Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica.

abstract：:The spatial distribution of plant defenses within a leaf may be critical in explaining patterns of herbivory. The generalist lepidopteran larvae, Helicoverpa armigera (the cotton bollworm), avoided the midvein and periphery of Arabidopsis thaliana rosette leaves and fed almost exclusively on the inner lamina. This fee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shroff R,Vergara F,Muck A,Svatos A,Gershenzon J

更新日期：2008-04-22 00:00:00

abstract：:G9a is an epigenetic regulator that methylates H3K9, generally causing repression of gene expression, and participates in diverse cellular functions. G9a is genetically deregulated in a variety of tumor types and can silence tumor suppressor genes and, therefore, is important for carcinogenesis. Although hypoxia is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casciello F,Al-Ejeh F,Kelly G,Brennan DJ,Ngiow SF,Young A,Stoll T,Windloch K,Hill MM,Smyth MJ,Gannon F,Lee JS

更新日期：2017-07-03 00:00:00

abstract：:The TFIID transcription initiation complex is composed of TBP and multiple TAFs. Studies in unicellular systems indicate that TAF250 is required for progression through G(1)/S of the cell cycle and repression of apoptosis. Here we extend these in vivo studies by determining the developmental requirements for TAF250 in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wassarman DA,Aoyagi N,Pile LA,Schlag EM

更新日期：2000-02-01 00:00:00

abstract：:By using both double-colony hybridization and an in situ immunostaining assay for transformants, 39 cDNA clones (clone p-16 alpha) encoding mouse liver microsomal testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha) were isolated from a cDNA library constructed in the cloning vector pUC-9 with poly(A)+ RNA i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada N,Negishi M

更新日期：1985-04-01 00:00:00

abstract：:A polypeptide was purified from rat hypothalamic extracts on the basis of its high intrinsic activity to release corticotropin (ACTH) from cultured rat anterior pituitary cells and its immunoactivity in a radioimmunoassay directed against the NH2 terminus (residues 4-20) of ovine hypothalamic corticotropin-releasing f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rivier J,Spiess J,Vale W

更新日期：1983-08-01 00:00:00

abstract：:Cardiotoxin VII4 from Naja mossambica mossambica crystallizes in space group P61 (a = b = 73.9 A; c = 59.0 A) with two molecules of toxin (molecular mass = 6715 Da) in the asymmetric unit. The structure was solved by using a combination of multiple isomorphous replacement and density modification methods. Model buildi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rees B,Samama JP,Thierry JC,Gilibert M,Fischer J,Schweitz H,Lazdunski M,Moras D

更新日期：1987-05-01 00:00:00

abstract：:The origins of the five groups of living seed plants, including the single relictual species Ginkgo biloba, are poorly understood, in large part because of very imperfect knowledge of extinct seed plant diversity. Here we describe well-preserved material from the Early Cretaceous of Mongolia of the previously enigmati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herrera F,Shi G,Ichinnorov N,Takahashi M,Bugdaeva EV,Herendeen PS,Crane PR

更新日期：2017-03-21 00:00:00

abstract：:Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal loss. The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type I transmembrane protein located...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breithaupt C,Schubart A,Zander H,Skerra A,Huber R,Linington C,Jacob U

更新日期：2003-08-05 00:00:00

abstract：:Numerous investigations have focused on DNA damage induced by ionizing radiation; however, photoionization threshold energies of nucleic acid components in aqueous solution are not known. Herein, data from gas-phase photoelectron experiments have been combined with results from self-consistent field and post-self-cons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernando H,Papadantonakis GA,Kim NS,LeBreton PR

更新日期：1998-05-12 00:00:00

abstract：:The cochlear implant (CI) is a neuroprosthesis that allows profoundly deaf patients to recover speech intelligibility. This recovery goes through long-term adaptative processes to build coherent percepts from the coarse information delivered by the implant. Here we analyzed the longitudinal postimplantation evolution ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rouger J,Lagleyre S,Fraysse B,Deneve S,Deguine O,Barone P

更新日期：2007-04-24 00:00:00

abstract：:A human liver cDNA library was screened by colony hybridization with a bovine factor X cDNA probe. Three of the positive plasmids contained overlapping DNA that coded for most of human factor X mRNA. DNA sequence analysis of these three clones allowed the prediction of the complete amino acid sequence of plasma factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fung MR,Hay CW,MacGillivray RT

更新日期：1985-06-01 00:00:00

abstract：:Tropospheric O(3) and sulfate both contribute to air pollution and climate forcing. There is a growing realization that air quality and climate change issues are strongly connected. To date, the importance of the coupling between O(3) and sulfate has not been fully appreciated, and thus regulations treat each pollutan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Unger N,Shindell DT,Koch DM,Streets DG

更新日期：2006-03-21 00:00:00

abstract：:Although it is known that the human genome contains hundreds of microRNA (miRNA) genes and that each miRNA can regulate a large number of mRNA targets, the overall effect of miRNAs on mRNA tissue profiles has not been systematically elucidated. Here, we show that predicted human mRNA targets of several highly tissue-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sood P,Krek A,Zavolan M,Macino G,Rajewsky N

更新日期：2006-02-21 00:00:00

abstract：:We report on the production of tumor necrosis factor (TNF)-alpha and TNF-beta by mitogen-activated peripheral blood lymphocytes or enriched monocyte subpopulations from human leukocyte antigen (HLA)-typed healthy subjects. The results indicate that HLA-DR2- and DQw1-positive donors frequently exhibit low production of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacob CO,Fronek Z,Lewis GD,Koo M,Hansen JA,McDevitt HO

更新日期：1990-02-01 00:00:00

abstract：:We analyze Niels Bohr's proposed two-slit interference experiment with highly charged particles which argues that the consistency of elementary quantum mechanics requires that the electromagnetic field must be quantized. In the experiment a particle's path through the slits is determined by measuring the Coulomb field...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baym G,Ozawa T

更新日期：2009-03-03 00:00:00

abstract：:Ontogenetic changes in the protein phosphorylation/dephosphorylation systems in rat brain were investigated. It was found that the activity level of phospholipid-sensitive Ca2+-dependent protein kinase (PL-Ca-PK) in the particulate fraction of grey and white matter and the soluble fraction of grey matter increased rap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner RS,Raynor RL,Mazzei GJ,Girard PR,Kuo JF

更新日期：1984-05-01 00:00:00

abstract：:Alterations in synaptic input, persisting for hours to days, elicit homeostatic plastic changes in the axon initial segment (AIS), which is pivotal for spike generation. Here, in hippocampal pyramidal neurons of both primary cultures and slices, we triggered a unique form of AIS plasticity by selectively targeting M-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lezmy J,Lipinsky M,Khrapunsky Y,Patrich E,Shalom L,Peretz A,Fleidervish IA,Attali B

更新日期：2017-11-21 00:00:00

abstract：:One of the strategies used by organisms to adapt to life under conditions of short energy supply is to use the by-product pyrophosphate to support cation gradients in membranes. Transport reactions are catalyzed by membrane-integral pyrophosphatases (PPases), which are classified into two homologous subfamilies: H(+)-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luoto HH,Baykov AA,Lahti R,Malinen AM

更新日期：2013-01-22 00:00:00

abstract：:Treatment of lymphocytes with inducers of interferon alpha (IFN-alpha) results in the production of corticotropin (ACTH) and endorphin-like activities. The pro-opiomelanocortin-derived hormones ACTH and alpha-, beta-, and gamma-endorphin and the structurally related hormones [Leu]- and [Met]enkephalin were therefore t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson HM,Smith EM,Torres BA,Blalock JE

更新日期：1982-07-01 00:00:00

abstract：:Endocytic protein trafficking is directed by sorting signals on cargo molecules that are recognized by cytosolic adaptor proteins. However, the steps necessary to segregate the variety of cargoes during endocytosis remain poorly defined. Using Caenorhabditis elegans, we demonstrate that multiple plasma membrane endocy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayers JR,Wang L,Pramanik J,Johnson A,Sarkeshik A,Wang Y,Saengsawang W,Yates JR 3rd,Audhya A

更新日期：2013-07-16 00:00:00

abstract：:Biological soil crusts (biocrusts)—communities of mosses, lichens, cyanobacteria, and heterotrophs living at the soil surface—are fundamental components of drylands worldwide, and destruction of biocrusts dramatically alters biogeochemical processes, hydrology, surface energy balance, and vegetation cover. Although th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrenberg S,Reed SC,Belnap J

更新日期：2015-09-29 00:00:00

abstract：:We have inserted the sequence 5'-AAG-GAGGU-3', which is complementary to the 3' terminus of Escherichia coli 16S rRNA, in a reading frame and analyzed its effect on the accuracy and overall rate of translation in vivo. Translation over the sequence yields a 50% ribosomal frameshift if the reading phase is A-AGG-AGG-U....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanjaard RA,van Duin J

更新日期：1988-11-01 00:00:00

abstract：:The oxygen isotope record of the last million years, as provided by a deep sea core sediment, is analyzed by a method recently developed in the theory of dynamical systems. The analysis suggests that climatic variability is the manifestation of a chaotic dynamics described by an attractor of fractal dimensionality. A ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicolis C,Nicolis G

更新日期：1986-02-01 00:00:00

abstract：:An experimental study of the configurational thermodynamics for a series of near-eutectic Pt80-x Cu x P20 bulk metallic glass-forming alloys is reported where 14 < x < 27. The undercooled liquid alloys exhibit very high fragility that increases as x decreases, resulting in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Na JH,Corona SL,Hoff A,Johnson WL

更新日期：2020-02-11 00:00:00

abstract：:Epstein-Barr virus (EBV)-genome-negative human lymphoma lines, Ramos and BJAB, can be converted by EBV in vitro into EBV-genome-positive virus nonproducer lines. These cell lines have been used to identify surface antigens unique to EBV, with the expectation that such determinants might be related to the antigenic tar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lasky RD,Troy FA

更新日期：1984-01-01 00:00:00

abstract：:New important applications of copper metal, e.g., in the areas of hydrogen production, fuel cell operation, and spent nuclear fuel disposal, require accurate knowledge of the physical and chemical properties of stable and metastable copper compounds. Among the copper(I) compounds with oxygen and hydrogen, cuprous oxid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korzhavyi PA,Soroka IL,Isaev EI,Lilja C,Johansson B

更新日期：2012-01-17 00:00:00

abstract：:The recent isolation and identification of alpha-N-acetyl forms of the C-Fragment of lipotropin (beta-endorphin, residues 61-91) and the C'-Fragment (residues 61-87) [Smyth, D.G., Massey, D.E., Zakarian, S. & Finnie, M. (1979) Nature (London) 279, 252-254] has led to a study of their distribution in the pituitary and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zakarian S,Smyth D

更新日期：1979-11-01 00:00:00

abstract：:Despite considerable interest in the forces shaping the relationship between brain size and cognitive abilities, it remains controversial whether larger-brained animals are, indeed, better problem-solvers. Recently, several comparative studies have revealed correlations between brain size and traits thought to require...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benson-Amram S,Dantzer B,Stricker G,Swanson EM,Holekamp KE

更新日期：2016-03-01 00:00:00

abstract：:The demonstration of enzymatic capabilities of certain RNAs, in addition to their well-known template properties, has led to the recognition that RNAs are the only biological macromolecules that can function both as genotype and phenotype, hence raising the possibility of Darwinian selection and precellular evolution ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diener TO

更新日期：1989-12-01 00:00:00

abstract：:Salicylic acid (SA) plays an important role in activating various plant defense responses, including expression of the pathogenesis-related (PR) genes and systemic acquired resistance. A critical positive regulator of the SA signaling pathway in Arabidopsis is encoded by the NPR1 gene. However, there is growing eviden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kachroo P,Shanklin J,Shah J,Whittle EJ,Klessig DF

更新日期：2001-07-31 00:00:00