Contribution of zinc and other metals to the biological activity of the serum thymic factor.

abstract：:Ecological interactions shape adaptations through coevolution not only between pairs of species but also through entire multispecies assemblages. Local coevolution can then be further altered through spatial processes that have been formally partitioned in the geographic mosaic theory of coevolution. A major current c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medeiros LP,Garcia G,Thompson JN,Guimarães PR Jr

更新日期：2018-11-20 00:00:00

abstract：:The expression of at least 24 distinct genes of Pseudomonas aeruginosa PAO1 is under direct control of the "ferric uptake regulator" (Fur). Novel targets of the Fur protein were isolated in a powerful SELEX (systematic evolution of ligands by exponential enrichment)-like cycle selection consisting of in vitro DNA-Fur ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochsner UA,Vasil ML

更新日期：1996-04-30 00:00:00

abstract：:The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers. The multiplicity and invasiveness of intestinal adenomas of Apc(Min/+) (Min) mice was enhanced by deficiency for p53. In addition, the occurrence of desm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halberg RB,Katzung DS,Hoff PD,Moser AR,Cole CE,Lubet RA,Donehower LA,Jacoby RF,Dove WF

更新日期：2000-03-28 00:00:00

abstract：:Donor DNA molecules carrying Tn1 or Tn3 deletion mutants do not need to replicate in order to participate in replicon fusion recombination events during which the Tn1/Tn3 element is duplicated. We have assayed Tn1 delta Ap-mediated replicon fusion events involving plasmid R388 and the bacteriophage lambda-derived plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muster CJ,Shapiro JA,MacHattie LA

更新日期：1983-04-01 00:00:00

abstract：:Reactions of a membrane-bound multienzyme complex (electron-transport chain of rat-liver microsomes) suspended in aqueous-organic solvent used as antifreeze at temperatures below 0 degrees were studied. In the presence of a relatively high concentration of ethylene glycol, electron transfer can still be observed and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debey P,Balny C,Douzou P

更新日期：1973-09-01 00:00:00

abstract：:As a structure involved in learning and memory, the hippocampus functions as a network. The functional differentiation along the longitudinal axis of the hippocampus is poorly demarcated in comparison with the transverse axis. Using patch clamp recordings in conjunction with post hoc anatomy, we have examined the patt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gloveli T,Dugladze T,Rotstein HG,Traub RD,Monyer H,Heinemann U,Whittington MA,Kopell NJ

更新日期：2005-09-13 00:00:00

abstract：:The covalent joining of topoisomerases to DNA is normally a transient step in the reaction cycle of these important enzymes. However, under a variety of circumstances, the covalent complex is converted to a long-lived or dead-end product that can result in chromosome breakage and cell death. We have discovered and par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SW,Burgin AB Jr,Huizenga BN,Robertson CA,Yao KC,Nash HA

更新日期：1996-10-15 00:00:00

abstract：:Seasonal changes of daylength (photoperiod) affect the expression of hormonal and behavioral circadian rhythms in a variety of organisms. In mammals, such effects might reflect photoperiodic changes in the circadian pace-making system [located in the suprachiasmatic nucleus (SCN) of the hypothalamus] that governs thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumová A,Trávnícková Z,Peters R,Schwartz WJ,Illnerová H

更新日期：1995-08-15 00:00:00

abstract：:Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have studied two host factors, the spleen and antibody, that influence sequest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： David PH,Hommel M,Miller LH,Udeinya IJ,Oligino LD

更新日期：1983-08-01 00:00:00

abstract：:Complexin activates Ca(2+)-triggered neurotransmitter release and regulates spontaneous release in the presynaptic terminal by cooperating with the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and the Ca(2+)-sensor synaptotagmin. The N-terminal domain of complexin is importa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Y,Choi UB,Zhang Y,Zhao M,Pfuetzner RA,Wang AL,Diao J,Brunger AT

更新日期：2016-08-09 00:00:00

abstract：:We investigate energy transport through an alpha-aminoisobutyric acid-based 3(10)-helix dissolved in chloroform in a combined experimental-theoretical approach. Vibrational energy is locally deposited at the N terminus of the helix by ultrafast internal conversion of a covalently attached, electronically excited, azob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Botan V,Backus EH,Pfister R,Moretto A,Crisma M,Toniolo C,Nguyen PH,Stock G,Hamm P

更新日期：2007-07-31 00:00:00

abstract：:Setting aside high-quality large areas of habitat to protect threatened populations is becoming increasingly difficult as humans fragment and degrade the environment. Biologists and managers therefore must determine the best way to shepherd small populations through the dual challenges of reductions in both the number...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hufbauer RA,Szűcs M,Kasyon E,Youngberg C,Koontz MJ,Richards C,Tuff T,Melbourne BA

更新日期：2015-08-18 00:00:00

abstract：:Two 1,4-benzoquinone derivatives, found in the venom of the scorpion Diplocentrus melici following exposure to air, have been isolated, characterized, synthesized, and assessed for antimicrobial activities. Initially a white, viscous liquid, the extracted venom colors within minutes under ambient conditions. From this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo-Noriega EN,Sathyamoorthi S,Banerjee S,Gnanamani E,Mendoza-Trujillo M,Mata-Espinosa D,Hernández-Pando R,Veytia-Bucheli JI,Possani LD,Zare RN

更新日期：2019-06-25 00:00:00

abstract：:KRAS mutant tumors are largely recalcitrant to targeted therapies. Genetically engineered mouse models (GEMMs) of Kras mutant cancer recapitulate critical aspects of this disease and are widely used for preclinical validation of targets and therapies. Through comprehensive profiling of exomes and matched transcriptome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung WJ,Daemen A,Cheng JH,Long JE,Cooper JE,Wang BE,Tran C,Singh M,Gnad F,Modrusan Z,Foreman O,Junttila MR

更新日期：2017-12-19 00:00:00

abstract：:A panel of rat monoclonal antibodies was used to classify mouse mast cells from four different sources on the basis of their surface determinants. Three populations of mast cells were derived by culturing normal bone marrow, spleen, and peripheral blood cells, whereas the fourth population was isolated directly from t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katz HR,LeBlanc PA,Russell SW

更新日期：1983-10-01 00:00:00

abstract：:We consider the sequential estimation of p, the probability of success in an infinite sequence of Bernoulli trials, when the loss incurred in stopping after n trials and estimating p by some function delta(n) of the first n outcomes is taken to be [Formula: see text] The loss due to error of estimation is thus the sym...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cabilio P,Robbins H

更新日期：1975-01-01 00:00:00

abstract：:Participation of two medial temporal lobe structures, the hippocampal region and the amygdala, in long-term declarative memory encoding was examined by using positron emission tomography of regional cerebral glucose. Positron emission tomography scanning was performed in eight healthy subjects listening passively to a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alkire MT,Haier RJ,Fallon JH,Cahill L

更新日期：1998-11-24 00:00:00

abstract：:An explosion of new information linking activation of cell surface signal initiators to changes in gene expression has recently emerged. The focus of much of this information has centered around the agonist-dependent activation of the mitogen-activated protein (MAP) kinases. Although this intracellular signal transduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blenis J

更新日期：1993-07-01 00:00:00

abstract：:A 38-base-pair region required for normal CYC1 mRNA 3' end formation in Saccharomyces cerevisiae was shown to be necessary for the termination of transcription in vivo by examining the stability of CEN3 plasmids. CEN3 plasmids were stably maintained during vegetative growth, unless a GAL1 transcript impinged on the CE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russo P,Sherman F

更新日期：1989-11-01 00:00:00

abstract：:The coat protein of bacteriophage MS-2 was cleaved with cyanogen bromide to yield three fragments, possessing the sequence 1-88 (P1), 89-108 (P2), and 109-129 (P3), respectively. The mixture of peptides P2 and P3, which could not be separated, was found capable of inhibiting the neutralization of the phage by antiseru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langbeheim H,Arnon R,Sela M

更新日期：1976-12-01 00:00:00

abstract：:Here we study the effects of many-body interactions on rate and mechanism in protein folding by using the results of molecular dynamics simulations on numerous coarse-grained Calpha-model single-domain proteins. After adding three-body interactions explicitly as a perturbation to a Gō-like Hamiltonian with native pair...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ejtehadi MR,Avall SP,Plotkin SS

更新日期：2004-10-19 00:00:00

abstract：:A new type of self-assembling peptide (sapeptide) scaffolds that serve as substrates for neurite outgrowth and synapse formation is described. These peptide-based scaffolds are amenable to molecular design by using chemical or biotechnological syntheses. They can be tailored to a variety of applications. The sapeptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes TC,de Lacalle S,Su X,Liu G,Rich A,Zhang S

更新日期：2000-06-06 00:00:00

abstract：:Synergism between transcriptional activators is a powerful way of potentiating their function. Here we show that the glial POU domain protein Tst-1 (also known as Oct-6 and SCIP) and large tumor antigen (T antigen) synergistically increased transcription from both the early and the late promoters of papovavirus JC in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renner K,Leger H,Wegner M

更新日期：1994-07-05 00:00:00

abstract：:Most class I MHC ligands are generated from the vast majority of cellular proteins by proteolysis within the ubiquitin-proteasome pathway and are presented on the cell surface by MHC class I molecules. Here, we present the crystallographic analysis of yeast 20S proteasome in complex with the inhibitor homobelactosin C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groll M,Larionov OV,Huber R,de Meijere A

更新日期：2006-03-21 00:00:00

abstract：:There are numerous studies on the immune response against malignant human tumors. This study was aimed to address the complexity and specificity of humoral immune response against a benign human tumor. We assembled a panel of 62 meningioma-expressed antigens that show reactivity with serum antibodies of meningioma pat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Comtesse N,Zippel A,Walle S,Monz D,Backes C,Fischer U,Mayer J,Ludwig N,Hildebrandt A,Keller A,Steudel WI,Lenhof HP,Meese E

更新日期：2005-07-05 00:00:00

abstract：:To understand the biogeochemical roles of microorganisms in the environment, it is important to determine when and under which conditions they are metabolically active. Bioorthogonal noncanonical amino acid tagging (BONCAT) can reveal active cells by tracking the incorporation of synthetic amino acids into newly synth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hatzenpichler R,Connon SA,Goudeau D,Malmstrom RR,Woyke T,Orphan VJ

更新日期：2016-07-12 00:00:00

abstract：:Seemingly similar individuals often experience drastically different success trajectories, with some repeatedly failing and others consistently succeeding. One explanation is preexisting variability along unobserved fitness dimensions that is revealed gradually through differential achievement. Alternatively, positive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van de Rijt A,Kang SM,Restivo M,Patil A

更新日期：2014-05-13 00:00:00

abstract：:Electrogenic sodium- and chloride-dependent gamma-aminobutyric acid (GABA) transport in crude synaptosomal membrane vesicles is partly inhibited by saturating levels of either of the substrate analogues cis-3-aminocyclohexanecarboxylic acid (ACHC) or beta-alanine. However, both of them together potently and fully inhi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanner BI,Bendahan A

更新日期：1990-04-01 00:00:00

abstract：:During exercise, increased energy demands are met by increased glucose production that occurs simultaneously with the increased glucose uptake. We had previously observed that, during exercise, metabolic clearance rate of glucose (MCR) increases markedly in normal, but only marginally in poorly controlled diabetic dog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles PD,Yamatani K,Lickley HL,Vranic M

更新日期：1991-02-15 00:00:00

abstract：:When purified dimers of hemagglutinin-neuraminidase molecules released by protease digestion from three strains of human parainfluenza virus 1 were used in crystallization trials, long thin needle crystals formed. Electron microscopic analysis of these needle crystals revealed that they are composed of stacks of tripl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murti KG,Takimoto T,Laver WG,Portner A

更新日期：1993-02-15 00:00:00