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Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection.

Abstract：

:CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the mouse homolog of the human virus of smallpox, large numbers of CD4(+) T cells in the draining lymph node and liver of resistant mice have a cytotoxic phenotype. We also show that these cells kill targets in vivo in a perforin-dependent manner and that mice with specific deficiency of perforin in CD4(+) T cells have impaired virus control. Thus, perforin-dependent CD4(+) T-cell killing of infected cells is an important mechanism of antiviral defense.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Fang M,Siciliano NA,Hersperger AR,Roscoe F,Hu A,Ma X,Shamsedeen AR,Eisenlohr LC,Sigal LJ

doi

10.1073/pnas.1202143109

subject

Has Abstract

pub_date

2012-06-19 00:00:00

pages

9983-8

issue

25

eissn

0027-8424

issn

1091-6490

pii

1202143109

journal_volume

109

pub_type

杂志文章

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