Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria.

abstract：:The importance of core histones in the regulation of DNA function by chromatin is clear. However, little is known about the role of the linker histone. We investigated the role of H1 in Saccharomyces cerevisiae during extensive transcriptional reprogramming in stationary phase. Although the levels of linker histone Hh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer G,McEvoy CR,Patterton HG

更新日期：2008-09-30 00:00:00

abstract：:The basolateral membranes of Aplysia californica foregut absorptive cells contain both Cl(-)-stimulated ATPase and ATP-dependent Cl- transport activities, and each was inhibited by orthovanadate. Both of these orthovanadate-sensitive activities were reconstituted into proteoliposomes. The reaction sequence kinetics we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerencser GA,Zelezna B

更新日期：1993-09-01 00:00:00

abstract：:The emerging method of femtosecond crystallography (FX) may extend the diffraction resolution accessible from small radiation-sensitive crystals and provides a means to determine catalytically accurate structures of acutely radiation-sensitive metalloenzymes. Automated goniometer-based instrumentation developed for us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen AE,Soltis SM,González A,Aguila L,Alonso-Mori R,Barnes CO,Baxter EL,Brehmer W,Brewster AS,Brunger AT,Calero G,Chang JF,Chollet M,Ehrensberger P,Eriksson TL,Feng Y,Hattne J,Hedman B,Hollenbeck M,Holton JM,Keab

更新日期：2014-12-02 00:00:00

abstract：:Wild and managed bees are well documented as effective pollinators of global crops of economic importance. However, the contributions by pollinators other than bees have been little explored despite their potential to contribute to crop production and stability in the face of environmental change. Non-bee pollinators ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rader R,Bartomeus I,Garibaldi LA,Garratt MP,Howlett BG,Winfree R,Cunningham SA,Mayfield MM,Arthur AD,Andersson GK,Bommarco R,Brittain C,Carvalheiro LG,Chacoff NP,Entling MH,Foully B,Freitas BM,Gemmill-Herren B,Ghazoul

更新日期：2016-01-05 00:00:00

abstract：:We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human alpha-synuclein in the substantia nigra of adult marmosets. The alpha-synuclein protein was expressed in 90-95% of all nigral dopamine neurons and distributed by anterograde transport throughout their axonal and dendrit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirik D,Annett LE,Burger C,Muzyczka N,Mandel RJ,Björklund A

更新日期：2003-03-04 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is believed to arise through a multistep model comprised of putative precursor lesions known as pancreatic intraepithelial neoplasia (PanIN). Recent genetically engineered mouse models of PDAC demonstrate a comparable morphologic spectrum of murine PanIN (mPanIN) lesions. The hi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Habbe N,Shi G,Meguid RA,Fendrich V,Esni F,Chen H,Feldmann G,Stoffers DA,Konieczny SF,Leach SD,Maitra A

更新日期：2008-12-02 00:00:00

abstract：:We have tried to find out why Ascaris hemoglobin has such an exceptionally high oxygen affinity (P50 approximately 0.004 mmHg; 1 mmHg = 133 Pa). Following Kloek et al., we have synthesized the N-terminal globin domain of Ascaris hemoglobin in Escherichia coli [Kloek, A. P., Yang, J., Mathews, F. S. & Goldberg, D. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Baere I,Perutz MF,Kiger L,Marden MC,Poyart C

更新日期：1994-02-15 00:00:00

abstract：:An earthquake of magnitude M and linear source dimension L(M) is preceded within a few years by certain patterns of seismicity in the magnitude range down to about (M - 3) in an area of linear dimension about 5L-10L. Prediction algorithms based on such patterns may allow one to predict approximately 80% of strong eart...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keilis-Borok VI

更新日期：1996-04-30 00:00:00

abstract：:The partial purification of mouse mammary gland stem cells (MaSCs) using combinatorial cell surface markers (Lin(-)CD24(+)CD29(h)CD49f(h)) has improved our understanding of their role in normal development and breast tumorigenesis. Despite the significant improvement in MaSC enrichment, there is presently no methodolo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： dos Santos CO,Rebbeck C,Rozhkova E,Valentine A,Samuels A,Kadiri LR,Osten P,Harris EY,Uren PJ,Smith AD,Hannon GJ

更新日期：2013-04-30 00:00:00

abstract：:Heat-shock protein of 90 kDa (Hsp90) is an essential molecular chaperone that adopts different 3D structures associated with distinct nucleotide states: a wide-open, V-shaped dimer in the apo state and a twisted, N-terminally closed dimer with ATP. Although the N domain is known to mediate ATP binding, how Hsp90 sense...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sung N,Lee J,Kim JH,Chang C,Joachimiak A,Lee S,Tsai FT

更新日期：2016-03-15 00:00:00

abstract：:Most human tumors are clonal in origin, although the cells may be diverse in their properties. Since the tumors evolve through progressive stages over decades of time, it is possible that the conditions that induced the tumor transform many cells, but that selective overgrowth of the fastest growing lead to a clonal p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao A,Rubin H

更新日期：1993-11-15 00:00:00

abstract：:We have long known that language is lateralized to the left hemisphere (LH) in most neurologically healthy adults. In contrast, findings on lateralization of function during development are more complex. As in adults, anatomical, electrophysiological, and neuroimaging studies in infants and children indicate LH latera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olulade OA,Seydell-Greenwald A,Chambers CE,Turkeltaub PE,Dromerick AW,Berl MM,Gaillard WD,Newport EL

更新日期：2020-09-22 00:00:00

abstract：:Recent genome-wide association studies have revealed some genetic loci associated with serum uric acid levels and susceptibility to gout/hyperuricemia which contain potential candidates of physiologically important urate transporters. One of these novel loci is located upstream of SGK1 and SLC2A12, suggesting that var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyoda Y,Takada T,Miyata H,Matsuo H,Kassai H,Nakao K,Nakatochi M,Kawamura Y,Shimizu S,Shinomiya N,Ichida K,Hosoyamada M,Aiba A,Suzuki H

更新日期：2020-08-04 00:00:00

abstract：:A murine hybridoma-derived antibody (IPH.134) has been produced which has apparent high binding specificity for an extract of Schistosoma japonicum adult worms. No binding was detected to extracts of S. japonicum eggs or to extracts from other adult trematodes (Fasciola hepatica, Paragonimus westermanii, Clonorchis si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell GF,Cruise KM,Garcia EG,Anders RF

更新日期：1981-05-01 00:00:00

abstract：:Diffuse celestial sources of relatively low surface brightness such as the Milky Way, zodiacal light, and gegenschein (or contre lumière) can be studied most reliably from above the earth's atmosphere with equipment flown in artificial satellites. We review the techniques used and some of the difficulties encountered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roach FE,Carroll B,Aller LH,Smith L

更新日期：1972-03-01 00:00:00

abstract：:Recessive Stargardt's macular degeneration is a blinding disease of children caused by mutations in the ABCA4 (ABCR) gene. Mice with a knockout mutation in abcr accumulate toxic lipofuscin pigments in ocular tissues, similar to affected humans. The major fluorophore of lipofuscin is the bis-retinoid, N-retinylidene-N-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radu RA,Mata NL,Bagla A,Travis GH

更新日期：2004-04-20 00:00:00

abstract：:Plants have evolved adaptive strategies that involve transcriptional networks to cope with and survive environmental challenges. Key transcriptional regulators that mediate responses to environmental fluctuations in nitrate have been identified; however, little is known about how these regulators interact to orchestra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan P,Ripoll JJ,Wang R,Vuong L,Bailey-Steinitz LJ,Ye D,Crawford NM

更新日期：2017-02-28 00:00:00

abstract：:Effective therapies for most solid cancers, especially those that have progressed to metastasis, remain elusive because of inherent and acquired resistance of tumor cells to conventional treatments. Additionally, the effective therapeutic window for many protocols can be very narrow, frequently resulting in toxicity. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lebedeva IV,Washington I,Sarkar D,Clark JA,Fine RL,Dent P,Curiel DT,Turro NJ,Fisher PB

更新日期：2007-02-27 00:00:00

abstract：:Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation, peripheral ILC3s become activated, secrete cytokin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Burg N,Chappaz S,Baerenwaldt A,Horvath E,Bose Dasgupta S,Ashok D,Pieters J,Tacchini-Cottier F,Rolink A,Acha-Orbea H,Finke D

更新日期：2014-09-02 00:00:00

abstract：:The prediction of binding sites and the understanding of interfaces associated with protein complexation remains an open problem in molecular biophysics. This work shows that a crucial factor in predicting and rationalizing protein-protein interfaces can be inferred by assessing the extent of intramolecular desolvatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Scheraga HA

更新日期：2003-01-07 00:00:00

abstract：:Mechanisms that enabled primitive cell membranes to self-reproduce have been discussed based on the physicochemical properties of fatty acids; however, there must be a transition to modern cell membranes composed of phospholipids [Budin I, Szostak JW (2011) Proc Natl Acad Sci USA 108:5249-5254]. Thus, a growth-divisio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terasawa H,Nishimura K,Suzuki H,Matsuura T,Yomo T

更新日期：2012-04-17 00:00:00

abstract：:The study of development has relied primarily on the isolation of mutations in genes with specific functions in development and on the comparison of their expression patterns in normal and mutant phenotypes. Comparative evolutionary analyses can complement these approaches. Phylogenetic analyses of Sonic hedgehog (Shh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zardoya R,Abouheif E,Meyer A

更新日期：1996-11-12 00:00:00

abstract：:Seawater Mg:Ca and Sr:Ca ratios are biogeochemical parameters reflecting the Earth-ocean-atmosphere dynamic exchange of elements. The ratios' dependence on the environment and organisms' biology facilitates their application in marine sciences. Here, we present a measured single-laboratory dataset, combined with previ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lebrato M,Garbe-Schönberg D,Müller MN,Blanco-Ameijeiras S,Feely RA,Lorenzoni L,Molinero JC,Bremer K,Jones DOB,Iglesias-Rodriguez D,Greeley D,Lamare MD,Paulmier A,Graco M,Cartes J,Barcelos E Ramos J,de Lara A,Sanchez-Lea

更新日期：2020-09-08 00:00:00

abstract：:G protein-gated inwardly rectifying potassium (GIRK) channels are critical regulators of neuronal excitability and can be directly activated by ethanol. Constitutive deletion of the GIRK3 subunit has minimal phenotypic consequences, except in response to drugs of abuse. Here we investigated how the GIRK3 subunit contr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herman MA,Sidhu H,Stouffer DG,Kreifeldt M,Le D,Cates-Gatto C,Munoz MB,Roberts AJ,Parsons LH,Roberto M,Wickman K,Slesinger PA,Contet C

更新日期：2015-06-02 00:00:00

abstract：:The 1.1 Å, ultrahigh resolution neutron structure of hydrogen/deuterium (H/D) exchanged crambin is reported. Two hundred ninety-nine out of 315, or 94.9%, of the hydrogen atom positions in the protein have been experimentally derived and resolved through nuclear density maps. A number of unconventional interactions ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen JC,Hanson BL,Fisher SZ,Langan P,Kovalevsky AY

更新日期：2012-09-18 00:00:00

abstract：:A human Burkitt lymphoma cell line, Raji-HN2, made 10-fold more resistant to nitrogen mustard (HN2) than the parental Raji cell line, exhibited the following characteristics when compared to the parental Raji cells: (i) decreased HN2-induced DNA interstrand crosslinking; (ii) increased (3-fold) DNA topoisomerase II [D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan KB,Mattern MR,Boyce RA,Schein PS

更新日期：1987-11-01 00:00:00

abstract：:In an unprecedented finding, Davis et al. [Davis, R. E., Miller, S., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinobu, L. A., Galasko, D., Thal, L. J., Beal, M. F., Howell, N. & Parker, W. D., Jr. (1997) Proc. Natl. Acad. Sci. USA 94, 4526-4531] used an unusual DNA isolation method to show that healthy adults harbor a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirano M,Shtilbans A,Mayeux R,Davidson MM,DiMauro S,Knowles JA,Schon EA

更新日期：1997-12-23 00:00:00

abstract：:A transcript generated by the distal part of the Duchenne Muscular Dystrophy (DMD) gene was initially detected in cells where the full size 14-kilobase (kb) messenger RNA is not found at a significant level. This transcript, approximately 4.5 kb long, corresponds to the cysteine-rich and carboxyl-terminal domains of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hugnot JP,Gilgenkrantz H,Vincent N,Chafey P,Morris GE,Monaco AP,Berwald-Netter Y,Koulakoff A,Kaplan JC,Kahn A

更新日期：1992-08-15 00:00:00

abstract：:Animal studies have shown that the brain is an insulin-responsive organ and that central nervous insulin resistance induces obesity and disturbances in glucose metabolism. In humans, insulin effects in the brain are poorly characterized. We used a magnetoencephalography approach during a two-step hyperinsulinemic eugl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tschritter O,Preissl H,Hennige AM,Stumvoll M,Porubska K,Frost R,Marx H,Klösel B,Lutzenberger W,Birbaumer N,Häring HU,Fritsche A

更新日期：2006-08-08 00:00:00

abstract：:Plasmons, the collective oscillations of interacting electrons, possess emergent properties that dramatically alter the optical response of metals. We predict the existence of a new class of plasmons-chiral Berry plasmons (CBPs)-for a wide range of 2D metallic systems including gapped Dirac materials. As we show, in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song JC,Rudner MS

更新日期：2016-04-26 00:00:00