Photooxidation of cytochrome P450-BM3.

abstract：:Gold nanoparticles (NPs) wrapped in a membrane can be utilized as artificial virus nanoparticles (AVNs) that combine the large nonblinking or bleaching optical cross-section of the NP core with the biological surface properties and functionalities provided by a self-assembled lipid membrane. We used these hybrid nanom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Bandara A,Akiyama H,Eshaghi B,Stelter D,Keyes T,Straub JE,Gummuluru S,Reinhard BM

更新日期：2018-09-25 00:00:00

abstract：:The growth of actin filament networks is a fundamental biological process that drives a variety of cellular and intracellular motions. During motility, eukaryotic cells and intracellular pathogens are propelled by actin networks organized by nucleation-promoting factors that trigger the formation of nascent filaments ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaevitz JW,Fletcher DA

更新日期：2007-10-02 00:00:00

abstract：:Sialyl Lewis x (sLe(x)) and sialyl Lewis a (sLe(a)) glycans are expressed on highly metastatic colon cancer cells. They promote extravasation of cancer cells and tumor angiogenesis via interacting with E-selectin on endothelial cells. Recently, epithelial-mesenchymal transition (EMT) has been noted as a critical pheno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakuma K,Aoki M,Kannagi R

更新日期：2012-05-15 00:00:00

abstract：:Rap phosphatases are a recently discovered family of protein aspartate phosphatases that dephosphorylate the Spo0F--P intermediate of the phosphorelay, thus preventing sporulation of Bacillus subtilis. They are regulators induced by physiological processes that are antithetical to sporulation. The RapA phosphatase is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perego M,Hoch JA

更新日期：1996-02-20 00:00:00

abstract：:Fibroblasts cultured from the skin of a patient with metachromatic leukodystrophy have been found to manifest the biochemical defect of this inborn error of metabolism, a deficiency of arylsulfatase A. Diseased cells had less than five per cent of normal arylsulfatase-A activity, while activities of other lysosomal en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter MT,Fluharty AL,Kihara H

更新日期：1969-03-01 00:00:00

abstract：:The human foamy virus (HFV) genome possesses three open reading frames (bel 1, 2, and 3) located between env and the 3' long terminal repeat. By analogy to other human retroviruses this region was selected as the most likely candidate to encode the viral transactivator. Results presented here confirmed this and showed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rethwilm A,Erlwein O,Baunach G,Maurer B,ter Meulen V

更新日期：1991-02-01 00:00:00

abstract：:During the last 15 years several laboratories have attempted to generate rabbit monoclonal antibodies, mainly because rabbits recognize antigens and epitopes that are not immunogenic in mice or rats, two species from which monoclonal antibodies are usually generated. Monoclonal antibodies from rabbits could not be gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spieker-Polet H,Sethupathi P,Yam PC,Knight KL

更新日期：1995-09-26 00:00:00

abstract：:Women outnumber men in undergraduate enrollments, but they are much less likely than men to major in mathematics or science or to choose a profession in these fields. This outcome often is attributed to the effects of negative sex-based stereotypes. We studied the effect of such stereotypes in an experimental market, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reuben E,Sapienza P,Zingales L

更新日期：2014-03-25 00:00:00

abstract：:Most climate models are large dynamical systems involving a million (or more) variables on big computers. Given that they are nonlinear and not perfect, what can we expect to learn from them about the earth's climate? How can we determine which aspects of their output might be useful and which are noise? And how shoul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith LA

更新日期：2002-02-19 00:00:00

abstract：:In the normal development of retinotectal connections, the site in the tectum at which an optic fiber synapses is related to the position of its ganglion-cell body in the retina. How and when the ganglion cells acquire information about their positions is unknown, but the positional information that each ganglion cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-10-01 00:00:00

abstract：:Rod and cone opsin genes are expressed in a mutually exclusive manner in their respective photoreceptor subtypes in the mammalian retina. Previous transgenic mouse studies showed that functional interactions between the distal enhancer and proximal promoter of rhodopsin and long/medium-wavelength (L/M) opsin genes are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng GH,Chen S

更新日期：2011-10-25 00:00:00

abstract：:The nature of domestic cattle origins in Africa are unclear as archaeological data are relatively sparse. The earliest domesticates were humpless, or Bos taurus, in morphology and may have shared a common origin with the ancestors of European cattle in the Near East. Alternatively, local strains of the wild ox, the au...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bradley DG,MacHugh DE,Cunningham P,Loftus RT

更新日期：1996-05-14 00:00:00

abstract：:A panel of 26 mouse-human somatic cell hybrids containing different human chromosome complements was analyzed with a cloned human pepsinogen cDNA probe to determine the chromosomal location and the number of genes encoding these proteins. A complex containing variable numbers of pepsinogen genes was localized to the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taggart RT,Mohandas TK,Shows TB,Bell GI

更新日期：1985-09-01 00:00:00

abstract：:Homologous recombination is an important biological process that occurs in all organisms and facilitates genome rearrangements and repair of DNA double-strand breaks. Eukaryotic Rad51 proteins (Rad51sp or Rhp51 in fission yeast) are functional and structural homologs of bacterial RecA protein, an evolutionarily conser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akamatsu Y,Dziadkowiec D,Ikeguchi M,Shinagawa H,Iwasaki H

更新日期：2003-12-23 00:00:00

abstract：:Alveolar type II (AT2) cell dysfunction contributes to a number of significant human pathologies including respiratory distress syndrome, lung adenocarcinoma, and debilitating fibrotic diseases, but the critical transcription factors that maintain AT2 cell identity are unknown. Here we show that the E26 transformation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Z,Newton K,Kummerfeld SK,Webster J,Kirkpatrick DS,Phu L,Eastham-Anderson J,Liu J,Lee WP,Wu J,Li H,Junttila MR,Dixit VM

更新日期：2017-04-11 00:00:00

abstract：:The study of specific trans-acting transcription factors in prokaryotes and lower eukaryotes has been greatly facilitated by genetic analysis of mutant strains deficient in such factors. We have developed such a system to study mammalian trans-acting factors that regulate the transcription of class II major histocompa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calman AF,Peterlin BM

更新日期：1988-12-01 00:00:00

abstract：:Human lymphocytes obtained from fasted adult subjects and cultured human tumor lymphocytes were investigated for specific insulin receptors. By use of monoiodoinsulin, specific insulin binding sites were demonstrated in peripheral human lymphocytes, cultured human lymphocytes, and in other types of human circulating c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gavin JR 3rd,Roth J,Jen P,Freychet P

更新日期：1972-03-01 00:00:00

abstract：:Endosomal cargo travels through a dynamic vesicle network en route to degradation by lysosomes or recycling through the Golgi apparatus back to the cell surface. Rab5 is a key determinant of the early endosomes by organizing effector proteins in specific subdomains and mediating early endosome fusion. We find that ear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antignani A,Youle RJ

更新日期：2008-06-10 00:00:00

abstract：:In many eukaryotic systems during immune responses, mitogen-activated protein kinases (MAPKs) link cytoplasmic signaling to chromatin events by targeting transcription factors, chromatin remodeling complexes, and the RNA polymerase machinery. So far, knowledge on these events is scarce in plants and no attempts have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayapuram N,Jarad M,Alhoraibi HM,Bigeard J,Abulfaraj AA,Völz R,Mariappan KG,Almeida-Trapp M,Schlöffel M,Lastrucci E,Bonhomme L,Gust AA,Mithöfer A,Arold ST,Pflieger D,Hirt H

更新日期：2021-01-19 00:00:00

abstract：:Three fluorescein-labeled lectins have been shown to exhibit specificity for the surface of cells in different layers of the epidermis in the newborn rat. An isolectin from seeds of Bandeiraea simplicifolia with specificity for alpha-D-galactosyl end groups labeled the basal and lower spinous cells; a lectin from Ulex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brabec RK,Peters BP,Bernstein IA,Gray RH,Goldstein IJ

更新日期：1980-01-01 00:00:00

abstract：:Plants have intercellular channels, plasmodesmata (PD), that span the cell wall to enable cell-to-cell transport of micro- and macromolecules. We identified an Arabidopsis thaliana embryo lethal mutant increased size exclusion limit 1 (ise1) that results in increased PD-mediated transport of fluorescent tracers. The i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stonebloom S,Burch-Smith T,Kim I,Meinke D,Mindrinos M,Zambryski P

更新日期：2009-10-06 00:00:00

abstract：:Cocaine exposure in utero causes severe alterations in the development of the central nervous system. To study the basis of these teratogenic effects in vitro, we have used cocultures of neurons and glial cells from mouse embryonic brain. Cocaine selectively affected embryonic neuronal cells, causing first a dramatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nassogne MC,Evrard P,Courtoy PJ

更新日期：1995-11-21 00:00:00

abstract：:Immunoglobulin kappa chain gene formation involves site-specific somatic recombination between one of several hundred germ-line variable region genes and a joining site (or "J segment") encoded close to the constant region gene. We have cloned and determined the nucleotide sequence of major portions of the recombinati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Max EE,Seidman JG,Leder P

更新日期：1979-07-01 00:00:00

abstract：:p97/VCP (Cdc48 in yeast) is an essential and abundant member of the AAA+ family of ATPases and is involved in a number of diverse cellular pathways through interactions with different adaptor proteins. The two most characterized adaptors for p97 are p47 and the Ufd1 (ubiquitin fusion degradation 1)-Npl4 (nuclear prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pye VE,Beuron F,Keetch CA,McKeown C,Robinson CV,Meyer HH,Zhang X,Freemont PS

更新日期：2007-01-09 00:00:00

abstract：:We compute parameters characterizing many-body quantum chaos for a critical Fermi surface without quasiparticle excitations. We examine a theory of [Formula: see text] species of fermions at nonzero density coupled to a [Formula: see text] gauge field in two spatial dimensions and determine the Lyapunov rate and the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel AA,Sachdev S

更新日期：2017-02-21 00:00:00

abstract：:Expressions are developed for weak single pair emission probability and strong emission average number of pairs. The water transparency cutoff is closely realized, showing that the fundamental time scale is even shorter. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwinger J

更新日期：1993-05-15 00:00:00

abstract：:The region of the murine major histocompatibility complex (MHC) between the Pb (A beta 3) and Ob (A beta 2) genes controls the expression of an intracellular complex named the LMP (low molecular weight polypeptide) complex. DNA probes for at least seven different genes mapping to this region were isolated. These hybri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho S,Attaya M,Brown MG,Monaco JJ

更新日期：1991-06-15 00:00:00

abstract：:A predictive coarse-grained protein force field [associative memory, water-mediated, structure, and energy model for molecular dynamics (AWSEM)-MD] is used to study the energy landscapes and relative stabilities of amyloid-β protein (1-40) in the monomer and all of its oligomeric forms up to an octamer. We find that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng W,Tsai MY,Chen M,Wolynes PG

更新日期：2016-10-18 00:00:00

abstract：:RNA interference, mediated by small interfering RNAs (siRNAs), is a conserved regulatory process that has evolved as an antiviral defense mechanism in plants and animals. It is not known whether host cells also use siRNAs as an antibacterial defense mechanism in eukaryotes. Here, we report the discovery of an endogeno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katiyar-Agarwal S,Morgan R,Dahlbeck D,Borsani O,Villegas A Jr,Zhu JK,Staskawicz BJ,Jin H

更新日期：2006-11-21 00:00:00

abstract：:The metal complex [(tpy)(Mebim-py)Ru(II)(S)](2+) (tpy = 2,2' : 6',2''-terpyridine; Mebim-py = 3-methyl-1-pyridylbenzimidazol-2-ylidene; S = solvent) is a robust, reactive electrocatalyst toward both water oxidation to oxygen and carbon dioxide reduction to carbon monoxide. Here we describe its use as a single electroc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Concepcion JJ,Brennaman MK,Kang P,Norris MR,Hoertz PG,Meyer TJ

更新日期：2012-09-25 00:00:00