The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias.

abstract：:The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)-pyrimido[1, 2-a]purin-10(3H)-one (M1G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG).d(CGGACACC) or d(ATCGCMCGGCATG). d(C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao H,Schnetz-Boutaud NC,Weisenseel JP,Marnett LJ,Stone MP

更新日期：1999-06-08 00:00:00

abstract：:The human brain relies upon the dynamic formation and dissolution of a hierarchy of functional networks to support ongoing cognition. However, how functional connectivities underlying such networks are supported by cortical microstructure remains poorly understood. Recent animal work has demonstrated that electrical a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt BA,Tewarie PK,Mougin OE,Geades N,Jones DK,Singh KD,Morris PG,Gowland PA,Brookes MJ

更新日期：2016-11-22 00:00:00

abstract：:Maturation of Asn-linked oligosaccharides in the eukaryotic secretory pathway requires the trimming of nascent glycan chains to remove all glucose and several mannose residues before extension into complex-type structures on the cell surface and secreted glycoproteins. Multiple glycoside hydrolase family 47 (GH47) α-m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiang Y,Karaveg K,Moremen KW

更新日期：2016-12-06 00:00:00

abstract：:Dendrite morphogenesis is regulated by neuronal activity or neurotrophins, which may function by activating intrinsic signaling proteins, including Rho family GTPases. Here we report that activity- and brain-derived neurotrophic factor (BDNF)-dependent dendritic morphogenesis requires activation of geranylgeranyltrans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou XP,Wu KY,Liang B,Fu XQ,Luo ZG

更新日期：2008-11-04 00:00:00

abstract：:Plant cells sense environmental nitrogen levels and alter their gene expression accordingly to survive; however, the underlying regulatory mechanisms still remains to be elucidated. Here, we identified and characterized a transcription factor that is responsible for expression of nitrogen assimilation genes in a unice...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imamura S,Kanesaki Y,Ohnuma M,Inouye T,Sekine Y,Fujiwara T,Kuroiwa T,Tanaka K

更新日期：2009-07-28 00:00:00

abstract：:The conserved two-component regulatory system GacS/GacA determines the expression of extracellular products and virulence factors in a variety of Gram-negative bacteria. In the biocontrol strain CHA0 of Pseudomonas fluorescens, the response regulator GacA is essential for the synthesis of extracellular protease (AprA)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumer C,Heeb S,Pessi G,Haas D

更新日期：1999-11-23 00:00:00

abstract：:Hereditary deficiency of factor IXa (fIXa), a key enzyme in blood coagulation, causes hemophilia B, a severe X chromosome-linked bleeding disorder afflicting 1 in 30,000 males; clinical studies have identified nearly 500 deleterious variants. The x-ray structure of porcine fIXa described here shows the atomic origins ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandstetter H,Bauer M,Huber R,Lollar P,Bode W

更新日期：1995-10-10 00:00:00

abstract：:In typical force spectroscopy experiments, a small biomolecule is attached to a soft polymer linker that is pulled with a relatively large bead or cantilever. At constant force, the total extension stochastically changes between two (or more) values, indicating that the biomolecule undergoes transitions between two (o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cossio P,Hummer G,Szabo A

更新日期：2015-11-17 00:00:00

abstract：:In the replication of human immunodeficiency virus type 1 (HIV-1), gag MA (matrix), a major structural protein of the virus, carries out opposing targeting functions. During virus assembly, gag MA is cotranslationally myristoylated, a modification required for membrane targeting of gag polyproteins. During virus infec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bukrinskaya AG,Ghorpade A,Heinzinger NK,Smithgall TE,Lewis RE,Stevenson M

更新日期：1996-01-09 00:00:00

abstract：:The timing of human colonization of East Polynesia, a vast area lying between Hawai'i, Rapa Nui, and New Zealand, is much debated and the underlying causes of this great migration have been enigmatic. Our study generates evidence for human dispersal into eastern Polynesia from islands to the west from around AD 900 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sear DA,Allen MS,Hassall JD,Maloney AE,Langdon PG,Morrison AE,Henderson ACG,Mackay H,Croudace IW,Clarke C,Sachs JP,Macdonald G,Chiverrell RC,Leng MJ,Cisneros-Dozal LM,Fonville T,Pearson E

更新日期：2020-04-21 00:00:00

abstract：:Stability of the long noncoding-polyadenylated nuclear (PAN) RNA from Kaposi's sarcoma-associated herpesvirus is conferred by an expression and nuclear retention element (ENE). The ENE protects PAN RNA from a rapid deadenylation-dependent decay pathway via formation of a triple helix between the U-rich internal loop o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JA,Valenstein ML,Yario TA,Tycowski KT,Steitz JA

更新日期：2012-11-20 00:00:00

abstract：:Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that restrains cancer progression at premalignant stages, in part by causing telomere dysfunction. Currently it is unknown whether this proliferative arrest presents a stable and therefore irreversible barrier to cancer progression. Here we de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel PL,Suram A,Mirani N,Bischof O,Herbig U

更新日期：2016-08-23 00:00:00

abstract：:Cotransfection assays were used to show that the members of the GTP-binding protein Gq class of alpha subunits could activate phospholipase C (PLC) beta 2. Similar experiments also demonstrated that G beta 1 gamma 1, G beta 1 gamma 5, and G beta 2 gamma 5 could activate the beta 2 isoform of PLC but not the beta 1 iso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu D,Katz A,Simon MI

更新日期：1993-06-01 00:00:00

abstract：:The basic biochemical mechanisms underlying many heritable human polycystic diseases are unknown despite evidence that most cases are caused by mutations in members of several protein families, the most prominent being the polycystin gene family, whose products are found on the primary cilia, or due to mutations in po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Condac E,Silasi-Mansat R,Kosanke S,Schoeb T,Towner R,Lupu F,Cummings RD,Hinsdale ME

更新日期：2007-05-29 00:00:00

abstract：:Gene delivery to skeletal muscle is a promising strategy for the treatment of muscle disorders and for the systemic secretion of therapeutic proteins. However, present DNA delivery technologies have to be improved with regard to both the level of expression and interindividual variability. We report very efficient pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mir LM,Bureau MF,Gehl J,Rangara R,Rouy D,Caillaud JM,Delaere P,Branellec D,Schwartz B,Scherman D

更新日期：1999-04-13 00:00:00

abstract：:Dual-color fluorescence cross-correlation spectroscopy (dual-color FCS) has previously been shown to be a suitable tool not only for binding but also for catalytic rate studies. In this work, its application as a rapid method for high-throughput screening (HTS) and evolutionary biotechnology is described. This applica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koltermann A,Kettling U,Bieschke J,Winkler T,Eigen M

更新日期：1998-02-17 00:00:00

abstract：:Aptamers recognize their targets with extraordinary affinity and specificity. The aptamer-based therapeutic, Macugen, is derived from a modified 2'fluoro pyrimidine RNA inhibitor to vascular endothelial growth factor (VEGF) and is now being used to treat the wet form of age-related macular degeneration. This VEGF(165)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JH,Canny MD,De Erkenez A,Krilleke D,Ng YS,Shima DT,Pardi A,Jucker F

更新日期：2005-12-27 00:00:00

abstract：:Alternaria solani, the causal agent of early blight disease in potato, produces two host-specific, lipidlike toxins in culture. Both compounds are required in the leaf bioassay for the elicitation of typical early blight symptoms, but the compounds are individually inactive. The procedures for the preparation of both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matern U,Strobel G,Shepard J

更新日期：1978-10-01 00:00:00

abstract：:The influence of language familiarity upon speaker identification is well established, to such an extent that it has been argued that "Human voice recognition depends on language ability" [Perrachione TK, Del Tufo SN, Gabrieli JDE (2011) Science 333(6042):595]. However, 7-mo-old infants discriminate speakers of their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleming D,Giordano BL,Caldara R,Belin P

更新日期：2014-09-23 00:00:00

abstract：:Cells are nonequilibrium systems that exchange matter and energy with the environment to sustain their metabolic needs. The nonequilibrium nature of this system presents considerable challenges to developing a general theory describing its behavior; however, when studied at appropriate spatiotemporal scales, the behav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang AY,Marshall WF

更新日期：2019-10-22 00:00:00

abstract：:Junctions that mediate excitation-contraction (e-c) coupling are formed between the sarcoplasmic reticulum (SR) and either the surface membrane or the transverse (T) tubules in normal skeletal muscle. Two structural components of the junctions, the feet of the SR and the tetrads of T tubules, have been identified resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takekura H,Nishi M,Noda T,Takeshima H,Franzini-Armstrong C

更新日期：1995-04-11 00:00:00

abstract：:The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak agonist peptide var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghendler Y,Teng MK,Liu JH,Witte T,Liu J,Kim KS,Kern P,Chang HC,Wang JH,Reinherz EL

更新日期：1998-08-18 00:00:00

abstract：:Hypertension increases the pressure load on the heart and is associated with a poorly understood chronic systemic inflammatory state. Interleukin 33 (IL-33) binds to membrane-bound ST2 (ST2L) and has antihypertrophic and antifibrotic effects in the myocardium. In contrast, soluble ST2 appears to act as a decoy recepto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen WY,Hong J,Gannon J,Kakkar R,Lee RT

更新日期：2015-06-09 00:00:00

abstract：:Many models of morphogenesis are forced to assume specific mechanical properties of cells, because the actual mechanical properties of living tissues are largely unknown. Here, we measure the rheology of epithelial cells in the cellularizing Drosophila embryo by injecting magnetic particles and studying their response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doubrovinski K,Swan M,Polyakov O,Wieschaus EF

更新日期：2017-01-31 00:00:00

abstract：:Leptin acts as a potent inhibitory factor against obesity by regulating energy expenditure, food intake, and adiposity. The obese diabetic db/db mouse, which has defects in leptin receptor, displays enhanced neural responses and elevated behavioral preference to sweet stimuli. Here, we show the effects of leptin on th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawai K,Sugimoto K,Nakashima K,Miura H,Ninomiya Y

更新日期：2000-09-26 00:00:00

abstract：:In the United States, the iconic groundfish fishery for Gulf of Maine cod has endured several dramatic reductions in annual catch limits and been federally declared an economic disaster. Using a repeated cross-sectional survey of fishing captains to assess potential social impacts of the fishery failure, we found that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scyphers SB,Picou JS,Grabowski JH

更新日期：2019-11-12 00:00:00

abstract：:The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SY,Asano M

更新日期：2008-08-26 00:00:00

abstract：:We synthesized a series of octapeptide analogs of somatostatin, containing N-terminal tryptophan or another amino acid followed by the hexapeptide sequences Cys-Phe-D-Trp-Lys-Thr-Cys or Cys-Tyr-D-Trp-Lys-Val-Cys and a C-terminal threoninamide or tryptophanamide. After purification by HPLC, the inhibitory activities of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai RZ,Karashima T,Guoth J,Szoke B,Olsen D,Schally AV

更新日期：1987-04-01 00:00:00

abstract：:Senescent cell antigen (SCA), an aging antigen, is a protein that appears on old cells and marks them for removal by the immune system in mammals. It is derived from band 3, a ubiquitous membrane transport protein found in diverse cell types and tissues. We have used synthetic peptides to identify aging antigenic site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM,Marchalonis JJ,Hughes J,Watanabe K,Schluter SF

更新日期：1990-08-01 00:00:00

abstract：:Despite their importance for biological activity, slower molecular motions beyond the nanosecond range remain poorly understood. We have assembled an unprecedented set of experimental NMR data, comprising up to 27 residual dipolar couplings per amino acid, to define the nature and amplitude of backbone motion in prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bouvignies G,Bernadó P,Meier S,Cho K,Grzesiek S,Brüschweiler R,Blackledge M

更新日期：2005-09-27 00:00:00