Structural implications of sequence variability in immunoglobulins.

abstract：:The Rhizobium common nod gene products NodABC are involved in the synthesis of the core lipochitooligosaccharide (Nod factor) structure, whereas the products of the host-specific nod genes are necessary for diverse structural modifications, which vary in different Rhizobium species. The sulfate group attached to the R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schultze M,Staehelin C,Röhrig H,John M,Schmidt J,Kondorosi E,Schell J,Kondorosi A

更新日期：1995-03-28 00:00:00

abstract：:Superhydrophobic surfaces display water contact angles greater than 150 degrees in conjunction with low contact angle hysteresis. Microscopic pockets of air trapped beneath the water droplets placed on these surfaces lead to a composite solid-liquid-air interface in thermodynamic equilibrium. Previous experimental and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuteja A,Choi W,Mabry JM,McKinley GH,Cohen RE

更新日期：2008-11-25 00:00:00

abstract：:The zinc finger protein LMO4 is overexpressed in a high proportion of breast carcinomas. Here, we report that overexpression of a mouse mammary tumor virus (MMTV)-Lmo4 transgene in the mouse mammary gland elicits hyperplasia and mammary intraepithelial neoplasia or adenosquamous carcinoma in two transgenic strains wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sum EY,Segara D,Duscio B,Bath ML,Field AS,Sutherland RL,Lindeman GJ,Visvader JE

更新日期：2005-05-24 00:00:00

abstract：:Eye blinking is one of the most frequent human actions. The control of blinking is thought to reflect complex interactions between maintaining clear and healthy vision and influences tied to central dopaminergic functions including cognitive states, psychological factors, and medical conditions. The most imminent cons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoppe D,Helfmann S,Rothkopf CA

更新日期：2018-02-27 00:00:00

abstract：:A spherical harmonic analysis is made of the hydrodynamic equation governing the flow of an incompressible liquid in a rotating sphere in the presence of the magnetic Lorentz force. Nonlinear partial differential equations are derived for the functions S(n)(r,t) and T(n)(r,t) entering the spherical harmonic representa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pekeris CL,Accad Y

更新日期：1975-04-01 00:00:00

abstract：:In previous studies we showed that 5 days of treatment with granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) mobilized murine repopulating cells to the peripheral blood (PB) and that these cells could be efficiently transduced with retroviral vectors. We also found that, 7-14 days after cytokin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunbar CE,Seidel NE,Doren S,Sellers S,Cline AP,Metzger ME,Agricola BA,Donahue RE,Bodine DM

更新日期：1996-10-15 00:00:00

abstract：:Two mutations are described that alter the pattern of inheritance of chloroplast genes in Chlamydomonas. The mutant gene mat-1 linked to the mating type allele mt(-) greatly increases the frequency of exceptional zygotes, i.e., zygotes that transmit chloroplast genes from the mt(-) (male) parent. In some crosses, 80-9...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sager R,Ramanis Z

更新日期：1974-12-01 00:00:00

abstract：:A study of the near-infrared absorption spectra of three oxygen compounds of membrane-bound cytochrome oxidase (ferrocytochrome c:oxygen oxidoreductase; EC 1.9.3.1) shows that the formation of compound A (oxycytochrome oxidase) causes no significant infrared absorbance changes at -103 degrees. At -64 degrees, the form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance B,Leigh JS Jr

更新日期：1977-11-01 00:00:00

abstract：:The development of the luminescence system in Beneckea harveyi is controlled by cyclic nucleotides at the level of transcription. In the wild type, it is repressed by exogenously added guanosine 3':5'-cyclic monophosphate and this repression is overcome by the addition of adenosine 3':5'-cyclic monophosphate. These ob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulitzur S,Yashphe J,Hastings JW

更新日期：1976-12-01 00:00:00

abstract：:Synthesis of the 31-amino acid, inner membrane protein MgtS (formerly denoted YneM) is induced by very low Mg2+ in a PhoPQ-dependent manner in Escherichia coli Here we report that MgtS acts to increase intracellular Mg2+ levels and maintain cell integrity upon Mg2+ depletion. Upon development of a functional tagged de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Yin X,Wu Orr M,Dambach M,Curtis R,Storz G

更新日期：2017-05-30 00:00:00

abstract：:Pentameric ligand-gated ion channels (pLGICs), which mediate chemo-electric signal transduction in animals, have been recently found in bacteria. Despite clear sequence and 3D structure homology, the phylogenetic distance between prokaryotic and eukaryotic homologs suggests significant structural divergences, especial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duret G,Van Renterghem C,Weng Y,Prevost M,Moraga-Cid G,Huon C,Sonner JM,Corringer PJ

更新日期：2011-07-19 00:00:00

abstract：:Natively unfolded proteins play key roles in normal and pathological biochemical processes. Despite their importance for function, this category of proteins remains beyond the reach of classical structural biology because of their inherent conformational heterogeneity. We present a description of the intrinsic conform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bernadó P,Blanchard L,Timmins P,Marion D,Ruigrok RW,Blackledge M

更新日期：2005-11-22 00:00:00

abstract：:Protective immunity against human schistosome infection develops slowly, for reasons that are not yet fully understood. For many decades, researchers have attempted to infer properties of the immune response from epidemiological studies, with mathematical models frequently being used to bridge the gap between immunolo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell KM,Mutapi F,Savill NJ,Woolhouse ME

更新日期：2012-08-14 00:00:00

abstract：:Life history events, such as traumatic stress, illness, or starvation, can influence us through molecular changes that are recorded in a pattern of characteristic chromatin modifications. These modifications are often associated with adaptive adjustments in gene expression that can persist throughout the lifetime of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demoinet E,Li S,Roy R

更新日期：2017-03-28 00:00:00

abstract：:Phosphorylation plays a critical role in controlling the function of cytoskeletal assemblies but no direct method yet exists to measure the phosphorylation state of proteins at the level of individual molecules and assemblies. Herein, we apply scanning transmission electron microscopy in combination with electron ener...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leapman RD,Gallant PE,Reese TS,Andrews SB

更新日期：1997-07-22 00:00:00

abstract：:Construction of deletion derivative plasmids and cloning of restriction fragments from plasmids containing the Salmonella typhimurium origin of replication (ori) were used to locate the functional origin to within a DNA fragment of 296 base pairs between the genes uncB and asn. The nucleotide sequence of the S. typhim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zyskind JW,Smith DW

更新日期：1980-05-01 00:00:00

abstract：:Pertussis toxin (PT), a protein produced by Bordetella pertussis, was studied for its effect on lipolysis in isolated rat epididymal adipocytes. Exposure of adipocytes to pertussis toxin resulted in a significant increase in cyclic AMP levels and lipolysis after a lag of 1-2 hr. Both the maximal rate of lipolysis and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olansky L,Myers GA,Pohl SL,Hewlett EL

更新日期：1983-11-01 00:00:00

abstract：:We investigated the possibility of positive selection acting on members of the putative seven-pass chemoreceptor superfamily in Caenorhabditis elegans, which comprises approximately 1,300 genes encoding seven-pass G protein-coupled receptors (GPCRs). Using a maximum-likelihood approach, we conducted statistical tests ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas JH,Kelley JL,Robertson HM,Ly K,Swanson WJ

更新日期：2005-03-22 00:00:00

abstract：:The innate immune system detects viral nucleic acids and induces type I interferon (IFN) responses. The RNA- and DNA-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor IFN-regulatory factor 3 (IRF3). Activation of the IFN signaling pathway is known to trigger the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seo M,Lee SO,Kim JH,Hong Y,Kim S,Kim Y,Min DH,Kong YY,Shin J,Ahn K

更新日期：2016-12-13 00:00:00

abstract：:A perversion in an otherwise uniform helical structure, such as a climbing plant tendril, refers to a kink that connects two helices with opposite chiralities. Such singularity structures are widely seen in natural and artificial mechanical systems, and they provide the fundamental mechanism of helical symmetry breaki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Yao Z,Chiou K,Stupp SI,Olvera de la Cruz M

更新日期：2016-06-28 00:00:00

abstract：:Resistance to cobalt, zinc, and cadmium specified by the czc determinant on plasmid pMOL30 in Alcaligenes eutrophus results from a cation efflux system. Five membrane-bound polypeptides that were expressed in Escherichia coli from this determinant under the control of a phage T7 promoter were assigned to four open rea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nies DH,Nies A,Chu L,Silver S

更新日期：1989-10-01 00:00:00

abstract：:Using chimeric recombinants transfected into HeLa cells and a transient expression assay, we demonstrate that the 5'-flanking region of the pS2 gene from position -428 to position -324 exhibits both constitutive and estrogen-inducible enhancer activity. The estrogen-inducible activity, but not the constitutive activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry M,Nunez AM,Chambon P

更新日期：1989-02-01 00:00:00

abstract：:Our previous work [Levinger, L. & Varshavsky, A. (1982) Cell 28, 375-385] has shown that D1, a 50-kilodalton chromosomal protein of Drosophila melanogaster, is specifically associated with isolated nucleosomes that contain a complex A + T-rich satellite DNA with buoyant density of 1.688 g/ml. We show here that D1 is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinger L,Varshavsky A

更新日期：1982-12-01 00:00:00

abstract：:Micrometeorites with diameter approximately 100-200 microm dominate the flux of extraterrestrial matter on Earth. The vast majority of micrometeorites are chemically, mineralogically, and isotopically related to carbonaceous chondrites, which amount to only 2.5% of meteorite falls. Here, we report the discovery of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gounelle M,Chaussidon M,Morbidelli A,Barrat JA,Engrand C,Zolensky ME,McKeegan KD

更新日期：2009-04-28 00:00:00

abstract：:Three components of differentiated muscle membrane, the acetylcholine receptor, acetylcholinesterase (EC 3.1.1.7; acetylcholine hydrolase), and adenylate cyclase [EC 4.6.1.1; ATP pyrophosphate-lyase (cyclizing)], appear simultaneously during myogenesis in cultures of embryonic chick muscle, after the main period of ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prives JM,Paterson BM

更新日期：1974-08-01 00:00:00

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00

abstract：:Bacterial transpeptidase and transglycosylase on the surface are essential for cell wall synthesis, and many antibiotics have been developed to target the transpeptidase; however, the problem of antibiotic resistance has arisen and caused a major threat in bacterial infection. The transglycosylase has been considered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CY,Shih HW,Lin LY,Tien YW,Cheng TJ,Cheng WC,Wong CH,Ma C

更新日期：2012-04-24 00:00:00

abstract：:Volcanic eruptions caused major weather and climatic changes on timescales ranging from hours to centuries in the past. Volcanic particles are injected in the atmosphere both as primary particles rapidly deposited due to their large sizes on time scales of minutes to a few weeks in the troposphere, and secondary parti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boulon J,Sellegri K,Hervo M,Laj P

更新日期：2011-07-26 00:00:00

abstract：:Inferring causal effects from observational and interventional data is a highly desirable but ambitious goal. Many of the computational and statistical methods are plagued by fundamental identifiability issues, instability, and unreliable performance, especially for large-scale systems with many measured variables. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meinshausen N,Hauser A,Mooij JM,Peters J,Versteeg P,Bühlmann P

更新日期：2016-07-05 00:00:00

abstract：:Most teenage fears subside with age, a change that may reflect brain maturation in the service of refined fear learning. Whereas adults clearly demarcate safe situations from real dangers, attenuating fear to the former but not the latter, adolescents' immaturity in prefrontal cortex function may limit their ability t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau JY,Britton JC,Nelson EE,Angold A,Ernst M,Goldwin M,Grillon C,Leibenluft E,Lissek S,Norcross M,Shiffrin N,Pine DS

更新日期：2011-03-15 00:00:00