The Saccharomyces cerevisiae linker histone Hho1p is essential for chromatin compaction in stationary phase and is displaced by transcription.

abstract：:Duplexes constituted by closed or open RNA circles paired to single-stranded oligonucleotides terminating with 3'-CCAOH form resected pseudoknots that are substrates of yeast histidyl-tRNA synthetase. Design of this RNA fold is linked to the mimicry of the pseudoknotted amino acid accepting branch of the tRNA-like dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felden B,Giegé R

更新日期：1998-09-01 00:00:00

abstract：:In this paper we demonstrate that near infrared Fourier transform Raman spectroscopy provides unprecedented biochemical information about the extent of atherosclerosis in human aorta. In particular, elastin, collagen, cholesterol, cholesterol esters, lipids, carotenoids, and calcium apatite deposits all can be discern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraga JJ,Feld MS,Rava RP

更新日期：1992-04-15 00:00:00

abstract：:Plants balance their competing requirements for growth and stress tolerance via a sophisticated regulatory circuitry that controls responses to the external environments. We have identified a plant-specific gene, COST1 (constitutively stressed 1), that is required for normal plant growth but negatively regulates droug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bao Y,Song WM,Wang P,Yu X,Li B,Jiang C,Shiu SH,Zhang H,Bassham DC

更新日期：2020-03-31 00:00:00

abstract：:Sequence comparisons of genomes or expressed sequence tags (ESTs) from related organisms provide insight into functional conservation and diversification. We compare the sequences of ESTs from the male accessory gland of Drosophila simulans to their orthologs in its close relative Drosophila melanogaster, and demonstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson WJ,Clark AG,Waldrip-Dail HM,Wolfner MF,Aquadro CF

更新日期：2001-06-19 00:00:00

abstract：:The beta 2-adrenergic receptor (beta 2AR) can be constitutively activated by mutations in the third intracellular loop. Whereas the wild-type receptor exists predominantly in an inactive conformation (R) in the absence of agonist, the mutant receptor appears to spontaneously adopt an active conformation (R*). We now d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pei G,Samama P,Lohse M,Wang M,Codina J,Lefkowitz RJ

更新日期：1994-03-29 00:00:00

abstract：:The different isoforms of PDGF bind with different affinities to two different receptor types. Previously, these receptors have been demonstrated mainly on mesenchymal and glial cells. We show here that PDGF beta-type receptors are present also on rat brain neurons in vivo as well as in vitro. Immunohistochemical anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smits A,Kato M,Westermark B,Nistér M,Heldin CH,Funa K

更新日期：1991-09-15 00:00:00

abstract：:The assembly of the three neuronal soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) proteins synaptobrevin 2, syntaxin-1A, and SNAP-25 is the key step that leads to exocytotic fusion of synaptic vesicles. In the fully assembled SNARE complex, these three proteins form a coiled-coil ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang B,Kiessling V,Tamm LK

更新日期：2013-11-26 00:00:00

abstract：:Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated with current chemotherapies for non-small-cell lung cancers (NSCLCs) have a survival rate of approximately 15% after 5 years. Novel approaches are needed to treat this disease. We show elevated NAD(P)H:quinone oxidoreductase-1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bey EA,Bentle MS,Reinicke KE,Dong Y,Yang CR,Girard L,Minna JD,Bornmann WG,Gao J,Boothman DA

更新日期：2007-07-10 00:00:00

abstract：:Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludwig B,Ludwig S,Steffen A,Knauf Y,Zimerman B,Heinke S,Lehmann S,Schubert U,Schmid J,Bleyer M,Schönmann U,Colton CK,Bonifacio E,Solimena M,Reichel A,Schally AV,Rotem A,Barkai U,Grinberg-Rashi H,Kaup FJ,Avni Y,J

更新日期：2017-10-31 00:00:00

abstract：:Nature is rife with networks that are functionally optimized to propagate inputs to perform specific tasks. Whether via genetic evolution or dynamic adaptation, many networks create functionality by locally tuning interactions between nodes. Here we explore this behavior in two contexts: strain propagation in mechanic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rocks JW,Ronellenfitsch H,Liu AJ,Nagel SR,Katifori E

更新日期：2019-02-12 00:00:00

abstract：:Soret-excited resonance Raman spectroscopy yields direct information regarding the iron-carbon bonding interactions in the cyanomet and carbonmonoxy complexes of hemoglobin III from Chironomus thummi thummi (CTT III) in solution. By isotope exchange in cyanide (13CN-, C15N-, and 13C15N-) and carbon monoxide (13CO, C18...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu NT,Benko B,Kerr EA,Gersonde K

更新日期：1984-08-01 00:00:00

abstract：:Malaria transmission has been substantially reduced across Africa through the distribution of long-lasting insecticidal nets (LLINs). However, the emergence of insecticide resistance within mosquito vectors risks jeopardizing the future efficacy of this control strategy. The severity of this threat is uncertain becaus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Viana M,Hughes A,Matthiopoulos J,Ranson H,Ferguson HM

更新日期：2016-08-09 00:00:00

abstract：:Bordetella dermonecrotizing toxin causes assembly of actin stress fibers and focal adhesions in some cultured cells and induces mobility shifts of the small GTP-binding protein Rho on electrophoresis. We attempted to clarify the molecular basis of the toxin action on Rho. Analysis of the amino acid sequence of toxin-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horiguchi Y,Inoue N,Masuda M,Kashimoto T,Katahira J,Sugimoto N,Matsuda M

更新日期：1997-10-14 00:00:00

abstract：:We have investigated whether the large (5- to 15-fold) stimulation of synthesis of growth hormone (somatotropin) observed upon exposure of a strain of rat pituitary (GH3) cells to dexamethasone (a synthetic glucocorticoid) arises from a stimulation of pregrowth hormone mRNA. A good agreement was observed between the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tushinski RJ,Sussman PM,Yu LY,Bancroft FC

更新日期：1977-06-01 00:00:00

abstract：:The activation of additional promoter sites by production of an alternative sigma subunit for RNA polymerase is a common strategy for the coordinate regulation of gene expression. Many alternative sigma factors control genes for specialized, and often narrowly distributed, functions. For example, most of the alternati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YF,Helmann JD

更新日期：1992-06-01 00:00:00

abstract：:The topology of the tight junction is probed by introducing dipicrylamine (dpa-), a lipid-soluble anion, into the membranes of hepatocyte pairs in culture. Once partitioned into the membrane, dpa- ions are free to move in the hydrophobic core of the membrane, where their mobile charges greatly increase membrane capaci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turin L,Béhé P,Plonsky I,Dunina-Barkovskaya A

更新日期：1991-10-15 00:00:00

abstract：:Rat superior cervical sympathetic ganglion was used to begin studying the regulation of molecular components of the synapse. Ganglionic postsynaptic densities (PSDs)exhibited a thin, disc-shaped profile electron microscopically, comparable to that described for brain. Moreover, the presumptive ganglionic PSD protein (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu K,Black IB

更新日期：1987-12-01 00:00:00

abstract：:When the proximal and distal elements of wire-frame cubes are conflated, observers perceive illusory structures that no longer behave veridically. These phenomena suggest that what we normally see depends on visual associations generated by experience. The necessity of such learning may explain why the mammalian visua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purves D,Andrews TJ

更新日期：1997-06-10 00:00:00

abstract：:We have attempted to model human metastatic disease by implanting human target organs into the immunodeficient C.B-17 scid/scid (severe combined immunodeficiency; SCID) mouse, creating SCID-hu mice. Preferential metastasis to implants of human fetal lung and human fetal bone marrow occurred after i.v. injection of hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shtivelman E,Namikawa R

更新日期：1995-05-09 00:00:00

abstract：:Transcription initiation is a dynamic process in which RNA polymerase (RNAP) and promoter DNA act as partners, changing in response to one another, to produce a polymerase/promoter open complex (RPo) competent for transcription. In Escherichia coli RNAP, region 1.1, the N-terminal 100 residues of sigma(70), is thought...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hook-Barnard IG,Hinton DM

更新日期：2009-01-20 00:00:00

abstract：:Some dinosaurs reached masses that were approximately 8 times those of the largest, ecologically equivalent terrestrial mammals. The factors most responsible for setting the maximal body size of vertebrates are resource quality and quantity, as modified by the mobility of the consumer, and the vertebrate's rate of ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNab BK

更新日期：2009-07-21 00:00:00

abstract：:Mechanisms of estrogen-induced tumorigenesis in the target organ are not well understood. It has been suggested that oxidative stress resulting from metabolic activation of carcinogenic estrogens plays a critical role in estrogen-induced carcinogenesis. We tested this hypothesis by using an estrogen-induced hamster re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhat HK,Calaf G,Hei TK,Loya T,Vadgama JV

更新日期：2003-04-01 00:00:00

abstract：:Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) was found to increase the adherence of purified peripheral blood monocytes to plastic surfaces and to monolayers of human umbilical vein endothelial cells. With plastic surfaces as a model 9-hr culture with GM-CSF was necessary for enhancement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gamble JR,Elliott MJ,Jaipargas E,Lopez AF,Vadas MA

更新日期：1989-09-01 00:00:00

abstract：:Small molecules that specifically bind with high affinity to any designated DNA sequence in the human genome would be useful tools in molecular biology and potentially in human medicine. Simple rules have been developed to rationally alter the sequence specificity of minor groove-binding polyamides containing N-methyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho J,Parks ME,Dervan PB

更新日期：1995-10-24 00:00:00

abstract：:I have determined the nucleotide sequence of the ampicillin resistance gene of pBR322, an Escherichia coli plasmid that encodes a penicillin beta-lactamase. This gene codes for a protein of 286 amino acid residues. The first 23 amino acids presumably form a signal for secretion, because they do not appear in the matur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sutcliffe JG

更新日期：1978-08-01 00:00:00

abstract：:We have isolated and sequenced cDNA clones corresponding to the DR beta 1 and DR beta 2 loci from two homozygous B-cell lines typed as DR7 (Burkhart) and DR9 (ISK). These nucleotide sequences were compared to beta 1 and beta 2 chains of other DR haplotypes. The first-domain sequences of beta 2 chains are identical in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregersen PK,Moriuchi T,Karr RW,Obata F,Moriuchi J,Maccari J,Goldberg D,Winchester RJ,Silver J

更新日期：1986-12-01 00:00:00

abstract：:To scrutinize how a protein folds at atomic resolution, we performed 200 molecular dynamics simulations (each of 50 ns) of the miniprotein Trp-cage on the computational grid. Within the trajectories, 58 folding and 31 unfolding events were identified and subjected to extensive comparison and classification. Based on a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ota M,Ikeguchi M,Kidera A

更新日期：2004-12-21 00:00:00

abstract：:Natural killer (NK) cells play a critical role in controlling malignancies. Susceptibility or resistance to lung cancer, for example, specifically depends on NK cell function. Nevertheless, intrinsic factors that control NK cell-mediated clearance of lung cancer are unknown. Here we report that NK cells exposed to exo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi L,Li K,Guo Y,Banerjee A,Wang Q,Lorenz UM,Parlak M,Sullivan LC,Onyema OO,Arefanian S,Stelow EB,Brautigan DL,Bullock TNJ,Brown MG,Krupnick AS

更新日期：2018-11-13 00:00:00

abstract：:The total amount of noncoding sequences on chromosomes of contemporary organisms varies significantly from species to species. We propose a hypothesis for the origin of these noncoding sequences that assumes that (i) an approximately equal to 0.55-kilobase (kb)-long reading frame composed the primordial gene and (ii) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naora H,Miyahara K,Curnow RN

更新日期：1987-09-01 00:00:00

abstract：:The light-entrained master central circadian clock (CC) located in the suprachiasmatic nucleus (SCN) not only controls the diurnal alternance of the active phase (the light period of the human light-dark cycle, but the mouse dark period) and the rest phase (the human dark period, but the mouse light period), but also ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherji A,Kobiita A,Damara M,Misra N,Meziane H,Champy MF,Chambon P

更新日期：2015-12-01 00:00:00