Evidence that cochlear-implanted deaf patients are better multisensory integrators.

abstract：:We describe a unique conductance-based model of awake thalamic alpha and some of its implications for function. The full model includes a model for a specialized class of high-threshold thalamocortical cells (HTC cells), which burst at the alpha frequency at depolarized membrane potentials (~-56 mV). Our model generat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vijayan S,Kopell NJ

更新日期：2012-11-06 00:00:00

abstract：:We have previously shown that the G protein of vesicular stomatitis virus (VSV-G) can be incorporated into the virions of retroviruses. Since expression of VSV-G is toxic to most mammalian cells, development of stable VSV-G packaging cell lines requires inducible VSV-G expression. We have modified the tetracycline-ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ST,Iida A,Guo L,Friedmann T,Yee JK

更新日期：1996-09-17 00:00:00

abstract：:The molecular basis of pathogen clone emergence is relatively poorly understood. Acquisition of a bacteriophage encoding a previously unknown secreted phospholipase A(2) (designated SlaA) has been implicated in the rapid emergence in the mid-1980s of a new hypervirulent clone of serotype M3 group A Streptococcus. Alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sitkiewicz I,Nagiec MJ,Sumby P,Butler SD,Cywes-Bentley C,Musser JM

更新日期：2006-10-24 00:00:00

abstract：:By indirect immunofluorescence techniques, microtubules and mitochondria were localized in normal rat kidney cells, human WI38 fibroblasts, mouse peritoneal macrophages, and a putative smooth muscle rat cell line, in monolayer culture. The mitochondria were found to be arranged along the cytoplasmic microtubules in ea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heggeness MH,Simon M,Singer SJ

更新日期：1978-08-01 00:00:00

abstract：:The primate visual motion system performs numerous functions essential for survival in a dynamic visual world. Prominent among these functions is the ability to recover and represent the trajectories of objects in a form that facilitates behavioral responses to those movements. The first step toward this goal, which c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albright TD,Stoner GR

更新日期：1995-03-28 00:00:00

abstract：:Inorganic elements, although required only in trace amounts, permit life and primary productivity because of their functions in catalysis. Every organism has a minimal requirement of each metal based on the intracellular abundance of proteins that use inorganic cofactors, but elemental sparing mechanisms can reduce th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kropat J,Gallaher SD,Urzica EI,Nakamoto SS,Strenkert D,Tottey S,Mason AZ,Merchant SS

更新日期：2015-03-03 00:00:00

abstract：:Whereas the importance of macrophages in chronic inflammatory diseases is well recognized, there is an increasing awareness that neutrophils may also play an important role. In addition to the well-documented heterogeneity of macrophage phenotypes and functions, neutrophils also show remarkable phenotypic diversity am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss M,Byrne AJ,Blazek K,Saliba DG,Pease JE,Perocheau D,Feldmann M,Udalova IA

更新日期：2015-09-01 00:00:00

abstract：:Fibroblasts can condense a hydrated collagen lattice to a tissue-like structure 1/28th the area of the starting gel in 24 hr. The rate of the process can be regulated by varying the protein content of the lattice, the cell number, or the concentration of an inhibitor such as Colcemid. Fibroblasts of high population do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bell E,Ivarsson B,Merrill C

更新日期：1979-03-01 00:00:00

abstract：:Inducer-mediated murine erythroleukemia cell (MELC) differentiation provides a model for examining factors determining terminal cell differentiation. The nuclear protein, p53, has been implicated as a potential determinant of cell cycle progression and cell differentiation. In this study p53 content and synthesis, dur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen DW,Real FX,DeLeo AB,Old LJ,Marks PA,Rifkind RA

更新日期：1983-10-01 00:00:00

abstract：:The complete amino acid sequence of Xenopus laevis nonmuscle myosin heavy chain B (MHC-B) has been deduced from overlapping cDNA clones isolated from an XTC cell library. RNA blots of various developmental stages, adult tissues, and XTC cells detect a single transcript of 7.5 kb which is expressed at similar levels th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhatia-Dey N,Adelstein RS,Dawid IB

更新日期：1993-04-01 00:00:00

abstract：:Tissue cultures of Actinidia kolomikta can be maintained as callus through repeated passages on a nutrient medium devoid of cytokinin but containing inorganic nutrients, sucrose, and other basal organics plus auxin. Under these conditions, actively growing callus contained 2 and 0.5 nmol of the cytokinins zeatin [io(6...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Einset JW

更新日期：1986-02-01 00:00:00

abstract：:The Miocene is characterized by a series of key climatic events that led to the founding of the late Cenozoic icehouse mode and the dawn of modern biota. The processes that caused these developments, and particularly the role of atmospheric CO2 as a forcing factor, are poorly understood. Here we present a CO2 record b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kürschner WM,Kvacek Z,Dilcher DL

更新日期：2008-01-15 00:00:00

abstract：:Relatively little is known about the biochemical mechanisms through which the Epstein-Barr virus latent infection integral membrane protein 1 (LMP1) transmembrane domains cause constitutive LMP1 aggregation and continuous cytoplasmic C terminus-mediated signal transduction. We now evaluate the role of the three consec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasui T,Luftig M,Soni V,Kieff E

更新日期：2004-01-06 00:00:00

abstract：:Metabolic engineering seeks to reprogram microbial cells to efficiently and sustainably produce value-added compounds. Since chemical production can be at odds with the cell's natural objectives, strategies have been developed to balance conflicting goals. For example, dynamic regulation modulates gene expression to f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinh CV,Prather KLJ

更新日期：2019-12-17 00:00:00

abstract：:T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ structures dedicated to antibody production. As such, follicular T (Tfol) cells are supposed to be specific for immunizing antigens, which has been reported for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritvo PG,Saadawi A,Barennes P,Quiniou V,Chaara W,El Soufi K,Bonnet B,Six A,Shugay M,Mariotti-Ferrandiz E,Klatzmann D

更新日期：2018-09-18 00:00:00

abstract：:Male (NZW x BXSB)F1 (W/BF1) mice develop systemic autoimmunity involving autoantibodies, thrombocytopenia, lupus nephritis, and coronary vascular disease (CVD) with myocardial infarction. To determine whether this murine lupus-associated CVD can be prevented by the reduction of dietary calories, male W/BF1 mice were s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mizutani H,Engelman RW,Kinjoh K,Kurata Y,Ikehara S,Matsuzawa Y,Good RA

更新日期：1994-05-10 00:00:00

abstract：:We have determined the complete primary structure of human hemopexin, a plasma beta-glycoprotein that specifically binds one heme with high affinity and transports it to hepatocytes for salvage of the iron. Human hemopexin (Mr approximately equal to 63,000) consists of a single polypeptide chain containing 439 amino a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Takahashi Y,Putnam FW

更新日期：1985-01-01 00:00:00

abstract：:cDNA clones for the (S)-tetrahydroberberine (H4Ber) oxidase of cultured berberine-producing Coptis japonica cells were isolated by screening a C. japonica cDNA library with synthetic nucleotides that can encode the NH2-terminal sequence of this enzyme. Analyses of the nucleotide sequences of the cloned cDNA inserts re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada N,Koizumi N,Tanaka T,Ohkubo H,Nakanishi S,Yamada Y

更新日期：1989-01-01 00:00:00

abstract：:Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of Jun probably results from transcriptional deregulation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu Sl,Bottoli I,Goller M,Vogt PK

更新日期：1999-05-11 00:00:00

abstract：:The cyclic enzymatic function of a cytochrome P450, as it catalyzes the oxygen-dependent metabolism of many organic chemicals, requires the delivery of two electrons to the hemeprotein. In general these electrons are transferred from NADPH to the P450 via an FMN- and FAD-containing flavoprotein (NADPH-P450 reductase)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faulkner KM,Shet MS,Fisher CW,Estabrook RW

更新日期：1995-08-15 00:00:00

abstract：:The expression of CD5 increases progressively as thymocytes mature. We have shown that CD5 expression is controlled by a tissue-specific regulatory promoter located upstream of the CD5 translation start sites. Deletion of this regulatory promoter, which contains three potential transcription factor binding sites (CCAA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Contag CH,Felsher D,Shachaf CM,Cao Y,Herzenberg LA,Herzenberg LA,Tung JW

更新日期：2004-03-16 00:00:00

abstract：:Four macrocyclic cystine-knot peptides of 29-31 residues, kalata, circulin A and B (CirA and CirB), and cyclopsychotride, have been isolated from coffee plants but have undetermined physiological functions. These macrocycles and 10 of their analogs prepared by chemical synthesis were tested against nine strains of mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tam JP,Lu YA,Yang JL,Chiu KW

更新日期：1999-08-03 00:00:00

abstract：:Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to understand the biology of myelin diseases and to develop treatments for such disorders. Here, we demonstrate that the induction of three transcription f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ehrlich M,Mozafari S,Glatza M,Starost L,Velychko S,Hallmann AL,Cui QL,Schambach A,Kim KP,Bachelin C,Marteyn A,Hargus G,Johnson RM,Antel J,Sterneckert J,Zaehres H,Schöler HR,Baron-Van Evercooren A,Kuhlmann T

更新日期：2017-03-14 00:00:00

abstract：:In 2005 four outstanding multiple burials were discovered near Eulau, Germany. The 4,600-year-old graves contained groups of adults and children buried facing each other. Skeletal and artifactual evidence and the simultaneous interment of the individuals suggest the supposed families fell victim to a violent event. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haak W,Brandt G,de Jong HN,Meyer C,Ganslmeier R,Heyd V,Hawkesworth C,Pike AW,Meller H,Alt KW

更新日期：2008-11-25 00:00:00

abstract：:Intermolecular electronic coupling dictates the optical properties of molecular aggregate systems. Of particular interest are photosynthetic pigment-protein complexes that absorb sunlight then efficiently direct energy toward the photosynthetic reaction center. Two-dimensional (2D) ultrafast spectroscopy has been used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Read EL,Engel GS,Calhoun TR,Mancal T,Ahn TK,Blankenship RE,Fleming GR

更新日期：2007-09-04 00:00:00

abstract：:Pith parenchyma cells store water in various plant organs. These cells are especially important for producing sugar and ethanol from the sugar juice of grass stems. In many plants, the death of pith parenchyma cells reduces their stem water content. Previous studies proposed that a hypothetical D gene might be respons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujimoto M,Sazuka T,Oda Y,Kawahigashi H,Wu J,Takanashi H,Ohnishi T,Yoneda JI,Ishimori M,Kajiya-Kanegae H,Hibara KI,Ishizuna F,Ebine K,Ueda T,Tokunaga T,Iwata H,Matsumoto T,Kasuga S,Yonemaru JI,Tsutsumi N

更新日期：2018-09-11 00:00:00

abstract：:Genomic and cDNA clones for the human nerve growth factor receptor have been used in conjunction with somatic cell hybrid analysis and in situ hybridization to localize the nerve growth factor receptor locus to human chromosome region 17q12-q22. Additionally, part, if not all, of the nerve growth factor receptor locus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huebner K,Isobe M,Chao M,Bothwell M,Ross AH,Finan J,Hoxie JA,Sehgal A,Buck CR,Lanahan A

更新日期：1986-03-01 00:00:00

abstract：:Minimally invasive detection of cell death could prove an invaluable resource in many physiologic and pathologic situations. Cell-free circulating DNA (cfDNA) released from dying cells is emerging as a diagnostic tool for monitoring cancer dynamics and graft failure. However, existing methods rely on differences in DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann-Werman R,Neiman D,Zemmour H,Moss J,Magenheim J,Vaknin-Dembinsky A,Rubertsson S,Nellgård B,Blennow K,Zetterberg H,Spalding K,Haller MJ,Wasserfall CH,Schatz DA,Greenbaum CJ,Dorrell C,Grompe M,Zick A,Hubert A,M

更新日期：2016-03-29 00:00:00

abstract：:A 37-kDa glycoprotein has been described recently, whose synthesis is dramatically increased after injury of the rat sciatic and optic nerves. Cells in the nerve sheath, distal to the site of injury, produce and secrete large amounts of this protein, so that by 3 weeks after injury, it represents 2-5% of the total sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ignatius MJ,Gebicke-Härter PJ,Skene JH,Schilling JW,Weisgraber KH,Mahley RW,Shooter EM

更新日期：1986-02-01 00:00:00

abstract：:HIV type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry into target cells. Here we show that the HIV-1 envelope gp120 (Env) activates multiple ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo. Env from both CCR5-dependent JRFL (R5) an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu QH,Williams DA,McManus C,Baribaud F,Doms RW,Schols D,De Clercq E,Kotlikoff MI,Collman RG,Freedman BD

更新日期：2000-04-25 00:00:00