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Insulin receptors in human circulating cells and fibroblasts.

Abstract：

:Human lymphocytes obtained from fasted adult subjects and cultured human tumor lymphocytes were investigated for specific insulin receptors. By use of monoiodoinsulin, specific insulin binding sites were demonstrated in peripheral human lymphocytes, cultured human lymphocytes, and in other types of human circulating cells. Insulins and insulin derivatives that varied in their potency to stimulate glucose oxidation in the fat cell and to inhibit binding of [(125)I]insulin to purified plasma membranes, varied in an analogous fashion in their ability to inhibit the binding of labeled insulin to human lymphocytes. Hormones that had no effect on the binding of insulin to fat cells or liver membranes also had no effect on the binding of insulin to lymphocytes. Binding was time and temperature dependent; dissociation of [(125)I]insulin was rapid upon addition of 10 muM insulin. These findings afford a direct approach to the study of endocrine disorders in man.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Gavin JR 3rd,Roth J,Jen P,Freychet P

doi

10.1073/pnas.69.3.747

subject

Has Abstract

pub_date

1972-03-01 00:00:00

pages

747-51

issue

3

eissn

0027-8424

issn

1091-6490

journal_volume

69

pub_type

杂志文章

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