Phase locking between human primary and secondary somatosensory cortices.

abstract：:Transient Receptor Potential Melastatin-8 (TRPM8), a recently identified member of the transient receptor potential (TRP) family of ion channels, is activated by mild cooling and by chemical compounds such as the supercooling agent, icilin. Since cooling, possibly involving TRPM8 stimulation, diminishes injury-induced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramachandran R,Hyun E,Zhao L,Lapointe TK,Chapman K,Hirota CL,Ghosh S,McKemy DD,Vergnolle N,Beck PL,Altier C,Hollenberg MD

更新日期：2013-04-30 00:00:00

abstract：:The photosystem II (PSII) subunit S (PsbS) plays a key role in nonphotochemical quenching, a photoprotective mechanism for dissipation of excess excitation energy in plants. The precise function of PsbS in nonphotochemical quenching is unknown. By reconstituting PsbS together with the major light-harvesting complex of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilk L,Grunwald M,Liao PN,Walla PJ,Kühlbrandt W

更新日期：2013-04-02 00:00:00

abstract：:Many Drosophila non-long terminal repeat (LTR) retrotransposons actively transpose into internal, gene-rich regions of chromosomes but do not transpose onto chromosome ends. HeT-A and TART are remarkable exceptions; they form telomeres of Drosophila by repeated transpositions onto the ends of chromosomes and never tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rashkova S,Karam SE,Pardue ML

更新日期：2002-03-19 00:00:00

abstract：:Tracing interisland and interarchipelago movements of people and artifacts in prehistoric Polynesia has posed a challenge to archaeologists due to the lack of pottery and obsidian, two materials most readily used in studies of prehistoric trade or exchange. Here we report the application of nondestructive energy-dispe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weisler MI,Kirch PV

更新日期：1996-02-20 00:00:00

abstract：:Archaea of the phylum Thaumarchaeota are among the most abundant prokaryotes on Earth and are widely distributed in marine, terrestrial, and geothermal environments. All studied Thaumarchaeota couple the oxidation of ammonia at extremely low concentrations with carbon fixation. As the predominant nitrifiers in the oce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Könneke M,Schubert DM,Brown PC,Hügler M,Standfest S,Schwander T,Schada von Borzyskowski L,Erb TJ,Stahl DA,Berg IA

更新日期：2014-06-03 00:00:00

abstract：:A patterning method termed "RIPPLE" (reactive interface patterning promoted by lithographic electrochemistry) is applied to the fabrication of arrays of dielectric and metallic optical elements. This method uses cyclic voltammetry to impart patterns onto the working electrode of a standard three-electrode electrochemi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kempa TJ,Bediako DK,Kim SK,Park HG,Nocera DG

更新日期：2015-04-28 00:00:00

abstract：:Pyochelin, an endogenous growth promoter that solubilizes ferric iron, has been isolated from Pseudomonas aeruginosa, including clinical strains. The structure of pyochelin has been assigned as 2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid and is of a different type from those previousl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox CD,Rinehart KL Jr,Moore ML,Cook JC Jr

更新日期：1981-07-01 00:00:00

abstract：:Within the trimeric HIV-1 envelope (Env) spike, the first and second variable loops (V1V2 region) and the third variable loop (V3) of the gp120 subunit play dual roles in antibody recognition, because they contain neutralization epitopes and also participate in epitope masking. The spatial relationships between V1V2 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Cimbro R,Lusso P,Berger EA

更新日期：2011-12-13 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is an often fatal disease primarily affecting young women in which tuberin (TSC2)-null cells metastasize to the lungs. The mechanisms underlying the striking female predominance of LAM are unknown. We report here that 17-beta-estradiol (E(2)) causes a 3- to 5-fold increase in pulmonary m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu JJ,Robb VA,Morrison TA,Ariazi EA,Karbowniczek M,Astrinidis A,Wang C,Hernandez-Cuebas L,Seeholzer LF,Nicolas E,Hensley H,Jordan VC,Walker CL,Henske EP

更新日期：2009-02-24 00:00:00

abstract：:mRNA coding for mouse major transplantation antigens of the d haplotype was partially purified, copied into double-stranded cDNA, and cloned in Escherichia coli. Clones were selected by their ability to hybridize specifically with mRNA coding for H-2K, D, or L antigens. One of these clones, pH-2d-1, carries a 1200-bas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kvist S,Bregegere F,Rask L,Cami B,Garoff H,Daniel F,Wiman K,Larhammar D,Abastado JP,Gachelin G,Peterson PA,Dobberstein B,Kourilsky P

更新日期：1981-05-01 00:00:00

abstract：:Human activities increasingly take place in online environments, providing novel opportunities for relating individual behaviors to population-level outcomes. In this paper, we introduce a simple generative model for the collective behavior of millions of social networking site users who are deciding between different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gleeson JP,Cellai D,Onnela JP,Porter MA,Reed-Tsochas F

更新日期：2014-07-22 00:00:00

abstract：:Experiments reported here show that some UV-irradiated wild-type T7 phage markers can be rescued efficiently by coinfection with T7 amber mutant phage in a permissive host. Other results show that the segments of a UV-irradiated genome that replicate efficiently are those that also are rescued efficiently during a mar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burck KB,Miller RC Jr

更新日期：1978-12-01 00:00:00

abstract：:Immunoglobulin sequences were compared by using a technique that takes into account the dissimilarity in physicochemical properties of amino acids. Exterior residues showed greater structural variability than interior residues. High structural variability was found at positions known from crystallographic studies to b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padlan EA

更新日期：1977-06-01 00:00:00

abstract：:A photosensitizer conjugate, chlorin e6 (Ce6) covalently bound to 1-micron-diameter polystyrene microspheres, has been investigated in the photodynamic destruction of MGH-U1 human bladder carcinoma cells in vitro. The microspheres were taken up avidly by the carcinoma cells; confocal laser scanning fluorescence micros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachor R,Shea CR,Gillies R,Hasan T

更新日期：1991-02-15 00:00:00

abstract：:Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same period...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-Emmenegger C,Xiao Q,Kostina NY,Sherman SE,Rahimi K,Partridge BE,Li S,Sahoo D,Reveron Perez AM,Buzzacchera I,Han H,Kerzner M,Malhotra I,Möller M,Wilson CJ,Good MC,Goulian M,Baumgart T,Klein ML,Percec V

更新日期：2019-03-19 00:00:00

abstract：:Fungi must recognize plant-specific signals to initiate subsequent morphogenetic events such as filamentation that lead to infection. Here we show that the plant hormone indoleacetic acid (IAA) induces adhesion and filamentation of Saccharomyces cerevisiae. Genome expression profiling of cells treated with IAA identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prusty R,Grisafi P,Fink GR

更新日期：2004-03-23 00:00:00

abstract：:The transcription factor and tumor suppressor protein p53 is frequently inactivated in human cancers. In many cases, p53 gene mutations result in high levels of inactive, full-length p53 protein with one amino acid change in the core domain that recognizes p53 DNA-binding sites. The ability to endow function to mutate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baroni TE,Wang T,Qian H,Dearth LR,Truong LN,Zeng J,Denes AE,Chen SW,Brachmann RK

更新日期：2004-04-06 00:00:00

abstract：:CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang M,Siciliano NA,Hersperger AR,Roscoe F,Hu A,Ma X,Shamsedeen AR,Eisenlohr LC,Sigal LJ

更新日期：2012-06-19 00:00:00

abstract：:The integrity of the endothelial barrier between circulating blood and tissue is important for blood vessel function and, ultimately, for organ homeostasis. Here, we developed a vessel-on-a-chip with perfused endothelialized channels lined with human bone marrow stromal cells, which adopt a mural cell-like phenotype t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alimperti S,Mirabella T,Bajaj V,Polacheck W,Pirone DM,Duffield J,Eyckmans J,Assoian RK,Chen CS

更新日期：2017-08-15 00:00:00

abstract：:The trace fossil record is important in determining the timing of the appearance of bilaterian animals. A conservative estimate puts this time at approximately equal 555 million years ago. The preservational potential of traces made close to the sediment-water interface is crucial to detecting early benthic activity. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Droser ML,Jensen S,Gehling JG

更新日期：2002-10-01 00:00:00

abstract：:The membrane currents of chicken embryo fibroblasts (CEFs) transformed by Rous sarcoma virus (RSV) were compared with the currents of their nontransformed counterparts by using the whole-cell patch-clamp technique. In nontransformed CEFs, the main membrane current is a delayed outward K+ current that is sensitive to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Repp H,Draheim H,Ruland J,Seidel G,Beise J,Presek P,Dreyer F

更新日期：1993-04-15 00:00:00

abstract：:Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an exte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai SY,Pokrass MJ,Klauer NR,Nohara H,Su TP

更新日期：2015-05-26 00:00:00

abstract：:Small solutes affect protein and nucleic acid processes because of favorable or unfavorable chemical interactions of the solute with the biopolymer surface exposed or buried in the process. Large solutes also exclude volume and affect processes where biopolymer molecularity and/or shape changes. Here, we develop an an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles DB,LaCroix AS,Deines NF,Shkel I,Record MT Jr

更新日期：2011-08-02 00:00:00

abstract：:The latency-associated nuclear antigen (LANA) of Kaposi sarcoma herpesvirus (KSHV) is mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role in the replication and maintenance of latent viral episomal DNA. In addition, N-terminally truncated cytoplasmic isoforms of LANA, resul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang G,Chan B,Samarina N,Abere B,Weidner-Glunde M,Buch A,Pich A,Brinkmann MM,Schulz TF

更新日期：2016-02-23 00:00:00

abstract：:The Tol2 element of the medaka fish Oryzias latipes belongs to the hAT family of transposons (hobo/Ac/Tam3). We report here identification of a functional transposase of Tol2 that is capable of catalyzing its transposition in the germ line of zebrafish Danio rerio. A transcript produced from Tol2 encodes a putative tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami K,Shima A,Kawakami N

更新日期：2000-10-10 00:00:00

abstract：:We have examined the functional consequences of mutations present in defective alleles of the retinoblastoma susceptibility gene (RB1) isolated from two spontaneously arising tumors. Unlike cDNA clones expressing the wild-type protein p110Rb, those encoding the two mutant proteins failed to induce the appearance of se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Templeton DJ,Park SH,Lanier L,Weinberg RA

更新日期：1991-04-15 00:00:00

abstract：:Male oriental fruit flies (Dacus dorsalis) from colonies in Taiwan and Hawaii were evaluated for limit of response to various analogues of methyl eugenol. The results are interpreted in terms of the geometry and allosteric requirements of the antennal receptor that triggers the characteristic methyl eugenol reflex. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf RL,Metcalf ER,Mitchell WC,Lee LW

更新日期：1979-04-01 00:00:00

abstract：:A method is presented for detection of lysosomal hydrolase activity in situ in colonies of Chinese hamster ovary cells. This method was used to screen for mutants deficient in lysosomal alpha-mannosidase. Mutagenized cells were replicated onto filter papers [Esko, J. D. & Raetz, C. R. H. (1978) Proc. Natl. Acad. Sci. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robbins AR

更新日期：1979-04-01 00:00:00

abstract：:We have examined the effect of diphtheria toxin, Pseudomonas aeruginosa exotoxin A, and cycloheximide on the CV-1 cell cytoskeleton. Within a few hours after producing an inhibition of cellular protein synthesis, all these agents specifically disrupted the organization of the vimentin filament system with no discernab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharpe AH,Chen LB,Murphy JR,Fields BN

更新日期：1980-12-01 00:00:00

abstract：:Parts of the primary structure of the NAD-specific glutamate dehydrogenase [L-glutamate:NAD oxidoreductase (deaminating), EC 1.4.1.2] from Neurospora crassa are presented. Segments of the sequence representing 886 unique amino-acid residues have been determined; the largest contains 267 residues. There are only short ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austen BM,Nyc JF,Degani Y,Smith EL

更新日期：1975-12-01 00:00:00