Abstract:
:Reactive oxygen species (ROS) are well-known accelerants of aging, but, paradoxically, we show that physiological levels of ROS extend life span in pupae of the moth Helicoverpa armigera, resulting in the dormant state of diapause. This developmental switch appears to operate through a variant of the conventional insulin-signaling pathway, as evidenced by the facts that Akt, p-Akt, and PRMT1 are elevated by ROS, but not insulin, and that high levels of p-Akt fail to phosphorylate FoxO through PRMT1-mediated methylation. These results suggest a distinct signaling pathway culminating in the elevation of FoxO, which in turn promotes the extension of life span characteristic of diapause.
journal_name
Proc Natl Acad Sci U S Aauthors
Zhang XS,Wang T,Lin XW,Denlinger DL,Xu WHdoi
10.1073/pnas.1711042114subject
Has Abstractpub_date
2017-09-12 00:00:00pages
E7832-E7840issue
37eissn
0027-8424issn
1091-6490pii
1711042114journal_volume
114pub_type
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