Phylogeny of protein-folding trajectories reveals a unique pathway to native structure.

abstract：:Groundwater arsenic (As) is elevated in the shallow Holocene aquifers of Bangladesh. In the dry season, the shallow groundwater discharges to major rivers. This process may influence the chemistry of the river and the hyporheic zone sediment. To assess the fate of As during discharge, surface (0-5 cm) and subsurface (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Mailloux B,Jung HB,Hoque MA,Stute M,Ahmed KM,Zheng Y

更新日期：2009-10-06 00:00:00

abstract：:Agrobacterium tumefaciens is routinely used to engineer desirable genes into dicotyledonous plants. However, the economically important graminaceous plant maize is refractory to tumor induction by inoculation with virulent strains of A. tumefaciens. Currently, the only clearcut evidence for transferred DNA (T-DNA) tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen WH,Escudero J,Schläppi M,Ramos C,Hohn B,Koukolíková-Nicola Z

更新日期：1993-02-15 00:00:00

abstract：:Newly emerging plants provide the best forage for herbivores. To exploit this fleeting resource, migrating herbivores align their movements to surf the wave of spring green-up. With new technology to track migrating animals, the Green Wave Hypothesis has steadily gained empirical support across a diversity of migrator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geremia C,Merkle JA,Eacker DR,Wallen RL,White PJ,Hebblewhite M,Kauffman MJ

更新日期：2019-12-17 00:00:00

abstract：:We have determined the complete primary structure of human hemopexin, a plasma beta-glycoprotein that specifically binds one heme with high affinity and transports it to hepatocytes for salvage of the iron. Human hemopexin (Mr approximately equal to 63,000) consists of a single polypeptide chain containing 439 amino a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Takahashi Y,Putnam FW

更新日期：1985-01-01 00:00:00

abstract：:Modifier screens have been powerful genetic tools to define signaling pathways in lower organisms. The identification of modifier loci in mice has begun to allow a similar dissection of mammalian signaling pathways. Transgenic mice (Btk(lo)) expressing 25% of endogenous levels of Bruton's tyrosine kinase (Btk) have B ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Satterthwaite AB,Willis F,Kanchanastit P,Fruman D,Cantley LC,Helgason CD,Humphries RK,Lowell CA,Simon M,Leitges M,Tarakhovsky A,Tedder TF,Lesche R,Wu H,Witte ON

更新日期：2000-06-06 00:00:00

abstract：:The NMR structures of three single-amino acid variants of the C-terminal domain of the human prion protein, hPrP(121-230), are presented. In hPrP(M166V) and hPrP(R220K) the substitution is with the corresponding residue in murine PrP, and in hPrP(S170N) it is with the corresponding Syrian hamster residue. All three su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calzolai L,Lysek DA,Guntert P,von Schroetter C,Riek R,Zahn R,Wüthrich K

更新日期：2000-07-18 00:00:00

abstract：:Ler, a homolog of H-NS in enteropathogenic Escherichia coli (EPEC), plays a critical role in the expression of virulence genes encoded by the pathogenic island, locus of enterocyte effacement (LEE). Although Ler acts as an antisilencer of multiple LEE operons by alleviating H-NS-mediated silencing, it represses its ow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhat A,Shin M,Jeong JH,Kim HJ,Lim HJ,Rhee JH,Paik SY,Takeyasu K,Tobe T,Yen H,Lee G,Choy HE

更新日期：2014-06-24 00:00:00

abstract：:We present a model describing how Mg(2+) binds and stabilizes specific RNA structures. In this model, RNA stabilization arises from two energetically distinct modes of Mg(2+) binding: diffuse- and site-binding. Diffusely bound Mg(2+) are electrostatically attracted to the strong anionic field around the RNA and are ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Misra VK,Draper DE

更新日期：2001-10-23 00:00:00

abstract：:Unilateral stimulation of human peripheral nerves activates the primary somatosensory cortex (SI) contralaterally and the secondary somatosensory cortex (SII) bilaterally. We aimed at characterizing phase locking between SI and SII in response to electric stimuli applied once every 3 s to the right median nerve at the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simões C,Jensen O,Parkkonen L,Hari R

更新日期：2003-03-04 00:00:00

abstract：:Peroxisome proliferators (PP) induce a highly predictable pleiotropic response in rat and mouse liver that is characterized by hepatomegaly, increase in peroxisome number in hepatocytes, and induction of certain peroxisomal enzymes. The PP-binding protein (PPbP) was purified from rat liver cytosol by a two-step proced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalwani ND,Alvares K,Reddy MK,Reddy MN,Parikh I,Reddy JK

更新日期：1987-08-01 00:00:00

abstract：:Capturing carbon dioxide from the atmosphere ("air capture") in an industrial process has been proposed as an option for stabilizing global CO(2) concentrations. Published analyses suggest these air capture systems may cost a few hundred dollars per tonne of CO(2), making it cost competitive with mainstream CO(2) miti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： House KZ,Baclig AC,Ranjan M,van Nierop EA,Wilcox J,Herzog HJ

更新日期：2011-12-20 00:00:00

abstract：:CSB/ERCC6 belongs to an orphan subfamily of SWI2/SNF2-related chromatin remodelers and plays crucial roles in gene expression, DNA damage repair, and the maintenance of genome integrity. The molecular basis of chromatin remodeling by Cockayne syndrome B protein (CSB) is not well understood. Here we investigate the mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Xu J,Limbo O,Fei J,Kassavetis GA,Chong J,Kadonaga JT,Russell P,Li B,Wang D

更新日期：2019-03-26 00:00:00

abstract：:The potential involvement of ceramide-related signaling processes in the induction of apoptosis by tumor necrosis factor alpha was assessed by multiple biochemical strategies in the human leukemic cell lines HL-60 and U937 and the murine fibrosarcoma cell lines L929/LM and WEHI 164/13. Exposure of these cells to tumor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis WD,Kolesnick RN,Fornari FA,Traylor RS,Gewirtz DA,Grant S

更新日期：1994-01-04 00:00:00

abstract：:The basolateral membranes of Aplysia californica foregut absorptive cells contain both Cl(-)-stimulated ATPase and ATP-dependent Cl- transport activities, and each was inhibited by orthovanadate. Both of these orthovanadate-sensitive activities were reconstituted into proteoliposomes. The reaction sequence kinetics we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerencser GA,Zelezna B

更新日期：1993-09-01 00:00:00

abstract：:Copper is a required metal nutrient for life, but global or local alterations in its homeostasis are linked to diseases spanning genetic and metabolic disorders to cancer and neurodegeneration. Technologies that enable longitudinal in vivo monitoring of dynamic copper pools can help meet the need to study the complex ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffern MC,Park HM,Au-Yeung HY,Van de Bittner GC,Ackerman CM,Stahl A,Chang CJ

更新日期：2016-12-13 00:00:00

abstract：:The generation of high levels of new catalytic activities on natural and artificial protein scaffolds is a major goal of enzyme engineering. Here, we used random mutagenesis and selection in vivo to establish a sugar isomerisation reaction on both a natural (beta alpha)(8)-barrel enzyme and a catalytically inert chime...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Claren J,Malisi C,Höcker B,Sterner R

更新日期：2009-03-10 00:00:00

abstract：:Calcium/phospholipid-dependent protein kinase (protein kinase C, PKC) has been suggested to play a role in the sensitivity of gamma-aminobutyrate type A (GABAA) receptors to ethanol. We tested a line of null mutant mice that lacks the gamma isoform of PKC (PKC gamma) to determine the role of this brain-specific isoenz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris RA,McQuilkin SJ,Paylor R,Abeliovich A,Tonegawa S,Wehner JM

更新日期：1995-04-25 00:00:00

abstract：:Lod scores provide a method to unify linkage tests based on identity by descent and identity in marker state while permitting selection of the most informative individuals through their disease-related phenotypes and markers in relatives. After parametric lods are reviewed, a nonparametric approach that depends on a s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton NE

更新日期：1996-04-16 00:00:00

abstract：:Six groups of Munich-Wistar rats underwent micropuncture study 2-10 weeks and morphologic studies 11-13 months after induction of streptozotocin diabetes or after sham treatment. Diabetic rats received diets containing 6% (group D6), 12% (D12), or 50% protein (D50) and were maintained under similar conditions of moder...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zatz R,Meyer TW,Rennke HG,Brenner BM

更新日期：1985-09-01 00:00:00

abstract：:We have constructed bovine papilloma virus recombinants carrying a hybrid gene in which human growth hormone structural sequences are fused to the promoter and presumptive control region of the mouse metallothionein-I gene. Mouse cells transformed with the recombinants synthesize metallothionein-growth hormone hybrid ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pavlakis GN,Hamer DH

更新日期：1983-01-01 00:00:00

abstract：:We study the electrophoretic transport of single-stranded RNA molecules through 1.5-nm-wide pores of carbon nanotube membranes by molecular dynamics simulations. From approximately 170 individual RNA translocation events analyzed at full atomic resolution of solvent, membrane, and RNA, we identify key factors in membr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh IC,Hummer G

更新日期：2004-08-17 00:00:00

abstract：:The genotypic proportions for major histocompatibility complex loci, HLA-A and HLA-B, of progeny in families in 23 South Amerindian tribes in which segregation for homozygotes and heterozygotes could occur are examined. Overall, there is a large deficiency of homozygotes compared with Mendelian expectations (for HLA-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black FL,Hedrick PW

更新日期：1997-11-11 00:00:00

abstract：:From 1980 to 1992, a series of influential papers reported on the discovery, genetics, and evolution of a periodic cycling of the interval between Drosophila male courtship song pulses. The molecular mechanisms underlying this periodicity were never described. To reinitiate investigation of this phenomenon, we previou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern DL,Clemens J,Coen P,Calhoun AJ,Hogenesch JB,Arthur BJ,Murthy M

更新日期：2017-09-12 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE), an autoimmune model of multiple sclerosis, is a complex disease influenced by genetic, intrinsic, and environmental factors. In this study, we questioned whether parent-of-origin effects influence EAE, using reciprocal F2 intercross progeny generated between EAE-susceptib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teuscher C,Noubade R,Spach K,McElvany B,Bunn JY,Fillmore PD,Zachary JF,Blankenhorn EP

更新日期：2006-05-23 00:00:00

abstract：:Increasing global temperature and sea-level rise have led to concern about expansions in the distribution and prevalence of complex-lifecycle parasites (CLPs). Indeed, numerous environmental variables can influence the infectivity and reproductive output of many pathogens. Digenean trematodes are CLPs with intermediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huntley JW,Fürsich FT,Alberti M,Hethke M,Liu C

更新日期：2014-12-23 00:00:00

abstract：:Antigen stimulation of mast cells via FcepsilonRI, the high-affinity receptor for IgE, triggers a signaling cascade that requires Ca(2+) mobilization for exocytosis of secretory granules during an allergic response. This study investigates critical signaling components by using mutant RBL mast cells that are defective...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong-Geller E,Holowka D,Siraganian RP,Baird B,Cerione RA

更新日期：2001-01-30 00:00:00

abstract：:A mutation in RPB5 (rpb5-9), an essential RNA polymerase subunit assembled into RNA polymerases I, II, and III, revealed a role for this subunit in transcriptional activation. Activation by GAL4-VP16 was impaired upon in vitro transcription with mutant whole-cell extracts. In vivo experiments using inducible reporter ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyao T,Woychik NA

更新日期：1998-12-22 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) in the human ether-a-go-go-related gene 1, hERG1, are associated with cardiac arrhythmias. The Kv11.1 channels encoded by hERG1 are also essential for rhythmic excitability of the pituitary, where they are regulated by thyroid hormone through a signal transduction cascade involvi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gentile S,Martin N,Scappini E,Williams J,Erxleben C,Armstrong DL

更新日期：2008-09-23 00:00:00

abstract：:KCNE β-subunits assemble with and modulate the properties of voltage-gated K+ channels. In the heart, KCNE1 associates with the α-subunit KCNQ1 to generate the slowly activating, voltage-dependent potassium current (IKs) in the heart that controls the repolarization phase of cardiac action potentials. By contrast, in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barro-Soria R,Ramentol R,Liin SI,Perez ME,Kass RS,Larsson HP

更新日期：2017-08-29 00:00:00

abstract：:Protein O-mannosylation represents an evolutionarily conserved, essential posttranslational modification with immense impact on a variety of cellular processes. In humans, O-mannosylation defects result in Walker-Warburg syndrome, a severe recessive congenital muscular dystrophy associated with defects in neuronal mig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hutzler J,Schmid M,Bernard T,Henrissat B,Strahl S

更新日期：2007-05-08 00:00:00