Redox trapping of arsenic during groundwater discharge in sediments from the Meghna riverbank in Bangladesh.

abstract：:To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin S,Yu W,Wang B,Zhao Y,En K,Zhu J,Cheng X,Zhou C,Lin H,Wang Z,Hojaiji H,Yeung C,Milla C,Davis RW,Emaminejad S

更新日期：2020-08-11 00:00:00

abstract：:Gram-negative bacteria deliver a cadre of virulence factors directly into the cytoplasm of eukaryotic host cells to promote pathogenesis and/or commensalism. Recently, families of virulence proteins have been recognized that function as E3 Ubiquitin-ligases. How these bacterial ligases integrate into the ubiquitin (Ub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin I,Eakin C,Blanc MP,Klevit RE,Miller SI,Brzovic PS

更新日期：2010-02-16 00:00:00

abstract：:Seamless and minimally invasive integration of 3D electronic circuitry within host materials could enable the development of materials systems that are self-monitoring and allow for communication with external environments. Here, we report a general strategy for preparing ordered 3D interconnected and addressable macr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Xie C,Dai X,Jin L,Zhou W,Lieber CM

更新日期：2013-04-23 00:00:00

abstract：:The effect of Zn2+ on a voltage-dependent, transient potassium current (IA) in acutely dissociated neurons from the suprachiasmatic nucleus was studied with the whole-cell patch-clamp technique. At micromolar concentrations, Zn2+ markedly potentiated IA activated from a holding potential of -60 mV, which is the restin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang RC,Peng YW,Yau KW

更新日期：1993-12-15 00:00:00

abstract：:Electron microscopy is arguably the most powerful tool for spatial imaging of structures. As such, 2D and 3D microscopies provide static structures with subnanometer and increasingly with angstrom-scale spatial resolution. Here we report the development of 4D ultrafast electron microscopy, whose capability imparts ano...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lobastov VA,Srinivasan R,Zewail AH

更新日期：2005-05-17 00:00:00

abstract：:The embryonic neuroepithelium gives rise to the components of the central nervous system in the mature animal. To study the early development of the murine central nervous system we have sought to isolate growth factor receptors from the neuroepithelium of the neural tube of 10-day-old mouse embryos. Because many grow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid HH,Wilks AF,Bernard O

更新日期：1990-02-01 00:00:00

abstract：:Protein kinase P (PK-P) activated by histones or certain other basic compounds has been purified previously from yeast [Yanagita, Y., Abdel-Ghany, M., Raden, D., Nelson, N. & Racker, E. (1987) Proc. Natl. Acad. Sci. USA 84, 925-929]. It is shown here that PK-P is present in solubilized membranes of A-431 carcinoma cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abdel-Ghany M,Kole HK,Racker E

更新日期：1987-12-01 00:00:00

abstract：:Activation of eukaryotic class II gene expression involves the formation of a transcription initiation complex that includes RNA polymerase II, general transcription factors, and SRB components of the holoenzyme. Negative regulators of transcription have been described, but it is not clear whether any are general repr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gadbois EL,Chao DM,Reese JC,Green MR,Young RA

更新日期：1997-04-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) most frequently occurs in southern China and southeast Asia. Epidemiology studies link NPC to genetic predisposition, Epstein-Barr virus (EBV) infection, and environmental factors. Genetic studies indicate that mutations in chromatin-modifying enzymes are the most frequent genetic altera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ke L,Zhou H,Wang C,Xiong G,Xiang Y,Ling Y,Khabir A,Tsao GS,Zeng Y,Zeng M,Busson P,Kieff E,Guo X,Zhao B

更新日期：2017-09-05 00:00:00

abstract：:Achieving label-free, molecular-specific imaging with high spatial resolution in deep tissue is often considered the grand challenge of optical imaging. To accomplish this goal, significant optical scattering in tissues has to be overcome while achieving molecular specificity without resorting to extrinsic labeling. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yakovlev VV,Zhang HF,Noojin GD,Denton ML,Thomas RJ,Scully MO

更新日期：2010-11-23 00:00:00

abstract：:Walker-256 carcinosarcoma cells grown in tissue culture medium containing inhibitory DNA prepared from the tumor are shown to have an unaltered growth in vitro, but a diminished capacity to produce malignant tumors on injection into the rat. Coincident with this change in virulence is the induction of tRNA methylase i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern BC,Halpern RM,Chaney SQ,Smith RA

更新日期：1970-12-01 00:00:00

abstract：:We have selected from a mixture of random polynucleotides an RNA that is able to replicate in the presence of the DNA-dependent RNA polymerase of Escherichia coli, provided the medium contains Mn(2+) and ITP, in addition to ATP, CTP, and UTP. The RNA consists of a chain of about 125 (+/-25) nucleotides and appears to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biebricher CK,Orgel LE

更新日期：1973-03-01 00:00:00

abstract：:Monoamines, including dopamine (DA), have been linked to aggression in various species. However, the precise role or roles served by the amine in aggression have been difficult to define because dopaminergic systems influence many behaviors, and all can be altered by changing the function of dopaminergic neurons. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alekseyenko OV,Chan YB,Li R,Kravitz EA

更新日期：2013-04-09 00:00:00

abstract：:Fully atomistic molecular-dynamics (MD) simulations of perfluoroalkylalkane molecules at the surface of water show the spontaneous formation of aggregates whose size and topography closely resemble the experimentally observed hemimicelles for this system. Furthermore, the grazing incidence X-ray diffraction (GIXD) pat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva GMC,Morgado P,Lourenço P,Goldmann M,Filipe EJM

更新日期：2019-07-23 00:00:00

abstract：:Tiazofurin (2-beta-D-ribofuranosyl-4-thiazole-carboxamide; NSC 286193), an antitumor carbon-linked nucleoside that inhibits IMP dehydrogenase (IMP:NAD+ oxidoreductase; EC 1.1.1.205) and depletes guanylate levels, can activate the erythroid differentiation program of K-562 human leukemia cells. Tiazofurin-mediated cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olah E,Natsumeda Y,Ikegami T,Kote Z,Horanyi M,Szelenyi J,Paulik E,Kremmer T,Hollan SR,Sugar J

更新日期：1988-09-01 00:00:00

abstract：:The thylakoid compartments of plant chloroplasts are a vital destination for copper. Copper is needed to form holo-plastocyanin, which must shuttle electrons between photosystems to convert light into biologically useful chemical energy. Copper can bind tightly to proteins, so it has been hypothesized that copper part...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banci L,Bertini I,Ciofi-Baffoni S,Kandias NG,Robinson NJ,Spyroulias GA,Su XC,Tottey S,Vanarotti M

更新日期：2006-05-30 00:00:00

abstract：:Immune-mediated pulmonary diseases are a significant public health concern. Analysis of leukocyte behavior in the lung is essential for understanding cellular mechanisms that contribute to normal and diseased states. Here, we used two-photon imaging to study neutrophil extravasation from pulmonary vessels and subseque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kreisel D,Nava RG,Li W,Zinselmeyer BH,Wang B,Lai J,Pless R,Gelman AE,Krupnick AS,Miller MJ

更新日期：2010-10-19 00:00:00

abstract：:Evolution of an oxygenic atmosphere required primordial life to accommodate the toxicity associated with reactive oxygen species. We have characterized an archaeal antioxidant from the hyperthermophilic acidophile Sulfolobus solfataricus. The amino acid sequence of this approximately 22-kDa protein shares little seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiedenheft B,Mosolf J,Willits D,Yeager M,Dryden KA,Young M,Douglas T

更新日期：2005-07-26 00:00:00

abstract：:We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moser MB,Moser EI,Forrest E,Andersen P,Morris RG

更新日期：1995-10-10 00:00:00

abstract：:Transcriptional regulation of gene expression is a major mechanism used by plants to confer phenotypic plasticity, and yet compared with other eukaryotes or bacteria, little is known about the design principles. We generated an extensive catalog of nascent and steady-state transcripts in Arabidopsis thaliana seedlings...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hetzel J,Duttke SH,Benner C,Chory J

更新日期：2016-10-25 00:00:00

abstract：:Memory CD4(+) T helper (Th) cells are central to long-term protection against pathogens, but they can also be pathogenic and drive chronic inflammatory disorders. How these pathogenic memory Th cells are maintained, particularly at sites of local inflammation, remains unclear. We found that ectopic lymphoid-like struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinoda K,Hirahara K,Iinuma T,Ichikawa T,Suzuki AS,Sugaya K,Tumes DJ,Yamamoto H,Hara T,Tani-Ichi S,Ikuta K,Okamoto Y,Nakayama T

更新日期：2016-05-17 00:00:00

abstract：:The amino acid sequence for chicken smooth muscle myosin light chain kinase (smMLCK) was deduced from a full-length cDNA. This has allowed definition of both the complete sequence of the inactive 64-kDa proteolytic fragment, which contains the pseudosubstrate autoregulatory sequence, and of the active 61-kDa Ca2+/calm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olson NJ,Pearson RB,Needleman DS,Hurwitz MY,Kemp BE,Means AR

更新日期：1990-03-01 00:00:00

abstract：:The neuraminidase inhibitors oseltamivir and zanamivi are used to treat H5N1 influenza. However, oseltamivir-resistant H5N1 viruses have been isolated from oseltamivir-treated patients. Moreover, reassortment between H5N1 viruses and oseltamvir-resistant human H1N1 viruses currently circulating could create oseltamivi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiso M,Takahashi K,Sakai-Tagawa Y,Shinya K,Sakabe S,Le QM,Ozawa M,Furuta Y,Kawaoka Y

更新日期：2010-01-12 00:00:00

abstract：:Reaction networks displaying bistability provide a chemical mechanism for long-term memory storage in cells, as exemplified by many epigenetic switches. These biological systems are not only bistable but switchable, in the sense that they can be flipped from one state to the other by application of specific molecular ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padirac A,Fujii T,Rondelez Y

更新日期：2012-11-20 00:00:00

abstract：:The development of new antimicrobial drugs is a priority to combat the increasing spread of multidrug-resistant bacteria. This development is especially problematic in gram-negative bacteria due to the outer membrane (OM) permeability barrier and multidrug efflux pumps. Therefore, we screened for compounds that target...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hart EM,Mitchell AM,Konovalova A,Grabowicz M,Sheng J,Han X,Rodriguez-Rivera FP,Schwaid AG,Malinverni JC,Balibar CJ,Bodea S,Si Q,Wang H,Homsher MF,Painter RE,Ogawa AK,Sutterlin H,Roemer T,Black TA,Rothman DM,Walker

更新日期：2019-10-22 00:00:00

abstract：:Colon carcinoma is one of the leading causes of death from cancer and is characterized by a heterogenic pool of cells with distinct differentiation patterns. Recently, it was reported that a population of undifferentiated cells from a primary tumor, so-called cancer stem cells (CSC), can reconstitute the original tumo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vermeulen L,Todaro M,de Sousa Mello F,Sprick MR,Kemper K,Perez Alea M,Richel DJ,Stassi G,Medema JP

更新日期：2008-09-09 00:00:00

abstract：:Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT genetic polymorphisms represent a striking example of the potential clinical value of pharmacogenetics. Subjects homozygous for TPMT*3A, the most common variant allele for low activity, an allele that encodes a protein with two...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Nguyen TV,McLaughlin RW,Sikkink LA,Ramirez-Alvarado M,Weinshilboum RM

更新日期：2005-06-28 00:00:00

abstract：:Previous work has uncovered the existence of an Escherichia coli locus, groE, that is essential for bacterial growth, lambda phage and T4 phage head morphogenesis, and T5 phage tail assembly. Our genetic and biochemical analyses of lambda groE+ transducing phages and their deletion and point mutant derivatives show th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilly K,Murialdo H,Georgopoulos C

更新日期：1981-03-01 00:00:00

abstract：:CSB/ERCC6 belongs to an orphan subfamily of SWI2/SNF2-related chromatin remodelers and plays crucial roles in gene expression, DNA damage repair, and the maintenance of genome integrity. The molecular basis of chromatin remodeling by Cockayne syndrome B protein (CSB) is not well understood. Here we investigate the mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Xu J,Limbo O,Fei J,Kassavetis GA,Chong J,Kadonaga JT,Russell P,Li B,Wang D

更新日期：2019-03-26 00:00:00

abstract：:Circular dichroism (CD) and magnetic circular dichroism (MCD) spectra of nitrogenase components (MoFe protein and Fe protein) from Azotobacter vinelandii (Av) and Klebsiella pneumoniae (Kp) have been obtained in the near infrared-visible-near ultraviolet spectral region. Previously, visible CD was reported to be absen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephens PJ,McKenna CE,Smith BE,Nguyen HT,McKenna MC,Thomson AJ,Devlin F,Jones JB

更新日期：1979-06-01 00:00:00