Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts.

abstract：:Whereas the laws of thermodynamics prohibit extraction of useful work from the Brownian motion of particles in equilibrium, these motions can be "rectified" under nonequilibrium conditions, for example, in the presence of asymmetric geometrical obstacles. Here, we describe a class of systems in which aerobic bacteria ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokolov A,Apodaca MM,Grzybowski BA,Aranson IS

更新日期：2010-01-19 00:00:00

abstract：:Despite early speculation to the contrary, all tropical forests studied to date display seasonal variations in the presence of new leaves, flowers, and fruits. Past studies were focused on the timing of phenological events and their cues but not on the accompanying changes in leaf area that regulate vegetation-atmosph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Myneni RB,Yang W,Nemani RR,Huete AR,Dickinson RE,Knyazikhin Y,Didan K,Fu R,Negrón Juárez RI,Saatchi SS,Hashimoto H,Ichii K,Shabanov NV,Tan B,Ratana P,Privette JL,Morisette JT,Vermote EF,Roy DP,Wolfe RE,Friedl MA,

更新日期：2007-03-20 00:00:00

abstract：:Night-shift workers are at high risk of drowsiness-related motor vehicle crashes as a result of circadian disruption and sleep restriction. However, the impact of actual night-shift work on measures of drowsiness and driving performance while operating a real motor vehicle remains unknown. Sixteen night-shift workers ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee ML,Howard ME,Horrey WJ,Liang Y,Anderson C,Shreeve MS,O'Brien CS,Czeisler CA

更新日期：2016-01-05 00:00:00

abstract：:Glutamyl-tRNA (Glu-tRNA), formed by Glu-tRNA synthetase (GluRS), is a substrate for protein biosynthesis and tetrapyrrole formation by the C(5) pathway. In this route Glu-tRNA is transformed to delta-aminolevulinic acid, the universal precursor of tetrapyrroles (e.g., heme and chlorophyll) by the action of Glu-tRNA re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levicán G,Katz A,de Armas M,Núñez H,Orellana O

更新日期：2007-02-27 00:00:00

abstract：:Although much is known about the underlying mechanisms of p53 activity and regulation, the factors that influence the diversity and duration of p53 responses are not well understood. Here we describe a unique mode of p53 regulation involving alternative splicing of the TP53 gene. We found that the use of an alternativ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senturk S,Yao Z,Camiolo M,Stiles B,Rathod T,Walsh AM,Nemajerova A,Lazzara MJ,Altorki NK,Krainer A,Moll UM,Lowe SW,Cartegni L,Sordella R

更新日期：2014-08-12 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential to class-switch recombination (CSR) and somatic hypermutation (SHM) in both V region SHM and S region SHM (s-SHM). Uracil DNA glycosylase (UNG), a member of the base excision repair (BER) complex, is required for CSR. Strikingly, however, UNG deficiency causes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yousif AS,Stanlie A,Mondal S,Honjo T,Begum NA

更新日期：2014-03-18 00:00:00

abstract：:In view of the extensive literature on phytochrome mutants in the Ler accession of Arabidopsis, we sought to secure a phytochrome-null line in the same genetic background for comparative studies. Here we report the isolation and phenotypic characterization of phyABCDE quintuple and phyABDE quadruple mutants in the Ler...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu W,Franklin KA,Sharrock RA,Jones MA,Harmer SL,Lagarias JC

更新日期：2013-01-22 00:00:00

abstract：:The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beirowski B,Gustin J,Armour SM,Yamamoto H,Viader A,North BJ,Michán S,Baloh RH,Golden JP,Schmidt RE,Sinclair DA,Auwerx J,Milbrandt J

更新日期：2011-10-25 00:00:00

abstract：:Soybean plants and Rhizobium japonicum 122 DES, a hydrogen uptake-positive strain, were cultured in media purified to remove Ni. Supplemental Ni had no significant effect on the dry matter or total N content of plants. However, the addition of Ni to both nitrate-grown and symbiotically grown plants resulted in a 7- to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klucas RV,Hanus FJ,Russell SA,Evans HJ

更新日期：1983-04-01 00:00:00

abstract：:13C-labeled precorrin-6x is biosynthesized by cell-free protein preparations from Pseudomonas denitrificans in separate experiments using delta-amino[5-13C]levulinic acid and the corresponding delta-amino[4-13C]- and delta-amino[3-13C]levulinic acid-labeled forms in conjunction with S-[methyl-13C]adenosylmethionine fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thibaut D,Blanche F,Debussche L,Leeper FJ,Battersby AR

更新日期：1990-11-01 00:00:00

abstract：:Ecosystem restoration aims to restore biodiversity and valuable functions that have been degraded or lost. The Coral Triangle is a hotspot for marine biodiversity held in its coral reefs, seagrass meadows, and mangrove forests, all of which are in global decline. These coastal ecosystems support valuable fisheries and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams SL,Ambo-Rappe R,Sur C,Abbott JM,Limbong SR

更新日期：2017-11-07 00:00:00

abstract：:Plant litter decomposition is a critical step in the formation of soil organic matter, the mineralization of organic nutrients, and the carbon balance in terrestrial ecosystems. Biotic decomposition in mesic ecosystems is generally negatively correlated with the concentration of lignin, a group of complex aromatic pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austin AT,Ballaré CL

更新日期：2010-03-09 00:00:00

abstract：:The ability of basic/leucine zipper transcription factors to form homo- and heterodimers potentially increases the diversity of signaling pathways that can impinge upon a single genetic element. The capacity of these proteins to dimerize in various combinations complicates the analysis of their functional properties, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loriaux MM,Rehfuss RP,Brennan RG,Goodman RH

更新日期：1993-10-01 00:00:00

abstract：:Glucose entry, as measured by 5-min uptake into the acid-soluble fraction, is enhanced 15-30 times by long-term (12-24 hr) hexose starvation of chick fibroblasts. The rate of galactose accumulation in the cells increases only 5 times under the same conditions of starvation. Several carbon and energy sources that were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martineau R,Kohlbacher M,Shaw SN,Amos H

更新日期：1972-11-01 00:00:00

abstract：:Vibrational modes in mechanical resonators provide a promising candidate to interface and manipulate classical and quantum information. The observation of coherent dynamics between distant mechanical resonators can be a key step toward scalable phonon-based applications. Here we report tunable coherent phonon dynamics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang ZZ,Song XX,Luo G,Su ZJ,Wang KL,Cao G,Li HO,Xiao M,Guo GC,Tian L,Deng GW,Guo GP

更新日期：2020-03-17 00:00:00

abstract：:"Evolution behaves like a tinkerer" (François Jacob, Science, 1977). Software systems provide a singular opportunity to understand biological processes using concepts from network theory. The Debian GNU/Linux operating system allows us to explore the evolution of a complex network in a unique way. The modular design d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fortuna MA,Bonachela JA,Levin SA

更新日期：2011-12-13 00:00:00

abstract：:Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs' biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with a monoclonal Ab (DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrelli A,Circosta P,Granziero L,Mazzone M,Pisacane A,Fenoglio S,Comoglio PM,Giordano S

更新日期：2006-03-28 00:00:00

abstract：:Defining the molecules that regulate tumor cell survival is an essential prerequisite for the development of targeted approaches to cancer treatment. Whereas many studies aimed at identifying such targets use human tumor cells grown in vitro or as s.c. xenografts, it is unclear whether such experimental models replica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Camphausen K,Purow B,Sproull M,Scott T,Ozawa T,Deen DF,Tofilon PJ

更新日期：2005-06-07 00:00:00

abstract：:A genomic clone containing two linked human pregnancy-specific beta 1-glycoprotein (PS beta G) genes has been isolated and characterized. The two genes are arranged in the same 5'----3' orientation; the 3' region (including the A2 and B-C exons) of the upstream gene, PSGGA, is linked to the 5' region (including the 5'...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leslie KK,Watanabe S,Lei KJ,Chou DY,Plouzek CA,Deng HC,Torres J,Chou JY

更新日期：1990-08-01 00:00:00

abstract：:Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of <10%. Contributing to this poor prognosis is the fact that these patients generally do not tolerate standard heart failure therapies. The molecular mechanisms unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi J,Guan J,Jiang B,Brenner DA,Del Monte F,Ward JE,Connors LH,Sawyer DB,Semigran MJ,Macgillivray TE,Seldin DC,Falk R,Liao R

更新日期：2010-03-02 00:00:00

abstract：:Although many types of ancient bacteria and archea rely on hydrogen sulfide (H(2)S) for their energy production, eukaryotes generate ATP in an oxygen-dependent fashion. We hypothesize that endogenous H(2)S remains a regulator of energy production in mammalian cells under stress conditions, which enables the body to co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu M,Zhang W,Wu L,Yang G,Li H,Wang R

更新日期：2012-02-21 00:00:00

abstract：:The skeletal remains of a diminutive small-brained hominin found in Late Pleistocene cave deposits on the island of Flores, Indonesia were assigned to a new species, Homo floresiensis [Brown P, et al. (2004) A new small-bodied hominin from the Late Pleistocene of Flores, Indonesia. Nature 431: 1055-1061]. A dramatical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon AD,Nevell L,Wood B

更新日期：2008-03-25 00:00:00

abstract：:Voltage-gated Na(+) channels initiate action potentials during electrical signaling in excitable cells. Opening and closing of the pore of voltage-gated ion channels are mechanically linked to voltage-driven outward movement of the positively charged S4 transmembrane segment in their voltage sensors. Disulfide locking...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeCaen PG,Yarov-Yarovoy V,Scheuer T,Catterall WA

更新日期：2011-11-15 00:00:00

abstract：:We have found a defect in the ouabain-sensitive Na+, K+-ATPase (Na+ pump, EC 3.6.1.37) of erythrocytes from streptozocin diabetic rats. This defect was accompanied by an increase in cell volume and osmotic fragility and a decrease in the cytosolic K+/Na+ ratio. There was also a doubling in the time needed for diabetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kowluru R,Bitensky MW,Kowluru A,Dembo M,Keaton PA,Buican T

更新日期：1989-05-01 00:00:00

abstract：:Serine is the only amino acid that is encoded by two disjoint codon sets so that a tandem substitution of two nucleotides is required to switch between the two sets. Previously published evidence suggests that, for the most evolutionarily conserved serines, the codon set switch occurs by simultaneous substitution of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogozin IB,Belinky F,Pavlenko V,Shabalina SA,Kristensen DM,Koonin EV

更新日期：2016-11-15 00:00:00

abstract：:We have isolated and characterized a fragment of the gene encoding adipose fatty acid-binding protein (gene 422) from a 3T3-L1 adipocyte genomic library. The 5'-flanking sequence of the 422 gene contains potential regulatory regions for adipose-specific expression. At position -120 there is a fat-specific element that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JS,Lucas JJ,Sibley E,Bolanowski MA,Christy RJ,Kelly TJ,Lane MD

更新日期：1988-05-01 00:00:00

abstract：:The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous leishmaniasis. In each situation, there was a dermal accumulation of monocytes and T cells, and the epidermis exhibited thickeni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan G,Witmer MD,Nath I,Steinman RM,Laal S,Prasad HK,Sarno EN,Elvers U,Cohn ZA

更新日期：1986-05-01 00:00:00

abstract：:Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+). Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermosura MC,Nayakanti H,Dorovkov MV,Calderon FR,Ryazanov AG,Haymer DS,Garruto RM

更新日期：2005-08-09 00:00:00

abstract：:How climate change influences the dynamics of plant populations is not well understood, as few plant studies have measured responses of vital rates to climatic variables and modeled the impact on population growth. The present study used 25 y of demographic data to analyze how survival, growth, and fecundity respond t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell DR

更新日期：2019-06-25 00:00:00

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00