The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system.

abstract：:Crop species experienced strong selective pressure directed at genes controlling traits of agronomic importance during their domestication and subsequent episodes of selective breeding. Consequently, these genes are expected to exhibit the signature of selection. We screened 501 maize genes for the signature of select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vigouroux Y,McMullen M,Hittinger CT,Houchins K,Schulz L,Kresovich S,Matsuoka Y,Doebley J

更新日期：2002-07-23 00:00:00

abstract：:gC1qR is one of the C1q receptors implicated in the regulation of innate and adaptive immunity. We found that gC1qR inhibits RIG-I and MDA5-dependent antiviral signaling. Double stranded RNA and virus trigger the translocation of gC1qR to the mitochondrial outer membrane leading to the interaction of gC1qR with the RI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu L,Xiao N,Liu F,Ren H,Gu J

更新日期：2009-02-03 00:00:00

abstract：:A wide diversity of biological molecules are modified by the addition of sugar residues, and a large number of glycosyltransferases have been identified that are responsible for these reactions. Despite catalyzing closely related reactions, many of these transferases show little apparent sequence homology. By comparin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiggins CA,Munro S

更新日期：1998-07-07 00:00:00

abstract：:Single-stranded DNA oligonucleotides can achieve targeted base-pair substitution with modest efficiency but high precision. We show that "oligo targeting" can be used effectively to study missense mutations in DNA mismatch repair (MMR) genes. Inherited inactivating mutations in DNA MMR genes are causative for the canc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houlleberghs H,Dekker M,Lantermans H,Kleinendorst R,Dubbink HJ,Hofstra RM,Verhoef S,Te Riele H

更新日期：2016-04-12 00:00:00

abstract：:Fibronectin mediates the adhesion of cells to collagen by first binding to the collagen substrate, followed by attachment of the cells to the fibronectin-collagen complex. Bovine brain gangliosides were found to block fibronectin-mediated cell adhesion to collagen in a concentration-dependent manner. The gangliosides ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinman HK,Martin GR,Fishman PH

更新日期：1979-07-01 00:00:00

abstract：:The last 2 decades have seen discoveries in highly excited states of atoms and molecules of phenomena that are qualitatively different from the "planetary" model of the atom, and the near-rigid model of molecules, characteristic of these systems in their low-energy states. A unified view is emerging in terms of approx...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kellman ME

更新日期：1996-12-10 00:00:00

abstract：:Signaling pathways regulating proliferation, differentiation, and apoptosis are commonly mediated through protein-protein interactions as well as reversible phosphorylation of proteins. To facilitate the study of regulated protein-protein interactions in cells and living animals, we optimized firefly luciferase protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luker KE,Smith MC,Luker GD,Gammon ST,Piwnica-Worms H,Piwnica-Worms D

更新日期：2004-08-17 00:00:00

abstract：:Increasing interest in the role of the frontal lobe in relation to psychiatric and neurologic disorders has popularized tests of frontal function. One of these is the antisaccade task, in which both frontal lobe patients and schizophrenics are impaired despite normal performance on (pro)saccadic tasks. We used positio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Driscoll GA,Alpert NM,Matthysse SW,Levy DL,Rauch SL,Holzman PS

更新日期：1995-01-31 00:00:00

abstract：:Hydrogen/deuterium exchange followed by trapping of the labeled species in the aprotic solvent DMSO has been used to elucidate structure in both the burst-phase molten globule-folding intermediate of apomyoglobin and in an equilibrium intermediate that models the kinetic intermediate. Precise estimates can be made of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishimura C,Dyson HJ,Wright PE

更新日期：2005-03-29 00:00:00

abstract：:Nascent replicative form type II (RFII) DNA of coliphage M13 synthesized in an Escherichia coli mutant deficient in the 5' leads to 3' exonuclease associated uith DNA polymerase I contains ribonucleotides that are retained in the covalently closed RFI DNA sealed in vitro by the joint action of T5 phage DNA polymerase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dasgupta S,Mitra S

更新日期：1978-01-01 00:00:00

abstract：:Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due to their unique structural and biophysical features. We here present the development of a binding scaffold based on variable lymphocyte receptors, which are nonimmunoglobulin antibodies composed of Leucine-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SC,Park K,Han J,Lee JJ,Kim HJ,Hong S,Heu W,Kim YJ,Ha JS,Lee SG,Cheong HK,Jeon YH,Kim D,Kim HS

更新日期：2012-02-28 00:00:00

abstract：:A census of the biomass on Earth is key for understanding the structure and dynamics of the biosphere. However, a global, quantitative view of how the biomass of different taxa compare with one another is still lacking. Here, we assemble the overall biomass composition of the biosphere, establishing a census of the ≈5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-On YM,Phillips R,Milo R

更新日期：2018-06-19 00:00:00

abstract：:Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. Here, we found that isolation of neonatal rats induced glucocorticoid-dependent social dominance ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tada H,Miyazaki T,Takemoto K,Takase K,Jitsuki S,Nakajima W,Koide M,Yamamoto N,Komiya K,Suyama K,Sano A,Taguchi A,Takahashi T

更新日期：2016-11-08 00:00:00

abstract：:Extracellular cAMP plays a crucial role in regulating the developmental program of Dictyostelium discoideum, functioning as a chemotactic agent, as well as a signal that regulates expression of developmentally expressed genes. These activities appear to be mediated by a cell-surface receptor for cAMP. We have studied ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chisholm RL,Hopkinson S,Lodish HF

更新日期：1987-02-01 00:00:00

abstract：:c-Mpl, a member of the hematopoietic cytokine receptor family, is the receptor for thrombopoietin. To investigate signal transduction by c-Mpl, a chimeric receptor, composed of the extracellular domain of human growth hormone receptor and the intracellular domain of c-Mpl, was introduced into the interleukin 3-depende...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gurney AL,Wong SC,Henzel WJ,de Sauvage FJ

更新日期：1995-06-06 00:00:00

abstract：:2-Deoxy-D-[14C]glucose autoradiography was used in awake rats to map neural activity in the sensorimotor sector of striatum. Stimulation of hindlimb, trunk, or forelimb activated primary sensory cortex in a localized columnar pattern, indicating activation of somatosensory receptors and a discrete cortical functional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown LL

更新日期：1992-08-15 00:00:00

abstract：:Dimyristoyl lecithin liposomes, containing cytochrome b5 reductase (NADH:ferricytochrome b5 oxidoreductase, EC 1.6.2.2) and varying amounts of cytochrome b5, were used to measure flavoprotein catalysis alone and catalysis requiring electron transfer between the reductase and cytochrome as a function of temperature. Wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strittmatter P,Rogers MJ

更新日期：1975-07-01 00:00:00

abstract：:Strain OU122, a dnaB mutant of HfrH which stops vegetative DNA synthesis immediately when the temperature is shifted to 43 degrees, was mated at 43 degrees with minicells with and without 1 mM Zn2+. Synthesis of DNA was detected in the mating mixture containing minicells derived from either Fchi925 or F+chi115 cells, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ou JT

更新日期：1975-09-01 00:00:00

abstract：:A genomic clone containing two linked human pregnancy-specific beta 1-glycoprotein (PS beta G) genes has been isolated and characterized. The two genes are arranged in the same 5'----3' orientation; the 3' region (including the A2 and B-C exons) of the upstream gene, PSGGA, is linked to the 5' region (including the 5'...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leslie KK,Watanabe S,Lei KJ,Chou DY,Plouzek CA,Deng HC,Torres J,Chou JY

更新日期：1990-08-01 00:00:00

abstract：:Despite decades of declining crime rates, longstanding tensions between police and the public continue to frustrate the formation of cooperative relationships necessary for the function of the police and the provision of public safety. In response, policy makers continue to promote community-oriented policing (COP) an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peyton K,Sierra-Arévalo M,Rand DG

更新日期：2019-10-01 00:00:00

abstract：:Ovulation induces cyclic rupture and regenerative repair of the ovarian coelomic epithelium. This process of repeated disruption and repair accompanied by complex remodeling typifies a somatic stem/progenitor cell-mediated process. Using BrdU incorporation and doxycycline inducible histone2B-green fluorescent protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szotek PP,Chang HL,Brennand K,Fujino A,Pieretti-Vanmarcke R,Lo Celso C,Dombkowski D,Preffer F,Cohen KS,Teixeira J,Donahoe PK

更新日期：2008-08-26 00:00:00

abstract：:The pattern of antibody specificities in sera from patients with myasthenia gravis (MG) was determined by the ability of monoclonal antibodies against defined determinants on the acetylcholine receptor molecule to inhibit binding of the serum antibodies to receptor from human muscle. We found that MG patients produce ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzartos SJ,Seybold ME,Lindstrom JM

更新日期：1982-01-01 00:00:00

abstract：:Circulating peripheral blood cells and disaggregated yolk sac cells were obtained from normal mouse embryos as early as day 9 of gestation, prior to the formation of the fetal liver. These were cultured in vitro in plasma clots or methylcellulose, in the presence of either embryonic fluid or adult spleen cell-conditio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong PM,Clarke BJ,Carr DH,Chui DH

更新日期：1982-05-01 00:00:00

abstract：:DNA methylation may be a component of a multilevel control mechanism that regulates eukaryotic gene expression. We used synthetic oligonucleotides to investigate the effect of cytosine methylation on the binding of the transcription factor Sp1 to its target sequence (a G + C-rich sequence known as a "GC box"). Concate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrington MA,Jones PA,Imagawa M,Karin M

更新日期：1988-04-01 00:00:00

abstract：:Small, single-module proteins that fold in a single cooperative step may be paradigms for understanding early events in protein-folding pathways generally. Recent experimental studies of the 64-residue chymotrypsin inhibitor 2 (CI2) support a nucleation mechanism for folding, as do some computer stimulations. CI2 has ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fersht AR

更新日期：1995-11-21 00:00:00

abstract：:A close correlation was observed between intracellular Ca2+ pool depletion and refilling and the onset of DNA synthesis and proliferation of DDT1MF-2 smooth muscle cells. The intracellular Ca2+ pump inhibitors 2,5-di-tert-butyl-hydroquinone (DBHQ) and thapsigargin (TG) specifically emptied identical inositol 1,4,5-tri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Short AD,Bian J,Ghosh TK,Waldron RT,Rybak SL,Gill DL

更新日期：1993-06-01 00:00:00

abstract：:Coatomer, the major component of the coat of COPI transport vesicles, binds both to the dilysine motif of resident membrane proteins of the endoplasmic reticulum and to the cytoplasmic domain of p23, a major type I membrane protein of COPI vesicles. Using a photocrosslinking approach, we find that under native conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harter C,Wieland FT

更新日期：1998-09-29 00:00:00

abstract：:The only major glutamate receptor membrane-associated guanylate kinase scaffolds expressed in the young superficial superior colliculus (SC) are synapse-associated protein 102 (SAP102) and postsynaptic density protein 95 (PSD95). In this, as in all visual brain regions examined, synaptic PSD95 increases rapidly follow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao JP,Murata Y,Constantine-Paton M

更新日期：2013-01-08 00:00:00

abstract：:T cell recognition typically involves both the engagement of a specific T cell receptor with a peptide/major histocompatibility complex (MHC) and a number of accessory interactions. One of the most important interactions is between the integrin lymphocyte function-associated antigen 1 (LFA-1) on the T cell and intrace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wülfing C,Sjaastad MD,Davis MM

更新日期：1998-05-26 00:00:00

abstract：:Current understanding of the integration of cell division and expansion in the development of plant lateral organs such as leaves is limited. Cell number is established during a mitotic phase, and subsequent growth into a mature organ relies primarily on cell expansion accompanied by endocycles. Here we show that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dewitte W,Scofield S,Alcasabas AA,Maughan SC,Menges M,Braun N,Collins C,Nieuwland J,Prinsen E,Sundaresan V,Murray JA

更新日期：2007-09-04 00:00:00