Association of the adenovirus DNA-binding protein with RNA both in vitro and in vivo.

abstract：:Superoxide dismutases (SODs; superoxide: superoxide oxidoreductase, EC 1.15.1.1) play a key role in protection against oxygen radicals, and SOD gene expression is highly induced during environmental stress. To determine the conditions of SOD induction, the promoter of the cytosolic copper/zinc SOD (Cu/ZnSODcyt) gene w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hérouart D,Van Montagu M,Inzé D

更新日期：1993-04-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development and progression by regulating genes that are vital for proliferation, glycolysis, angiogenesis, and metastasis. To identify strategies of targeting the HIF-1 pathway, we screened a siRNA library against the entire druggable genome and a sm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin X,David CA,Donnelly JB,Michaelides M,Chandel NS,Huang X,Warrior U,Weinberg F,Tormos KV,Fesik SW,Shen Y

更新日期：2008-01-08 00:00:00

abstract：:The 20S proteasome core particle (20S CP) plays an integral role in cellular homeostasis by degrading proteins no longer required for function. The process is, in part, controlled via gating residues localized to the ends of the heptameric barrel-like CP structure that occlude substrate entry pores, preventing unregul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang R,Pérez F,Kay LE

更新日期：2017-11-14 00:00:00

abstract：:Jasmonates (JAs) are plant-specific signaling molecules that steer a diverse set of physiological and developmental processes. Pathogen attack and wounding inflicted by herbivores induce the biosynthesis of these hormones, triggering defense responses both locally and systemically. We report on alterations in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauwels L,Morreel K,De Witte E,Lammertyn F,Van Montagu M,Boerjan W,Inzé D,Goossens A

更新日期：2008-01-29 00:00:00

abstract：:A photolyzable derivative of dipeptidyl-tRNA, p-azido-N-tBoc-Phe-[3H]Phe-tRNA, bound reversibly to 70S ribosomes in the presence of poly(U), becomes, when irradiated, covalently attached to components of the 50S ribosomal subunit. Most of the reaction occurs within the 23S RNA, while ribosomal proteins are only weakly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sonenberg N,Wilchek M,Zamir A

更新日期：1975-11-01 00:00:00

abstract：:The compact steep-spectrum sources (CSSs) are an interesting class of objects which are of subgalactic dimensions; they occur more frequently in high-frequency surveys because their spectra often turn over at lower frequencies. We have estimated the symmetry parameters of a well-defined sample of CSSs and compared the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saikia DJ

更新日期：1995-12-05 00:00:00

abstract：:Persephin (Pspn), a recently cloned member of the transforming growth factor-beta superfamily (TGF-beta) and glial cell line-derived neurotrophic factor (GDNF) subfamily, is distributed throughout the nervous system at extremely low levels and is thought to function as a survival factor for midbrain dopaminergic and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomac AC,Agulnick AD,Haughey N,Chang CF,Zhang Y,Bäckman C,Morales M,Mattson MP,Wang Y,Westphal H,Hoffer BJ

更新日期：2002-07-09 00:00:00

abstract：:Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily detectable even in 2-year-old mice, despite the fact that the proportion of the peripheral T cell pool comprised of RTEs declines with age. Alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hale JS,Boursalian TE,Turk GL,Fink PJ

更新日期：2006-05-30 00:00:00

abstract：:Studies of phage lambda in vivo have indicated that its own recombination enzymes, beta protein and lambda exonuclease, are capable of catalyzing two dissimilar pathways of homologous recombination that are widely distributed in nature: single-strand annealing and strand invasion. The former is an enzymatic splicing o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rybalchenko N,Golub EI,Bi B,Radding CM

更新日期：2004-12-07 00:00:00

abstract：:Summertime Arctic shipboard observations of oxygenated volatile organic compounds (OVOCs) such as organic acids, key precursors of climatically active secondary organic aerosol (SOA), are consistent with a novel source of OVOCs to the marine boundary layer via chemistry at the sea surface microlayer. Although this sou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mungall EL,Abbatt JPD,Wentzell JJB,Lee AKY,Thomas JL,Blais M,Gosselin M,Miller LA,Papakyriakou T,Willis MD,Liggio J

更新日期：2017-06-13 00:00:00

abstract：:The nuclear receptor REV-ERBα integrates the circadian clock with hepatic glucose and lipid metabolism by nucleating transcriptional comodulators at genomic regulatory regions. An interactomic approach identified O-GlcNAc transferase (OGT) as a REV-ERBα-interacting protein. By shielding cytoplasmic OGT from proteasoma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berthier A,Vinod M,Porez G,Steenackers A,Alexandre J,Yamakawa N,Gheeraert C,Ploton M,Maréchal X,Dubois-Chevalier J,Hovasse A,Schaeffer-Reiss C,Cianférani S,Rolando C,Bray F,Duez H,Eeckhoute J,Lefebvre T,Staels B,Lef

更新日期：2018-11-20 00:00:00

abstract：:In a culture medium of pH 7.4 and a folic acid concentration of 100 mug/liter that contains 5% heat-inactivated chicken plasma rather than serum, the rate of proliferation of normal chicken fibroblasts is determined by the concentration of calcium. Proliferation, rapid when the calcium concentration is physiological, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balk SD,Whitfield JF,Youdale T,Braun AC

更新日期：1973-03-01 00:00:00

abstract：:Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sachdeva V,Husain K,Sheng J,Wang S,Murugan A

更新日期：2020-06-09 00:00:00

abstract：:A 600-base-pair region essential for ColE1 and pMBl plasmid replication contains two promoters responsible for the synthesis of two RNA molecules central to copy number control. One promoter directs synthesis of the primer RNA precursor. The second promoter directs the synthesis of a small RNA molecule, RNAl, which ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cesareni G,Muesing MA,Polisky B

更新日期：1982-10-01 00:00:00

abstract：:Visual crowding is a breakdown in object identification that occurs in cluttered scenes, a process that represents the principle restriction on visual performance in the periphery. When crowded objects are presented experimentally, a key finding is that observers frequently report nearby flanking items instead of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenwood JA,Bex PJ,Dakin SC

更新日期：2009-08-04 00:00:00

abstract：:Periodic fluctuations in past biodiversity, speciation, and extinction have been proposed, with extremely long periods ranging from 26 to 62 million years, although forcing mechanisms remain speculative. In contrast, well-understood periodic Milankovitch climate forcing represents a viable driver for macroevolutionary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crampton JS,Meyers SR,Cooper RA,Sadler PM,Foote M,Harte D

更新日期：2018-05-29 00:00:00

abstract：:Rod signals in the mammalian retina are thought to reach ganglion cells over the circuit rod-->rod depolarizing bipolar cell-->AII amacrine cell-->cone bipolar cells-->ganglion cells. A possible alternative pathway involves gap junctions linking the rods and cones, the circuit being rod-->cone-->cone bipolar cells-->g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeVries SH,Baylor DA

更新日期：1995-11-07 00:00:00

abstract：:Characterizing the entropy of a system is a crucial, and often computationally costly, step in understanding its thermodynamics. It plays a key role in the study of phase transitions, pattern formation, protein folding, and more. Current methods for entropy estimation suffer from a high computational cost, lack of gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nir A,Sela E,Beck R,Bar-Sinai Y

更新日期：2020-12-01 00:00:00

abstract：:The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large B cell lymphoma (DLBCL). We compared the gene-expression profiles between transformed DLBCL and their antecedent FL. No genes were observed to increase or decrease their expression in all of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lossos IS,Alizadeh AA,Diehn M,Warnke R,Thorstenson Y,Oefner PJ,Brown PO,Botstein D,Levy R

更新日期：2002-06-25 00:00:00

abstract：:Bacillus anthrax lethal toxin can be engineered to deliver foreign proteins to the cytosol for antigen presentation to CD8 T cells. Vaccination with modified toxins carrying 8-9 amino acid peptide epitopes induces protective immunity in mice. To evaluate whether large protein antigens can be used with this system, rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Y,Friedman R,Kushner N,Doling A,Thomas L,Touzjian N,Starnbach M,Lieberman J

更新日期：2000-07-05 00:00:00

abstract：:We used positron emission tomography (PET) to examine the role of the hippocampal formation in implicit and explicit memory. Human volunteers studied a list of familiar words, and then they either provided the first word that came to mind in response to three-letter cues (implicit memory) or tried to recall studied wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schacter DL,Alpert NM,Savage CR,Rauch SL,Albert MS

更新日期：1996-01-09 00:00:00

abstract：:Human telomeres terminate with a single-stranded 3' G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray S,Bandaria JN,Qureshi MH,Yildiz A,Balci H

更新日期：2014-02-25 00:00:00

abstract：:Yawn contagion in humans has been proposed to be related to our capacity for empathy. It is presently unclear whether this capacity is uniquely human or shared with other primates, especially monkeys. Here, we show that in gelada baboons (Theropithecus gelada) yawning is contagious between individuals, especially thos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palagi E,Leone A,Mancini G,Ferrari PF

更新日期：2009-11-17 00:00:00

abstract：:Among the multiple steps constituting the kinesin mechanochemical cycle, one of the most interesting events is observed when kinesins move an 8-nm step from one microtubule (MT)-binding site to another. The stepping motion that occurs within a relatively short time scale ( approximately 100 mus) is, however, beyond th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyeon C,Onuchic JN

更新日期：2007-10-30 00:00:00

abstract：:Hydrocarbon films confined between smooth mica surfaces have long provided an experimental playground for model studies of structure and dynamics of confined liquids. However, fundamental questions regarding the phase behavior and shear properties in this simple system remain unsolved. With ultrasensitive resolution i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith AM,Hallett JE,Perkin S

更新日期：2019-12-17 00:00:00

abstract：:The Hippo pathway is an evolutionarily conserved regulator of organ growth and tumorigenesis. In Drosophila, oncogenic RasV12 cooperates with loss-of-cell polarity to promote Hippo pathway-dependent tumor growth. To identify additional factors that modulate this signaling, we performed a genetic screen utilizing the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo X,Sun Y,Azad T,Janse van Rensburg HJ,Luo J,Yang S,Liu P,Lv Z,Zhan M,Lu L,Zhou Y,Ma X,Zhang X,Yang X,Xue L

更新日期：2020-12-01 00:00:00

abstract：:Three lines of evidence indicate that RNA-dependent RNA synthesis occurs in mouse erythroleukemia cells. The first involves labeling studies with [3H]uridine and shows a greater initial labeling rate of globin RNA in the cytoplasm than in the nucleus. Labeled globin RNA found in the cytoplasm after a very short pulse ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volloch V

更新日期：1986-03-01 00:00:00

abstract：:Using the technique of DNA fingerprinting, we investigated the genetic structure within and among four wild-caught colonies (n = 50 individuals) of a eusocial mammal, the naked mole-rat (Heterocephalus glaber; Rodentia: Bathyergidae). We found that DNA fingerprints of colony-mates were strikingly similar and that betw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve HK,Westneat DF,Noon WA,Sherman PW,Aquadro CF

更新日期：1990-04-01 00:00:00

abstract：:Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of inducing actin tail formation within the cytoplasm of macrophages, leading to actin-based motility and intercellular spread. Actin tail formation by M. marinum is markedly reduced in macrophages deficient in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamm LM,Pak MA,Morisaki JH,Snapper SB,Rottner K,Lommel S,Brown EJ

更新日期：2005-10-11 00:00:00

abstract：:The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells. Mice with germ-line (null) deletion of SHIP develop a myeloproliferative-like syndrome that causes early lethality. Lymphocyte anomalies have been obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarasenko T,Kole HK,Chi AW,Mentink-Kane MM,Wynn TA,Bolland S

更新日期：2007-07-03 00:00:00