Nonvisual light responses in the Rpe65 knockout mouse: rod loss restores sensitivity to the melanopsin system.

abstract：:The H2O2-requiring ligninase of the basidiomycete Phanerochaete chrysosporium oxidatively cleaves both lignin and lignin model compounds between C alpha and C beta (C-1 and C-2) of their aliphatic side chains. Previous work has demonstrated a reaction mechanism by which ligninase oxidizes aromatic substrates to their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammel KE,Kalyanaraman B,Kirk TK

更新日期：1986-06-01 00:00:00

abstract：:The multifunctional DNA-binding protein (DBP) encoded by human adenovirus binds RNA. The association of purified DBP with RNA in vitro was demonstrated by using either a gel filtration or a filter binding assay. This association is sensitive to ionic strength and exhibits no apparent sequence specificity. DBP also int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleghon VG,Klessig DF

更新日期：1986-12-01 00:00:00

abstract：:The preliminary structural characterization of a reversible ferrous dioxygen complex is reported. Mono(N-methyl imidazole) (dioxygen) meso-tetra (alpha,alpha,alpha,alpha-o-pivalamidephenyl) porphinatorino(II), [Fe(O(2))-(N-Me imid) (alpha,alpha,alpha,alpha-TpivPP)], 1, isolated from toluene solution, crystallizes in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collman JP,Gagne RR,Reed CA,Robinson WT,Rodley GA

更新日期：1974-04-01 00:00:00

abstract：:By using an indirect immunofluorescence technique, the distribution of poly(ADP-ribose) synthesis in human blood cells was investigated. The antibody used was reactive with poly(ADP-ribose) larger than trimers. The specific immunofluorescence of poly(ADP-ribose) synthesized in situ from NAD+ was observed in nuclei of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikai K,Ueda K,Fukushima M,Nakamura T,Hayaishi O

更新日期：1980-06-01 00:00:00

abstract：:Naive CD4 T cells differentiate into several effector lineages, which generate a stronger and more rapid response to previously encountered immunological challenges. Although effector function is a key feature of adaptive immunity, the molecular basis of this process is poorly understood. Here, we investigated the spa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zorca CE,Kim LK,Kim YJ,Krause MR,Zenklusen D,Spilianakis CG,Flavell RA

更新日期：2015-03-31 00:00:00

abstract：:The medial preoptic area has been shown to be intricately involved in many behaviors, including locomotion, sexual behavior, maternal care, and aggression. The gene encoding estrogen receptor-α (ERα) protein is expressed in preoptic area neurons, and a very dense immunoreactive field of ERα is found in the preoptic re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro AC,Musatov S,Shteyler A,Simanduyev S,Arrieta-Cruz I,Ogawa S,Pfaff DW

更新日期：2012-10-02 00:00:00

abstract：:The mammalian retina contains an autonomous circadian clock system that controls many physiological functions within this tissue. Previous studies on young mice have reported that removal of the key circadian clock gene Bmal1 from the retina affects the circadian regulation of visual function, but does not affect phot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baba K,Piano I,Lyuboslavsky P,Chrenek MA,Sellers JT,Zhang S,Gargini C,He L,Tosini G,Iuvone PM

更新日期：2018-12-18 00:00:00

abstract：:The usual bias in earthquake catalogs against shocks of small magnitudes can be removed by testing the randomness of the magnitudes of successive shocks. The southern California catalog, 1933-1967, is found to be unbiased in the sense of the test at magnitude 4 or above; the cutoff is improved to M = 3 for the subcata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knopoff L,Gardner JK

更新日期：1969-08-01 00:00:00

abstract：:The SOS-inducible ruvA and ruvB gene products of Escherichia coli are required for normal levels of genetic recombination and DNA repair. In vitro, RuvA protein interacts specifically with Holliday junctions and, together with RuvB (an ATPase), promotes their movement along DNA. This process, known as branch migration...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsaneva IR,Müller B,West SC

更新日期：1993-02-15 00:00:00

abstract：:Oxidation of molecular hydrogen catalyzed by [NiFe] hydrogenases is a widespread mechanism of energy generation among prokaryotes. Biosynthesis of the H2-oxidizing enzymes is a complex process subject to positive control by H2 and negative control by organic energy sources. In this report we describe a novel signal tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lenz O,Friedrich B

更新日期：1998-10-13 00:00:00

abstract：:The conformational change in amyloid beta (Abeta) peptide from its monomeric form to aggregates is crucial in the pathogenesis of Alzheimer's disease (AD). In the healthy brain, some unidentified chaperones appear to prevent the aggregation of Abeta. Here we reported that lipocalin-type prostaglandin D synthase (L-PGD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanekiyo T,Ban T,Aritake K,Huang ZL,Qu WM,Okazaki I,Mohri I,Murayama S,Ozono K,Taniike M,Goto Y,Urade Y

更新日期：2007-04-10 00:00:00

abstract：:Stat3 protein has an important role in oncogenesis and is a promising anticancer target. Indirubin, the active component of a traditional Chinese herbal medicine, has been shown previously to inhibit cyclin-dependent kinases, resulting in cell cycle arrest. Here, we show that the indirubin derivatives E564, E728, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nam S,Buettner R,Turkson J,Kim D,Cheng JQ,Muehlbeyer S,Hippe F,Vatter S,Merz KH,Eisenbrand G,Jove R

更新日期：2005-04-26 00:00:00

abstract：:Using currently available gene fusion techniques, we have constructed plasmids that direct the overproduction of the carboxyl-terminal two-thirds of DNA polymerase I, corresponding to the proteolytically derived "Klenow fragment." We have obtained overproduction amounting to several percent of the cellular protein usi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joyce CM,Grindley ND

更新日期：1983-04-01 00:00:00

abstract：:Agrobacterium tumefaciens can transfer part of its Ti plasmid, the T-DNA, to plant cells where it integrates into the nuclear genome via illegitimate recombination. Integration of the T-DNA results in small deletions of the plant target DNA, and may lead to truncation of the T-DNA borders and the production of filler ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bundock P,Hooykaas PJ

更新日期：1996-12-24 00:00:00

abstract：:A method is presented for detection of lysosomal hydrolase activity in situ in colonies of Chinese hamster ovary cells. This method was used to screen for mutants deficient in lysosomal alpha-mannosidase. Mutagenized cells were replicated onto filter papers [Esko, J. D. & Raetz, C. R. H. (1978) Proc. Natl. Acad. Sci. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robbins AR

更新日期：1979-04-01 00:00:00

abstract：:Neuronal signal integration as well as synaptic transmission and plasticity highly depend on the morphology of dendrites and their spines. Nogo-A is a membrane protein enriched in the adult central nervous system (CNS) myelin, where it restricts the capacity of axons to grow and regenerate after injury. Nogo-A is also...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrinovic MM,Hourez R,Aloy EM,Dewarrat G,Gall D,Weinmann O,Gaudias J,Bachmann LC,Schiffmann SN,Vogt KE,Schwab ME

更新日期：2013-01-15 00:00:00

abstract：:Researchers have documented many cases in which individuals rationalize their regrettable actions. Four experiments examine situations in which people go beyond merely explaining away their misconduct to actively deceiving themselves. We find that those who exploit opportunities to cheat on tests are likely to engage ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance Z,Norton MI,Gino F,Ariely D

更新日期：2011-09-13 00:00:00

abstract：:Chromophore-assisted light inactivation (CALI) offers the only method capable of modulating specific protein activities in localized regions and at particular times. Here, we generalize CALI so that it can be applied to a wider range of tasks. Specifically, we show that CALI can work with a genetically inserted epitop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Surrey T,Elowitz MB,Wolf PE,Yang F,Nédélec F,Shokat K,Leibler S

更新日期：1998-04-14 00:00:00

abstract：:Many native proteins occasionally form partially unfolded forms (PUFs), which can be detected by hydrogen/deuterium exchange and NMR spectroscopy. Knowledge about these metastable states is required to better understand the onset of folding-related diseases. So far, not much is known about where PUFs reside within the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bollen YJ,Kamphuis MB,van Mierlo CP

更新日期：2006-03-14 00:00:00

abstract：:Daytime sleepiness impairs cognitive ability, but recent evidence suggests it is also an important driver of human motivation and behavior. We aimed to investigate the relationship between sleepiness and a behavior strongly associated with better health: social activity. We additionally aimed to investigate whether a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holding BC,Sundelin T,Schiller H,Åkerstedt T,Kecklund G,Axelsson J

更新日期：2020-09-01 00:00:00

abstract：:Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in frozen glassy matrices). This approach has shown enormous pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gajan D,Bornet A,Vuichoud B,Milani J,Melzi R,van Kalkeren HA,Veyre L,Thieuleux C,Conley MP,Grüning WR,Schwarzwälder M,Lesage A,Copéret C,Bodenhausen G,Emsley L,Jannin S

更新日期：2014-10-14 00:00:00

abstract：:The sequence of oligonucleotides produced by the action of bleomycin and ferrous ion on double- and single-stranded DNA has been determined. In the presence of ferrous ion, bleomycin promotes cleavage at G-T and G-C sequences, while high concentrations of ferrous ion alone result in strand scission that is not base sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeshita M,Grollman AP,Ohtsubo E,Ohtsubo H

更新日期：1978-12-01 00:00:00

abstract：:Accumulating evidence suggests that subcutaneous and visceral adipose tissues are differentially associated with metabolic disorders. In obesity, subcutaneous adipose tissue is beneficial for metabolic homeostasis because of repressed inflammation. However, the underlying mechanism remains unclear. Here, we demonstrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang I,Jo K,Shin KC,Kim JI,Ji Y,Park YJ,Park J,Jeon YG,Ka S,Suk S,Noh HL,Choe SS,Alfadda AA,Kim JK,Kim S,Kim JB

更新日期：2019-06-11 00:00:00

abstract：:We have determined the molecular genetic basis of congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency. This common disorder of cortisol biosynthesis is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OHase deficiency and always carries a null allele at the locus encodi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White PC,New MI,Dupont B

更新日期：1984-12-01 00:00:00

abstract：:Telomeric repeat-containing RNA (referred to as TERRA), a noncoding RNA molecule, has recently been found in mammalian cells. The detailed structural features and function of the TERRA RNA at human chromosome ends remain unclear, although this RNA molecule may be a key component of the telomere machinery. In the prese...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Y,Suzuki Y,Ito K,Komiyama M

更新日期：2010-08-17 00:00:00

abstract：:Intermolecular energy transfer between appropriately chosen pairs of dyes can be used to induce or enhance banding patterns in human metaphase chromosomes. Energy transfer, calibrated by fluorometric studies on soluble dye.DNA complexes, can also be detected by photometric measurements on cytological preparations of m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sahar E,Latt SA

更新日期：1978-11-01 00:00:00

abstract：:An expression for the equilibrium of the mean phenotypic value of a quantitative character is derived for a model in which the fitness of an individual depends on its own phenotype and the mean phenotypic value of a group of related individuals. When selection is weak the equilibrium mean is well predicted by Hamilton...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd R,Richerson PJ

更新日期：1980-12-01 00:00:00

abstract：:Replication and transcription of viral RNA genomes rely on host-donated proteins. Qbeta virus infects Escherichia coli and replicates and transcribes its own genomic RNA by Qbeta replicase. Qbeta replicase requires the virus-encoded RNA-dependent RNA polymerase (beta-subunit), and the host-donated translational elonga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeshita D,Tomita K

更新日期：2010-09-07 00:00:00

abstract：:Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER+) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the efficacy of current ER-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao T,Li W,Wang X,Xu H,Yang J,Wu Q,Huang Y,Geradts J,Jiang P,Fei T,Chi D,Zang C,Liao Q,Rennhack J,Andrechek E,Li N,Detre S,Dowsett M,Jeselsohn RM,Liu XS,Brown M

更新日期：2018-07-31 00:00:00

abstract：:Seven morphologically nontransformed (flat) revertants with reduced tumorigenicity in vivo have been isolated from populations of Kirsten sarcoma virus-transformed NIH 3T3 cells transfected with a cDNA expression library of normal human fibroblasts. Each revertant harbors 1-10 recombinant plasmids per cell and retains...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noda M,Kitayama H,Matsuzaki T,Sugimoto Y,Okayama H,Bassin RH,Ikawa Y

更新日期：1989-01-01 00:00:00