybridized with bulk nuclear DNA or cellular RNA in great excess. At least one-third of ss-DNA belonging to the nonrepetitious part of the cell genome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leibovitch SA,Tapiero H,Harel J

更新日期：1977-09-01 00:00:00

abstract：:Based largely on studies in xenograft models, lipocalin-2 (Lcn2) has been implicated in the progression of multiple types of human tumors, including breast cancer. Here we examine the role of Lcn2 in mammary tumorigenesis and lung metastasis using an in vivo molecular genetics approach. We crossed a well-characterized...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berger T,Cheung CC,Elia AJ,Mak TW

更新日期：2010-02-16 00:00:00

abstract：:In most animals, longevity is achieved at the expense of fertility, but queen honey bees do not show this tradeoff. Queens are both long-lived and fertile, whereas workers, derived from the same genome, are both relatively short-lived and normally sterile. It has been suggested, on the basis of results from workers, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corona M,Velarde RA,Remolina S,Moran-Lauter A,Wang Y,Hughes KA,Robinson GE

更新日期：2007-04-24 00:00:00

abstract：:Phototropin is a blue light photoreceptor for tropic responses, relocation of chloroplasts, and stomata opening in plants. Phototropin has two chromophoric domains named light-oxygen-voltage-sensing (LOV) 1 and 2 in the N-terminal half, and a serine/threonine (Ser/Thr) protein kinase motif in the C-terminal half. Conc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuoka D,Tokutomi S

更新日期：2005-09-13 00:00:00

abstract：:Mutations in the DAX-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita (AHC) critical region on the X chromosome; NR0B1] gene cause X-linked AHC associated with hypogonadotropic hypogonadism. DAX-1 encodes an unusual orphan member of the nuclear hormone receptor superfamily, acting as a transcriptional rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann SG,Lalli E,Sassone-Corsi P

更新日期：2002-06-11 00:00:00

abstract：:An essential element in the web-trap architecture, the capture silk spun by ecribellate orb spiders consists of glue droplets sitting astride a silk filament. Mechanically this thread presents a mixed solid-liquid behavior unknown to date. Under extension, capture silk behaves as a particularly stretchy solid, owing t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elettro H,Neukirch S,Vollrath F,Antkowiak A

更新日期：2016-05-31 00:00:00

abstract：:Spiperone, a dopamine antagonist widely used as a specific ligand for dopamine and serotonin receptors, is actively accumulated into the F4C1 strain of rat pituitary tumor cells. The accumulation of 10 nM [3H]spiperone was linear for 3 min and reached a steady state after 10 min. Spiperone accumulation was reduced 50%...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dannies PS,Rudnick MS,Fishkes H,Rudnick G

更新日期：1984-03-01 00:00:00

abstract：:Humans and other primates are distinct among placental mammals in having exceptionally slow rates of growth, reproduction, and aging. Primates' slow life history schedules are generally thought to reflect an evolved strategy of allocating energy away from growth and reproduction and toward somatic investment, particul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pontzer H,Raichlen DA,Gordon AD,Schroepfer-Walker KK,Hare B,O'Neill MC,Muldoon KM,Dunsworth HM,Wood BM,Isler K,Burkart J,Irwin M,Shumaker RW,Lonsdorf EV,Ross SR

更新日期：2014-01-28 00:00:00

abstract：:Understanding the heritability of neural systems linked to psychopathology is not sufficient to implicate them as intergenerational neural mediators. By closely examining how individual differences in neural phenotypes and psychopathology cosegregate as they fall through the family tree, we can identify the brain syst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox AS,Oler JA,Shackman AJ,Shelton SE,Raveendran M,McKay DR,Converse AK,Alexander A,Davidson RJ,Blangero J,Rogers J,Kalin NH

更新日期：2015-07-21 00:00:00

abstract：:Heat shock factors (HSFs) are the master regulators of transcription under protein-damaging conditions, acting in an environment where the overall transcription is silenced. We determined the genomewide transcriptional program that is rapidly provoked by HSF1 and HSF2 under acute stress in human cells. Our results rev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vihervaara A,Sergelius C,Vasara J,Blom MA,Elsing AN,Roos-Mattjus P,Sistonen L

更新日期：2013-09-03 00:00:00

abstract：:The heat shock protein (Hsp)70 family of molecular chaperones interacts with unfolded proteins through a C-terminal substrate-binding domain (SBD) that is controlled by nucleotide binding to the N-terminal domain. The ATPase cycle is regulated by cochaperones, including DnaJ proteins that accelerate ATP hydrolysis to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awad W,Estrada I,Shen Y,Hendershot LM

更新日期：2008-01-29 00:00:00

abstract：:Exposure of adipocytes to antibodies to the insulin receptor results in a blockade of (125)I-labeled insulin binding, stimulation of glucose oxidation, and many more insulin-like effects. Allowing for differences in purity, antireceptor antibody is equipotent with insulin on a molar basis. Both the bivalent F(ab')(2) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn CR,Baird KL,Jarrett DB,Flier JS

更新日期：1978-09-01 00:00:00

abstract：:The beta plasmid from Streptococcus faecalis strain DS5, which codes for resistance to erythromycin and lincomycin, was introduced into a Lancefield group F streptococcus, strain DR1501, by transformation. This strain, DR1501 (beta), was found to be an excellent donor of the beta plasmid and readily transferred the re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LeBlanc DJ,Hawley RJ,Lee LN,St Martin EJ

更新日期：1978-07-01 00:00:00

abstract：:We present data that demonstrate that three MR elements isolated from wild populations of Drosophila melanogaster on two continents can cause large deletions of the X chromosome in males. The deleted chromosomes, termed mini-X chromosomes, are induced at a frequency of approximately 1:4000 in chromosomes that are init...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green MM,Yamamoto MT,Miklos GL

更新日期：1987-07-01 00:00:00

abstract：:β subunits of high voltage-gated Ca2+ (CaV) channels promote cell-surface expression of pore-forming α1 subunits and regulate channel gating through binding to the α-interaction domain (AID) in the first intracellular loop. We addressed the stability of CaV α1B-β interactions by rapamycin-translocatable CaV β subunits...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeon JH,Park CG,Hille B,Suh BC

更新日期：2018-10-16 00:00:00

abstract：:The mammary gland consists of an adipose tissue that, in a process called branching morphogenesis, is invaded by a ductal epithelial network comprising basal and luminal epithelial cells. Stem and progenitor cells drive mammary growth, and their proliferation is regulated by multiple extracellular cues. One of the key...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kessenbrock K,Smith P,Steenbeek SC,Pervolarakis N,Kumar R,Minami Y,Goga A,Hinck L,Werb Z

更新日期：2017-03-21 00:00:00

abstract：:Most studies of cytoskeletal organelles have concentrated on molecular analyses of abundant and biochemically accessible structures. In many of the classical cases, however, the nature of the system chosen has precluded a concurrent genetic analysis. The mitotic spindle of the yeast Saccharomyces cerevisiae is one exa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pillus L,Solomon F

更新日期：1986-04-01 00:00:00

abstract：:Calls for the eradication of malaria require the development of global and regional strategies based on a strong and consistent evidence base. Evidence from the previous global malaria eradication program and more recent transborder control campaigns have shown the importance of accounting for human movement in introd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatem AJ,Smith DL

更新日期：2010-07-06 00:00:00

abstract：:Metalloproteases from at least two Gram-negative organisms selectively hydrolyze the surface of human fixed washed platelets. The protease-treated platelets lose their ability to aggregate with bovine von Willebrand factor and human von Willebrand factor plus ristocetin. The present study reports the membrane glycopro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper HA,Bennett WP,White GC 2nd,Wagner RH

更新日期：1982-03-01 00:00:00

abstract：:SapB is a morphogenetic peptide that is important for aerial mycelium formation by the filamentous bacterium Streptomyces coelicolor. Production of SapB commences during aerial mycelium formation and depends on most of the genes known to be required for the morphogenesis of aerial hyphae. Furthermore, the application ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kodani S,Hudson ME,Durrant MC,Buttner MJ,Nodwell JR,Willey JM

更新日期：2004-08-03 00:00:00

abstract：:Influenza is a lipid-enveloped, pleomorphic virus. We combine electron cryotomography and analysis of images of frozen-hydrated virions to determine the structural organization of filamentous influenza A virus. Influenza A/Udorn/72 virions are capsule-shaped or filamentous particles of highly uniform diameter. We show...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calder LJ,Wasilewski S,Berriman JA,Rosenthal PB

更新日期：2010-06-08 00:00:00

abstract：:The locus control region of the beta-globin gene is composed of four erythroid-specific hypersensitive sites. Hypersensitive site 2 has been shown to be a powerful enhancer and contains a tandem repeat sequence for the transcription factors AP1 and NFE2 (activating protein 1 and nuclear factor erythroid 2, respectivel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan K,Lu R,Chang JC,Kan YW

更新日期：1996-11-26 00:00:00

abstract：:We have cloned and completely sequenced a gene encoding the heavy chain of Dictyostelium myosin I. Like the myosin I molecules from Acanthamoeba, the Dictyostelium myosin I heavy chain is composed of a globular head domain fused to a 45-kDa glycine-, proline-, and alanine-rich carboxyl-terminal domain, rather than the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung G,Saxe CL 3rd,Kimmel AR,Hammer JA 3rd

更新日期：1989-08-01 00:00:00

abstract：:Egg activation is the process by which a mature oocyte becomes capable of supporting embryo development. In vertebrates and echinoderms, activation is induced by fertilization. Molecules introduced into the egg by the sperm trigger progressive release of intracellular calcium stores in the oocyte. Calcium wave(s) spre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaneuchi T,Sartain CV,Takeo S,Horner VL,Buehner NA,Aigaki T,Wolfner MF

更新日期：2015-01-20 00:00:00

abstract：:Synaptic vesicles release neurotransmitter by following a process of vesicle docking and exocytosis. Although these steps are well established, it has been difficult to observe and measure these rates directly in living synapses. Here, by combining the direct imaging of single synaptic vesicles and synaptic ribbons, I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zenisek D

更新日期：2008-03-25 00:00:00

abstract：:Viral infection leads to activation of the transcription factors interferon regulatory factor-3 and NF-kappaB, which collaborate to induce type I IFNs. The RNA helicase proteins RIG-I and MDA5 were recently identified as two cytoplasmic viral RNA sensors that recognize different species of viral RNAs produced during v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diao F,Li S,Tian Y,Zhang M,Xu LG,Zhang Y,Wang RP,Chen D,Zhai Z,Zhong B,Tien P,Shu HB

更新日期：2007-07-10 00:00:00

abstract：:Mononucleated myogenic cells from 11-day-old chicken embryos were infected with tsLA24 or tsNY68, temperature-sensitive transformation mutants of Rous sarcoma virus. The infected mononucleated myogenic cells were incubated at the nonpermissive temperature (41 degrees C) and allowed to develop into multinucleated myotu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi N,Kaji A

更新日期：1978-11-01 00:00:00