In vivo function of mutated spliced leader RNAs in Caenorhabditis elegans.

abstract：:For a distribution F on R(p) and a point x in R(p) the simplicial depth D(x), which is the probability that x be inside a random simplex whose vertices are p + 1 independent observations from F, is introduced. D(x) can be viewed as a measure of depth of the point x relative to F, and its empirical version gives rise t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu RY

更新日期：1988-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng Y,Dai Y,Hitchcock C,Yang X,Kassis ES,Liu L,Luo Z,Sun HL,Cui R,Wei H,Kim T,Lee TJ,Jeon YJ,Nuovo GJ,Volinia S,He Q,Yu J,Nana-Sinkam P,Croce CM

更新日期：2013-09-10 00:00:00

abstract：:Low-barrier hydrogen bonds (LBHBs) have been proposed to play roles in protein functions, including enzymatic catalysis and proton transfer. Transient formation of LBHBs is expected to stabilize specific reaction intermediates. However, based on experimental results and theoretical considerations, arguments against th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi S,Kamikubo H,Kurihara K,Kuroki R,Niimura N,Shimizu N,Yamazaki Y,Kataoka M

更新日期：2009-01-13 00:00:00

abstract：:The type 6 secretion system (T6SS) is a nanomachine used by many Gram-negative bacteria, including Vibrio cholerae, to deliver toxic effector proteins into adjacent eukaryotic and bacterial cells. Because the activity of the T6SS is dependent on direct contact between cells, its activity is limited to bacteria growing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toska J,Ho BT,Mekalanos JJ

更新日期：2018-07-31 00:00:00

abstract：:Human serum albumin (HSA) derivatized with cis-aconitic anhydride was covalently coupled to liposomes with a size of approximately 100 nm [polyaconitylated HSA (Aco-HSA) liposomes]. Within 30 min after injection into a rat, Aco-HSA liposomes were completely cleared from the blood and almost exclusively taken up by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamps JA,Morselt HW,Swart PJ,Meijer DK,Scherphof GL

更新日期：1997-10-14 00:00:00

abstract：:After intravitreal injection of gamma-[3H] aminobutyric acid (GAB), 2% of the neurons at the outer margin of the inner plexiform layer were intensely labeled. Reconstructions of these neurons from serial electron microscope autoradiograms showed that they are interplexiform cells, which synapse on bipolar processes in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,McGuire BA,Sterling P

更新日期：1980-01-01 00:00:00

abstract：:Transgenic sorghum plants have been obtained after microprojectile bombardment of immature zygotic embryos of a drought-resistant sorghum cultivar, P898012. DNA delivery parameters were optimized based on transient expression of R and C1 maize anthocyanin regulatory elements in scutellar cells. The protocol for obtain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casas AM,Kononowicz AK,Zehr UB,Tomes DT,Axtell JD,Butler LG,Bressan RA,Hasegawa PM

更新日期：1993-12-01 00:00:00

abstract：:For almost a century the plant hormone auxin has been central to theories on apical dominance, whereby the growing shoot tip suppresses the growth of the axillary buds below. According to the classic model, the auxin indole-3-acetic acid is produced in the shoot tip and transported down the stem, where it inhibits bud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason MG,Ross JJ,Babst BA,Wienclaw BN,Beveridge CA

更新日期：2014-04-22 00:00:00

abstract：:The ability to regulate gene expression through transcription initiation underlies the adaptability and survival of all bacteria. Recent work has revealed that the transcription machinery in many bacteria diverges from the paradigm that has been established in Escherichia coliMycobacterium tuberculosis (Mtb) encodes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu DX,Garner AL,Galburt EA,Stallings CL

更新日期：2019-07-02 00:00:00

abstract：:Seasonal cycles govern life on earth, from setting the time for the mating season to influencing migrations and governing physiological conditions like hibernation. The effect of such changing conditions on behavior is well-appreciated, but their impact on the brain remains virtually unknown. We investigate long-term ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray S,Li M,Koch SP,Mueller S,Boehm-Sturm P,Wang H,Brecht M,Naumann RK

更新日期：2020-12-15 00:00:00

abstract：:This paper explores the explanations for, and consequences of, the early appearance of food production outside the Fertile Crescent of Southwest Asia, where it originated in the 10th/9th millennia cal BC. We present evidence that cultivation appeared in Central Anatolia through adoption by indigenous foragers in the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird D,Fairbairn A,Jenkins E,Martin L,Middleton C,Pearson J,Asouti E,Edwards Y,Kabukcu C,Mustafaoğlu G,Russell N,Bar-Yosef O,Jacobsen G,Wu X,Baker A,Elliott S

更新日期：2018-04-03 00:00:00

abstract：:The present study determined the effect of [Sar(1)-Ile(8)]-angiotensin II on steroidogenesis and induced aldosterone synthesis by the octapeptide angiotensin II, the heptapeptide des-Asp(1)-angiotensin II, and adrenocorticotropic hormone. Rabbit adrenal cells were suspended by incubation of the capsular cortical tissu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiu AT,Peach MJ

更新日期：1974-02-01 00:00:00

abstract：:Electron spectroscopic imaging, a new technique that permits the quantitative detection of the spatial distributions of atomic elements at high resolution, has been applied to the epiphyseal zone of hypertrophy in the mouse for the visualization of calcium, phosphorus, and sulfur. Longitudinally sectioned epiphyseal g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsenault AL,Ottensmeyer FP

更新日期：1983-03-01 00:00:00

abstract：:Control of iron homeostasis is essential for healthy central nervous system function: iron deficiency is associated with cognitive impairment, yet iron overload is thought to promote neurodegenerative diseases. Specific genetic markers have been previously identified that influence levels of transferrin, the protein t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jahanshad N,Kohannim O,Hibar DP,Stein JL,McMahon KL,de Zubicaray GI,Medland SE,Montgomery GW,Whitfield JB,Martin NG,Wright MJ,Toga AW,Thompson PM

更新日期：2012-04-03 00:00:00

abstract：:It has been reported that expression of familial amyotrophic lateral sclerosis (FALS)-associated mutant Cu/Zn superoxide dismutase-1 (SOD) induces apoptosis of neuronal cells in culture associated with an increase in reactive oxygen species. SOD recently has been shown to prevent calcineurin inactivation, initiating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JP,Palfrey HC,Bindokas VP,Ghadge GD,Ma L,Miller RJ,Roos RP

更新日期：1999-03-16 00:00:00

abstract：:Among the myriad complications involved in the current food crisis, the relationship between agriculture and the rest of nature is one of the most important yet remains only incompletely analyzed. Particularly in tropical areas, agriculture is frequently seen as the antithesis of the natural world, where the problem i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perfecto I,Vandermeer J

更新日期：2010-03-30 00:00:00

abstract：:The possible role of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) in protein synthesis by Escherichia coli ribosomes and protein factors was examined. Although pppGpp could effectively substitute for GTP in reactions catalyzed by initiation factor 2 (ribosomal binding of fMet-tRNA and formation of N-formylmethion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamel E,Cashel M

更新日期：1973-11-01 00:00:00

abstract：:Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To examine venom evolution, we sequenced and interrogated the genome of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonk FJ,Casewell NR,Henkel CV,Heimberg AM,Jansen HJ,McCleary RJ,Kerkkamp HM,Vos RA,Guerreiro I,Calvete JJ,Wüster W,Woods AE,Logan JM,Harrison RA,Castoe TA,de Koning AP,Pollock DD,Yandell M,Calderon D,Renjifo C,Cur

更新日期：2013-12-17 00:00:00

abstract：:The three-dimensional structure of alpha-cobra-toxin, the "long" neurotoxin from the venom of Naja naja siamensis, has been determined at 2.8-A resolution. Crystals grown as hexagonal needles have space group P6522 with unit cell parameters a = b = 74.59 A, c = 42.89 A; one molecule per asymmetric unit. Phases were de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walkinshaw MD,Saenger W,Maelicke A

更新日期：1980-05-01 00:00:00

abstract：:Extensive utilization of pesticides against insects provides us with a good model for studying the adaptation of a eukaryotic genome to a strong selective pressure. One mechanism of resistance is the alteration of acetylcholinesterase (EC 3.1.1.7), the molecular target for organophosphates and carbamates. Here, we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mutero A,Pralavorio M,Bride JM,Fournier D

更新日期：1994-06-21 00:00:00

abstract：:Active coping underlies a healthy stress response, but neural processes supporting such resilient coping are not well-known. Using a brief, sustained exposure paradigm contrasting highly stressful, threatening, and violent stimuli versus nonaversive neutral visual stimuli in a functional magnetic resonance imaging (fM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinha R,Lacadie CM,Constable RT,Seo D

更新日期：2016-08-02 00:00:00

abstract：:A culture of mouse A9 cells yielded clones of both high and low malignancy. Confirmation of the differences in malignancy of the clones was obtained after their hybridization with subclones of YACIR a lymphoma induced by Moloney leukemia virus. Low malignant A9 clones suppressed the malignancy of the YACIR partner in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clements GB,Fenyö EM,Klein G

更新日期：1976-06-01 00:00:00

abstract：:An explicitly polarizable force field based exclusively on quantum data is applied to calculations of relative binding affinities of ligands to proteins. Five ligands, differing by replacement of an atom or functional group, in complexes with three serine proteases-trypsin, thrombin, and urokinase-type plasminogen act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khoruzhii O,Donchev AG,Galkin N,Illarionov A,Olevanov M,Ozrin V,Queen C,Tarasov V

更新日期：2008-07-29 00:00:00

abstract：:Cosuppression results in the degradation of RNA from host genes and homologous transgenes after transcription in the nucleus. By using grafting experiments, we have shown previously that a systemic signal mediates the propagation of cosuppression of Nia host genes and 35S-Nia2 transgenes from silenced 35S-Nia2 transge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palauqui JC,Vaucheret H

更新日期：1998-08-04 00:00:00

abstract：:The survival of motor neurons is controlled by multiple factors that regulate different aspects of their physiology. The identification of these factors is important because of their relationship to motor neuron disease. We investigate here whether Mullerian Inhibiting Substance (MIS) is a motor neuron survival factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang PY,Koishi K,McGeachie AB,Kimber M,Maclaughlin DT,Donahoe PK,McLennan IS

更新日期：2005-11-08 00:00:00

abstract：:Aconitase (Aco1p) is a multifunctional protein: It is an enzyme of the tricarboxylic acid cycle. In animal cells, Aco1p also is a cytosolic protein binding to mRNAs to regulate iron metabolism. In yeast, Aco1p was identified as a component of mtDNA nucleoids. Here we show that yeast Aco1p protects mtDNA from excessive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen XJ,Wang X,Butow RA

更新日期：2007-08-21 00:00:00

abstract：:We have examined the role of a cell surface galactosyltransferase, laminin, and laminin-binding protein (receptor) in the invasion of clonal derivatives of a murine adrenal carcinoma cell line. Although a 10-fold variation was found in the ability to invade a reconstituted basement membrane matrix, levels of intracell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penno MB,Passaniti A,Fridman R,Hart GW,Jordan C,Kumar S,Scott AF

更新日期：1989-08-01 00:00:00

abstract：:A 900-base-pair (bp) sequence from a cDNA clone of the rye endosperm-storage-protein gene Sec-1 was labeled with biotin and hybridized to Secale cereale 'Blanco' chromosomes. Hybridization was seen on the satellite part of the short arm of chromosome 1R, where the Sec-1 gene has been genetically mapped, in approximate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustafson JP,Butler E,McIntyre CL

更新日期：1990-03-01 00:00:00

abstract：:We present a synthetic adaptation of the fibrillar adhesion surfaces found in nature. The structure consists of protruding fibrils topped by a thin plate and shows an experimentally measured enhancement in adhesion energy of up to a factor of 9 over a flat control. Additionally, this structure solves the robustness pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glassmaker NJ,Jagota A,Hui CY,Noderer WL,Chaudhury MK

更新日期：2007-06-26 00:00:00

abstract：:We construct counterexamples to classical calculus facts such as the inverse and implicit function theorems in scale calculus-a generalization of multivariable calculus to infinite-dimensional vector spaces, in which the reparameterization maps relevant to symplectic geometry are smooth. Scale calculus is a corner sto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filippenko B,Zhou Z,Wehrheim K

更新日期：2019-04-30 00:00:00