Evidence for secretory pathway localization of a voltage-dependent anion channel isoform.

abstract：:Dopamine is believed to contribute to the degeneration of dopamine-containing neurons in the brain. However, whether dopamine affects the survival of other neuronal populations has remained unclear. Here we document that mice with persistently elevated extracellular dopamine, resulting from inactivation of the dopamin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cyr M,Beaulieu JM,Laakso A,Sotnikova TD,Yao WD,Bohn LM,Gainetdinov RR,Caron MG

更新日期：2003-09-16 00:00:00

abstract：:Polyploidy, which results from whole genome duplication (WGD), has shaped the long-term evolution of eukaryotic genomes in all kingdoms. Polyploidy is also implicated in adaptation, domestication, and speciation. Yet when WGD newly occurs, the resulting neopolyploids face numerous challenges. A particularly pernicious...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan C,Zhang H,Henry CE,Franklin FCH,Bomblies K

更新日期：2020-04-21 00:00:00

abstract：:Generation of nanomechanical cantilever motion from biomolecular interactions can have wide applications, ranging from high-throughput biomolecular detection to bioactuation. Although it has been suggested that such motion is caused by changes in surface stress of a cantilever beam, the origin of the surface-stress ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu G,Ji H,Hansen K,Thundat T,Datar R,Cote R,Hagan MF,Chakraborty AK,Majumdar A

更新日期：2001-02-13 00:00:00

abstract：:High-affinity ligands of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) were isolated by the SELEX procedure (systematic evolution of ligands by exponential enrichment) from RNA populations randomized at 32 positions. Analysis of these ligands revealed a pseudoknot consensus with primary sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuerk C,MacDougal S,Gold L

更新日期：1992-08-01 00:00:00

abstract：:Using short-term cultures of hamster embryo cells, we have examined the effects of the free-radical scavenger superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) and the enzyme catalase (hydrogen-peroxide:hydrogenperoxide oxidoreductase, EC 1.11.1.6) on x-ray- and bleomycin-induced transformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borek C,Troll W

更新日期：1983-03-01 00:00:00

abstract：:We have devised a general strategy for gene mapping based upon the direct amplification of a target sequence within a single microdissected Giemsa-banded chromosomal segment using the polymerase chain reaction. The usefulness of this approach was demonstrated by mapping a cloned human brain sodium channel (alpha subun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han JA,Lu CM,Brown GB,Rado TA

更新日期：1991-01-15 00:00:00

abstract：:Artemis gene mutations are responsible for the development of a severe combined immunodeficiency [radiation-sensitive (RS) SCID] characterized by a severe B and T cell deficiency and a normal natural killer cell population. To establish the feasibility of a gene therapy approach to the treatment of RS-SCID, we generat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mostoslavsky G,Fabian AJ,Rooney S,Alt FW,Mulligan RC

更新日期：2006-10-31 00:00:00

abstract：:The mechanisms that are essential for the maintenance of nutrient status in breast milk are unclear. Our data demonstrate that the intestine via hypoxia-inducible factor (HIF)-2α is an essential regulatory mechanism for maintaining the quality of breast milk. During lactation, intestinal HIF-2α is highly increased, le...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnan SK,Anderson ER,Martin A,Centofanti B,Shah YM

更新日期：2015-07-14 00:00:00

abstract：:In the primary visual cortex, neurons with similar response preferences are grouped into domains forming continuous maps of stimulus orientation and direction of movement. These properties are widely believed to result from the combination of ascending and lateral interactions in the visual system. We have tested this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galuske RA,Schmidt KE,Goebel R,Lomber SG,Payne BR

更新日期：2002-12-24 00:00:00

abstract：:Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine's antidepressant and adverse effects, the potency of (2R,6R)-HNK to inhibit NMDARs has not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lumsden EW,Troppoli TA,Myers SJ,Zanos P,Aracava Y,Kehr J,Lovett J,Kim S,Wang FH,Schmidt S,Jenne CE,Yuan P,Morris PJ,Thomas CJ,Zarate CA Jr,Moaddel R,Traynelis SF,Pereira EFR,Thompson SM,Albuquerque EX,Gould TD

更新日期：2019-03-12 00:00:00

abstract：:5 alpha-Cholest-8(14)-en-3 beta-ol-15-one has been found to have significant hypocholesterolemic activity upon oral administration at a daily dosage of 75 mg/kg of body weight to Rhesus monkeys fed a diet of moderate cholesterol (Chol) content [0.19 mg/kcal (1 cal = 4.184 J) of diet]. The reductions in total serum Cho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schroepfer GJ Jr,Sherrill BC,Wang KS,Wilson WK,Kisic A,Clarkson TB

更新日期：1984-11-01 00:00:00

abstract：:Human-caused environmental changes are creating regional combinations of environmental conditions that, within the next 50 to 100 years, may fall outside the envelope within which many of the terrestrial plants of a region evolved. These environmental modifications might become a greater cause of global species extinc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilman D,Lehman C

更新日期：2001-05-08 00:00:00

abstract：:Genetic variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset SLC6A4 repeat region (AC/C/G and CT/T/C) associated with individual differences in anxiety-like trait, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santangelo AM,Sawiak SJ,Fryer T,Hong Y,Shiba Y,Clarke HF,Riss PJ,Ferrari V,Tait R,Suckling J,Aigbirhio FI,Roberts AC

更新日期：2019-07-16 00:00:00

abstract：:Sinuous patterns traced by fluid flows are a ubiquitous feature of physical landscapes on Earth, Mars, the volcanic floodplains of the Moon and Venus, and other planetary bodies. Typically discussed as a consequence of migration processes in meandering rivers, sinuosity is also expressed in channel types that show lit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lazarus ED,Constantine JA

更新日期：2013-05-21 00:00:00

abstract：:A central problem in understanding enzyme regulation is to define the conformational states that account for allosteric changes in catalytic activity. For Escherichia coli aspartate transcarbamoylase (ATCase; EC) the active, relaxed (R state) holoenzyme is generally assumed to be represented by the crystal structure o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Endrizzi JA,Beernink PT,Alber T,Schachman HK

更新日期：2000-05-09 00:00:00

abstract：:Maternal deletion of the NESP55 differentially methylated region (DMR) (delNESP55/ASdel3-4(m), delNAS(m)) from the GNAS locus in humans causes autosomal dominant pseudohypoparathyroidism type Ib (AD-PHP-Ib(delNASm)), a disorder of proximal tubular parathyroid hormone (PTH) resistance associated with loss of maternal G...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández-Rebollo E,Maeda A,Reyes M,Turan S,Fröhlich LF,Plagge A,Kelsey G,Jüppner H,Bastepe M

更新日期：2012-04-24 00:00:00

abstract：:A major function of innate immune receptors is to recognize pathogen-associated molecular patterns and then evoke immune responses appropriate to the nature of the invading pathogen(s). Because innate immune cells express various types of these receptors, distinct combinations of signaling pathways are activated in re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negishi H,Matsuki K,Endo N,Sarashina H,Miki S,Matsuda A,Fukazawa K,Taguchi-Atarashi N,Ikushima H,Yanai H,Nishio J,Honda K,Fujioka Y,Ohba Y,Noda T,Taniguchi S,Nishida E,Zhang Y,Chi H,Flavell RA,Taniguchi T

更新日期：2013-12-03 00:00:00

abstract：:Loquacious-PD (Loqs-PD) is required for biogenesis of many endogenous siRNAs in Drosophila In vitro, Loqs-PD enhances the rate of dsRNA cleavage by Dicer-2 and also enables processing of substrates normally refractory to cleavage. Using purified components, and Loqs-PD truncations, we provide a mechanistic basis for L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trettin KD,Sinha NK,Eckert DM,Apple SE,Bass BL

更新日期：2017-09-19 00:00:00

abstract：:Enhanced transductional recombination between specialized transducing phage lambda plac5 and plasmid F42lac depends on cis- and trans-acting factors. By constructing a series of recombinant molecules, the cis-acting site required for enhanced recombination has been identified as oriT, the origin of conjugational trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seifert HS,Porter RD

更新日期：1984-12-01 00:00:00

abstract：:Conformational aspects of the acetylcholine receptor (AcChoR) of Electrophorus electricus have been examined by studies of its interaction with structurally related, constrained aromatic bis quaternary compounds. Among the compounds synthesized was 3,3'-bis[alpha-(trimethylammonium)-methyl]azobenzene dibromide (3,3'-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wassermann NH,Bartels E,Erlanger BF

更新日期：1979-01-01 00:00:00

abstract：:Targeted gene modification mediated by single-stranded oligonucleotides (SSOs) holds great potential for widespread use in a number of biological and biomedical fields, including functional genomics and gene therapy. By using this approach, specific genetic changes have been created in a number of prokaryotic and euka...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu XS,Xin L,Yin WX,Shang XY,Lu L,Watt RM,Cheah KS,Huang JD,Liu DP,Liang CC

更新日期：2005-02-15 00:00:00

abstract：:Fodrin, a protein composed of two polypeptides with molecular weights of 250,000 and 240,000, is concentrated in the cortical cytoplasm of neurons, and moves down the axons by the process of axonal transport. We have used immunofluorescence techniques to determine whether fodrin antigens also move in non-neuronal cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine J,Willard M

更新日期：1983-01-01 00:00:00

abstract：:Cholera and enterotoxigenic Escherichia coli (ETEC) are among the most common causes of acute infantile gastroenteritis globally. We previously developed a rice-based vaccine that expressed cholera toxin B subunit (MucoRice-CTB) and had the advantages of being cold chain-free and providing protection against cholera t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhara D,Yuki Y,Nochi T,Kodama T,Mejima M,Kurokawa S,Takahashi Y,Nanno M,Nakanishi U,Takaiwa F,Honda T,Kiyono H

更新日期：2010-05-11 00:00:00

abstract：:Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas, and several other types of human cancers. Because among normal tissues, mesothelin is present only on mesothelial cells, it represents a good target for antibody-mediated delivery of cytotoxic agents. In the present study...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chowdhury PS,Viner JL,Beers R,Pastan I

更新日期：1998-01-20 00:00:00

abstract：:Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dhonukshe P,Grigoriev I,Fischer R,Tominaga M,Robinson DG,Hasek J,Paciorek T,Petrásek J,Seifertová D,Tejos R,Meisel LA,Zazímalová E,Gadella TW Jr,Stierhof YD,Ueda T,Oiwa K,Akhmanova A,Brock R,Spang A,Friml J

更新日期：2008-03-18 00:00:00

abstract：:High-volume hydraulic fracturing (HVHF) has revolutionized the oil and gas industry worldwide but has been accompanied by highly controversial incidents of reported water contamination. For example, groundwater contamination by stray natural gas and spillage of brine and other gas drilling-related fluids is known to o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llewellyn GT,Dorman F,Westland JL,Yoxtheimer D,Grieve P,Sowers T,Humston-Fulmer E,Brantley SL

更新日期：2015-05-19 00:00:00

abstract：:Auditory scene analysis requires the listener to parse the incoming flow of acoustic information into perceptual "streams," such as sentences from a single talker in the midst of background noise. Behavioral and neural data show that the formation of streams is not instantaneous; rather, streaming builds up over time ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo HM,Pressnitzer D,Toshima I,Kashino M

更新日期：2012-04-24 00:00:00

abstract：:Viruses have been implicated in the development of neurodegenerative diseases, such as Alzheimer's, Parkinson's, and multiple sclerosis. Human herpesvirus-6 (HHV-6) is a neurotropic virus that has been associated with a wide variety of neurologic disorders, including encephalitis, mesial temporal lobe epilepsy, and mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harberts E,Yao K,Wohler JE,Maric D,Ohayon J,Henkin R,Jacobson S

更新日期：2011-08-16 00:00:00

abstract：:Since cdc48 mutants were isolated by the first genetic screens for cell division cycle (cdc) mutants in yeast, the requirement of the chaperone-like ATPase Cdc48/p97 during cell division has remained unclear. Here, we discover an unanticipated function for Caenorhabditis elegans CDC-48 in DNA replication linked to cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mouysset J,Deichsel A,Moser S,Hoege C,Hyman AA,Gartner A,Hoppe T

更新日期：2008-09-02 00:00:00

abstract：:A human beta-globin gene derived from an established human lymphoblast cell line was introduced into murine erythroleukemia (MEL) cells by cell fusion. The globin genes in MEL cells are inducible by dimethyl sulfoxide (Me2SO); induction leads to the accumulation of mouse globin mRNA and hemoglobin. Globin mRNA was not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyati J,Kucherlapati RS,Skoultchi AI

更新日期：1980-06-01 00:00:00