The neural origins of shell structure and pattern in aquatic mollusks.

abstract：:The phase transition for turbulent diffusion, reported by Avellaneda and Majda [Avellaneda, M. & Majda, A. J. (1994) Philos. Trans. R. Soc. London A 346, 205-233, and several earlier papers], is traced to a modeling assumption in which the energy spectrum of the turbulent fluid is singularly dependent on the viscosity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallstrom TC

更新日期：1995-11-21 00:00:00

abstract：:Retrieval of recently acquired declarative memories depends on the hippocampus, but with time, retrieval is increasingly sustainable by neocortical representations alone. This process has been conceptualized as system-level consolidation. Using functional magnetic resonance imaging, we assessed over the course of thre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takashima A,Petersson KM,Rutters F,Tendolkar I,Jensen O,Zwarts MJ,McNaughton BL,Fernández G

更新日期：2006-01-17 00:00:00

abstract：:Activins and inhibins, members of the type beta transforming growth factor superfamily of growth regulatory proteins, are produced in multiple tissues and affect diverse physiologic processes. Using embryonic stem cell technology, we previously demonstrated that inhibin can function as a gonadal tumor suppressor. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matzuk MM,Finegold MJ,Mather JP,Krummen L,Lu H,Bradley A

更新日期：1994-09-13 00:00:00

abstract：:Loss of ATP accompanying accumulation of dATP has recently been reported to occur in the erythrocytes and lymphoblasts of patients with T lymphocytic leukemia during treatment with deoxycoformycin, an inhibitor of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) that causes the accumulation of deoxyadenosine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bagnara AS,Hershfield MS

更新日期：1982-04-01 00:00:00

abstract：:A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Presente A,Boyles RS,Serway CN,de Belle JS,Andres AJ

更新日期：2004-02-10 00:00:00

abstract：:In the T-cell somatic mutant J.CaM1, the T-cell antigen receptor complex is poorly coupled to the inositolphospholipid second messenger system; some antibodies against the invariant CD3 subunit of the receptor retain their agonist function in J.CaM1. Here we show by a combination of complementation assays that the mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldsmith MA,Dazin PF,Weiss A

更新日期：1988-11-01 00:00:00

abstract：:Groundwater arsenic (As) is elevated in the shallow Holocene aquifers of Bangladesh. In the dry season, the shallow groundwater discharges to major rivers. This process may influence the chemistry of the river and the hyporheic zone sediment. To assess the fate of As during discharge, surface (0-5 cm) and subsurface (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Mailloux B,Jung HB,Hoque MA,Stute M,Ahmed KM,Zheng Y

更新日期：2009-10-06 00:00:00

abstract：:Peripheral blood leukocytes, obtained from volunteers after vaccination or natural illness with influenza, were assayed for cytotoxicity against influenza virus-infected cells. Approximately 7 days after vaccination or the onset of respiratory illness, peak cytotoxicity was demonstrated in a chromium-release assay. Se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenberg SB,Six HR,Drake S,Couch RB

更新日期：1979-09-01 00:00:00

abstract：:The persistent tetrodotoxin (TTX)-sensitive sodium current, detected in neurons of many regions of mammalian brains, is associated with many essential neuronal activities, including boosting of excitatory synaptic inputs, acceleration of firing rates, and promotion of oscillatory neuronal activities. However, the orig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Song W,Dong K

更新日期：2004-08-10 00:00:00

abstract：:We postulated that a synergistic combination of two innate immune functions, pathogen surface recognition and lysis, in a protein chimera would lead to a robust class of engineered antimicrobial therapeutics for protection against pathogens. In support of our hypothesis, we have engineered such a chimera to protect ag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dandekar AM,Gouran H,Ibáñez AM,Uratsu SL,Agüero CB,McFarland S,Borhani Y,Feldstein PA,Bruening G,Nascimento R,Goulart LR,Pardington PE,Chaudhary A,Norvell M,Civerolo E,Gupta G

更新日期：2012-03-06 00:00:00

abstract：:The importance of carbon in Earth's mantle greatly exceeds its modest abundance of approximately 1,000-4,000 ppm. Carbon is a constituent of key terrestrial volatiles (CO, CO(2), CH(4)), it forms diamonds, and it may also contribute to the bulk electrical properties of the silicate Earth. In contrast to that of the ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayden LA,Watson EB

更新日期：2008-06-24 00:00:00

abstract：:We present ab initio calculations of the phase diagram of liquid CO(2) and its melting curve over a wide range of pressure and temperature conditions, including those relevant to the Earth. Several distinct liquid phases are predicted up to 200 GPa and 10,000 K based on their structural and electronic characteristics....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boates B,Teweldeberhan AM,Bonev SA

更新日期：2012-09-11 00:00:00

abstract：:NFATc (a member of the family of nuclear factors of activated T cells) is a transcriptional factor responsible for the Ca(2+)-inducible activation of cytokine genes during the immune response. In resting T cells, NFATc is retained in the cytoplasm by a mechanism that depends on multiple phosphorylations in an N-termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park S,Uesugi M,Verdine GL

更新日期：2000-06-20 00:00:00

abstract：:T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and extraterminal domain (BET) family proteins regulate gene transcription during lineage-specific differentiation of naïve CD4+ T cells to produce mature T-helper cells. Inhib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung K,Lu G,Sharma R,Vincek A,Zhang R,Plotnikov AN,Zhang F,Zhang Q,Ju Y,Hu Y,Zhao L,Han X,Meslamani J,Xu F,Jaganathan A,Shen T,Zhu H,Rusinova E,Zeng L,Zhou J,Yang J,Peng L,Ohlmeyer M,Walsh MJ,Zhang DY,

更新日期：2017-03-14 00:00:00

abstract：:Several overlapping chromosomal deletions spanning the albino locus in the mouse cause perinatal lethality when homozygous and a block in the transcriptional induction of various unlinked hepatocyte-specific genes. Studies of such lethal albino deletion homozygotes in perinatal stages revealed a deficiency in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaret KS,Milos P,Lia M,Bali D,Gluecksohn-Waelsch S

更新日期：1992-07-15 00:00:00

abstract：:Whereas 234(92)U142 and other actinon nuclei have ground-state bands that indicate that each nucleus consists of a sphere and a single revolving cluster with constant composition and with only a steady increase in the moment of inertia with increase in J, the angular-momentum quantum number, many of the lanthanon grou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1991-02-01 00:00:00

abstract：:The rapid worldwide spread of severe acute respiratory syndrome demonstrated the potential threat an infectious disease poses in a closely interconnected and interdependent world. Here we introduce a probabilistic model that describes the worldwide spread of infectious diseases and demonstrate that a forecast of the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hufnagel L,Brockmann D,Geisel T

更新日期：2004-10-19 00:00:00

abstract：:Interleukin 6 (IL-6) is a cytokine that acts on various cell types. Here we show that IL-6 mRNA is produced in vivo in two self-limiting physiologic angiogenic processes: (i) the formation of the vascular system accompanying development of ovarian follicles and (ii) the formation of a capillary network in the maternal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Motro B,Itin A,Sachs L,Keshet E

更新日期：1990-04-01 00:00:00

abstract：:The Arabidopsis thaliana disease resistance genes RPS2 and RPM1 belong to a class of plant disease resistance genes that encode proteins that contain an N-terminal tripartite nucleotide binding site (NBS) and a C-terminal tandem array of leucine-rich repeats. RPS2 and RPM1 confer resistance to strains of the bacterial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leister RT,Ausubel FM,Katagiri F

更新日期：1996-12-24 00:00:00

abstract：:By combining the pairwise interactions between proteins, as predicted by the conserved co-occurrence of their genes in operons, we obtain protein interaction networks. Here we study the properties of such networks to identify functional modules: sets of proteins that together are involved in a biological process. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snel B,Bork P,Huynen MA

更新日期：2002-04-30 00:00:00

abstract：:We predict by first principles a phase transition in alumina at approximately 3.7 Mbar and room temperature from the CaIrO(3)-type polymorph to another with the U(2)S(3)-type structure. Because alumina is used as window material in shock-wave experiments, this transformation should be important for the analysis of sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Umemoto K,Wentzcovitch RM

更新日期：2008-05-06 00:00:00

abstract：:Epidermal growth factor (EGF) receptor monomers and noncovalently associated dimers were isolated by sucrose density gradient centrifugation, and their respective binding and autophosphorylation activities were determined. We find that monomers are low-affinity receptors and dimers are high-affinity receptors. In the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Böni-Schnetzler M,Pilch PF

更新日期：1987-11-01 00:00:00

abstract：:Chromosomal RNA was isolated from several rat tissues by a new technique. It is shown by RNA-DNA hybridization that each tissue contains a distinct population of chromosomal RNA sequences. This finding is compatible with the proposal that chromosomal RNA is involved in the process of gene activation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayfield JE,Bonner J

更新日期：1971-11-01 00:00:00

abstract：:Niemann-Pick type C (NPC) 1 protein plays important roles in moving cholesterol and other lipids out of late endosomes by means of vesicular trafficking, but it is not known whether NPC1 directly interacts with cholesterol. We performed photoaffinity labeling of intact cells expressing fluorescent protein (FP)-tagged ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohgami N,Ko DC,Thomas M,Scott MP,Chang CC,Chang TY

更新日期：2004-08-24 00:00:00

abstract：:Chemokine homologs are encoded by many large DNA viruses, suggesting that they contribute to control of host leukocyte transmigration and trafficking during viral infection. Murine cytomegalovirus carries a CC (beta) chemokine homolog gene giving rise to two related proteins, murine cytomegalovirus chemokine 1 and 2 (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saederup N,Lin YC,Dairaghi DJ,Schall TJ,Mocarski ES

更新日期：1999-09-14 00:00:00

abstract：:X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disease associated with an antisense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1 This unique insertion coincides with six additional noncoding sequence changes in TAF1, the gene that encodes TATA-binding protein-associated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bragg DC,Mangkalaphiban K,Vaine CA,Kulkarni NJ,Shin D,Yadav R,Dhakal J,Ton ML,Cheng A,Russo CT,Ang M,Acuña P,Go C,Franceour TN,Multhaupt-Buell T,Ito N,Müller U,Hendriks WT,Breakefield XO,Sharma N,Ozelius LJ

更新日期：2017-12-19 00:00:00

abstract：:Previous studies implicate the hypothalamic ventromedial nucleus (VMN) in glycemic control. Here, we report that selective inhibition of the subset of VMN neurons that express the transcription factor steroidogenic-factor 1 (VMN(SF1) neurons) blocks recovery from insulin-induced hypoglycemia whereas, conversely, activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meek TH,Nelson JT,Matsen ME,Dorfman MD,Guyenet SJ,Damian V,Allison MB,Scarlett JM,Nguyen HT,Thaler JP,Olson DP,Myers MG Jr,Schwartz MW,Morton GJ

更新日期：2016-04-05 00:00:00

abstract：:I summarize recent computational and experimental work that addresses the inherent variability in the synaptic and intrinsic conductances in normal healthy brains and shows that multiple solutions (sets of parameters) can produce similar circuit performance. I then discuss a number of issues raised by this observation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marder E

更新日期：2011-09-13 00:00:00

abstract：:The DNA-containing Epstein-Barr herpesvirus has been implicated in the etiology of Burkitt's lymphoma, a malignant tumor of children in Africa. Recently, however, particles possessing four biochemical characteristics of RNA tumor viruses have also been identified in these tumors. The fact that both types of viruses ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peters WP,Kufe D,Schlom J,Frankel JW,Prickett CO,Groupé V,Spiegelman S

更新日期：1973-11-01 00:00:00

abstract：:Soil systems are being increasingly exposed to the interactive effects of biological invasions and climate change, with rising temperatures expected to benefit alien over indigenous species. We assessed this expectation for an important soil-dwelling group, the springtails, by determining whether alien species show br...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Janion-Scheepers C,Phillips L,Sgrò CM,Duffy GA,Hallas R,Chown SL

更新日期：2018-01-02 00:00:00