Cytotactin binding: inhibition of stimulated proliferation and intracellular alkalinization in fibroblasts.

abstract：:Although they lie at the conceptual core of a wide range of scientific questions, the notions of irregular or "random" arrangement and the process of randomization itself have never been unambiguously defined. Algorithmic implementation of these concepts requires a combinatorial, rather than a probability-theoretic, f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singer BH,Pincus S

更新日期：1998-02-17 00:00:00

abstract：:Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gee DG,Gabard-Durnam LJ,Flannery J,Goff B,Humphreys KL,Telzer EH,Hare TA,Bookheimer SY,Tottenham N

更新日期：2013-09-24 00:00:00

abstract：:Chlamydia trachomatis R2c is the prototype for a recently discovered group of ribonucleotide reductase R2 proteins that use a heterodinuclear Mn/Fe redox cofactor for radical generation and storage. Here, we show that the Mycobacterium tuberculosis protein Rv0233, an R2 homologue and a potential virulence factor, cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andersson CS,Högbom M

更新日期：2009-04-07 00:00:00

abstract：:Complete inactivation of the human retinoblastoma gene (RB) is believed to be an essential step in tumorigenesis of several different cancers. To provide a framework for understanding inactivation mechanisms, the structure of RB was delineated. The RB transcript is encoded in 27 exons dispersed over about 200 kilobase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong FD,Huang HJ,To H,Young LJ,Oro A,Bookstein R,Lee EY,Lee WH

更新日期：1989-07-01 00:00:00

abstract：:Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3). The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI3K signaling by dephosphorylating PIP3, and is inhibited...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hodakoski C,Hopkins BD,Barrows D,Mense SM,Keniry M,Anderson KE,Kern PA,Hawkins PT,Stephens LR,Parsons R

更新日期：2014-01-07 00:00:00

abstract：:A chimeric mouse-human antibody has been created that recognizes an antigen found on the surface of cells from many carcinomas. Immunoglobulin constant (C) domains of the mouse monoclonal antibody L6, C gamma 2a and C kappa, were substituted by the human C gamma 1 and C kappa by recombining cDNA modules encoding varia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu AY,Robinson RR,Hellström KE,Murray ED Jr,Chang CP,Hellström I

更新日期：1987-05-01 00:00:00

abstract：:In a posterior silk gland extract, covalently closed circular (ccc) DNA is in a superhelical state that supports more transcription of fibroin gene than does linear DNA. A HeLa cell extract showed neither the supercoiling activity nor the preference for the transcription of ccc DNA over linear DNA. These activities co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirose S,Suzuki Y

更新日期：1988-02-01 00:00:00

abstract：:Many neurodegenerative diseases are characterized by the accumulation of amyloid fibers in the brain, which can occur when a protein misfolds into an extended beta-sheet conformation. The nucleation of these beta-sheet aggregates is of particular interest, not only because it is the rate-determining step toward fiber ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petty SA,Decatur SM

更新日期：2005-10-04 00:00:00

abstract：:Three naturally occurring dermorphin-like peptides from the skin of the frog Phyllomedusa bicolor, the related carboxyl-terminal amides, and some substituted analogs were synthesized, their binding profiles to opioid receptors were determined, and their biological activities were studied in isolated organ preparations...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negri L,Erspamer GF,Severini C,Potenza RL,Melchiorri P,Erspamer V

更新日期：1992-08-01 00:00:00

abstract：:Despite being a fundamental electronic component for over 70 years, it is still possible to develop different transistor designs, including the addition of a diode-like Schottky source electrode to thin-film transistors. The discovery of a dependence of the source barrier height on the semiconductor thickness and deri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang J,Wilson J,Auton G,Wang Y,Xu M,Xin Q,Song A

更新日期：2019-03-12 00:00:00

abstract：:Ras is a guanine nucleotide-binding protein that cycles between inactive GDP-bound and active GTP-bound states to regulate a diverse array of cellular processes, including cell growth, apoptosis, and differentiation. The guanine nucleotide-bound state of Ras is tightly maintained by regulatory factors to promote regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JG,Pappu K,Campbell SL

更新日期：2003-05-27 00:00:00

abstract：:Exocytosis allows the release of secretory products and the delivery of new membrane material to the plasma membrane. So far, little is known about the underlying molecular mechanism and its control in plant cells. We have used the whole-cell patch-clamp technique to monitor changes in membrane capacitance to study ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Homann U,Tester M

更新日期：1997-06-10 00:00:00

abstract：:Genetic analysis of Parkinson disease (PD) has identified several genes whose mutation causes inherited parkinsonism, as well as risk loci for sporadic PD. PTEN-induced kinase 1 (PINK1) and parkin, linked to autosomal recessive PD, act in a common genetic pathway regulating the autophagic degradation of mitochondria, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivatt RM,Sanchez-Martinez A,Godena VK,Brown S,Ziviani E,Whitworth AJ

更新日期：2014-06-10 00:00:00

abstract：:Swimming Escherichia coli responds to changes in temperature by modifying its motor behavior. Previous studies using populations of cells have shown that E. coli accumulate in spatial thermal gradients, but these experiments did not cleanly separate thermal responses from chemotactic responses. Here we have isolated t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paster E,Ryu WS

更新日期：2008-04-08 00:00:00

abstract：:By combining the pairwise interactions between proteins, as predicted by the conserved co-occurrence of their genes in operons, we obtain protein interaction networks. Here we study the properties of such networks to identify functional modules: sets of proteins that together are involved in a biological process. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snel B,Bork P,Huynen MA

更新日期：2002-04-30 00:00:00

abstract：:cDNAs representing the alpha subunit of polyomavirus enhancer binding protein 2 (PEBP2; also called PEA2) were isolated. The products of the cDNAs are highly homologous to that of Drosophila segmentation gene runt (run) for an N-proximal 128-amino acid region showing 66% identity. The run homology region encompasses t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogawa E,Maruyama M,Kagoshima H,Inuzuka M,Lu J,Satake M,Shigesada K,Ito Y

更新日期：1993-07-15 00:00:00

abstract：:Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine's antidepressant and adverse effects, the potency of (2R,6R)-HNK to inhibit NMDARs has not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lumsden EW,Troppoli TA,Myers SJ,Zanos P,Aracava Y,Kehr J,Lovett J,Kim S,Wang FH,Schmidt S,Jenne CE,Yuan P,Morris PJ,Thomas CJ,Zarate CA Jr,Moaddel R,Traynelis SF,Pereira EFR,Thompson SM,Albuquerque EX,Gould TD

更新日期：2019-03-12 00:00:00

abstract：:Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types. Using stringent thresholding criteria, we identified 3,707 s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Londin E,Loher P,Telonis AG,Quann K,Clark P,Jing Y,Hatzimichael E,Kirino Y,Honda S,Lally M,Ramratnam B,Comstock CE,Knudsen KE,Gomella L,Spaeth GL,Hark L,Katz LJ,Witkiewicz A,Rostami A,Jimenez SA,Hollingsworth MA,

更新日期：2015-03-10 00:00:00

abstract：:The FMS gene encodes the functional cell surface receptor for colony-stimulating factor 1, the macrophage- and monocyte-specific growth factor. Codons 969 and 301 have been identified as potentially involved in promoting the transforming activity of FMS. Mutations at codon 301 are believed to lead to neoplastic transf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ridge SA,Worwood M,Oscier D,Jacobs A,Padua RA

更新日期：1990-02-01 00:00:00

abstract：:In Drosophila, P-element transposition causes mutagenesis and genome instability during hybrid dysgenesis. The P-element 31-bp terminal inverted repeats (TIRs) contain sequences essential for transposase cleavage and have been implicated in DNA repair via protein-DNA interactions with cellular proteins. The identity a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Francis MJ,Roche S,Cho MJ,Beall E,Min B,Panganiban RP,Rio DC

更新日期：2016-11-15 00:00:00

abstract：:The role of the serum proteolytic system plasminogen/plasminogen activator as a biochemical tool used by the glia or neurons, or both, for maintaining their temporary and flexible cellular interactions during histogenesis of the nervous system is under study. The present report identifies a glia cell type, the Schwann...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalderon N

更新日期：1984-11-01 00:00:00

abstract：:Extracellular potassium concentration is actively maintained within narrow limits in all higher organisms. Slight variations in extracellular potassium levels can induce major alterations of essential physiological functions in excitable tissues. Here we describe that superfusion of cultured rat hippocampal neurones w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo LA,Heinemann SH,Terlau H,Ludewig U,Lorra C,Pongs O,Stühmer W

更新日期：1992-03-15 00:00:00

abstract：:Creatine kinase (CK; EC 2.7.3.2) plays an important role in energy metabolism in brain and muscle. Expression of CK isoenzymes is regulated during development and is tissue specific. To define the structures of canine CK isoenzymes and to elucidate the mechanism of regulation in their expression, CK cDNA clones from d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roman D,Billadello J,Gordon J,Grace A,Sobel B,Strauss A

更新日期：1985-12-01 00:00:00

abstract：:Arylhydrazinopyrimidines inhibit DNA synthesis in Bacillus subtilis by promoting formation of a specific, long-lived ternary complex with DNA polymerase III and the template-primer DNA. DNA polymerase III contains an associated, single-strand-selective exonuclease which generates 5'-mononucleotides. Drug inhibition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Low RL,Rashbaum SA,Cozzarelli NR

更新日期：1974-08-01 00:00:00

abstract：:Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this mechanism to contribute to tumor development depends on whether the genes affected are repressed because of their methylation. Many aberrantly methylated genes play important roles in development and are bivalently marked in ES...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sproul D,Nestor C,Culley J,Dickson JH,Dixon JM,Harrison DJ,Meehan RR,Sims AH,Ramsahoye BH

更新日期：2011-03-15 00:00:00

abstract：:The neuronal isoform of nitric oxide synthase (nNOS) is highly expressed in mammalian skeletal muscle, but its functional role has not been defined. NO has been implicated in the local metabolic regulation of blood flow in contracting skeletal muscle in part by antagonizing sympathetic vasoconstriction. We therefore h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas GD,Sander M,Lau KS,Huang PL,Stull JT,Victor RG

更新日期：1998-12-08 00:00:00

abstract：:Combinations of molecular tags visible in light and electron microscopes become particularly advantageous in the analysis of dynamic cellular components like the Golgi apparatus. This organelle disassembles at the onset of mitosis and, after a sequence of poorly understood events, reassembles after cytokinesis. The pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaietta GM,Giepmans BN,Deerinck TJ,Smith WB,Ngan L,Llopis J,Adams SR,Tsien RY,Ellisman MH

更新日期：2006-11-21 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) stimulated the phosphorylation of a 28-kDa protein (p28) in the ME-180 line of human cervical carcinoma cells. The effect of TNF-alpha on the phosphorylation state of p28 was rapid (4-fold increase within 15 min) and persistent, remaining above the basal level for at least 2 hr....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marino MW,Pfeffer LM,Guidon PT Jr,Donner DB

更新日期：1989-11-01 00:00:00

abstract：:Multiple protein subcomplexes of the kinetochore cooperate as a cohesive molecular unit that forms load-bearing microtubule attachments that drive mitotic chromosome movements. There is intriguing evidence suggesting that central kinetochore components influence kinetochore-microtubule attachment, but the mechanism re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kudalkar EM,Scarborough EA,Umbreit NT,Zelter A,Gestaut DR,Riffle M,Johnson RS,MacCoss MJ,Asbury CL,Davis TN

更新日期：2015-10-13 00:00:00

abstract：:We have examined the extent of tyrosine phosphorylation of talin, a component of the cytoskeleton localized in the focal adhesions and, therefore, a potential substrate of p60v-src, the transforming protein of Rous sarcoma virus. p60v-src is a tyrosine kinase that induces high levels of phosphotyrosine and the disorga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pasquale EB,Maher PA,Singer SJ

更新日期：1986-08-01 00:00:00