Talin is phosphorylated on tyrosine in chicken embryo fibroblasts transformed by Rous sarcoma virus.

abstract：:The role of spliced leader RNA (SL RNA) in trans-splicing in Caenorhabditis elegans has been studied through a combination of in vitro mutagenesis and in vivo complementation of rrs-1 mutant nematodes, which lack endogenous SL1 RNA. Three classes of mutant SL1 RNAs have been found-those that rescue the lethal phenotyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie H,Hirsh D

更新日期：1998-04-14 00:00:00

abstract：:Grasslands cover more than 20% of the Earth's terrestrial surface, and their rise to dominance is one of the most dramatic events of biome evolution in Earth history. Grasses possess two main photosynthetic pathways: the C(3) pathway that is typical of most plants and a specialized C(4) pathway that minimizes photores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards EJ,Smith SA

更新日期：2010-02-09 00:00:00

abstract：:Cancer is a genetic disease caused by genomic instability. In many cancers, this instability is manifested by chromosomal reconfigurations and karyotypic complexity. These features are particular hallmarks of the epithelial cancers that are some of the malignancies most resistant to long term control by current chemot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roschke AV,Lababidi S,Tonon G,Gehlhaus KS,Bussey K,Weinstein JN,Kirsch IR

更新日期：2005-02-22 00:00:00

abstract：:A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity in the basal ganglia orchestrates the control of coordinated movement in human subjects. Although human mutations in the PDE10A gene manifest in hyperkinetic movement disorders that phenocopy many features of early Huntington's...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tejeda GS,Whiteley EL,Deeb TZ,Bürli RW,Moss SJ,Sheridan E,Brandon NJ,Baillie GS

更新日期：2020-01-07 00:00:00

abstract：:The region of the simian virus 40 genome complementary to the 5' end of the most abundant poly(A)-containing 19S and 16S mRNAs was mapped by hybridization of double-labeled RNA ([3H]methyl group and [14C]uridine) to specific DNA fragments. Chemical identification of methylated residues indicated that a common "leader"...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavi S,Groner Y

更新日期：1977-12-01 00:00:00

abstract：:Recent analysis of complete eukaryotic genome sequences has revealed that gene duplication has been rampant. Moreover, next to a continuous mode of gene duplication, in many eukaryotic organisms the complete genome has been duplicated in their evolutionary past. Such large-scale gene duplication events have been assoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maere S,De Bodt S,Raes J,Casneuf T,Van Montagu M,Kuiper M,Van de Peer Y

更新日期：2005-04-12 00:00:00

abstract：:By using differential display PCR, we have identified 98 cDNA fragments from the rat dorsal hippocampus that are expressed differentially between the fast learners and slow learners in the water maze learning task. One of these cDNA fragments encodes the rat serum- and glucocorticoid-inducible kinase (sgk) gene. North...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai KJ,Chen SK,Ma YL,Hsu WL,Lee EH

更新日期：2002-03-19 00:00:00

abstract：:DNA restriction fragments of the genes encoding HLA class II-beta antigens were compared in 34 patients with insulin-dependent diabetes mellitus and 34 HLA-DR-matched healthy individuals. Ninety-three fragments, determined by six restriction enzymes (EcoRI, EcoRV, HindIII, BamHI, Pvu II, and Taq I), were analyzed: (i)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen-Haguenauer O,Robbins E,Massart C,Busson M,Deschamps I,Hors J,Lalouel JM,Dausset J,Cohen D

更新日期：1985-05-01 00:00:00

abstract：:The molecular basis of short-day-induced growth cessation and dormancy in the meristems of perennial plants (e.g., forest trees growing in temperate and high-latitude regions) is poorly understood. Using global transcript profiling, we show distinct stage-specific alterations in auxin responsiveness of the transcripto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baba K,Karlberg A,Schmidt J,Schrader J,Hvidsten TR,Bako L,Bhalerao RP

更新日期：2011-02-22 00:00:00

abstract：:Global loss of DNA methylation has been known for decades as an epigenomic aberration associated with carcinogenesis and cancer progression. Loss of DNA methylation affects predominantly repetitive elements, which encompass >50% of the CpG dinucleotides present in the human genome. Because of the lack of an effective ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie H,Wang M,Bonaldo Mde F,Rajaram V,Stellpflug W,Smith C,Arndt K,Goldman S,Tomita T,Soares MB

更新日期：2010-04-13 00:00:00

abstract：:Mesenteric fat is known to undergo inflammatory changes after 2,4,6,-trinitrobenzensulphonic acid (TNBS)-induced colitis. Neurotensin (NT) and neurotensin receptor 1 (NTR1) have been shown to play a major role in the pathogenesis of intestinal inflammation. This led us to explore whether NT and NTR1 are expressed in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koon HW,Kim YS,Xu H,Kumar A,Zhao D,Karagiannides I,Dobner PR,Pothoulakis C

更新日期：2009-05-26 00:00:00

abstract：:Bacillus anthracis is the etiologic agent of anthrax, an acute fatal disease among mammals. It was thought to differ from Bacillus cereus, an opportunistic pathogen and cause of food poisoning, by the presence of plasmids pXO1 and pXO2, which encode the lethal toxin complex and the poly-gamma-d-glutamic acid capsule, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffmaster AR,Ravel J,Rasko DA,Chapman GD,Chute MD,Marston CK,De BK,Sacchi CT,Fitzgerald C,Mayer LW,Maiden MC,Priest FG,Barker M,Jiang L,Cer RZ,Rilstone J,Peterson SN,Weyant RS,Galloway DR,Read TD,Popovic T,Fras

更新日期：2004-06-01 00:00:00

abstract：:Three major oxidation products of 2'-deoxycytidine (dC)--5-hydroxy-2'-deoxycytidine (oh5dC), 5-hydroxy-2'-deoxyuridine (oh5dU), and 5,6-dihydroxy-5,6-dihydro-2'-deoxyuridine (dUg)--were analyzed from enzymatically hydrolyzed DNA with reversed-phase high-performance liquid chromatography coupled to electrochemical dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner JR,Hu CC,Ames BN

更新日期：1992-04-15 00:00:00

abstract：:Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dhonukshe P,Grigoriev I,Fischer R,Tominaga M,Robinson DG,Hasek J,Paciorek T,Petrásek J,Seifertová D,Tejos R,Meisel LA,Zazímalová E,Gadella TW Jr,Stierhof YD,Ueda T,Oiwa K,Akhmanova A,Brock R,Spang A,Friml J

更新日期：2008-03-18 00:00:00

abstract：:Clonal deletion provides an important mechanism for the elimination of autoreactive T cells. Deletion is accomplished by programmed cell death directed by interaction of the T-cell receptor (TCR) of the developing thymocyte with major histocompatibility complex elements in the thymic environment. In this report we pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell JH,White CL,Loh DY,Meleedy-Rey P

更新日期：1991-03-15 00:00:00

abstract：:Cell-cell interactions organize lens fiber cells into highly ordered structures to maintain transparency. However, signals regulating such interactions have not been well characterized. We report here that ephrin-A5, a ligand of the Eph receptor tyrosine kinases, plays a key role in lens fiber cell shape and cell-cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper MA,Son AI,Komlos D,Sun Y,Kleiman NJ,Zhou R

更新日期：2008-10-28 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is the most common and lethal genetic muscle disorder, caused by recessive mutations in the dystrophin gene. One of every 3,500 males suffers from DMD, yet no treatment is currently available. Genetic therapeutic approaches, using primarily myoblast transplantation and adenovirus-medi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang B,Li J,Xiao X

更新日期：2000-12-05 00:00:00

abstract：:Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. The paracellular pathway in the collecting duct of the kidney is a predominant route for transepithelial chloride reabsorption that determines the extracellular NaCl content and the blood pressure. However, the molecular me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou J,Renigunta A,Yang J,Waldegger S

更新日期：2010-10-19 00:00:00

abstract：:Our understanding of membranes and membrane lipid function has lagged far behind that of nucleic acids and proteins, largely because it is difficult to manipulate cellular membrane lipid composition. To help solve this problem, we show that methyl-α-cyclodextrin (MαCD)-catalyzed lipid exchange can be used to maximally...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li G,Kim J,Huang Z,St Clair JR,Brown DA,London E

更新日期：2016-12-06 00:00:00

abstract：:In double-transgenic mice expressing a gene construct encoding hen egg lysozyme as well as rearranged anti-lysozyme antibody genes, large numbers of anti-lysozyme B cells are present in peripheral lymphoid tissues but are profoundly tolerant. The cellular basis for this form of non-deletional self-tolerance was explor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams E,Basten A,Goodnow CC

更新日期：1990-08-01 00:00:00

abstract：:Osmotic stress responses are critical not only to the survival of unicellular organisms but also to the normal function of the mammalian kidney. However, the extent to which cells outside the kidney rely on osmotic stress responses in vivo remains unknown. Nuclear factor of activated T cells 5 (NFAT5)/tonicity enhance...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Go WY,Liu X,Roti MA,Liu F,Ho SN

更新日期：2004-07-20 00:00:00

abstract：:Dynamic signals linking the actin cytoskeleton and cell adhesion receptors are essential for morphogenesis during development and normal tissue homeostasis. Abi1 is a central regulator of actin polymerization through interactions with multiple protein complexes. However, the in vivo role of Abi1 remains to be defined....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ring C,Ginsberg MH,Haling J,Pendergast AM

更新日期：2011-01-04 00:00:00

abstract：:It is well known that far fewer men than women enroll in tertiary education in the United States and other Western nations. Developed nations vary in the degree to which men are underrepresented, but the Organization for Economic Co-operation and Development (OECD) average lies around 45% male students. We use data fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoet G,Geary DC

更新日期：2020-06-23 00:00:00

abstract：:In plants, the AUXIN RESPONSE FACTOR (ARF) transcription factor family regulates gene expression in response to auxin. In the absence of auxin, ARF transcription factors are repressed by interaction with AUXIN/INDOLE 3-ACETIC ACID (Aux/IAA) proteins. Although the C termini of ARF and Aux/IAA proteins facilitate their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korasick DA,Westfall CS,Lee SG,Nanao MH,Dumas R,Hagen G,Guilfoyle TJ,Jez JM,Strader LC

更新日期：2014-04-08 00:00:00

abstract：:The importance of dystrophin and its associated proteins in normal muscle function is now well established. Many of these proteins are expressed in nonmuscle tissues, particularly the brain. Here we describe the characterization of beta-dystrobrevin, a dystrophin-related protein that is abundantly expressed in brain a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blake DJ,Nawrotzki R,Loh NY,Górecki DC,Davies KE

更新日期：1998-01-06 00:00:00

abstract：:Although common in birds, social monogamy, or pair-living, is rare among mammals because internal gestation and lactation in mammals makes it advantageous for males to seek additional mating opportunities. A number of hypotheses have been proposed to explain the evolution of social monogamy among mammals: as a male ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Opie C,Atkinson QD,Dunbar RI,Shultz S

更新日期：2013-08-13 00:00:00

abstract：:Dihydroisohistrionicotoxin inhibits acetylcholine receptor-dependent 22Na+ uptake of cultured chick muscle cells with a KI of 0.2 micrometer. The inhibition is noncompetitive with respect to agonists. The toxin enhances desensitization of the receptor by agonists which is accompanied by a 10-fold increase in receptor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burgermeister W,Catterall WA,Witkop B

更新日期：1977-12-01 00:00:00

abstract：:A Mr 70,000 protein was isolated from cytotoxic human large granular lymphocytes and shown to have cytotoxic activity. The protein was demonstrated to be immunochemically related to the ninth component (C9) of complement and was therefore designated C9-related protein (C9RP). This finding suggests that C9RP and C9 sha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalman LS,Brothers MA,Chiu FJ,Müller-Eberhard HJ

更新日期：1986-07-01 00:00:00

abstract：:Proper initiation of transcription by RNA polymerase II requires the TATA-consensus-binding transcription factor TFIID. A cDNA clone encoding the Drosophila TFIID protein has been isolated and characterized. The deduced amino acid sequence reveals an open reading frame of 353 residues. The carboxyl-terminal 180 amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muhich ML,Iida CT,Horikoshi M,Roeder RG,Parker CS

更新日期：1990-12-01 00:00:00

abstract：:In the presence of the nucleotide analog adenosine 5'-[gamma-thio]triphosphate (ATP[gamma S]), effects of Ca2+ on stiffness and equatorial x-ray diffraction patterns of single skinned fibers of the rabbit psoas muscle were studied. It is shown that cross-bridges in the presence of ATP[gamma S] have properties of the w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraft T,Yu LC,Kuhn HJ,Brenner B

更新日期：1992-12-01 00:00:00