Sex-dependent expression of mouse testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha): cDNA cloning and pretranslational regulation.

abstract：:Loss-of-function mutations in the genes associated with primary microcephaly (MCPH) reduce human brain size by about two-thirds, without producing gross abnormalities in brain organization or physiology and leaving other organs largely unaffected [Woods CG, et al. (2005) Am J Hum Genet 76:717-728]. There is also evide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rimol LM,Agartz I,Djurovic S,Brown AA,Roddey JC,Kähler AK,Mattingsdal M,Athanasiu L,Joyner AH,Schork NJ,Halgren E,Sundet K,Melle I,Dale AM,Andreassen OA,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2010-01-05 00:00:00

abstract：:Improving global yields of important agricultural crops is a complex challenge. Enhancing yield and resource use by engineering improvements to photosynthetic carbon assimilation is one potential solution. During the last 40 million years C(4) photosynthesis has evolved multiple times, enabling plants to evade the cat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitney SM,Sharwood RE,Orr D,White SJ,Alonso H,Galmés J

更新日期：2011-08-30 00:00:00

abstract：:Rat cortical astrocytes in pure culture are functionally coupled to neighboring cells via connexin (Cx) 43 gap junctions under ordinary conditions. Small fluorescent molecules such as Lucifer yellow (LY) pass between cell interiors via gap junctions, but do not enter the cells when externally applied. Subjecting rat a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Contreras JE,Sánchez HA,Eugenin EA,Speidel D,Theis M,Willecke K,Bukauskas FF,Bennett MV,Sáez JC

更新日期：2002-01-08 00:00:00

abstract：:Recent advances in fluorescence microscopy provided tools for the investigation and the analysis of the viral replication steps in the cellular context. In the HIV field, the current visualization systems successfully achieve the fluorescent labeling of the viral envelope and proteins, but not the genome. Here, we dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Primio C,Quercioli V,Allouch A,Gijsbers R,Christ F,Debyser Z,Arosio D,Cereseto A

更新日期：2013-04-02 00:00:00

abstract：:Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERalpha also enhances insulin synthesis in cultured islets. Whether ERalpha stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these issues, we generated a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong WP,Tiano JP,Liu S,Hewitt SC,Le May C,Dalle S,Katzenellenbogen JA,Katzenellenbogen BS,Korach KS,Mauvais-Jarvis F

更新日期：2010-07-20 00:00:00

abstract：:Pin1 is a modular enzyme that accelerates the cis-trans isomerization of phosphorylated-Ser/Thr-Pro (pS/T-P) motifs found in numerous signaling proteins regulating cell growth and neuronal survival. We have used NMR to investigate the interaction of Pin1 with three related ligands that include a pS-P substrate peptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Namanja AT,Wang XJ,Xu B,Mercedes-Camacho AY,Wilson KA,Etzkorn FA,Peng JW

更新日期：2011-07-26 00:00:00

abstract：:A serpin was identified in normal mammary gland by differential cDNA sequencing. In situ hybridization has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammary epithelial side of the basement membrane and thus was named myoepithelium-derived serine proteinase inhibitor (MEP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao G,Liu YE,Gentz R,Sang QA,Ni J,Goldberg ID,Shi YE

更新日期：1999-03-30 00:00:00

abstract：:Two regions of human thyrotropin (thyroid-stimulating hormone, TSH) receptor (TSHR) (residues 12-44 and 308-364) were selected on the basis that they exhibit no sequence resemblance to luteinizing hormone/chorionic gonadotropin receptor. Five synthetic overlapping peptides (12-30, 24-44, 308-328, 324-344, and 339-364)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atassi MZ,Manshouri T,Sakata S

更新日期：1991-05-01 00:00:00

abstract：:Adenine-thymine (AT)-rich interactive domain 5a (Arid5a) is an RNA-binding protein found in the cytoplasm and nucleus of normally growing cells. Although Arid5a is known to play an important role in immune regulation, whether and how Arid5a subcellular localization impacts immune regulation has remained unclear. In th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higa M,Oka M,Fujihara Y,Masuda K,Yoneda Y,Kishimoto T

更新日期：2018-02-06 00:00:00

abstract：:Society places value on the multiple functions of ecosystems from soil fertility to erosion control to wildlife-carrying capacity, and these functions are potentially threatened by ongoing biodiversity losses. Recent empirically based models using individual species' traits suggest that higher species richness is requ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zavaleta ES,Pasari JR,Hulvey KB,Tilman GD

更新日期：2010-01-26 00:00:00

abstract：:Heme A is an essential cofactor for respiratory terminal oxidases and vital for respiration in aerobic organisms. The final step of heme A biosynthesis is formylation of the C-8 methyl group of heme molecule by heme A synthase (HAS). HAS is a heme-containing integral membrane protein, and its structure and reaction me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niwa S,Takeda K,Kosugi M,Tsutsumi E,Mogi T,Miki K

更新日期：2018-11-20 00:00:00

abstract：:A new common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses was demonstrated by the use of rabbit antiserum against feline leukemia virus and the indirect membrane immunofluorescence test. Common cell-surface antigen was found in all leukemias of all strains of mice tested, in norma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshiki T,Mellors RC,Hardy WD Jr

更新日期：1973-06-01 00:00:00

abstract：:A Drosophila cDNA encoding a human transcription factor TFIIB homologue was isolated by PCR methods. The deduced amino acid sequence indicates 85% sequence similarity with human TFIIB, and the corresponding cDNA product expressed in Escherichia coli is interchangeable with human TFIIB for both basal and GAL4-VP16-indu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamashita S,Wada K,Horikoshi M,Gong DW,Kokubo T,Hisatake K,Yokotani N,Malik S,Roeder RG,Nakatani Y

更新日期：1992-04-01 00:00:00

abstract：:During transcription, RNA polymerase II (RNAPII) must select the correct nucleotide, catalyze its addition to the growing RNA transcript, and move stepwise along the DNA until a gene is fully transcribed. In all kingdoms of life, transcription must be finely tuned to ensure an appropriate balance between fidelity and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larson MH,Zhou J,Kaplan CD,Palangat M,Kornberg RD,Landick R,Block SM

更新日期：2012-04-24 00:00:00

abstract：:Mast cells and nerve growth factor (NGF) have both been reported to be involved in neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells interact with the innervating fibers. Changes in the behaviors of both of these elements occur after tissue injury/inflammation. As such conditions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leon A,Buriani A,Dal Toso R,Fabris M,Romanello S,Aloe L,Levi-Montalcini R

更新日期：1994-04-26 00:00:00

abstract：:RNA movements and localization pervade biology, from embryonic development to disease. To identify RNAs at specific locations, we developed a strategy in which a uridine-adding enzyme is anchored to subcellular sites, where it directly marks RNAs with 3' terminal uridines. This localized RNA recording approach yields ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medina-Munoz HC,Lapointe CP,Porter DF,Wickens M

更新日期：2020-09-22 00:00:00

abstract：:RNA viruses are notorious for their genetic plasticity and propensity to exploit new host-range opportunities, which can lead to the emergence of human disease epidemics such as severe acute respiratory syndrome, AIDS, dengue, and influenza. However, the mechanisms of host-range change involved in most of these viral ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anishchenko M,Bowen RA,Paessler S,Austgen L,Greene IP,Weaver SC

更新日期：2006-03-28 00:00:00

abstract：:It is known from a variety of experimental systems that the ability of tumor cells to grow locally and metastasize can be affected by the presence of adjacent normal tissues and cells, particularly mesenchymally derived stromal cells such as fibroblasts. However, the comparative influence of such normal cell-tumor cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornil I,Theodorescu D,Man S,Herlyn M,Jambrosic J,Kerbel RS

更新日期：1991-07-15 00:00:00

abstract：:Pathogenetic processes that facilitate the entry, replication, and persistence of Mycobacterium tuberculosis (MTB) in the mammalian host likely include the regulated expression of specific sets of genes at different stages of infection. Identification of genes that are differentially expressed in vivo would provide in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Timm J,Post FA,Bekker LG,Walther GB,Wainwright HC,Manganelli R,Chan WT,Tsenova L,Gold B,Smith I,Kaplan G,McKinney JD

更新日期：2003-11-25 00:00:00

abstract：:Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, lipid-protein interactions, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Höglinger D,Nadler A,Haberkant P,Kirkpatrick J,Schifferer M,Stein F,Hauke S,Porter FD,Schultz C

更新日期：2017-02-14 00:00:00

abstract：:In Arabidopsis, the two-dimensional expansion of leaves is regulated via the polarized elongation of cells. The ROTUNDIFOLIA3 (ROT3) protein, a member of the family of cytochromes P450, is involved in this process and regulates leaf length. Transgenic plants that overexpressed a wild-type ROT3 gene had longer leaves t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim GT,Tsukaya H,Saito Y,Uchimiya H

更新日期：1999-08-03 00:00:00

abstract：:IL-17A is a therapeutic target in many autoimmune diseases. Most nonhematopoietic cells express IL-17A receptors and respond to extracellular IL-17A by inducing proinflammatory cytokines. The IL-17A signal transduction triggers two broad, TRAF6- and TRAF5-dependent, intracellular signaling pathways to produce represen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGowan J,Peter C,Kim J,Popli S,Veerman B,Saul-McBeth J,Conti H,Pruett-Miller SM,Chattopadhyay S,Chakravarti R

更新日期：2020-10-06 00:00:00

abstract：:Members of the tumor necrosis factor receptor (TNFR) superfamily are important for cell growth and survival. In addition to providing costimulatory signals for cell proliferation, ligation of both TNFR1 and Fas can result in programmed cell death or apoptosis. The underlying mechanism requires an intact 80-aa stretch ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prasad KV,Ao Z,Yoon Y,Wu MX,Rizk M,Jacquot S,Schlossman SF

更新日期：1997-06-10 00:00:00

abstract：:Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion cell (RGC) death. Angle closure glaucoma, a common cause of glaucoma in Asia that affects tens of millions of people worldwide, often presents acutely with loss o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi W,Li F,Chen H,Wang Y,Zhu Y,Yang X,Zhu J,Wu F,Ouyang H,Ge J,Weinreb RN,Zhang K,Zhuo Y

更新日期：2014-07-29 00:00:00

abstract：:We have shown that the long-term inhibition of IgE synthesis associated with perinatal inoculation of syngeneic IgE is accompanied by the synthesis of autoantibodies to IgE. Synthesis of IgE can also be inhibited by passive transfer of syngeneic anti-IgE antibodies. In the present investigation we made use of adoptive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haba S,Nisonoff A

更新日期：1994-01-18 00:00:00

abstract：:Ubc13 is a ubiquitin-conjugating enzyme responsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in Toll-like receptor and TNF-family cytokine receptor signaling, which are regulators of innate immunity. Gene ablation was used to study the function of Ubc13 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukushima T,Matsuzawa S,Kress CL,Bruey JM,Krajewska M,Lefebvre S,Zapata JM,Ronai Z,Reed JC

更新日期：2007-04-10 00:00:00

abstract：:The endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) comprises mitochondrial distribution and morphology 12 (Mdm12), maintenance of mitochondrial morphology 1 (Mmm1), Mdm34, and Mdm10 and mediates physical membrane contact sites and nonvesicular lipid trafficking between the ER and mitochondria in y...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeong H,Park J,Jun Y,Lee C

更新日期：2017-11-07 00:00:00

abstract：:We assess the significance of high-frequency variability of environmental parameters (sunlight, precipitation, temperature) for the structure and function of terrestrial ecosystems under current and future climate. We examine the influence of hourly, daily, and monthly variance using the Ecosystem Demography model ver...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medvigy D,Wofsy SC,Munger JW,Moorcroft PR

更新日期：2010-05-04 00:00:00

abstract：:BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the pathogenesis of Alzheimer's disease (AD). By an unknown mechanism, levels of BACE1 and a BACE1 mRNA-stabilizing antisense RNA (BACE1-AS) are elevated in the brains of AD patients, implicating that dysregulation of BACE1 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bahn G,Park JS,Yun UJ,Lee YJ,Choi Y,Park JS,Baek SH,Choi BY,Cho YS,Kim HK,Han J,Sul JH,Baik SH,Lim J,Wakabayashi N,Bae SH,Han JW,Arumugam TV,Mattson MP,Jo DG

更新日期：2019-06-18 00:00:00

abstract：:Conflict between groups of individuals is a prevalent feature in human societies. A common theoretical explanation for intergroup conflict is that it provides benefits to individuals within groups in the form of reproduction-enhancing resources, such as food, territory, or mates. However, it is not always the case tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henriques GJB,Simon B,Ispolatov Y,Doebeli M

更新日期：2019-07-09 00:00:00