Formation of triple-helical structures by the 3'-end sequences of MALAT1 and MENβ noncoding RNAs.

abstract：:Transgenic overexpression of Cu(+2)/Zn(+2) superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1(G93A)) in a Sprague-Dawley rat results in ALS-like motor neuron disease. Motor neuron disease in these rats depended on high levels of mutant SOD1 expression,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howland DS,Liu J,She Y,Goad B,Maragakis NJ,Kim B,Erickson J,Kulik J,DeVito L,Psaltis G,DeGennaro LJ,Cleveland DW,Rothstein JD

更新日期：2002-02-05 00:00:00

abstract：:Although the left and right human cerebral hemispheres differ both functionally and anatomically, little is known about the environmental or genetic factors that govern central nervous system asymmetry. Nevertheless, cerebral asymmetry is strongly correlated with handedness, and handedness does have a significant gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geschwind DH,Miller BL,DeCarli C,Carmelli D

更新日期：2002-03-05 00:00:00

abstract：:Atomic level characterization of proteins and other macromolecules in the living cell is challenging. Recent advances in NMR instrumentation and methods, however, have enabled in-cell studies with prospects for multidimensional spectral characterization of individual macromolecular components. We present NMR data on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Augustus AM,Reardon PN,Spicer LD

更新日期：2009-03-31 00:00:00

abstract：:Etioplasts isolated from barley leaves and purified on a Sephadex G-50 (coarse) column were characterized by electron microscopy and nucleic acid analysis. The majority of etioplasts retained an intact outer envelope, and contamination by other fragments was extremely low. The level of gibberellin-like substances extr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans A,Smith H

更新日期：1976-01-01 00:00:00

abstract：:Maintenance of genome stability is essential for the accurate propagation of genetic information and cell growth and survival. Organisms have therefore developed efficient strategies to prevent DNA lesions and rearrangements. Much of the information concerning these strategies has been obtained through the study of ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maréchal A,Parent JS,Véronneau-Lafortune F,Joyeux A,Lang BF,Brisson N

更新日期：2009-08-25 00:00:00

abstract：:The basidiomycete Ustilago maydis is the causative agent of the disease corn smut. To be pathogenic, strains of U. maydis must be heterozygous for a locus called "b," which appears to control both pathogenicity and sexual development. Two alleles of the b locus of U. maydis were isolated by complementation and hybridi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronstad JW,Leong SA

更新日期：1989-02-01 00:00:00

abstract：:Cadherin/catenin-based adhesions coordinate cellular growth, survival, migration, and differentiation within a tissue by mechanically anchoring cells to their neighbors. They also intersect with diverse signaling pathways in development and cancer. Although the adhesive functions of adherens junction proteins are well...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livshits G,Kobielak A,Fuchs E

更新日期：2012-03-27 00:00:00

abstract：:We test the conjecture that becoming unemployed erodes the extent to which a person acknowledges earned entitlement. We use behavioral experiments to generate incentive-compatible measures of individuals' tendencies to acknowledge earned entitlement and incorporate these experiments in a two-stage study. In the first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barr A,Miller L,Ubeda P

更新日期：2016-04-26 00:00:00

abstract：:Phosphorylation-based signaling pathways employ dephosphorylation mechanisms for signal termination. Histidine to aspartate phosphosignaling in the two-component system that controls bacterial chemotaxis has been studied extensively. Rhodobacter sphaeroides has a complex chemosensory pathway with multiple homologues o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter SL,Roberts MA,Manning CS,Armitage JP

更新日期：2008-11-25 00:00:00

abstract：:An in-depth knowledge of the interaction of water with amorphous silica is critical to fundamental studies of interfacial hydration water, as well as to industrial processes such as catalysis, nanofabrication, and chromatography. Silica has a tunable surface comprising hydrophilic silanol groups and moderately hydroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schrader AM,Monroe JI,Sheil R,Dobbs HA,Keller TJ,Li Y,Jain S,Shell MS,Israelachvili JN,Han S

更新日期：2018-03-20 00:00:00

abstract：:Estrogen signaling occurs through at least two distinct molecular pathways: (i) direct binding of liganded estrogen receptors (ERs) to estrogen-responsive DNA elements (EREs) (the "ER/ERE pathway") and (ii) indirect recruitment of liganded ERs to activating protein-1 (AP-1)-responsive DNA elements via heterodimers of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung E,Acevedo ML,Cole PA,Kraus WL

更新日期：2005-01-18 00:00:00

abstract：:Aposematic coloration, or warning coloration, is a visual signal that acts to minimize contact between predator and unprofitable prey. The conditions favoring the evolution of aposematic coloration remain largely unidentified. Recent work suggests that diet specialization and resultant toxicity may play a role in faci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prudic KL,Oliver JC,Sperling FA

更新日期：2007-12-04 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) DNA was treated with four restriction endonucleases (EcoRI, HincIII, Bgl II, and Xba I) and eight fragments were purified and labeled with 32P in vitro. The kinetics of renaturation of each of the fragments was measured in the presence of DNA extracted from 333-8-9, a hamster cell l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galloway DA,Copple CD,McDougall JK

更新日期：1980-02-01 00:00:00

abstract：:Migration of organisms (or cells) is typically an adaptive response to spatiotemporal variation in resources that requires individuals to detect and respond to long-range and noisy environmental gradients. Many organisms, from wildebeest to bacteria, migrate en masse in a process that can involve a vast number of indi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guttal V,Couzin ID

更新日期：2010-09-14 00:00:00

abstract：:Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soares JS,Barman I,Dingari NC,Volynskaya Z,Liu W,Klein N,Plecha D,Dasari RR,Fitzmaurice M

更新日期：2013-01-08 00:00:00

abstract：:Genomic and cDNA clones for the human nerve growth factor receptor have been used in conjunction with somatic cell hybrid analysis and in situ hybridization to localize the nerve growth factor receptor locus to human chromosome region 17q12-q22. Additionally, part, if not all, of the nerve growth factor receptor locus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huebner K,Isobe M,Chao M,Bothwell M,Ross AH,Finan J,Hoxie JA,Sehgal A,Buck CR,Lanahan A

更新日期：1986-03-01 00:00:00

abstract：:Understanding Hadean (>4 Ga) Earth requires knowledge of its crust. The composition of the crust and volatiles migrating through it directly influence the makeup of the atmosphere, the composition of seawater, and nutrient availability. Despite its importance, there is little known and less agreed upon regarding the n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boehnke P,Bell EA,Stephan T,Trappitsch R,Keller CB,Pardo OS,Davis AM,Harrison TM,Pellin MJ

更新日期：2018-06-19 00:00:00

abstract：:The structure of the adeno-associated virus (AAV-2) has been determined to 3-A resolution by x-ray crystallography. AAV is being developed as a vector for gene therapy to treat diseases including hemophilia, cancer, and cystic fibrosis. As in the distantly related autonomous parvoviruses, the capsid protein has a beta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie Q,Bu W,Bhatia S,Hare J,Somasundaram T,Azzi A,Chapman MS

更新日期：2002-08-06 00:00:00

abstract：:A cylindrical detonating explosive behaves like a non-Newtonian viscous fluid emerging from a cylindrical pipe. The expression for non-Newtonian viscous flow has been applied to detonating explosives. The resultant fit to emerging flame fronts from detonation is excellent for a wide variety of detonating explosives bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coon N,Ma SM,Redington PK,Brown B,Eyring H

更新日期：1980-10-01 00:00:00

abstract：:Antigen-independent cell lines were derived from mouse helper T-cell clones by culture in autologous supernatant obtained after stimulation with concanavalin A. A factor, termed P40, supporting the growth of these lines was purified and characterized as a basic 32- to 39-kDa single-chain glycoprotein functionally dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uyttenhove C,Simpson RJ,Van Snick J

更新日期：1988-09-01 00:00:00

abstract：:The ganglioside pattern of both SV40- and polyoma virus-transformed mouse cell lines differs from that of the parent cell lines or of cell lines that have transformed spontaneously in tissue culture. This is manifested by a dramatic decrease of gangliosides with an oligosaccharide chain larger than sialyllactose. Pres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cumar FA,Brady RO,Kolodny EH,McFarland VW,Mora PT

更新日期：1970-10-01 00:00:00

abstract：:HIV-1 envelope glycoprotein is the primary target for HIV-1-specific antibodies. The native HIV-1 envelope spike on the virion surface is a trimer, but trimeric gp140 and monomeric gp120 currently are believed to induce comparable immune responses. Indeed, most studies on the immunogenicity of HIV-1 envelope oligomers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovacs JM,Nkolola JP,Peng H,Cheung A,Perry J,Miller CA,Seaman MS,Barouch DH,Chen B

更新日期：2012-07-24 00:00:00

abstract：:Coastal hypoxia (dissolved oxygen ≤ 2 mg/L) is a growing problem worldwide that threatens marine ecosystem services, but little is known about economic effects on fisheries. Here, we provide evidence that hypoxia causes economic impacts on a major fishery. Ecological studies of hypoxia and marine fauna suggest multipl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith MD,Oglend A,Kirkpatrick AJ,Asche F,Bennear LS,Craig JK,Nance JM

更新日期：2017-02-14 00:00:00

abstract：:The role of gene interactions in the evolutionary process has long been controversial. Although some argue that they are not of importance, because most variation is additive, others claim that their effect in the long term can be substantial. Here, we focus on the long-term effects of genetic interactions under direc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paixão T,Barton NH

更新日期：2016-04-19 00:00:00

abstract：:The interrelationships of hexose feeding and insulin action were studied in the Chinese hamster fibroblast cell lines 023 and DS-7. The latter, derived from 023 and deficient in phosphoglucose isomerase, has been used to map the metabolic requirements for aldohexose-mediated down-regulation or "curbing" of hexose tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson C,Peterson SW,Ullrey DB,Kalckar HM

更新日期：1986-06-01 00:00:00

abstract：:Photo-triggered alpha-helix formation of a 16-residue peptide featuring a built-in conformational photoswitch is monitored by time-resolved IR spectroscopy. An experimental approach with 2-ps time resolution and a scanning range up to 30 micros is used to cover all time scales of the peptide dynamics. Experiments are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bredenbeck J,Helbing J,Kumita JR,Woolley GA,Hamm P

更新日期：2005-02-15 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00

abstract：:Learning the properties of an image associated with human gaze placement is important both for understanding how biological systems explore the environment and for computer vision applications. There is a large literature on quantitative eye movement models that seeks to predict fixations from images (sometimes termed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kümmerer M,Wallis TS,Bethge M

更新日期：2015-12-29 00:00:00

abstract：:Little is known about how members of the indigenous microflora interact with their mammalian hosts to establish mutually beneficial relationships. We have used a gnotobiotic mouse model to show that Bacteroides thetaiotaomicron, a component of the intestinal microflora of mice and humans, uses a repressor, FucR, as a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hooper LV,Xu J,Falk PG,Midtvedt T,Gordon JI

更新日期：1999-08-17 00:00:00

abstract：:In response to various pathological stresses, the heart undergoes a pathological remodeling process that is associated with cardiomyocyte hypertrophy. Because cardiac hypertrophy can progress to heart failure, a major cause of lethality worldwide, the intracellular signaling pathways that control cardiomyocyte growth ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Appert-Collin A,Cotecchia S,Nenniger-Tosato M,Pedrazzini T,Diviani D

更新日期：2007-06-12 00:00:00