Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.

abstract：:Sequence comparisons of genomes or expressed sequence tags (ESTs) from related organisms provide insight into functional conservation and diversification. We compare the sequences of ESTs from the male accessory gland of Drosophila simulans to their orthologs in its close relative Drosophila melanogaster, and demonstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson WJ,Clark AG,Waldrip-Dail HM,Wolfner MF,Aquadro CF

更新日期：2001-06-19 00:00:00

abstract：:Control over the fluorescence of supramolecular assemblies is crucial for the development of chemosensors and light-emitting materials. Consequently, the postsynthetic modification of supramolecular structures via host-guest interactions has emerged as an efficient strategy in recent years that allows the facile tunin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Yin S,Zhang J,Zhou Z,Saha ML,Lu C,Stang PJ

更新日期：2017-03-21 00:00:00

abstract：:Oil spills can lead to irreversible environmental degradation and are a potential hazard to human health. We study how onshore oil spills affect neonatal and infant mortality by combining spatial data from the Nigerian Oil Spill Monitor with Demographic and Health Surveys. To identify a causal effect, we compare sibli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruederle A,Hodler R

更新日期：2019-03-19 00:00:00

abstract：:Liquid RNA.DNA hybridization with separated strands of adenovirus type 2 DNA revealed that late nuclear RNA can hybridize to about 85% of the 1-strand and 10-15% of the h-strand, whereas late cytoplasmic RNA hybridizes to 65-70% and 25% of the l- and h-strand, respectively. With separated strands from the six EcoRI fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pettersson U,Philipson L

更新日期：1974-12-01 00:00:00

abstract：:Synthesis of mouse metallothionein (MT)-I and MT-II is transcriptionally induced by the synthetic glucocorticoid, dexamethasone (DEX) or both in vivo as well as in numerous cell lines. However, the location(s) of a glucocorticoid response element (GRE) has not been described. The observation that a marked MT-I gene, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly EJ,Sandgren EP,Brinster RL,Palmiter RD

更新日期：1997-09-16 00:00:00

abstract：:X chromosome-linked severe combined immunodeficiency disease (SCIDX1) is characterized by the absence of T-cell and natural killer cell development and results from molecular mutations of the interleukin 2 receptor (IL-2R) gamma chain. The IL-2R gamma chain is a common component of the IL-2, IL-4, and IL-7 receptor sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiSanto JP,Rieux-Laucat F,Dautry-Varsat A,Fischer A,de Saint Basile G

更新日期：1994-09-27 00:00:00

abstract：:We report potent inhibition of the Mg(II).ATP-dependent protein phosphatase, Fc.M, by the regulatory subunit dimer of type II cAMP-dependent protein kinase, RII2. The protein kinase catalytic subunit has no effect on phosphatase activity and is unable to substitute for kinase FA in the kinase FA- and Mg(II).ATP-mediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jurgensen SR,Chock PB,Taylor S,Vandenheede JR,Merlevede W

更新日期：1985-11-01 00:00:00

abstract：:It is generally believed that the old quantum theory, as presented by Niels Bohr in 1913, fails when applied to few electron systems, such as the H(2) molecule. Here, we find previously undescribed solutions within the Bohr theory that describe the potential energy curve for the lowest singlet and triplet states of H(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Svidzinsky AA,Scully MO,Herschbach DR

更新日期：2005-08-23 00:00:00

abstract：:Steroidogenic acute regulatory protein (StAR) appears to mediate the rapid increase in pregnenolone synthesis stimulated by tropic hormones. cDNAs encoding StAR were isolated from a human adrenal cortex library. Human StAR, coexpressed in COS-1 cells with cytochrome P450scc and adrenodoxin, increased pregnenolone synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugawara T,Holt JA,Driscoll D,Strauss JF 3rd,Lin D,Miller WL,Patterson D,Clancy KP,Hart IM,Clark BJ

更新日期：1995-05-23 00:00:00

abstract：:Neonatal ablation of the suprachiasmatic nucleus in the rat has two important consequences. First, the direct projection from the retina to the suprachiasmatic nucleus fails to develop and no other retinal projection to any hypothalamic nucleus is formed. Second, circadian rhythms in drinking and spontaneous locomotor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosko S,Moore RY

更新日期：1978-12-01 00:00:00

abstract：:Excitatory amino acid transporters (EAATs) buffer and remove synaptically released L-glutamate and maintain its concentrations below neurotoxic levels. EAATs also mediate a thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability. Here, we demonstrate that modification of a cys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seal RP,Shigeri Y,Eliasof S,Leighton BH,Amara SG

更新日期：2001-12-18 00:00:00

abstract：:Most of the activities of IFN-gamma are the result of STAT1-mediated transcriptional responses. In this study, we show that the BRCA1 tumor suppressor acts in concert with STAT1 to differentially activate transcription of a subset of IFN-gamma target genes and mediates growth inhibition by this cytokine. After IFN-gam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouchi T,Lee SW,Ouchi M,Aaronson SA,Horvath CM

更新日期：2000-05-09 00:00:00

abstract：:Combinatorial transcription codes generate the myriad of cell types during development and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in embryos. Here, we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Cuvillier JM,Lee B,Shen R,Lee JW,Lee SK

更新日期：2012-02-28 00:00:00

abstract：:Dendritic spines are of major importance in information processing and memory formation in central neurons. Estradiol has been shown to induce an increase of dendritic spine density on hippocampal neurons in vivo and in vitro. The neurotrophin brain-derived neurotrophic factor (BDNF) recently has been implicated in ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy DD,Cole NB,Segal M

更新日期：1998-09-15 00:00:00

abstract：:Ovine pulmonary surfactant is bactericidal for Pasteurella haemolytica when surfactant and bacteria mixtures are incubated with normal ovine serum. To isolate this component, surfactant (1 mg/ml) was centrifuged at 100,000 x gav, and the supernatant was fractionated by HPLC. Fractions were eluted with acetonitrile (10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brogden KA,De Lucca AJ,Bland J,Elliott S

更新日期：1996-01-09 00:00:00

abstract：:Intracellular transport is interspersed with frequent reversals in direction due to the presence of opposing kinesin and dynein motors on organelles that are carried as cargo. The cause and the mechanism of reversals are unknown, but are a key to understanding how cargos are delivered in a regulated manner to specific...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soppina V,Rai AK,Ramaiya AJ,Barak P,Mallik R

更新日期：2009-11-17 00:00:00

abstract：:The search for ever deeper relationships among the World's languages is bedeviled by the fact that most words evolve too rapidly to preserve evidence of their ancestry beyond 5,000 to 9,000 y. On the other hand, quantitative modeling indicates that some "ultraconserved" words exist that might be used to find evidence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pagel M,Atkinson QD,S Calude A,Meade A

更新日期：2013-05-21 00:00:00

abstract：:The DNA polymerase enzymes from avian, murine, and feline RNA tumor viruses can be distinguished by their ability to read specific, synthetic primertemplates. The copying of templates containing adenylic and thymidylic acids by all these DNA polymerases is inhibited by ethidium bromide, though this compound affects th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fridlender B,Weissbach A

更新日期：1971-12-01 00:00:00

abstract：:The water channel aquaporin 1 (AQP1) and certain Rh-family members are permeable to CO(2) and NH(3). Here, we use changes in surface pH (pH(S)) to assess relative CO(2) vs. NH(3) permeability of Xenopus oocytes expressing members of the AQP or Rh family. Exposed to CO(2) or NH(3), AQP1 oocytes exhibit a greater maxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Musa-Aziz R,Chen LM,Pelletier MF,Boron WF

更新日期：2009-03-31 00:00:00

abstract：:Proinflammatory macrophages are key mediators in several pathologies; thus, controlling their activation is necessary. The endocannabinoid system is implicated in various inflammatory processes. Here we show that in macrophages, the newly characterized enzyme α/β-hydrolase domain 6 (ABHD6) controls 2-arachidonoylglyce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alhouayek M,Masquelier J,Cani PD,Lambert DM,Muccioli GG

更新日期：2013-10-22 00:00:00

abstract：:Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta I,Ganguly S,Rozanas CR,Stuehr DJ,Panda K

更新日期：2016-07-19 00:00:00

abstract：:We reported previously that human cells after neoplastic transformation in culture had acquired an increased susceptibility to chromatid damage induced by x-irradiation during the G2 phase of the cell cycle. Evidence suggested that this results from deficient DNA repair during G2 phase. Cells derived from human tumors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parshad R,Sanford KK,Jones GM

更新日期：1985-08-01 00:00:00

abstract：:A study was undertaken to elucidate the molecular mechanisms by which glucocorticoids induce cleft palate in mice. It was hypothesized that a compound such as triamcinolone acetonide inhibits mRNA synthesis; that this results later in depressed protein synthesis; and that the latter is ultimately responsible for slowe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zimmerman EF,Andrew F,Kalter H

更新日期：1970-10-01 00:00:00

abstract：:The vertical occipital fasciculus (VOF) is the only major fiber bundle connecting dorsolateral and ventrolateral visual cortex. Only a handful of studies have examined the anatomy of the VOF or its role in cognition in the living human brain. Here, we trace the contentious history of the VOF, beginning with its origin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeatman JD,Weiner KS,Pestilli F,Rokem A,Mezer A,Wandell BA

更新日期：2014-12-02 00:00:00

abstract：:A discussion of the expected mechanism of radical reduction of carbonyl compounds by dihydroflavin as it relates to the structure of the carbonyl compound is provided. Factors which must be taken into account are the free energies of formation of the radical anions (CR2O), THE ACIDITY OF THE CONJUGATE ACID OF THE CARB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams RF,Shinkai S,Bruice TC

更新日期：1975-05-01 00:00:00

abstract：:In mice, recent thymic emigrants (RTEs) make up a large part of the naïve T cell pool and have been suggested to be a distinct short-lived pool. In humans, however, the life span and number of RTEs are unknown. Although (2)H(2)O labeling in young mice showed high thymic-dependent daily naïve T cell production, long te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vrisekoop N,den Braber I,de Boer AB,Ruiter AF,Ackermans MT,van der Crabben SN,Schrijver EH,Spierenburg G,Sauerwein HP,Hazenberg MD,de Boer RJ,Miedema F,Borghans JA,Tesselaar K

更新日期：2008-04-22 00:00:00

abstract：:Larger brains have an increasingly folded cerebral cortex whose white matter scales up faster than the gray matter. Here we analyze the cellular composition of the subcortical white matter in 11 primate species, including humans, and one Scandentia, and show that the mass of the white matter scales linearly across spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herculano-Houzel S,Mota B,Wong P,Kaas JH

更新日期：2010-11-02 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report the identification of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang SW,Liu X,Yepes M,Shepherd KR,Miller GW,Liu Y,Wilson WD,Xiao G,Blanchi B,Sun YE,Ye K

更新日期：2010-02-09 00:00:00

abstract：:The repair of DNA double-strand breaks (DSBs) requires open, flexible chromatin domains. The NuA4-Tip60 complex creates these flexible chromatin structures by exchanging histone H2A.Z onto nucleosomes and promoting acetylation of histone H4. Here, we demonstrate that the accumulation of H2A.Z on nucleosomes at DSBs is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gursoy-Yuzugullu O,Ayrapetov MK,Price BD

更新日期：2015-06-16 00:00:00

abstract：:The circular dichroism data on 17 adenine nucleosides show that the 260- and 207-mmu absorption systems of the adenine chromophore each contain at least two electronic transitions. The CD maxima are commonly found at around 260, 220, and 200 mmu, and occasionally at 240 mmu. Solvent studies suggest that these CD bands...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Robins MJ,Robins RK,Eyring H

更新日期：1969-01-01 00:00:00