Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA.

abstract：:The N-terminal domain of the vaccinia virus protein E3L (Z alpha(E3L)) is essential for full viral pathogenicity in mice. It has sequence similarity to the high-affinity human Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). Here, we report the solution structure of Z alpha(E3L) and the chemical shift map of it...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahmann JD,Wecking DA,Putter V,Lowenhaupt K,Kim YG,Schmieder P,Oschkinat H,Rich A,Schade M

更新日期：2004-03-02 00:00:00

abstract：:Cytotactin is an extracellular matrix protein that is dynamically and transiently expressed in a place-dependent fashion during development by glial cells, fibroblasts, and several other cell types. In the present study, the effects of cytotactin on cell proliferation were examined in fibroblastic cells in culture. NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crossin KL

更新日期：1991-12-15 00:00:00

abstract：:Humans choose actions based on both habit and planning. Habitual control is computationally frugal but adapts slowly to novel circumstances, whereas planning is computationally expensive but can adapt swiftly. Current research emphasizes the competition between habits and plans for behavioral control, yet many complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cushman F,Morris A

更新日期：2015-11-10 00:00:00

abstract：:Eukaryotic cells irradiated with high doses of UV exhibit cell-cycle responses referred to as G(1)/S, intraS, and G(2)/M checkpoints. After a moderate UV dose that approximates sunlight exposure and is lethal to fission yeast checkpoint mutants, we found unexpectedly that these cell-cycle responses do not occur. Inste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callegari AJ,Kelly TJ

更新日期：2006-10-24 00:00:00

abstract：:We reported in previous studies that prostaglandin E2 (PGE2) has central effects of augmenting wakefulness and suppressing slow-wave sleep (SWS) and paradoxical sleep (PS) in rats. In the present study, we tested the effect of AH 6809, an antagonist of PGE2 receptors, on sleep-wake activities. AH 6809 in saline was in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumura H,Honda K,Choi WS,Inoué S,Sakai T,Hayaishi O

更新日期：1989-07-01 00:00:00

abstract：:Vascular flow through tissues is regulated via a number of homeostatic mechanisms. Localized control of tissue blood flow, or autoregulation, is a key factor in regulating tissue perfusion and oxygenation. We show here that the net balance between two hypoxia-inducible factor (HIF) transcription factor isoforms, HIF-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowburn AS,Takeda N,Boutin AT,Kim JW,Sterling JC,Nakasaki M,Southwood M,Goldrath AW,Jamora C,Nizet V,Chilvers ER,Johnson RS

更新日期：2013-10-22 00:00:00

abstract：:An integral mitochondrial membrane protein (p32) of yeast has previously been molecularly cloned and sequenced and suggested to function as a mitochondrial import receptor. However, this protein has also been proposed to function as phosphate translocator [Guérin, B., Bukusoglu, C., Rakotomanana, F. & Wohlrab, H. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami H,Blobel G,Pain D

更新日期：1993-04-15 00:00:00

abstract：:The harvest of wildlife for human consumption is valued at several billion dollars annually and provides an essential source of meat for hundreds of millions of rural people living in poverty. This harvest is also considered among the greatest threats to biodiversity throughout Africa, Asia, and Latin America. Economi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brashares JS,Golden CD,Weinbaum KZ,Barrett CB,Okello GV

更新日期：2011-08-23 00:00:00

abstract：:Eukaryotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivity, proofreading activity, and DNA mismatch repair (MMR). Nucleotide selectivity and proofreading are affected by the balance and concentration of deoxyribonucleotide (dNTP) pools, which are strictly regulated by r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt TT,Reyes G,Gries K,Ceylan CÜ,Sharma S,Meurer M,Knop M,Chabes A,Hombauer H

更新日期：2017-05-30 00:00:00

abstract：:Ovine pulmonary surfactant is bactericidal for Pasteurella haemolytica when surfactant and bacteria mixtures are incubated with normal ovine serum. To isolate this component, surfactant (1 mg/ml) was centrifuged at 100,000 x gav, and the supernatant was fractionated by HPLC. Fractions were eluted with acetonitrile (10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brogden KA,De Lucca AJ,Bland J,Elliott S

更新日期：1996-01-09 00:00:00

abstract：:Ecological character displacement describes a pattern where morphological differences between sympatric species are enhanced through interspecific competition. Although widely considered a pervasive force in evolutionary ecology, few clear-cut examples have been documented. Here we report a case of ecological characte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams DC,Rohlf FJ

更新日期：2000-04-11 00:00:00

abstract：:Viral hepatitis is a disease of antiquity, but evidence for more than one etiologic agent has been recognized only since the 1940s, when two viruses (hepatitis A virus and hepatitis B virus) were thought to account for all disease. In the past 20 years, three additional hepatitis agents (hepatitis C virus, hepatitis D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purcell RH

更新日期：1994-03-29 00:00:00

abstract：:Expression systems based on the Escherichia coli arabinose operon P(BAD) promoter exhibit the all-or-nothing (autocatalytic) induction of expression that was first documented in the lac operon. Under conditions of subsaturating levels of inducer, some of the cells of the population are fully induced, whereas other cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan-Kiss RM,Wadler C,Cronan JE Jr

更新日期：2002-05-28 00:00:00

abstract：:Life in environments devoid of photosynthesis, such as on early Earth or in contemporary dark subsurface ecosystems, is supported by chemical energy. How, when, and where chemical nutrients released from the geosphere fuel chemosynthetic biospheres is fundamental to understanding the distribution and diversity of life...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunham EC,Dore JE,Skidmore ML,Roden EE,Boyd ES

更新日期：2021-01-12 00:00:00

abstract：:The patch-clamp technique allows currents to be recorded through single ion channels in patches of cell membrane in the tips of glass pipettes. When recording, voltage is typically applied across the membrane patch to drive ions through open channels and to probe the voltage-sensitivity of channel activity. In this st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gil Z,Silberberg SD,Magleby KL

更新日期：1999-12-07 00:00:00

abstract：:We have determined the nucleotide sequences of the Klebsiella pneumoniae nifL (regulation of N2 fixation genes) and the Escherichia coli glnA (glutamine synthetase) promoters. We compared these sequences with the published sequences of three other promoters that, like the nifL and glnA promoters, are activated by the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ow DW,Sundaresan V,Rothstein DM,Brown SE,Ausubel FM

更新日期：1983-05-01 00:00:00

abstract：:Apis mellifera originated in Africa and extended its range into Eurasia in two or more ancient expansions. In 1956, honey bees of African origin were introduced into South America, their descendents admixing with previously introduced European bees, giving rise to the highly invasive and economically devastating "Afri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zayed A,Whitfield CW

更新日期：2008-03-04 00:00:00

abstract：:Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the template for both transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox R,Pickar A,Qiu S,Tsao J,Rodenburg C,Dokland T,Elson A,He B,Luo M

更新日期：2014-10-21 00:00:00

abstract：:The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak agonist peptide var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghendler Y,Teng MK,Liu JH,Witte T,Liu J,Kim KS,Kern P,Chang HC,Wang JH,Reinherz EL

更新日期：1998-08-18 00:00:00

abstract：:The Eastern Arc Mountains of Tanzania and the Atlantic Forest of Brazil are two of the most fragmented biodiversity hotspots. Species-area relationships predict that their habitat fragments will experience a substantial loss of species. Most of these extinctions will occur over an extended time, and therefore, reconne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newmark WD,Jenkins CN,Pimm SL,McNeally PB,Halley JM

更新日期：2017-09-05 00:00:00

abstract：:Reactive oxygen species (ROS) are well-known accelerants of aging, but, paradoxically, we show that physiological levels of ROS extend life span in pupae of the moth Helicoverpa armigera, resulting in the dormant state of diapause. This developmental switch appears to operate through a variant of the conventional insu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang XS,Wang T,Lin XW,Denlinger DL,Xu WH

更新日期：2017-09-12 00:00:00

abstract：:Salmonella enterica serovar Typhi can colonize the gallbladder and persist in an asymptomatic carrier state that is frequently associated with the presence of gallstones. We have shown that salmonellae form bile-mediated biofilms on human gallstones and cholesterol-coated surfaces in vitro. Here, we test the hypothesi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crawford RW,Rosales-Reyes R,Ramírez-Aguilar Mde L,Chapa-Azuela O,Alpuche-Aranda C,Gunn JS

更新日期：2010-03-02 00:00:00

abstract：:Many important hominid-bearing fossil localities in East Africa are in regions that are extremely hot and dry. Although humans are well adapted to such conditions, it has been inferred that East African environments were cooler or more wooded during the Pliocene and Pleistocene when this region was a central stage of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Passey BH,Levin NE,Cerling TE,Brown FH,Eiler JM

更新日期：2010-06-22 00:00:00

abstract：:Viruses modulate biochemical cellular pathways to permit infection. A recently described mechanism mediates selective protein interactions between acidic domain readers and unacetylated, lysine-rich regions, opposite of bromodomain function. Kaposi´s sarcoma (KS)-associated herpesvirus (KSHV) is tightly linked with KS...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juillard F,de Miranda MP,Li S,Franco A,Seixas AF,Liu B,Álvarez ÁL,Tan M,Szymula A,Kaye KM,Simas JP

更新日期：2020-09-08 00:00:00

abstract：:Staphylococcus aureus colonizes the skin of the majority of patients with atopic dermatitis (AD), and its presence increases disease severity. Adhesion of S. aureus to corneocytes in the stratum corneum is a key initial event in colonization, but the bacterial and host factors contributing to this process have not bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Towell AM,Feuillie C,Vitry P,Da Costa TM,Mathelié-Guinlet M,Kezic S,Fleury OM,McAleer MA,Dufrêne YF,Irvine AD,Geoghegan JA

更新日期：2021-01-05 00:00:00

abstract：:Alpha-actinin-4 is a widely expressed protein that employs an actin-binding site with two calponin homology domains to crosslink actin filaments (F-actin) in a Ca(2+)-sensitive manner in vitro. An inherited, late-onset form of kidney failure is caused by point mutations in the alpha-actinin-4 actin-binding domain. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weins A,Schlondorff JS,Nakamura F,Denker BM,Hartwig JH,Stossel TP,Pollak MR

更新日期：2007-10-09 00:00:00

abstract：:Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure, but the cellular mechanisms for CaMKII-targeted proteins causing disordered cell membrane excitability and myocardial dysfunction remain uncertain. Failing human cardiomyocytes exhibit increased CaMKII and voltage-gated Ca(2+) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koval OM,Guan X,Wu Y,Joiner ML,Gao Z,Chen B,Grumbach IM,Luczak ED,Colbran RJ,Song LS,Hund TJ,Mohler PJ,Anderson ME

更新日期：2010-03-16 00:00:00

abstract：:Carbon nanotube (CNT) membranes were employed as the active element of a switchable transdermal drug delivery device that can facilitate more effective treatments of drug abuse and addiction. Due to the dramatically fast flow through CNT cores, high charge density, and small pore dimensions, highly efficient electroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Paudel KS,Strasinger C,Hammell D,Stinchcomb AL,Hinds BJ

更新日期：2010-06-29 00:00:00

abstract：:Young male baboons born in captivity were immunized with an attenuated, cryopreserved schistosomular vaccine derived from gamma-irradiated (50 krad) cercariae of the Puerto Rican strain of Schistosoma mansoni. Protection against a heterologous Kenyan strain of S. mansoni, after percutaneous infection, was assessed. Pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damian RT,Roberts ML,Powell MR,Clark JD,Lewis FA,Stirewalt MA

更新日期：1984-06-01 00:00:00

abstract：:Small, single-module proteins that fold in a single cooperative step may be paradigms for understanding early events in protein-folding pathways generally. Recent experimental studies of the 64-residue chymotrypsin inhibitor 2 (CI2) support a nucleation mechanism for folding, as do some computer stimulations. CI2 has ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fersht AR

更新日期：1995-11-21 00:00:00