当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain.

Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain.

Abstract：

:The embryonic neuroepithelium gives rise to the components of the central nervous system in the mature animal. To study the early development of the murine central nervous system we have sought to isolate growth factor receptors from the neuroepithelium of the neural tube of 10-day-old mouse embryos. Because many growth factor receptors are members of the protein-tyrosine kinase family, we have used the polymerase chain reaction to amplify mRNA sequences from 10-day-old mouse embryo neuroepithelium; these sequences lie between the nucleotide sequences of two highly conserved amino acid motifs from the catalytic domain of protein-tyrosine kinases. By using this technique we have isolated a clone encoding the murine basic fibroblast growth factor receptor (bFGF-R), as well as a shorter form of this mRNA. This latter cDNA comprised 75% of the bFGF-R cDNA clones isolated from the immortalized neuroepithelial cell lines. This variant mRNA, designated here as N-bFGF-R, appears to be expressed at higher levels in neuronal cells in early stages of development. The bFGF-R is a member of a multigene family, as demonstrated by Southern blot analysis and the cloning of two other members of this family.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Reid HH,Wilks AF,Bernard O

doi

10.1073/pnas.87.4.1596

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

1596-600

issue

4

eissn

0027-8424

issn

1091-6490

journal_volume

87

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response.

    abstract：:The induction of heat shock proteins (HSP) by cellular stress and the activation of the hypothalamic-pituitary-adrenal axis by physiologic stress are biological responses that aid in the maintenance of cellular and organismal homeostasis, respectively. In this report, restraint stress, known to activate the hypothalam...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.21.9873

    authors： Blake MJ,Udelsman R,Feulner GJ,Norton DD,Holbrook NJ

    更新日期：1991-11-01 00:00:00

  • Thy-1: a differentiation marker of potential mammary myoepithelial cells in vitro.

    abstract：:The rat mammary cell line Rama 25 [Bennett, D.C., Peachey, L.A., Durbin, H. & Rudland, P.S. (1978) Cell 15, 283--298] differentiates morphologically in vitro from a cuboidal form to a fusiform cell resembling myoepithelial cells. This differentiation occurs in all clonal isolates of the line. By using three different ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.12.6093

    authors： Lennon VA,Unger M,Dulbecco R

    更新日期：1978-12-01 00:00:00

  • Gas-phase water-mediated equilibrium between methylglyoxal and its geminal diol.

    abstract：:In aqueous solution, aldehydes, and to a lesser extent ketones, hydrate to form geminal diols. We investigate the hydration of methylglyoxal (MG) in the gas phase, a process not previously considered to occur in water-restricted environments. In this study, we spectroscopically identified methylglyoxal diol (MGD) and ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0912121107

    authors： Axson JL,Takahashi K,De Haan DO,Vaida V

    更新日期：2010-04-13 00:00:00

  • Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.

    abstract：:Recently, hepatic peroxisome proliferator-activated receptor (PPAR)γ has been implicated in hepatic lipid accumulation. We found that the C3H mouse strain does not express PPARγ in the liver and, when subject to a high-fat diet, is resistant to hepatic steatosis, compared with C57BL/6 (B6) mice. Adenoviral PPARγ2 inje...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1203218109

    authors： Lee YJ,Ko EH,Kim JE,Kim E,Lee H,Choi H,Yu JH,Kim HJ,Seong JK,Kim KS,Kim JW

    更新日期：2012-08-21 00:00:00

  • Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.

    abstract：:Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical loading. Pathological mechanical stress can lead to maladaptive ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1414298111

    authors： Lee W,Leddy HA,Chen Y,Lee SH,Zelenski NA,McNulty AL,Wu J,Beicker KN,Coles J,Zauscher S,Grandl J,Sachs F,Guilak F,Liedtke WB

    更新日期：2014-11-25 00:00:00

  • Translation of mRNAs for subunits of chloroplast coupling factor 1 in spinach.

    abstract：:The chloroplast coupling factor 1 consists of five nonidentical subunits, three of which (alpha, beta, and epsilon subunits) have been shown in several laboratories to be synthesized within chloroplasts. The site of synthesis of the remaining two (gamma and delta subunits) was investigated by analyzing products direct...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.79.20.6304

    authors： Watanabe A,Price CA

    更新日期：1982-10-01 00:00:00

  • Overt and covert effects of endogenous and exogenous ecdysone in puparium formation of flies.

    abstract：:Mature larvae of Sarcophaga argyrostoma fail to form puparia when kept in contact with water, but pupariate after having been subsequently exposed to dryness for 30 hr. They become increasingly more sensitive to injected ecdysone the longer the exposure to dry conditions. A second wet treatment halts the production of...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.67.1.331

    authors： Zdarek J,Fraenkel G

    更新日期：1970-09-01 00:00:00

  • Energy coupling in the lactose transport system of Escherichia coli.

    abstract：:A mutant (ML 308-22) was isolated from Escherichia coli ML 308, which had lost the normal capacity to accumulate lactose analogs despite an increase in the membrane carrier activity. The exit of thiomethylgalactoside was much faster than normal, accounting for the inability of the cell to maintain high intracellular c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.65.1.63

    authors： Wong PT,Kashket ER,Wilson TH

    更新日期：1970-01-01 00:00:00

  • Abnormal ambient glucose levels inhibit proteoglycan core protein gene expression and reduce proteoglycan accumulation during chondrogenesis: possible mechanism for teratogenic effects of maternal diabetes.

    abstract：:Using a tissue culture system based on a nearly pure population of avian precartilage mesenchymal cells, we have found that ambient glucose levels as little as 50% lower, or 100% higher, than normally present in embryonic sera are deleterious to cartilage development, as measured by the accumulation of highly sulfated...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.24.10113

    authors： Leonard CM,Bergman M,Frenz DA,Macreery LA,Newman SA

    更新日期：1989-12-01 00:00:00

  • Information dynamics shape the sexual networks of Internet-mediated prostitution.

    abstract：:Like many other social phenomena, prostitution is increasingly coordinated over the Internet. The online behavior affects the offline activity; the reverse is also true. We investigated the reported sexual contacts between 6,624 anonymous escorts and 10,106 sex buyers extracted from an online community from its beginn...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0914080107

    authors： Rocha LE,Liljeros F,Holme P

    更新日期：2010-03-30 00:00:00

  • Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: implications for the pathophysiology of psychiatric disorders.

    abstract：:Chronic administration of the atypical antipsychotic drug, clozapine, to rodents has been shown to increase the concentration of apolipoprotein D (apoD) in several area of the brain, suggesting that apoD could be involved in the therapeutic effects of antipsychotic drugs and/or the pathology of psychotic illnesses. He...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.071056198

    authors： Thomas EA,Dean B,Pavey G,Sutcliffe JG

    更新日期：2001-03-27 00:00:00

  • Signaling properties of a covalent modification cycle are altered by a downstream target.

    abstract：:We used a model system of purified components to explore the effects of a downstream target on the signaling properties of a covalent modification cycle, an example of retroactivity. In the experimental system used, a bifunctional enzyme catalyzed the modification and demodification of its substrate protein, with both...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0913815107

    authors： Ventura AC,Jiang P,Van Wassenhove L,Del Vecchio D,Merajver SD,Ninfa AJ

    更新日期：2010-06-01 00:00:00

  • Role of the nonheme Fe(II) center in the biosynthesis of the plant hormone ethylene.

    abstract：:The final step of ethylene biosynthesis in plants is catalyzed by the enzyme 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase (ACCO). In addition to ACC, Fe(II), O2, CO2, and ascorbate are required for in vitro enzyme activity. Direct evidence for the role of the Fe(II) center in the recombinant avocado ACCO has no...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.14.7905

    authors： Rocklin AM,Tierney DL,Kofman V,Brunhuber NM,Hoffman BM,Christoffersen RE,Reich NO,Lipscomb JD,Que L Jr

    更新日期：1999-07-06 00:00:00

  • Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions.

    abstract：:Integrins contain two structurally homologous but distantly related domains: an I-like domain that is present in all beta-subunits and an I domain that is present in some alpha-subunits. Atomic resolution and mutagenesis studies of alpha I domains demonstrate a C-terminal, axial displacement of the alpha7-helix that a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0307291101

    authors： Yang W,Shimaoka M,Chen J,Springer TA

    更新日期：2004-02-24 00:00:00

  • The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.

    abstract：:Acute and chronic injuries to the heart result in perturbation of intracellular calcium signaling, which leads to pathological cardiac hypertrophy and remodeling. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the transduction of calcium signals in the heart, but the specific isoforms o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0813013106

    authors： Backs J,Backs T,Neef S,Kreusser MM,Lehmann LH,Patrick DM,Grueter CE,Qi X,Richardson JA,Hill JA,Katus HA,Bassel-Duby R,Maier LS,Olson EN

    更新日期：2009-02-17 00:00:00

  • Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein engineering.

    abstract：:Of two closely related species of geese, one, the greylag goose, lives in the Indian plains all year round, while the other, the bar-headed goose, lives at the Tibetan lakes and migrates across the Himalayas to winter in India. Another species, the Andean goose, lives in the High Andes all year round. Possession of a ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.15.6519

    authors： Jessen TH,Weber RE,Fermi G,Tame J,Braunitzer G

    更新日期：1991-08-01 00:00:00

  • Monoclonal antibodies against polyoma virus tumor antigens.

    abstract：:A method is described for the production of hybridoma cell lines secreting antibodies directed against the polyoma virus tumor antigens (T-Ags). Ten cloned lines have been established by this procedure and designated alpha Py Cl and C4, with activities against all three T-Ags; alpha Py LT1, -4 and -7, with activities ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.79.4.1059

    authors： Dilworth SM,Griffin BE

    更新日期：1982-02-01 00:00:00

  • Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.

    abstract：:Understanding the pathways that control epithelial carcinogenesis is vital to the development of effective treatments. The Polycomb group family member Bmi1 is overexpressed in numerous epithelial tumors, but its role in their development has not been established. We now show a key role for Bmi1 in lung adenocarcinoma...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0803574105

    authors： Dovey JS,Zacharek SJ,Kim CF,Lees JA

    更新日期：2008-08-19 00:00:00

  • Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome.

    abstract：:Adeno-associated virus (AAV) is a small human Dependovirus whose low immunogenicity and capacity for long-term persistence have led to its widespread use as vector for gene therapy. Despite great recent successes in AAV-based gene therapy, further improvements in vector technology may be hindered by an inadequate unde...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1721883115

    authors： Smith-Moore S,Neil SJD,Fraefel C,Linden RM,Bollen M,Rowe HM,Henckaerts E

    更新日期：2018-04-10 00:00:00

  • The antisense bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides.

    abstract：:In most human follicular B cell lymphomas the bcl-2 gene is up-regulated as a result of the t(14;18) chromosomal translocation generating a hybrid bcl-2-IgH mRNA. Recently, we have identified in t(14;18)-positive cells a bcl-2-IgH mRNA in the antisense orientation, putatively responsible for the overexpression of bcl-...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.15.8150

    authors： Morelli S,Delia D,Capaccioli S,Quattrone A,Schiavone N,Bevilacqua A,Tomasini S,Nicolin A

    更新日期：1997-07-22 00:00:00

  • A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin.

    abstract：:Recently, a 29-residue cyclic peptide was synthesized (TrPepz) that was reported to possess nearly the same catalytic activity and specificity as the pancreatic serine protease, trypsin, for hydrolysis of a small ester substrate, N-tosyl-L-arginine methyl ester (TAME), and small and large peptides [Atassi, M. Z. & Man...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.10.4110

    authors： Wells JA,Fairbrother WJ,Otlewski J,Laskowski M Jr,Burnier J

    更新日期：1994-05-10 00:00:00

  • The tomato ethylene receptors NR and LeETR4 are negative regulators of ethylene response and exhibit functional compensation within a multigene family.

    abstract：:The plant hormone ethylene is involved in many developmental processes, including fruit ripening, abscission, senescence, and leaf epinasty. Tomato contains a family of ethylene receptors, designated LeETR1, LeETR2, NR, LeETR4, and LeETR5, with homology to the Arabidopsis ETR1 ethylene receptor. Transgenic plants with...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.090550597

    authors： Tieman DM,Taylor MG,Ciardi JA,Klee HJ

    更新日期：2000-05-09 00:00:00

  • Ras-independent transformation by v-Src.

    abstract：:Signaling by a variety of receptor and nonreceptor tyrosine kinases is mediated by Ras, a membrane-associated GTPase. Expression of v-Src, a transforming nonreceptor tyrosine kinase, results in Ras activation, and inhibition of Ras function in NIH 3T3 cells suppresses transformation by v-Src, indicating that in these ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.7.3028

    authors： Aftab DT,Kwan J,Martin GS

    更新日期：1997-04-01 00:00:00

  • Algorithmic design of self-assembling structures.

    abstract：:We study inverse statistical mechanics: how can one design a potential function so as to produce a specified ground state? In this article, we show that unexpectedly simple potential functions suffice for certain symmetrical configurations, and we apply techniques from coding and information theory to provide mathemat...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0901636106

    authors： Cohn H,Kumar A

    更新日期：2009-06-16 00:00:00

  • Nonplanar peptide bonds in proteins are common and conserved but not biased toward active sites.

    abstract：:The planarity of peptide bonds is an assumption that underlies decades of theoretical modeling of proteins. Peptide bonds strongly deviating from planarity are considered very rare features of protein structure that occur for functional reasons. Here, empirical analyses of atomic-resolution protein structures reveal t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1107115108

    authors： Berkholz DS,Driggers CM,Shapovalov MV,Dunbrack RL Jr,Karplus PA

    更新日期：2012-01-10 00:00:00

  • Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.

    abstract：:Inhibition of mitochondrial complex I is one of the leading hypotheses for dopaminergic neuron death associated with Parkinson's disease (PD). To test this hypothesis genetically, we used a mouse strain lacking functional Ndufs4, a gene encoding a subunit required for complete assembly and function of complex I. Delet...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0807581105

    authors： Choi WS,Kruse SE,Palmiter RD,Xia Z

    更新日期：2008-09-30 00:00:00

  • An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.

    abstract：:Influenza hemagglutinin (HA) glycoprotein is the primary surface antigen targeted by the host immune response and a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutics. HA enables viral entry into host cells via receptor binding and membrane fusion and is a validated targ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2006893117

    authors： Yao Y,Kadam RU,Lee CD,Woehl JL,Wu NC,Zhu X,Kitamura S,Wilson IA,Wolan DW

    更新日期：2020-08-04 00:00:00

  • Cytosolic rat brain synapsin I is a diacylglycerol kinase.

    abstract：:The phosphorylation of diacylglycerol (DG), a reaction catalyzed by DG kinase, may be critical in the termination of effector-induced signals mediated by protein kinase C. Synapsin I is a principal target of intracellular protein kinases and is thought to be involved in the release of neurotransmitter from axon termin...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.14.6137

    authors： Kahn DW,Besterman JM

    更新日期：1991-07-15 00:00:00

  • A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

    abstract：:Among 21 human mammary tumors analyzed for transforming genes by transfection of NIH/3T3 cells, only DNA of a carcinosarcoma cell line, HS578T, registered as positive. A Harvey (H)-ras oncogene identified in this line was cloned in biologically active form and the activating lesion was identified as a single nucleotid...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.81.17.5384

    authors： Kraus MH,Yuasa Y,Aaronson SA

    更新日期：1984-09-01 00:00:00

  • Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor.

    abstract：:Specific low-affinity receptors for leukemia inhibitory factor (LIF), oncostatin M (OSM; gp130), and ciliary neurotrophic factor (CNTF; receptor alpha, CNTFR alpha) may be utilized in various combinations to generate high-affinity binding sites and signal transduction. We have tested the ability of combinations of the...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.3.1119

    authors： Gearing DP,Ziegler SF,Comeau MR,Friend D,Thoma B,Cosman D,Park L,Mosley B

    更新日期：1994-02-01 00:00:00