Active opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor network.

abstract：:Block of Ca2+ currents by the dihydropyridine drug nitrendipine was studied in single canine ventricular cells by using the whole-cell variant of the patch clamp technique. When cells were held at depolarized membrane potentials at which Ca2+ currents were approximately equal to 70% inactivated, nitrendipine blocked C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bean BP

更新日期：1984-10-01 00:00:00

abstract：:Adenosine 3':5'-cyclic monophosphate added to exponentially growing cells of Hemophilus influenzae strain Rd increases competence for transformation 100- to 10,000-fold. Cyclic AMP added to near-stationary or stationary cells does not increase competence over the high level normally found in the early stationary phase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise EM Jr,Alexander SP,Powers M

更新日期：1973-02-01 00:00:00

abstract：:Biotin plays an essential role in growth of mycobacteria. Synthesis of the cofactor is essential for Mycobacterium tuberculosis to establish and maintain chronic infections in a murine model of tuberculosis. Although the late steps of mycobacterial biotin synthesis, assembly of the heterocyclic rings, are thought to f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Z,Cronan JE

更新日期：2020-09-22 00:00:00

abstract：:Our recent demonstration that many eukaryotic mRNAs contain sequences complementary to rRNA led to the hypothesis that these sequences might mediate specific interactions between mRNAs and ribosomes and thereby affect translation. In the present experiments, the ability of complementary sequences to bind to rRNA was i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tranque P,Hu MC,Edelman GM,Mauro VP

更新日期：1998-10-13 00:00:00

abstract：:Throughout the world, efforts are under way to restore watersheds, but restoration planning rarely accounts for future climate change. Using a series of linked models of climate, land cover, hydrology, and salmon population dynamics, we investigated the impacts of climate change on the effectiveness of proposed habita...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Battin J,Wiley MW,Ruckelshaus MH,Palmer RN,Korb E,Bartz KK,Imaki H

更新日期：2007-04-17 00:00:00

abstract：:Paleogenetics is an emerging field that resurrects ancestral proteins from now-extinct organisms to test, in the laboratory, models of protein function based on natural history and Darwinian evolution. Here, we resurrect digestive alcohol dehydrogenases (ADH4) from our primate ancestors to explore the history of prima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrigan MA,Uryasev O,Frye CB,Eckman BL,Myers CR,Hurley TD,Benner SA

更新日期：2015-01-13 00:00:00

abstract：:The bacterial actin homolog, MreB, forms helical cables within the cell that are required for maintenance of a rod shape. These helical structures are thought to be involved in the spatial organization of cell wall (peptidoglycan) synthesizing complexes of penicillin-binding proteins (PBPs). Here, we examined the role...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Divakaruni AV,Loo RR,Xie Y,Loo JA,Gober JW

更新日期：2005-12-20 00:00:00

abstract：:Genetic analysis for group selection is developed for the case of a biallelic locus (A, a) undergoing group selection of founder populations only. By contrast to R. Levins"E = E(x) models, extinction now depends on genetics at the propagule stage but acts uniformly on larger populations. Biological evidence supports t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boorman SA

更新日期：1978-04-01 00:00:00

abstract：:The mouse glucocorticoid receptor-interacting protein (GRIP1) is a member of the ERAP160 family of nuclear receptor (NR) coactivators (including SRC-1 and TIF2) which function as bridging proteins between ligand-activated NRs bound to cognate hormone-response elements (HREs) and the transcription initiation apparatus ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walfish PG,Yoganathan T,Yang YF,Hong H,Butt TR,Stallcup MR

更新日期：1997-04-15 00:00:00

abstract：:Aerobic glycolysis in yeast and cancer cells produces pyruvate beyond oxidative needs, a paradox noted by Warburg almost a century ago. To address this question, we reanalyzed extensive measurements from (13)C magnetic resonance spectroscopy of yeast glycolysis and the coupled pathways of futile cycling and glycogen a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shulman RG,Rothman DL

更新日期：2015-09-01 00:00:00

abstract：:Although the future often seems intangible, we can make it more concrete by imagining prospective events. Here, using functional MRI, we demonstrate a mechanism by which the ventromedial prefrontal cortex supports such episodic simulations, and thereby contributes to affective foresight: This region supports processes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benoit RG,Szpunar KK,Schacter DL

更新日期：2014-11-18 00:00:00

abstract：:The rotation of Paracoccus denitrificans F1-ATPase (PdF1) was studied using single-molecule microscopy. At all concentrations of adenosine triphosphate (ATP) or a slowly hydrolyzable ATP analog (ATPγS), above or below Km, PdF1 showed three dwells per turn, each separated by 120°. Analysis of dwell time between steps s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zarco-Zavala M,Watanabe R,McMillan DGG,Suzuki T,Ueno H,Mendoza-Hoffmann F,García-Trejo JJ,Noji H

更新日期：2020-11-24 00:00:00

abstract：:Normal monkeys and monkeys with lesions of the hippocampal formation and adjacent cortex (the H+ lesion) were trained on the delayed nonmatching to sample (DNMS) task with a delay of 0.5 s between the sample and the choice. The animals with H+ lesions learned the task normally at this short delay and also exhibited th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alvarez P,Zola-Morgan S,Squire LR

更新日期：1994-06-07 00:00:00

abstract：:Heparin-binding growth factor type 1 (HBGF-1; sometimes termed acidic fibroblast growth factor) is potentially an important factor in liver regeneration. HBGF-1 alone (half-maximal effect at 60 pM) stimulated hepatocyte DNA synthesis and bound to a high-affinity receptor (Kd = 62 pM; 5000 per cell). Epidermal growth f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kan M,Huang JS,Mansson PE,Yasumitsu H,Carr B,McKeehan WL

更新日期：1989-10-01 00:00:00

abstract：:Phosphorylation is a major mechanism regulating the activity of ion channels that remains poorly understood with respect to T-type calcium channels (Cav3). These channels are low voltage-activated calcium channels that play a key role in cellular excitability and various physiological functions. Their dysfunction has ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blesneac I,Chemin J,Bidaud I,Huc-Brandt S,Vandermoere F,Lory P

更新日期：2015-11-03 00:00:00

abstract：:Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodson BM,Song Y,Taylor RE,Schepkin VD,Brennan KM,Chingas GC,Budinger TF,Navon G,Pines A

更新日期：1997-12-23 00:00:00

abstract：:We previously identified rat8 in the pathway involved in epithelial cell differentiation that occurs in the rat mammary gland at pregnancy when tubules and alveoli are formed. rat8, which encodes an IFN-inducible membrane protein, is the rat homologue of the mouse gene fragilis. By differential detergent extraction an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zucchi I,Prinetti A,Scotti M,Valsecchi V,Valaperta R,Mento E,Reinbold R,Vezzoni P,Sonnino S,Albertini A,Dulbecco R

更新日期：2004-02-17 00:00:00

abstract：:Whereas the neurodegeneration associated with various polyglutamine (polyQ) diseases has prompted extensive studies of polyQ-induced cell death, the neuronal loss that typically appears during late stages of the diseases may not account for the preceding movement and mental disorders. The cellular basis for polyQ-indu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SB,Bagley JA,Lee HY,Jan LY,Jan YN

更新日期：2011-10-04 00:00:00

abstract：:Metalloproteases (MPs) are a large and diverse class of enzymes implicated in numerous physiological and pathological processes, including tissue remodeling, peptide hormone processing, and cancer. MPs are tightly regulated by multiple posttranslational mechanisms in vivo, hindering their functional analysis by conven...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saghatelian A,Jessani N,Joseph A,Humphrey M,Cravatt BF

更新日期：2004-07-06 00:00:00

abstract：:Amnesia produced by protein synthesis inhibitors such as anisomycin provides major support for the prevalent view that the formation of long-lasting memories requires de novo protein synthesis. However, inhibition of protein synthesis might disrupt other neural functions to interfere with memory formation. Intraamygda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canal CE,Chang Q,Gold PE

更新日期：2007-07-24 00:00:00

abstract：:The very low density lipoprotein (VLDL) receptor is a recently cloned member of the low density lipoprotein (LDL) receptor family that mediates the binding and uptake of VLDL when overexpressed in animal cells. Its sequence is 94% identical in humans and rabbits and 84% identical in humans and chickens, implying a con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frykman PK,Brown MS,Yamamoto T,Goldstein JL,Herz J

更新日期：1995-08-29 00:00:00

abstract：:The mouse p19Arf (human p14ARF) tumor suppressor protein, encoded in part from an alternative reading frame of the Ink4a (Cdkn2a) gene, inhibits the Mdm2 E3 ubiquitin ligase to activate p53. Arf is not expressed in most normal tissues of young mice but is induced by high thresholds of aberrant hyperproliferative signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Oosterwijk JG,Li C,Yang X,Opferman JT,Sherr CJ

更新日期：2017-07-11 00:00:00

abstract：:PUF proteins control both growth and differentiation in the C. elegans germ line. These conserved RNA-binding proteins inhibit expression of target mRNAs, either by repressing translation or promoting degradation. Previous studies showed that PUF-8, a PUF protein with striking similarity to human Pumilio, prevents ret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachorik JL,Kimble J

更新日期：2005-08-02 00:00:00

abstract：:Although the function of silicon (Si) in plant physiology has long been debated, its beneficial effects on plant resistance against abiotic and biotic stresses, including insect herbivory, have been well documented. In addition, the jasmonate (JA) signaling pathway plays a crucial role in mediating antiherbivore defen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye M,Song Y,Long J,Wang R,Baerson SR,Pan Z,Zhu-Salzman K,Xie J,Cai K,Luo S,Zeng R

更新日期：2013-09-17 00:00:00

abstract：:ROOT MERISTEM GROWTH FACTOR (RGF) 1 is an important peptide hormone that regulates root growth. Upon binding to its receptor, RGFR1, RGF1 regulates the expression of two transcription factors, PLETHORA 1 and 2 (PLT1/2), to influence root meristem development. Here, we show that the ubiquitin-specific proteases UBP12 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： An Z,Liu Y,Ou Y,Li J,Zhang B,Sun D,Sun Y,Tang W

更新日期：2018-01-30 00:00:00

abstract：:Fibroblasts cultured from the skin of a patient with metachromatic leukodystrophy have been found to manifest the biochemical defect of this inborn error of metabolism, a deficiency of arylsulfatase A. Diseased cells had less than five per cent of normal arylsulfatase-A activity, while activities of other lysosomal en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter MT,Fluharty AL,Kihara H

更新日期：1969-03-01 00:00:00

abstract：:For decades, scientists have debated whether supercooled liquids stop flowing below a glass transition temperature [Formula: see text] or whether motion continues to slow gradually down to zero temperature. Answering this question is challenging because human time scales set a limit on the largest measurable viscosity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jadhao V,Robbins MO

更新日期：2017-07-25 00:00:00

abstract：:Genome packaging is an essential step in virus replication and a potential drug target. Single-stranded RNA viruses have been thought to encapsidate their genomes by gradual co-assembly with capsid subunits. In contrast, using a single molecule fluorescence assay to monitor RNA conformation and virus assembly in real ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borodavka A,Tuma R,Stockley PG

更新日期：2012-09-25 00:00:00

abstract：:Although they lie at the conceptual core of a wide range of scientific questions, the notions of irregular or "random" arrangement and the process of randomization itself have never been unambiguously defined. Algorithmic implementation of these concepts requires a combinatorial, rather than a probability-theoretic, f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singer BH,Pincus S

更新日期：1998-02-17 00:00:00

abstract：:mAbs against tumor-associated carbohydrate antigens have the potential to play a prominent role in cancer immunotherapy. However, it has not been possible to fully exploit the clinical utility of such antibodies primarily, because those of adequate affinity could be derived only from murine sources. To address this pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao S,Gao C,Lo CH,Wirsching P,Wong CH,Janda KD

更新日期：1999-06-08 00:00:00