Structural studies of isolated native thick filaments from rabbit psoas muscle with AMP deaminase decoration.

abstract：:Vaccination has been used to control the spread of seasonal flu; however, the virus continues to evolve and escape from host immune response through mutation and increasing glycosylation. Efforts have been directed toward development of a universal vaccine with broadly protective activity against multiple influenza st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao HY,Wang SC,Ko YA,Lin KI,Ma C,Cheng TR,Wong CH

更新日期：2020-07-28 00:00:00

abstract：:Bones of the flightless sea duck (Chendytes lawi) from 14 archaeological sites along the California coast indicate that humans hunted the species for at least 8,000 years before it was driven to extinction. Direct (14)C dates on Chendytes bones show that the duck was exploited on the southern California islands as ear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones TL,Porcasi JF,Erlandson JM,Dallas H Jr,Wake TA,Schwaderer R

更新日期：2008-03-18 00:00:00

abstract：:Chromosomal locations of members of the xenotropic-related env gene family in the mouse genome have been determined. Endonuclease restriction site polymorphisms detected by molecular hybridization were used to study the inheritance of mink cell-focus inducing and xenotropic env gene-related sequences in recombinant in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blatt C,Mileham K,Haas M,Nesbitt MN,Harper ME,Simon MI

更新日期：1983-10-01 00:00:00

abstract：:Compared with the U.S., Japan is believed to have a collectivist culture that nurtures high trust. Results from laboratory and survey research, however, show that Americans are more likely to trust strangers than are Japanese. Why would trust be lower in a collectivist culture? We use an agent-based computational mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Macy MW,Sato Y

更新日期：2002-05-14 00:00:00

abstract：:Galanin is a neuropeptide with a wide variety of biological functions, including that of a strong endogenous anticonvulsant. No nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin, a combinatorial library was designed, synthesized, and screened at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saar K,Mazarati AM,Mahlapuu R,Hallnemo G,Soomets U,Kilk K,Hellberg S,Pooga M,Tolf BR,Shi TS,Hökfelt T,Wasterlain C,Bartfai T,Langel U

更新日期：2002-05-14 00:00:00

abstract：:Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b(+)Gr1(+) myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models. High G-CSF production has been associated with a poor prognosis in cancer patients. Here we show that activation of the RAS/MEK/ERK pathway reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phan VT,Wu X,Cheng JH,Sheng RX,Chung AS,Zhuang G,Tran C,Song Q,Kowanetz M,Sambrone A,Tan M,Meng YG,Jackson EL,Peale FV,Junttila MR,Ferrara N

更新日期：2013-04-09 00:00:00

abstract：:Excessive poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation kills cells via a cell-death process designated "parthanatos" in which PAR induces the mitochondrial release and nuclear translocation of apoptosis-inducing factor to initiate chromatinolysis and cell death. Accompanying the formation of PAR are the red...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrabi SA,Umanah GK,Chang C,Stevens DA,Karuppagounder SS,Gagné JP,Poirier GG,Dawson VL,Dawson TM

更新日期：2014-07-15 00:00:00

abstract：:Comparisons were made of the T1 ribonuclease digests of 32P-labeled nucleolar 45S RNA of intact Novikoff hepatoma cells and the RNA synthesized in vitro by isolated nucleoli. Approximately 200 oligonucleotide spots were found in the two-dimensional chromatogram of 45S nucleolar RNA labeled in vivo, which includes frag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ballal NR,Choi YC,Mouche R,Busche H

更新日期：1977-06-01 00:00:00

abstract：:Transgenic (Tg) mouse lines that express chimeric mouse-human prion protein (PrP), designated MHu2M, are susceptible to prions from patients with sporadic Creutzfeldt-Jakob disease (sCJD). With the aim of decreasing the incubation time to fewer than 200 days, we constructed transgenes in which one or more of the nine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korth C,Kaneko K,Groth D,Heye N,Telling G,Mastrianni J,Parchi P,Gambetti P,Will R,Ironside J,Heinrich C,Tremblay P,DeArmond SJ,Prusiner SB

更新日期：2003-04-15 00:00:00

abstract：:The kainate receptor (KAR), a subtype of glutamate receptor, mediates excitatory synaptic responses at a subset of glutamatergic synapses. However, the molecular mechanisms underlying the trafficking of its different subunits are poorly understood. Here we use the CA1 hippocampal pyramidal cell, which lacks KAR-mediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng N,Shi YS,Nicoll RA

更新日期：2017-01-31 00:00:00

abstract：:Insulin/Insulin-like growth factor signaling regulates homeostasis and growth in mammals, and is implicated in diseases from diabetes to cancer. In Drosophila melanogaster, as in other invertebrates, multiple Insulin-Like Peptides (DILPs) are encoded by a family of related genes. To assess DILPs' physiological roles, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Liu J,Li CR,Momen B,Kohanski RA,Pick L

更新日期：2009-11-17 00:00:00

abstract：:A general theory of the structure of complexes of the transition metals is developed on the basis of the enneacovalence of the metals and the requirements of the electroneutrality principle. An extra orbital may be provided through the small but not negligible amount of f and g character of spd bond orbitals, and an e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1977-12-01 00:00:00

abstract：:A procedure is described for selection of temperature-sensitive mutants affecting fatty-acid synthesis based upon radiation suicide of wild-type organisms by tritiated acetate selectively incorporated into fatty acids. At 37 degrees , two of the mutants extensively incorporate fatty-acid supplements provided in the me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harder ME,Beacham IR,Cronan JE Jr,Beacham K,Honegger JL,Silbert DF

更新日期：1972-11-01 00:00:00

abstract：:Resistance to ionizing radiation (IR), which is a conventional treatment for osteosarcoma that cannot be resected, undermines the efficacy of this therapy. However, the mechanism by which IR induces radioresistance in osteosarcoma is not defined. Here, we report that CR6-interacting factor-1 (CRIF1) is highly expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ran Q,Jin F,Xiang Y,Xiang L,Wang Q,Li F,Chen L,Zhang Y,Wu C,Zhou L,Xiao Y,Chen L,Wu J,Zhong JF,Li SC,Li Z

更新日期：2019-10-08 00:00:00

abstract：:2-Deoxy-D-[14C]glucose autoradiography was used in awake rats to map neural activity in the sensorimotor sector of striatum. Stimulation of hindlimb, trunk, or forelimb activated primary sensory cortex in a localized columnar pattern, indicating activation of somatosensory receptors and a discrete cortical functional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown LL

更新日期：1992-08-15 00:00:00

abstract：:We have postulated that the toxic neuropathies associated with neurofilament-filled axonal swellings have a common pathogenesis, the covalent crosslinking of neurofilaments during anterograde transport. The newly described gamma-diketone, 3,4-dimethyl-2,5-hexanedione (DMHD), is a more potent analogue of the toxic meta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graham DG,Szakál-Quin G,Priest JW,Anthony DC

更新日期：1984-08-01 00:00:00

abstract：:Export of LDL-derived cholesterol from lysosomes requires the cooperation of the integral membrane protein Niemann-Pick C1 (NPC1) and a soluble protein, Niemann-Pick C2 (NPC2). Mutations in the genes encoding these proteins lead to Niemann-Pick disease type C (NPC). NPC2 binds to NPC1's second (middle), lumenally orie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Saha P,Li J,Blobel G,Pfeffer SR

更新日期：2016-09-06 00:00:00

abstract：:The microsomal triglyceride (TG) transfer protein (MTP) is a heterodimeric lipid transfer protein that catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between membranes. Previous studies showing that the proximal cause of abetalipoproteinemia is an absence of MTP indicate that MTP f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jamil H,Gordon DA,Eustice DC,Brooks CM,Dickson JK Jr,Chen Y,Ricci B,Chu CH,Harrity TW,Ciosek CP Jr,Biller SA,Gregg RE,Wetterau JR

更新日期：1996-10-15 00:00:00

abstract：:Transcription in the human immunodeficiency virus type 1 (HIV-1) retrovirus is regulated by binding the viral Tat protein (trans-acting transcriptional activator) to the trans-activation response (TAR) RNA sequence. Here, vacuum UV circular dichroism (VUV-CD) is used to study the structure of TAR and its complex with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loret EP,Georgel P,Johnson WC Jr,Ho PS

更新日期：1992-10-15 00:00:00

abstract：:Ectopic expression of transcription factors can reprogram somatic cells to a pluripotent state. However, most of the studies used skin fibroblasts as the starting population for reprogramming, which usually take weeks for expansion from a single biopsy. We show here that induced pluripotent stem (iPS) cells can be gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun N,Panetta NJ,Gupta DM,Wilson KD,Lee A,Jia F,Hu S,Cherry AM,Robbins RC,Longaker MT,Wu JC

更新日期：2009-09-15 00:00:00

abstract：:Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). The catalytic subunit of the specific phosphatase, protein phosphatase 2A (PP2A) that dephosphorylates α-synuclein, is hypomethylated in these ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Zhang J,Park HJ,Park ES,Oh S,Zheng H,Junn E,Voronkov M,Stock JB,Mouradian MM

更新日期：2018-12-18 00:00:00

abstract：:The mouse insulin-like growth factor 2 (Igf2) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at this locus is regulated by parental imprinting. However, despite the existence of putative imprinting control elements in the Igf2 upstream region, imprinted tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Constancia M,Zubair M,Bailleul B,Feil R,Sasaki H,Reik W

更新日期：1997-11-11 00:00:00

abstract：:Plasmids containing the replication origin of the Escherichia coli chromosome (oriC plasmids) are unstable in certain recA strains of E. coli. However, they can be maintained more stably in other recA strains. This stable maintenance has allowed us to study the incompatibility properties of oriC plasmids. We have foun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi K,Yamaguchi M,Tomizawa J

更新日期：1982-09-01 00:00:00

abstract：:Helper-dependent adenoviral vectors deleted of all viral coding sequences have shown an excellent gene expression profile in a variety of animal models, as well as a reduced toxicity after systemic delivery. What is still unclear is whether long-term expression and therapeutic dosages of these vectors can be obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maione D,Della Rocca C,Giannetti P,D'Arrigo R,Liberatoscioli L,Franlin LL,Sandig V,Ciliberto G,La Monica N,Savino R

更新日期：2001-05-22 00:00:00

abstract：:Let X(0) be an unknown M by N matrix. In matrix recovery, one takes n < MN linear measurements y(1),…,y(n) of X(0), where y(i) = Tr(A(T)iX(0)) and each A(i) is an M by N matrix. A popular approach for matrix recovery is nuclear norm minimization (NNM): solving the convex optimization problem min ||X||*subject to y(i) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donoho DL,Gavish M,Montanari A

更新日期：2013-05-21 00:00:00

abstract：:Archaea (archaebacteria) are a phenotypically diverse group of microorganisms that share a common evolutionary history. There are four general phenotypic groups of archaea: the methanogens, the extreme halophiles, the sulfate-reducing archaea, and the extreme thermophiles. In the marine environment, archaeal habitats ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeLong EF

更新日期：1992-06-15 00:00:00

abstract：:We report evidence for a developmental role of acetylcholine in axon pathfinding in the Drosophila visual system. Acetylcholine was detected on photoreceptor axons during their navigation to target sites in the brain, a time well before the formation of functional synapses. The pattern of photoreceptor axon projection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang H,Kunes S

更新日期：2004-10-19 00:00:00

abstract：:In facultative photoperiodic flowering plants, noninductive photoperiods result in a delay in flowering, but such plants eventually flower, illustrating plasticity in an important developmental transition, flowering. The model plant, Arabidopsis, has a facultative photoperiod response. Although the inductive flowering...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DH,Sung S

更新日期：2010-09-28 00:00:00

abstract：:The generation of high levels of new catalytic activities on natural and artificial protein scaffolds is a major goal of enzyme engineering. Here, we used random mutagenesis and selection in vivo to establish a sugar isomerisation reaction on both a natural (beta alpha)(8)-barrel enzyme and a catalytically inert chime...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Claren J,Malisi C,Höcker B,Sterner R

更新日期：2009-03-10 00:00:00

abstract：:Probasin, a rat prostatic protein, is statistically related to members of a protein family that includes serum, cellular, and nuclear proteins. In vivo, probasin appears both in the secretions and in the nucleus of prostatic epithelial cells. Using primer extension and S1 nuclease protection assays we detected only on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spence AM,Sheppard PC,Davie JR,Matuo Y,Nishi N,McKeehan WL,Dodd JG,Matusik RJ

更新日期：1989-10-01 00:00:00