Alpha-helix formation in a photoswitchable peptide tracked from picoseconds to microseconds by time-resolved IR spectroscopy.

abstract：:The template for transcription and replication of negative-stranded RNA viruses is a ribonucleoprotein structure, the nucleocapsid. We have developed a system that supports assembly of the negative-stranded RNA genome of a defective interfering (DI) particle of vesicular stomatitis virus (VSV) into a nucleocapsid in v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirakhur B,Peluso RW

更新日期：1988-10-01 00:00:00

abstract：:The recent development of metallic glass-matrix composites represents a particular milestone in engineering materials for structural applications owing to their remarkable combination of strength and toughness. However, metallic glasses are highly susceptible to cyclic fatigue damage, and previous attempts to solve th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Launey ME,Hofmann DC,Johnson WL,Ritchie RO

更新日期：2009-03-31 00:00:00

abstract：:The virulence of many pathogens depends upon their ability to cope with immune-generated nitric oxide (NO·). In Escherichia coli, the major NO· detoxification systems are Hmp, an NO· dioxygenase (NOD), and NorV, an NO· reductase (NOR). It is well established that Hmp is the dominant system under aerobic conditions, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson JL,Brynildsen MP

更新日期：2016-03-22 00:00:00

abstract：:The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in ag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seo M,Seo K,Hwang W,Koo HJ,Hahm JH,Yang JS,Han SK,Hwang D,Kim S,Jang SK,Lee Y,Nam HG,Lee SJ

更新日期：2015-08-04 00:00:00

abstract：:Societies are complex systems, which tend to polarize into subgroups of individuals with dramatically opposite perspectives. This phenomenon is reflected-and often amplified-in online social networks, where, however, humans are no longer the only players and coexist alongside with social bots-that is, software-control...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stella M,Ferrara E,De Domenico M

更新日期：2018-12-04 00:00:00

abstract：:The ability to integrate visual information over space is a fundamental component of human pattern vision. Regardless of whether it is for detecting luminance contrast or for recognizing objects in a cluttered scene, the position of the target in the visual field governs the size of a window within which visual inform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon M,Liu R

更新日期：2019-02-26 00:00:00

abstract：:CrAs was observed to possess the bulk superconductivity under high-pressure conditions. To understand the superconducting mechanism and explore the correlation between the structure and superconductivity, the high-pressure structural evolution of CrAs was investigated using the angle-dispersive X-ray diffraction (XRD)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Z,Wu W,Hu Q,Zhao J,Li C,Yang K,Cheng J,Luo J,Wang L,Mao HK

更新日期：2015-12-01 00:00:00

abstract：:The serum thymic factor (FTS) utilized in its synthetic or natural form loses its biological activity in a rosette assay after treatment with a metal ion-chelating agent, Chelex 100. This activity is restored by the addition of Zn salts and, to a lesser extent, certain other metal salts. FTS activation is secondary to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dardenne M,Pléau JM,Nabarra B,Lefrancier P,Derrien M,Choay J,Bach JF

更新日期：1982-09-01 00:00:00

abstract：:Climate change is expected to influence the capacities of the land and oceans to act as repositories for anthropogenic CO2 and hence provide a feedback to climate change. A series of experiments with the National Center for Atmospheric Research-Climate System Model 1 coupled carbon-climate model shows that carbon sink...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fung IY,Doney SC,Lindsay K,John J

更新日期：2005-08-09 00:00:00

abstract：:A high density of galanin binding sites was found by using 125I-labeled galanin, iodinated by chloramine-T, followed by autoradiography in the ventral, but not in the dorsal, hippocampus of the rat. Lesions of the fimbria and of the septum caused disappearance of a major population of these binding sites, suggesting t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisone G,Wu CF,Consolo S,Nordström O,Brynne N,Bartfai T,Melander T,Hökfelt T

更新日期：1987-10-01 00:00:00

abstract：:Here we describe a strategy designed to identify RNAs that are actively transported to synapses during learning. Our approach is based on the characterization of RNA transport complexes carried by molecular motor kinesin. Using this strategy in Aplysia, we have identified 5,657 unique sequences consisting of both codi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puthanveettil SV,Antonov I,Kalachikov S,Rajasethupathy P,Choi YB,Kohn AB,Citarella M,Yu F,Karl KA,Kinet M,Morozova I,Russo JJ,Ju J,Moroz LL,Kandel ER

更新日期：2013-04-30 00:00:00

abstract：:The claudin-low subtype is a recently identified rare molecular subtype of human breast cancer that expresses low levels of tight and adherens junction genes and shows high expression of epithelial-to-mesenchymal transition (EMT) genes. These tumors are enriched in gene expression signatures derived from human tumor-i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herschkowitz JI,Zhao W,Zhang M,Usary J,Murrow G,Edwards D,Knezevic J,Greene SB,Darr D,Troester MA,Hilsenbeck SG,Medina D,Perou CM,Rosen JM

更新日期：2012-02-21 00:00:00

abstract：:The objective of this study has been to determine which Na,K-ATPase isoforms are expressed in red blood cells and whether kinetic differences in the uncoupled sodium efflux mode between the human red blood cell Na,K-ATPase and other preparations can be explained by differences in the underlying subunit composition. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stengelin MK,Hoffman JF

更新日期：1997-05-27 00:00:00

abstract：:The major Hsp70 of the mitochondrial matrix (Ssc1 in yeast) is critically important for the translocation of proteins from the cytosol, across the mitochondrial inner membrane, and into the matrix. Tim44, a peripheral inner membrane protein with limited sequence similarity to the J domain of J-type cochaperones, tethe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Silva PD,Schilke B,Walter W,Andrew A,Craig EA

更新日期：2003-11-25 00:00:00

abstract：:Myosins play countless critical roles in the cell, each requiring it to be activated at a specific location and time. To control myosin VI with this specificity, we created an optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa phototropin1 LOV2 domain to a peptide from Dab2 (LOVDab), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： French AR,Sosnick TR,Rock RS

更新日期：2017-02-28 00:00:00

abstract：:The effect of the IgG from amyotrophic lateral sclerosis (ALS) patients was tested on the voltage-dependent barium currents (IBa) in mammalian dissociated Purkinje cells and in isolated P-type calcium channels in lipid bilayers. Whole cell clamp of Purkinje cells demonstrates that ALS IgG increases the amplitude of IB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llinás R,Sugimori M,Cherksey BD,Smith RG,Delbono O,Stefani E,Appel S

更新日期：1993-12-15 00:00:00

abstract：:Island biogeography theory posits that species richness increases with island size and decreases with isolation. This logic underpins much conservation policy and regulation, with preference given to conserving large, highly connected areas, and relative ambivalence shown toward protecting small, isolated habitat patc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wintle BA,Kujala H,Whitehead A,Cameron A,Veloz S,Kukkala A,Moilanen A,Gordon A,Lentini PE,Cadenhead NCR,Bekessy SA

更新日期：2019-01-15 00:00:00

abstract：:NRSF/REST is a protein that silences transcription of a number of genes that contain a DNA element called the neuron-restrictive silencer element (NRSE). During embryogenesis, REST is expressed ubiquitously in nonneural cells, but is down-regulated during differentiation of neural progenitors into neurons. REST is als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenigsberger C,Chicca JJ 2nd,Amoureux MC,Edelman GM,Jones FS

更新日期：2000-02-29 00:00:00

abstract：:Complex phenotypes can be modeled as networks of component traits connected by genetic, developmental, or functional interactions. Aposematism, which has evolved multiple times in poison frogs (Dendrobatidae), links a warning signal to a chemical defense against predators. Other traits are involved in this complex phe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santos JC,Cannatella DC

更新日期：2011-04-12 00:00:00

abstract：:A human metallothionein (MT) gene was inserted into a bovine papillomavirus (BPV) vector. The chimeric vector (pMTII-BPV) transforms rodent fibroblasts to a cadmium-resistant phenotype. The resistance is due to the high level of expression of human MT-II in those cells. The vector is maintained in the cells as a free ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karin M,Cathala G,Nguyen-Huu MC

更新日期：1983-07-01 00:00:00

abstract：:We have detected a proteolytic mechanism in chloroplasts that selectively and rapidly degrades the imported small subunit of ribulose 1,5-bisphosphate carboxylase when pools of the chloroplast-synthesized large subunit are depleted. This degradation system is constitutively present and appears to be responsible for pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt GW,Mishkind ML

更新日期：1983-05-01 00:00:00

abstract：:Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus. A key mechanism that underlies this response is the slow, activity-dependent removal of responding molecules to a pool which is unavailable to respond immediately to the input. This mechanism is imple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friedlander T,Brenner N

更新日期：2009-12-29 00:00:00

abstract：:Uniparentally inherited mutations to antibiotic resistance and dependence in Chlamydomonas reinhardi exhibit an altered chloroplast ribosome phenotype. Genetic studies demonstrate an absolute correlation between the drug resistance or dependence and the ribosome phenotype in two such mutants. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillham NW,Boynton JE,Burkholder B

更新日期：1970-10-01 00:00:00

abstract：:We have used fast time-resolved infrared spectroscopy to characterize a series of organometallic methane and ethane complexes in solution at room temperature: W(CO)5(CH4) and M(eta5-C5R5)(CO)2(L) [where M = Mn or Re, R = H or CH3 (Re only); and L = CH4 or C2H6]. In all cases, the methane complexes are found to be shor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowan AJ,Portius P,Kawanami HK,Jina OS,Grills DC,Sun XZ,McMaster J,George MW

更新日期：2007-04-24 00:00:00

abstract：:Human cancer cells that had had high (greater than 160) tissue culture passages, when transplanted into antithymocyte-treated F344 newborn rats, caused induction of rat sarcomas in the rats within 2 or 3 subcultures, whereas human cancer cells with low (5-33) passages in vitro did not cause overt induction of rat sarc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huebner RJ,Fish DC,Djurickovic D,Trimmer RW,Bare AL,Bare RM,Smith GT

更新日期：1979-04-01 00:00:00

abstract：:We describe in this study punchless, a nonpathogenic mutant from the rice blast fungus M. grisea, obtained by plasmid-mediated insertional mutagenesis. As do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium. We show that punchless dif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clergeot PH,Gourgues M,Cots J,Laurans F,Latorse MP,Pepin R,Tharreau D,Notteghem JL,Lebrun MH

更新日期：2001-06-05 00:00:00

abstract：:Ubiquitination regulates, via different modes of modifications, a variety of biological processes, and aberrations in the process have been implicated in the pathogenesis of several neurodegenerative diseases. However, our ability to dissect the pathophysiological relevance of the ubiquitination code has been hampered...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haj-Yahya M,Fauvet B,Herman-Bachinsky Y,Hejjaoui M,Bavikar SN,Karthikeyan SV,Ciechanover A,Lashuel HA,Brik A

更新日期：2013-10-29 00:00:00

abstract：:Blood cells transplantation is largely replacing bone marrow transplantation because engraftment is more rapid. This accelerated engraftment is thought to be mediated by relatively mature committed hematopoietic progenitor cells. Herein, we have used a modified rhodamine (Rho) staining procedure to identify and purify...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zijlmans JM,Visser JW,Laterveer L,Kleiverda K,Heemskerk DP,Kluin PM,Willemze R,Fibbe WE

更新日期：1998-01-20 00:00:00

abstract：:Hitherto it has not been possible to obtain spore and stalk cell differentiation of the cellular slime molds in submerged cultures. It is shown here that cells, when placed in roller tubes under an atmosphere of oxygen, will form clumps and differentiate in 48-72 hr into mature spores and stalk cells. Although differe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternfeld J,Bonner JT

更新日期：1977-01-01 00:00:00

abstract：:Many Drosophila non-long terminal repeat (LTR) retrotransposons actively transpose into internal, gene-rich regions of chromosomes but do not transpose onto chromosome ends. HeT-A and TART are remarkable exceptions; they form telomeres of Drosophila by repeated transpositions onto the ends of chromosomes and never tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rashkova S,Karam SE,Pardue ML

更新日期：2002-03-19 00:00:00