Abstract:
:Cell-cell interactions organize lens fiber cells into highly ordered structures to maintain transparency. However, signals regulating such interactions have not been well characterized. We report here that ephrin-A5, a ligand of the Eph receptor tyrosine kinases, plays a key role in lens fiber cell shape and cell-cell interactions. Lens fiber cells in mice lacking ephrin-A5 function appear rounded and irregular in cross-section, in contrast to their normal hexagonal appearance in WT lenses. Cataracts eventually develop in 87% of ephrin-A5 KO mice. We further demonstrate that ephrin-A5 interacts with the EphA2 receptor to regulate the adherens junction complex by enhancing recruitment of beta-catenin to N-cadherin. These results indicate that the Eph receptors and their ligands are critical regulators of lens development and maintenance.
journal_name
Proc Natl Acad Sci U S Aauthors
Cooper MA,Son AI,Komlos D,Sun Y,Kleiman NJ,Zhou Rdoi
10.1073/pnas.0808987105subject
Has Abstractpub_date
2008-10-28 00:00:00pages
16620-5issue
43eissn
0027-8424issn
1091-6490pii
0808987105journal_volume
105pub_type
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