Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis.

abstract：:A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growing number of candidate risk genes and gene variants of unknown functional significance. Here, we used Caenorhabditis elegans to systematically functionally characterize ASD-associated genes in vivo. Using our custom machine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McDiarmid TA,Belmadani M,Liang J,Meili F,Mathews EA,Mullen GP,Hendi A,Wong WR,Rand JB,Mizumoto K,Haas K,Pavlidis P,Rankin CH

更新日期：2020-01-07 00:00:00

abstract：:We have synthesized pulmonary surfactant apoprotein SP-B peptides by solid-phase chemistry and demonstrated their ability to enhance the surface-active properties of synthetic lipid mixtures. The synthetic peptides were reactive with antiserum generated against the native bovine surfactant peptide. Both peptides confe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarin VK,Gupta S,Leung TK,Taylor VE,Ohning BL,Whitsett JA,Fox JL

更新日期：1990-04-01 00:00:00

abstract：:Voltage-dependent anion channels (VDACs) are pore-forming proteins (porins) that form the major pathway for movement of adenine nucleotides through the outer mitochondrial membrane. Electrophysiological studies indicate that VDAC-like channel activity is also prevalent in the cell membranes of many mammalian cells. Ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buettner R,Papoutsoglou G,Scemes E,Spray DC,Dermietzel R

更新日期：2000-03-28 00:00:00

abstract：:The breast and ovarian cancer suppressor BRCA2 controls the enzyme RAD51 during homologous DNA recombination (HDR) to preserve genome stability. BRCA2 binds to RAD51 through 8 conserved BRC repeat motifs dispersed in an 1127-residue region (BRCA2([BRC1-8])). Here, we show that BRCA2([BRC1-8]) exerts opposing effects o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shivji MK,Mukund SR,Rajendra E,Chen S,Short JM,Savill J,Klenerman D,Venkitaraman AR

更新日期：2009-08-11 00:00:00

abstract：:If excision repair-proficient human cells are allowed time for repair before onset of S phase, the premutagenic lesions formed by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy- 7,8,9,10-tetrahydrobenzo[a]pyrene (benzo[a]pyrene diol epoxide, BPDE) are lost from the transcribed strand of the hypoxanthine (guanin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen RH,Maher VM,Brouwer J,van de Putte P,McCormick JJ

更新日期：1992-06-15 00:00:00

abstract：:Using a comprehensive transcriptome analysis, a Z chromosome-linked chicken homolog of hemogen (cHEMGN) was identified and shown to be specifically involved in testis differentiation in early chicken embryos. Hemogen [Hemgn in mice, EDAG (erythroid differentiation-associated gene protein) in humans] was recently chara...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakata T,Ishiguro M,Aduma N,Izumi H,Kuroiwa A

更新日期：2013-02-26 00:00:00

abstract：:Myosins are molecular motors that power diverse cellular processes, such as rapid organelle transport, muscle contraction, and tension-sensitive anchoring. The structural adaptations in the motor that allow for this functional diversity are not known, due, in part, to the lack of high-resolution structures of highly t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shuman H,Greenberg MJ,Zwolak A,Lin T,Sindelar CV,Dominguez R,Ostap EM

更新日期：2014-02-11 00:00:00

abstract：:Outer membrane protein (OMP) biogenesis is critical to bacterial physiology because the cellular envelope is vital to bacterial pathogenesis and antibiotic resistance. The process of OMP biogenesis has been studied in vivo, and each of its components has been studied in isolation in vitro. This work integrates paramet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costello SM,Plummer AM,Fleming PJ,Fleming KG

更新日期：2016-08-16 00:00:00

abstract：:Spontaneous cross-linking in vitro, during incubation of purified collagen in nonstriated and native type fibrils, was studied to elucidate the relationship between intra and intermolecular cross-links. In nonbanded fibrils, the aldol condensation products of two allysyl residues, previously shown to constitute the in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang AH,Gross J

更新日期：1970-11-01 00:00:00

abstract：:The subcellular localization of cathepsin B activity (EC 3.4.22.1) in three murine melanomas of increasing metastatic potential (Cloudman less than B16-F1 less than B16 amelanotic) was determined. Cathepsin B activity was localized in the heavy mitochondrial fraction of normal murine liver but in the light mitochondri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sloane BF,Rozhin J,Johnson K,Taylor H,Crissman JD,Honn KV

更新日期：1986-04-01 00:00:00

abstract：:The evolutionary transition from single cells toward multicellular forms of life represents one of the major transitions in the evolution of complex organisms. In this transition, single autonomously reproducing cells became parts of larger reproducing entities that eventually constituted a new unit of selection. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeiffer T,Bonhoeffer S

更新日期：2003-02-04 00:00:00

abstract：:The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encompass t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams A,Lee GR,Spilianakis CG,Hwang SS,Eisenbarth SC,Flavell RA

更新日期：2013-04-23 00:00:00

abstract：:Biological diversity reflects an underlying molecular diversity. The molecules found in nature may be regarded as solutions to challenges that have been confronted and overcome during molecular evolution. As our understanding of these solutions deepens, the efficiency with which we can discover and/or design new treat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caporale LH

更新日期：1995-01-03 00:00:00

abstract：:Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in frozen glassy matrices). This approach has shown enormous pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gajan D,Bornet A,Vuichoud B,Milani J,Melzi R,van Kalkeren HA,Veyre L,Thieuleux C,Conley MP,Grüning WR,Schwarzwälder M,Lesage A,Copéret C,Bodenhausen G,Emsley L,Jannin S

更新日期：2014-10-14 00:00:00

abstract：:Infected cell protein 0 (ICP0) is a 775-residue multifunctional herpes simplex virus protein associated with numerous functions related to transactivation of gene expression and repression of host defenses to infection. We report that an uncharted domain of ICP0 located between residues 245 and 510 contains multiple S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang Y,Kurakin A,Roizman B

更新日期：2005-04-19 00:00:00

abstract：:Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as dextroamphetamine and methylphenidate are effective for increasing arousal and inducing reanimation, or active emergence from general anesthesia. DA neurons in the ventral tegmental area (VTA) are involved in reward processing, motivation, emoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor NE,Van Dort CJ,Kenny JD,Pei J,Guidera JA,Vlasov KY,Lee JT,Boyden ES,Brown EN,Solt K

更新日期：2016-11-08 00:00:00

abstract：:Refinement of neural circuits in the mammalian cerebral cortex shapes brain function during development and in the adult. However, the signaling mechanisms underlying the synapse-specific shrinkage and loss of spiny synapses when neural circuits are remodeled remain poorly defined. Here, we show that low-frequency glu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oh WC,Hill TC,Zito K

更新日期：2013-01-22 00:00:00

abstract：:Activator-dependent recruitment of TFIID initiates formation of the transcriptional preinitiation complex. TFIID binds core promoter DNA elements and directs the assembly of other general transcription factors, leading to binding of RNA polymerase II and activation of RNA synthesis. How TATA box-binding protein (TBP) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright KJ,Marr MT 2nd,Tjian R

更新日期：2006-08-15 00:00:00

abstract：:Despite the enormous theoretical attention given to the evolutionary consequences of sexual reproduction, the validity of the key assumptions on which the theory depends rarely has been evaluated. It is often argued that a reduced ability to purge deleterious mutations condemns asexual lineages to an early extinction....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Omilian AR,Cristescu ME,Dudycha JL,Lynch M

更新日期：2006-12-05 00:00:00

abstract：:Atmospheric oxidation of natural and anthropogenic volatile organic compounds (VOCs) leads to secondary organic aerosol (SOA), which constitutes a major and often dominant component of atmospheric fine particulate matter (PM2.5). Recent work demonstrates that rapid autoxidation of organic peroxy radicals (RO2) formed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pye HOT,D'Ambro EL,Lee BH,Schobesberger S,Takeuchi M,Zhao Y,Lopez-Hilfiker F,Liu J,Shilling JE,Xing J,Mathur R,Middlebrook AM,Liao J,Welti A,Graus M,Warneke C,de Gouw JA,Holloway JS,Ryerson TB,Pollack IB,Thornton

更新日期：2019-04-02 00:00:00

abstract：:Several findings suggest that signals from tyrosine kinases are transduced, at least in part, through ras proteins. These findings include (i) blockage of the transforming activity of constitutively active tyrosine kinases by inhibiting ras function and (ii) genetic screens in Caenorhabditis elegans and in Drosophila ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowtell D,Fu P,Simon M,Senior P

更新日期：1992-07-15 00:00:00

abstract：:The early detection of pathogens with epidemic potential is of major importance to public health. Most emerging infections result in dead-end "spillover" events in which a pathogen is transmitted from an animal reservoir to a human but is unable to achieve the sustained human-to-human transmission necessary for a full...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geoghegan JL,Senior AM,Di Giallonardo F,Holmes EC

更新日期：2016-04-12 00:00:00

abstract：:Mutation of the p53 gene is one of the most frequent genetic changes found in human cancers. Recent experiments indicated that p53 might contain a transcription-activating domain, which functions when directed to a promoter. This study shows that wild-type p53 suppresses transcription of the retinoblastoma (Rb) gene. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiio Y,Yamamoto T,Yamaguchi N

更新日期：1992-06-15 00:00:00

abstract：:Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are stochastically or hierarchically organized, we combined a reporter system where the nucleostemin (NS) promoter drives GFP expression (termed NS-GFP) with a mou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamase A,Muraguchi T,Naka K,Tanaka S,Kinoshita M,Hoshii T,Ohmura M,Shugo H,Ooshio T,Nakada M,Sawamoto K,Onodera M,Matsumoto K,Oshima M,Asano M,Saya H,Okano H,Suda T,Hamada J,Hirao A

更新日期：2009-10-06 00:00:00

abstract：:Frame-shift mutations at microsatellites occur as a time-dependent function of polymerase errors followed by failure of postreplicational mismatch repair. A cell-culture system was developed that allows identification of intermediate mutant cells that carry the mutation on a single DNA strand after the initial DNA pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gasche C,Chang CL,Natarajan L,Goel A,Rhees J,Young DJ,Arnold CN,Boland CR

更新日期：2003-02-18 00:00:00

abstract：:von Willebrand factor (VWF), a protein present in our circulatory system, is necessary to stop bleeding under high shear-stress conditions as found in small blood vessels. The results presented here help unravel how an increase in hydrodynamic shear stress activates VWF's adhesion potential, leading to the counterintu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider SW,Nuschele S,Wixforth A,Gorzelanny C,Alexander-Katz A,Netz RR,Schneider MF

更新日期：2007-05-08 00:00:00

abstract：:Sera from 30 patients with astrocytoma were tested for antibody reacting with cell surface antigens of cultured autologous astrocytoma cells. Ten percent of the patients had antibody detectable by mixed hemadsorption assays, approximately 50% by immune adherence and protein A assays, and 100% by anti-C3-mixed hemadsor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfreundschuh M,Shiku H,Takahashi T,Ueda R,Ransohoff J,Oettgen HF,Old LJ

更新日期：1978-10-01 00:00:00

abstract：:To study the permanency of response to selection for a quantitative character in finite populations and the nature of the genetic effects that contribute to this response, we have used the covariance between ancestors and descendents within populations. Effects and variances are defined for an initial equilibrium rand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cockerham CC,Tachida H

更新日期：1988-03-01 00:00:00

abstract：:We performed combinatorial peptide library screening in vivo on a novel human prostate cancer xenograft that is androgen-independent and induces a robust osteoblastic reaction in bonelike matrix and soft tissue. We found two peptides, PKRGFQD and SNTRVAP, which were enriched in the tumors, targeted the cell surface of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandelin J,Cardó-Vila M,Driessen WH,Mathew P,Navone NM,Lin SH,Logothetis CJ,Rietz AC,Dobroff AS,Proneth B,Sidman RL,Pasqualini R,Arap W

更新日期：2015-03-24 00:00:00

abstract：:CCAAT displacement protein (CDP), a nuclear protein of 180-190 kDa, contains a triplicated motif, the cut domain, similar (80-90% conserved) to three repeats of 60-65 amino acids first identified in Drosophila cut, a homeo-domain protein involved in cell-fate decisions in development. Cut repeats bind DNA and exhibit ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aufiero B,Neufeld EJ,Orkin SH

更新日期：1994-08-02 00:00:00