Abstract:
:Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. Here, we found that isolation of neonatal rats induced glucocorticoid-dependent social dominance over nonisolated control rats in juveniles from the same litter. Furthermore, neonatal isolation inactivated the actin-depolymerizing factor (ADF)/cofilin in the juvenile medial prefrontal cortex (mPFC). Isolation-induced inactivation of ADF/cofilin increased stable actin fractions at dendritic spines in the juvenile mPFC, decreasing glutamate synaptic AMPA receptors. Expression of constitutively active ADF/cofilin in the mPFC rescued the effect of isolation on social dominance. Thus, neonatal isolation affects spines in the mPFC by reducing actin dynamics, leading to altered social behavior later in life.
journal_name
Proc Natl Acad Sci U S Aauthors
Tada H,Miyazaki T,Takemoto K,Takase K,Jitsuki S,Nakajima W,Koide M,Yamamoto N,Komiya K,Suyama K,Sano A,Taguchi A,Takahashi Tdoi
10.1073/pnas.1606351113subject
Has Abstractpub_date
2016-11-08 00:00:00pages
E7097-E7105issue
45eissn
0027-8424issn
1091-6490pii
1606351113journal_volume
113pub_type
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