The rat suprachiasmatic nucleus is a clock for all seasons.

abstract：:The single-pass transmembrane domains (TMDs) of the syndecan family of cell surface adhesion molecules have been implicated in functional protein-protein interactions. Although each paralog contains a conserved GxxxG dimerization motif, we show here that the syndecan-1 TMD dimerizes weakly, the syndecan-3 and syndecan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dews IC,Mackenzie KR

更新日期：2007-12-26 00:00:00

abstract：:We have obtained the electron paramagnetic resonance spectrum of Cu2+ bound in a tetragonal single crystal of hen egg-white lysozyme. A part of this spectrum has been shown to originate from Cu2+ ions bound at the site designated as B by Teichberg et al. [Teichberg, V.I., Sharon, N., Moult, J., Smilansky, A. & Yonath,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hutchison CA Jr,Singel DJ,Hadad MN,Kemple MD

更新日期：1980-09-01 00:00:00

abstract：:The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux in macrophages, promotes bile acid synthesis in liver, and inhibits intestinal cholesterol absorption, actions that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joseph SB,McKilligin E,Pei L,Watson MA,Collins AR,Laffitte BA,Chen M,Noh G,Goodman J,Hagger GN,Tran J,Tippin TK,Wang X,Lusis AJ,Hsueh WA,Law RE,Collins JL,Willson TM,Tontonoz P

更新日期：2002-05-28 00:00:00

abstract：:Vertebrates, from zebra fish to humans, have an innate immune recognition of many bacterial flagellins. This involves a conserved eight-amino acid epitope in flagellin recognized by the Toll-like receptor 5 (TLR5). Several important human pathogens, such as Helicobacter pylori and Campylobacter jejuni, have escaped TL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kreutzberger MAB,Ewing C,Poly F,Wang F,Egelman EH

更新日期：2020-07-21 00:00:00

abstract：:In all but the poorest countries of South Asia and Africa, the supply and quality of food will rise to meet the demand. Biotechnology, accelerated by genomics, will create wealth for both producers and consumers by reducing the cost and increasing the quality of food. Famine and malnutrition in the poorest countries m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briggs SP

更新日期：1998-03-03 00:00:00

abstract：:Half-cystine peptic peptides representing the intrachain disulfide bonds of the light chain from an apparently homogeneous rabbit anti-p-azobenzoate antibody were isolated in good yields after reduction and alkylation with [(14)C]iodoacetate, and their sequences were determined. The sequence of the first 21 amino-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Appella E,Chersi A,Roholt OA,Pressman D

更新日期：1971-10-01 00:00:00

abstract：:Some cells from cultured embryonic mouse hypothalamus were found to express aromatic-L-amino acid decarboxylase (EC 4.1.1.28) activity and serotonin uptake and storage. These neuron-like cells differed from serotoninergic neurons in cultured embryonic mouse brain stem since they did not contain tryptophan hydroxylase....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Vitry F,Hamon M,Catelon J,Dubois M,Thibault J

更新日期：1986-11-01 00:00:00

abstract：:Fine finger and hand movements in humans, monkeys, and rats are under the direct control of the corticospinal tract (CST). CST lesions lead to severe, long-term deficits of precision movements. We transected completely both CSTs in adult rats and treated the animals for 2 weeks with an antibody that neutralized the ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raineteau O,Fouad K,Noth P,Thallmair M,Schwab ME

更新日期：2001-06-05 00:00:00

abstract：:Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin (OPN4), together with rods and cones, provide light information driving nonvisual light responses. We examined nonvisual photoreception in mice lacking RPE65, a protein that is required for regeneration of visual chromo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doyle SE,Castrucci AM,McCall M,Provencio I,Menaker M

更新日期：2006-07-05 00:00:00

abstract：:Prostaglandin J(2) (PGJ(2)) and its metabolites Delta(12)-PGJ(2) and 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) are naturally occurring derivatives of prostaglandin D(2) that have been suggested to exert antiinflammatory effects in vivo. 15d-PGJ(2) is a high-affinity ligand for the peroxisome proliferator-activated rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Straus DS,Pascual G,Li M,Welch JS,Ricote M,Hsiang CH,Sengchanthalangsy LL,Ghosh G,Glass CK

更新日期：2000-04-25 00:00:00

abstract：:This presentation reviews Chandra's major contribution to the understanding of nearby galaxies. After a brief summary on significant advances in characterizing various types of discrete x-ray sources, the presentation focuses on the global hot gas in and around galaxies, especially normal ones like our own. The hot ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang QD

更新日期：2010-04-20 00:00:00

abstract：:The nucleotide and predicted amino acid sequences of two variant cDNAs [rat brain thyroid hormone receptor (rTR alpha) vI and vII], isolated from a rat brain cDNA library by using the Pst I fragment of v-erbA, showed virtual identity with the rat brain thyroid hormone receptor (rTR alpha) [Thompson, C. C., Weinberger,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsuhashi T,Tennyson GE,Nikodem VM

更新日期：1988-08-01 00:00:00

abstract：:Excellent electrophoretic separations of a variety of biological molecules can be accomplished by using uncharged, triblock copolymers as the "gel" media. These copolymers form uncrosslinked, lyotropic liquid crystalline phases of large micelles between which molecules must travel. Unlike crosslinked hydrogels in comm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rill RL,Locke BR,Liu Y,Van Winkle DH

更新日期：1998-02-17 00:00:00

abstract：:Microinjection of plasmids encoding human tau (htau) protein into identified lamprey reticulospinal neurons (anterior bulbar cells, or ABCs) in situ induces chronic htau expression. htau protein is transported to both the axon and dendrites of expressing ABCs by mechanisms that require the C-terminal domain of htau pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hall GF,Yao J,Lee G

更新日期：1997-04-29 00:00:00

abstract：:To study the multistep process of cervical cancer development, we analyzed 128 frozen cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia (CIN1- CIN3), and cervical cancer (CxCa) from multiple perspectives, revealing a cascade of progressive changes. Compared with normal tissue, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： den Boon JA,Pyeon D,Wang SS,Horswill M,Schiffman M,Sherman M,Zuna RE,Wang Z,Hewitt SM,Pearson R,Schott M,Chung L,He Q,Lambert P,Walker J,Newton MA,Wentzensen N,Ahlquist P

更新日期：2015-06-23 00:00:00

abstract：:We have studied the in vivo signaling mechanisms involved in nociceptin/orphanin FQ (Noci)-induced pain responses by using a flexor-reflex paradigm. Noci was 10,000 times more potent than substance P (SP) in eliciting flexor responses after intraplantar injection into the hind limb of mice, but the action of Noci seem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue M,Kobayashi M,Kozaki S,Zimmer A,Ueda H

更新日期：1998-09-01 00:00:00

abstract：:The quantum mechanical problem of the hydrogen atom is treated by use of a finite difference equation in place of Schrödinger's differential equation. The exact solution leads to a wave vector energy expression that is readily converted to the Bohr-Rydberg formula. (The calculations here reported are limited to spheri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall FT

更新日期：1986-08-01 00:00:00

abstract：:Seep sediments are dominated by intensive microbial sulfate reduction coupled to the anaerobic oxidation of methane (AOM). Through geochemical measurements of incubation experiments with methane seep sediments collected from Hydrate Ridge, we provide insight into the role of iron oxides in sulfate-driven AOM. Seep sed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sivan O,Antler G,Turchyn AV,Marlow JJ,Orphan VJ

更新日期：2014-10-07 00:00:00

abstract：:Phosphoenolpyruvate carboxykinase (GTP) [GTP;oxaloacetate carboxy-lyase(transphosphorylating); EC 4.1.1.32] is absent in rat liver cytosol during fetal life and is synthesized initially at birth. De novo synthesis of the enzyme can be induced prematurely by injection of dibutyryl cyclic AMP or glucagon into fetal anim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia Ruiz JP,Ingram R,Hanson RW

更新日期：1978-09-01 00:00:00

abstract：:Feedback loops are ubiquitous features of biological networks and can produce significant phenotypic heterogeneity, including a bimodal distribution of gene expression across an isogenic cell population. In this work, a combination of experiments and computational modeling was used to explore the roles of multiple fee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venturelli OS,El-Samad H,Murray RM

更新日期：2012-11-27 00:00:00

abstract：:Turbulence in fluids is a ubiquitous, fascinating, and complex natural phenomenon that is not yet fully understood. Unraveling turbulence in high density, high temperature plasmas is an even bigger challenge because of the importance of electromagnetic forces and the typically violent environments. Fascinating and nov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mondal S,Narayanan V,Ding WJ,Lad AD,Hao B,Ahmad S,Wang WM,Sheng ZM,Sengupta S,Kaw P,Das A,Kumar GR

更新日期：2012-05-22 00:00:00

abstract：:The polypeptide precursor pr76 to the internal viral group specific (gs) antigen proteins of Rous sarcoma virus, synthesized in a cell-free system of ascites cells, has been processed in vitro into the viral proteins by purified viral protein p15 as well as by disrupted Rous sarcoma virus. Disrupted Rauscher murine le...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von der Helm K

更新日期：1977-03-01 00:00:00

abstract：:The restriction endonuclease, HindIII, gives rise to three fragments in each of the three mitochondrial DNAs isolated from the established mammalian cell lines LA9 (mouse), HeLa (human), and BSC-1 (African green monkey). The restriction endonuclease, EcoRI, gives rise to three fragments in mitochondrial DNA from HeLa ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown WM,Vinograd J

更新日期：1974-11-01 00:00:00

abstract：:The piriform cortex (PCX) is the largest component of the olfactory cortex and is hypothesized to be the locus of odor object formation. The distributed odorant representation found in PCX contrasts sharply with the topographical representation seen in other primary sensory cortices, making it difficult to test this v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CF,Zou DJ,Altomare CG,Xu L,Greer CA,Firestein SJ

更新日期：2014-11-25 00:00:00

abstract：:Binding of carbon monoxide and oxygen to sterically protected heme model compounds (basket-handle porphyrins) was investigated in liquid toluene at temperatures from 180 to 300 K by laser flash photolysis. Only a single exponential rebinding process from the solvent could be seen in the time range of 20 nsec to millis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tetreau C,Lavalette D,Momenteau M,Lhoste JM

更新日期：1987-04-01 00:00:00

abstract：:In higher eukaryotic cells, mitochondria are essential subcellular organelles for energy production, cell signaling, and the biosynthesis of biomolecules. The mitochondrial DNA (mtDNA) genome is indispensable for mitochondrial function because it encodes protein subunits of the electron transport chain and a full set ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu W,Boyd RM,Tree MO,Samkari F,Zhao L

更新日期：2019-09-03 00:00:00

abstract：:In plants, the AUXIN RESPONSE FACTOR (ARF) transcription factor family regulates gene expression in response to auxin. In the absence of auxin, ARF transcription factors are repressed by interaction with AUXIN/INDOLE 3-ACETIC ACID (Aux/IAA) proteins. Although the C termini of ARF and Aux/IAA proteins facilitate their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korasick DA,Westfall CS,Lee SG,Nanao MH,Dumas R,Hagen G,Guilfoyle TJ,Jez JM,Strader LC

更新日期：2014-04-08 00:00:00

abstract：:The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the sa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein A,Fischli W,Lowney LI,Hunkapiller M,Hood L

更新日期：1981-11-01 00:00:00

abstract：:The neurofibromatosis type 2 (NF2) tumor-suppressor protein Merlin is a member of the ERM family of proteins that links the cytoskeleton to the plasma membrane. In humans, mutations in the NF2 gene cause neurofibromatosis type-2 (NF2), a cancer syndrome characterized by the development of tumors of the nervous system....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benseñor LB,Barlan K,Rice SE,Fehon RG,Gelfand VI

更新日期：2010-04-20 00:00:00

abstract：:Genetic analysis has revealed that the accumulation of several chloroplast mRNAs of the green alga Chlamydomonas reinhardtii requires specific nucleus-encoded functions. To gain insight into this process, we have cloned the nuclear gene encoding the Mbb1 factor by genomic rescue of a mutant specifically deficient in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaistij FE,Boudreau E,Lemaire SD,Goldschmidt-Clermont M,Rochaix JD

更新日期：2000-12-19 00:00:00