Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

abstract：:The mitochondrial contact site and cristae organizing system (MICOS) is a multisubunit protein complex that is essential for the proper architecture of the mitochondrial inner membrane. MICOS plays a key role in establishing and maintaining crista junctions, tubular or slit-like structures that connect the cristae mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pape JK,Stephan T,Balzarotti F,Büchner R,Lange F,Riedel D,Jakobs S,Hell SW

更新日期：2020-08-25 00:00:00

abstract：:Erythropoietin, the hormone that is the primary regulator of erythrocyte production, has been purified from anemic-sheep plasma, with a purification factor of more than 1 million. Gel electrophoresis shows that the major contaminant is desialated erythropoietin. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldwasser E,Kung CK

更新日期：1971-04-01 00:00:00

abstract：:Restricted fetal growth is associated with postnatal mortality and morbidity and may be directly related to alterations in the capacity of the placenta to supply nutrients. We proposed previously that imprinted genes can regulate nutrient supply by the placenta. Here, we tested the hypothesis that the insulin-like gro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sibley CP,Coan PM,Ferguson-Smith AC,Dean W,Hughes J,Smith P,Reik W,Burton GJ,Fowden AL,Constância M

更新日期：2004-05-25 00:00:00

abstract：:Evidence indicates that the modulatory effects of the adrenergic stress hormone epinephrine as well as several other neuromodulatory systems on memory storage are mediated by activation of beta-adrenergic mechanisms in the amygdala. In view of our recent findings indicating that the amygdala is involved in mediating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quirarte GL,Roozendaal B,McGaugh JL

更新日期：1997-12-09 00:00:00

abstract：:Gyrate atrophy of the choroid and retina (GA) is an inherited chorioretinal degeneration caused by deficiency of ornithine delta-aminotransferase (OAT; L-ornithine: 2-oxo-acid aminotransferase; EC 2.6.1.13). GA is one of the "Finnish genetic diseases," a group of several rare monogenic disorders that occur with increa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell GA,Brody LC,Sipila I,Looney JE,Wong C,Engelhardt JF,Patel AS,Steel G,Obie C,Kaiser-Kupfer M

更新日期：1989-01-01 00:00:00

abstract：:Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth after premature birth. We show that lack of insulin-like growth factor I (IGF-I) in knockout mice prevents normal retinal vascular growth, despite the presence of vascular endothelial growth factor, important to vessel devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellstrom A,Perruzzi C,Ju M,Engstrom E,Hard AL,Liu JL,Albertsson-Wikland K,Carlsson B,Niklasson A,Sjodell L,LeRoith D,Senger DR,Smith LE

更新日期：2001-05-08 00:00:00

abstract：:Although biological cells are mostly transparent, they are phase objects that differ in shape and refractive index. Any image that is projected through layers of randomly oriented cells will normally be distorted by refraction, reflection, and scattering. Counterintuitively, the retina of the vertebrate eye is inverte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franze K,Grosche J,Skatchkov SN,Schinkinger S,Foja C,Schild D,Uckermann O,Travis K,Reichenbach A,Guck J

更新日期：2007-05-15 00:00:00

abstract：:The callipyge mutation (CLPG) is an A to G transition that affects a muscle-specific long-range control element located in the middle of the 90-kb DLK1-GTL2 intergenic (IG) region. It causes ectopic expression of a 327-kb cluster of imprinted genes in skeletal muscle, resulting in the callipyge muscular hypertrophy an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeda H,Caiment F,Smit M,Hiard S,Tordoir X,Cockett N,Georges M,Charlier C

更新日期：2006-05-23 00:00:00

abstract：:Downstream placement of a strong transcriptional termination signal has made possible the cloning of bacteriophage T5 promoters known to exhibit high signal strength. The cloning system constructed contains two easily assayable indicator functions whose expression is controlled by the integration of promoters and term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gentz R,Langner A,Chang AC,Cohen SN,Bujard H

更新日期：1981-08-01 00:00:00

abstract：:Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in mammals with 16 isoforms that differ in terms of catalytic activity as well as cellular and tissue distribution. CAs catalyze the conversion of CO2 to bicarbonate and protons and are involved in various physiological processes, including learning and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt SD,Costa A,Rani B,Godfried Nachtigall E,Passani MB,Carta F,Nocentini A,de Carvalho Myskiw J,Furini CRG,Supuran CT,Izquierdo I,Blandina P,Provensi G

更新日期：2020-07-07 00:00:00

abstract：:The human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR) sequences were inserted into adenovirus in place of the E1 region. The HIV-1 LTR contained in this recombinant adenovirus responds to trans-activation by tatIII in a HeLa cell line constitutively expressing that HIV-1 gene product. In addition, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice AP,Mathews MB

更新日期：1988-06-01 00:00:00

abstract：:Mechanisms by which macrophages discriminate between "mature-self" and "senescent-self" were investigated using the human red blood cell (RBC) system as a model. Conditions simulating those encountered in situ were adhered to as closely as possible by using short term culture techniques and incubating with autologous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM

更新日期：1975-09-01 00:00:00

abstract：:Microorganisms must sense their environment and rapidly tune their metabolism to ambient conditions to efficiently use available resources. We have identified a gene encoding a response regulator, NblR, that complements a cyanobacterial mutant unable to degrade its light-harvesting complex (phycobilisome), in response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwarz R,Grossman AR

更新日期：1998-09-01 00:00:00

abstract：:The floating water bridge phenomenon is a freestanding rope-shaped connection of pure liquid water, formed under the influence of a high potential difference (approximately 15 kV). Several recent spectroscopic, optical, and neutron scattering studies have suggested that the origin of the bridge is associated with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skinner LB,Benmore CJ,Shyam B,Weber JK,Parise JB

更新日期：2012-10-09 00:00:00

abstract：:The intrinsic role of endogenous IL-17A in spontaneous intestinal tumorigenesis has not been addressed previously to our knowledge. Ablation of IL-17A significantly reduced tumor development in mice bearing a heterozygote mutation in the adenomatous polyposis coli (APC) gene (Apc(Min/+) mice). There was also a decreas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chae WJ,Gibson TF,Zelterman D,Hao L,Henegariu O,Bothwell AL

更新日期：2010-03-23 00:00:00

abstract：:GM54VA human cells transformed by simian virus 40 (SV40) were fused with peritoneal macrophages obtained from three different mouse strains. All 27 hybrid clones studied were positive for SV40 tumor antigen in 100% of their cells and contained human chromosome 17. Human chromosome 17 was the only human chromosome pres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Croce CM

更新日期：1977-01-01 00:00:00

abstract：:High-valent iron-oxo species are thought to be intermediates in the catalytic cycles of oxygenases and peroxidases. An attractive route to these iron-oxo intermediates involves laser flash-quench oxidation of ferric hemes, as demonstrated by our work on the ferryl (compound II) and ferryl porphyrin radical cation (com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ener ME,Lee YT,Winkler JR,Gray HB,Cheruzel L

更新日期：2010-11-02 00:00:00

abstract：:Evidence from more than 100 y of research indicates that conscientiousness (C) is the most potent noncognitive construct for occupational performance. However, questions remain about the magnitudes of its effect sizes across occupational variables, its defining characteristics and functions in occupational settings, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilmot MP,Ones DS

更新日期：2019-11-12 00:00:00

abstract：:In mammals and insects, pheromones strongly influence social behaviors such as aggression and mate recognition. In Drosophila melanogaster, pheromones in the form of cuticular hydrocarbons play prominent roles in courtship. GC/MS is the primary analytical tool currently used to study Drosophila cuticular hydrocarbons....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yew JY,Cody RB,Kravitz EA

更新日期：2008-05-20 00:00:00

abstract：:Coastal hypoxia (dissolved oxygen ≤ 2 mg/L) is a growing problem worldwide that threatens marine ecosystem services, but little is known about economic effects on fisheries. Here, we provide evidence that hypoxia causes economic impacts on a major fishery. Ecological studies of hypoxia and marine fauna suggest multipl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith MD,Oglend A,Kirkpatrick AJ,Asche F,Bennear LS,Craig JK,Nance JM

更新日期：2017-02-14 00:00:00

abstract：:Mechanisms of estrogen-induced tumorigenesis in the target organ are not well understood. It has been suggested that oxidative stress resulting from metabolic activation of carcinogenic estrogens plays a critical role in estrogen-induced carcinogenesis. We tested this hypothesis by using an estrogen-induced hamster re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhat HK,Calaf G,Hei TK,Loya T,Vadgama JV

更新日期：2003-04-01 00:00:00

abstract：:The expression of at least 24 distinct genes of Pseudomonas aeruginosa PAO1 is under direct control of the "ferric uptake regulator" (Fur). Novel targets of the Fur protein were isolated in a powerful SELEX (systematic evolution of ligands by exponential enrichment)-like cycle selection consisting of in vitro DNA-Fur ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochsner UA,Vasil ML

更新日期：1996-04-30 00:00:00

abstract：:Oxidative stress is known to cause tumorigenesis through induction of DNA and lipid damage. It also promotes cancer progression through a largely unknown mechanism. Sulfiredoxin (Srx) is a novel oxidative stress-induced antioxidant protein whose function in tumorigenesis and cancer progression has not been well studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Q,Jiang H,Xiao Z,Baker A,Young MR,Veenstra TD,Colburn NH

更新日期：2011-04-26 00:00:00

abstract：:In the budding yeast Saccharomyces cerevisiae, self-recognition and the thereby promoted aggregation of thousands of cells into protective flocs is mediated by a family of cell-surface adhesins, the flocculins (Flo). Based on this social behavior FLO genes fulfill the definition of "greenbeard" genes, which direct coo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veelders M,Brückner S,Ott D,Unverzagt C,Mösch HU,Essen LO

更新日期：2010-12-28 00:00:00

abstract：:A series of pyrimidine nucleoside analogues containing [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino- 1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-ribofuranose as the pentose were found to inhibit human immunodeficiency virus type 1 [HIV-1(IIIB)] replication at a concentration of 0.06-0.8 microM but wer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balzarini J,Pérez-Pérez MJ,San-Félix A,Schols D,Perno CF,Vandamme AM,Camarasa MJ,De Clercq E

更新日期：1992-05-15 00:00:00

abstract：:Biochemically, the syntrophic bacteria constitute the missing link in our understanding of anaerobic flow of carbon in the biosphere. The completed genome sequence of Syntrophus aciditrophicus SB, a model fatty acid- and aromatic acid-degrading syntrophic bacterium, provides a glimpse of the composition and architectu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McInerney MJ,Rohlin L,Mouttaki H,Kim U,Krupp RS,Rios-Hernandez L,Sieber J,Struchtemeyer CG,Bhattacharyya A,Campbell JW,Gunsalus RP

更新日期：2007-05-01 00:00:00

abstract：:Recent research on rainforest speciation has highlighted the importance of habitat variation in generating population diversification but lacks evidence of an associated reduction in gene flow. This paper describes a study in which molecular markers were used to examine the effects of allopatric divergence and habitat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogden R,Thorpe RS

更新日期：2002-10-15 00:00:00

abstract：:Hookworms are hematophagous nematodes that infect a wide range of mammalian hosts, including humans. There has been speculation for nearly a century as to the identity of the anticoagulant substances) used by these organisms to subvert host hemostasis. Using molecular cloning, we describe a family of potent small prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stassens P,Bergum PW,Gansemans Y,Jespers L,Laroche Y,Huang S,Maki S,Messens J,Lauwereys M,Cappello M,Hotez PJ,Lasters I,Vlasuk GP

更新日期：1996-03-05 00:00:00

abstract：:In a posterior silk gland extract, covalently closed circular (ccc) DNA is in a superhelical state that supports more transcription of fibroin gene than does linear DNA. A HeLa cell extract showed neither the supercoiling activity nor the preference for the transcription of ccc DNA over linear DNA. These activities co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirose S,Suzuki Y

更新日期：1988-02-01 00:00:00

abstract：:Large changes in solvent accessibility to aspartate transcarbamylase (aspartate carbamoyltransferase, carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2), as monitored by tritium exchange, result from binding of substrates and substrate analogs to the catalytic subunit (c3), binding of nucleoside triphosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lennick M,Allewell NM

更新日期：1981-11-01 00:00:00