Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene.

abstract：:Most higher plants develop severe toxicity symptoms when grown on ammonium (NH(4)(+)) as the sole nitrogen source. Recently, NH(4)(+) toxicity has been implicated as a cause of forest decline and even species extinction. Although mechanisms underlying NH(4)(+) toxicity have been extensively sought, the primary events ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Britto DT,Siddiqi MY,Glass AD,Kronzucker HJ

更新日期：2001-03-27 00:00:00

abstract：:Overexpression of the Gossypium hirsutum sucrose synthase (SuSy) gene under the control of 2 promoters was examined in hybrid poplar (Populus alba x grandidentata). Analysis of RNA transcript abundance, enzyme activity, cell wall composition, and soluble carbohydrates revealed significant changes in the transgenic lin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman HD,Yan J,Mansfield SD

更新日期：2009-08-04 00:00:00

abstract：:Large quantities of mineral dust particles are frequently ejected into the atmosphere through the action of wind. The surface of dust particles acts as a sink for many gases, such as sulfur dioxide. It is well known that under most conditions, sulfur dioxide reacts on dust particle surfaces, leading to the production ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dupart Y,King SM,Nekat B,Nowak A,Wiedensohler A,Herrmann H,David G,Thomas B,Miffre A,Rairoux P,D'Anna B,George C

更新日期：2012-12-18 00:00:00

abstract：:Accurate replication in the presence of DNA damage is essential to genome stability and viability in all cells. In Escherichia coli, DNA replication forks blocked by UV-induced damage undergo a partial resection and RecF-catalyzed regression before synthesis resumes. These processing events generate distinct structura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeiranian HA,Schalow BJ,Courcelle CT,Courcelle J

更新日期：2013-07-09 00:00:00

abstract：:The electrical response of a pigmented lipid bilayer to a short laser pulse is measured by a tunable voltage clamp method. In this method, a variable access impedance permits "tuning" of the observed relaxations for optimal measurements. Analysis of the data so obtained leads to an equivalent circuit that contains a n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong FT,Mauzerall D

更新日期：1974-04-01 00:00:00

abstract：:Ethylene inhibits hypocotyl elongation in etiolated Arabidopsis seedlings. However, when Arabidopsis was grown in the light in the presence of ethylene or its precursor 1-aminocyclopropane-1-carboxylic acid (ACC), a marked induction of hypocotyl elongation occurred. This resulted from an increase in cell expansion rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smalle J,Haegman M,Kurepa J,Van Montagu M,Straeten DV

更新日期：1997-03-18 00:00:00

abstract：:Perhydrohistrionicotoxin, at concentrations of 10(-12)-10(-7) M, depressed the current generated by iontophoretic application of acetylcholine to endplate regions of soleus and extensor digitorum longus muscles of rats. However, no changes in the amplitude or time course of spontaneous miniature endplate potentials or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albuquerque EX,Gage PW

更新日期：1978-03-01 00:00:00

abstract：:Transfer of membrane between endoplasmic reticulum and Golgi apparatus in situ is considered to occur via 60-nm transition vesicles derived from part-rough, part-smooth transition elements of the endoplasmic reticulum. A procedure is described for the isolation of a fraction enriched in these transition elements from ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowack DD,Morré DM,Paulik M,Keenan TW,Morré DJ

更新日期：1987-09-01 00:00:00

abstract：:Spermiogenesis is a series of poorly understood morphological, physiological and biochemical processes that occur during the transition of immotile spermatids into motile, fertilization-competent spermatozoa. Here, we identified a Serpin (serine protease inhibitor) family protein (As_SRP-1) that is secreted from sperm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Y,Sun W,Zhang P,Chi H,Zhang MJ,Song CQ,Ma X,Shang Y,Wang B,Hu Y,Hao Z,Hühmer AF,Meng F,L'hernault SW,He SM,Dong MQ,Miao L

更新日期：2012-01-31 00:00:00

abstract：:Histone methylation has an important role in transcriptional regulation. However, unlike H3K4 and H3K9 methylation, the role of H4K20 monomethylation (H4K20me-1) in transcriptional regulation remains unclear. Here, we show that Wnt3a specifically stimulates H4K20 monomethylation at the T cell factor (TCF)-binding elem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Nie F,Wang S,Li L

更新日期：2011-02-22 00:00:00

abstract：:The discovery of RNAi has revolutionized loss-of-function genetic studies in mammalian systems. However, significant challenges still remain to fully exploit RNAi for mammalian genetics. For instance, genetic screens and in vivo studies could be broadly improved by methods that allow inducible and uniform gene express...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meerbrey KL,Hu G,Kessler JD,Roarty K,Li MZ,Fang JE,Herschkowitz JI,Burrows AE,Ciccia A,Sun T,Schmitt EM,Bernardi RJ,Fu X,Bland CS,Cooper TA,Schiff R,Rosen JM,Westbrook TF,Elledge SJ

更新日期：2011-03-01 00:00:00

abstract：:Inflammatory diseases are characterized by dysregulated cytokine production. Altered functions for most risk loci, including the inflammatory bowel disease and leprosy-associated tumor necrosis factor ligand superfamily member 15 (TNFSF15) region, are unclear. Regulation of pattern-recognition-receptor (PRR)-induced s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hedl M,Abraham C

更新日期：2014-09-16 00:00:00

abstract：:The explosive growth in citizen science combined with a recalcitrance on the part of mainstream science to fully embrace this data collection technique demands a rigorous examination of the factors influencing data quality and project efficacy. Patterns of contributor effort and task performance have been well reviewe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parrish JK,Jones T,Burgess HK,He Y,Fortson L,Cavalier D

更新日期：2019-02-05 00:00:00

abstract：:The sparking of cut grape hemispheres in a household microwave oven has been a poorly explained Internet parlor trick for over two decades. By expanding this phenomenon to whole spherical dimers of various grape-sized fruit and hydrogel water beads, we demonstrate that the formation of plasma is due to electromagnetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khattak HK,Bianucci P,Slepkov AD

更新日期：2019-03-05 00:00:00

abstract：:DNA sequence analysis of a region contained within a large, interspersed repetitive family of mice reveals a long open reading frame. This sequence extends 978 base pairs between two stop codons, creating a reading frame that is open for 326 amino acids. The DNA sequence in this region is conserved between three dista...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin SL,Voliva CF,Burton FH,Edgell MH,Hutchison CA 3rd

更新日期：1984-04-01 00:00:00

abstract：:Pheromone biosynthesis-activating neuropeptide (PBAN) regulates sex pheromone biosynthesis in female Helicoverpa (Heliothis) zea. Two oligonucleotide probes representing two overlapping amino acid regions of PBAN were used to screen 2.5 x 10(5) recombinant plaques, and a positive recombinant clone was isolated. Sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis MT,Vakharia VN,Henry J,Kempe TG,Raina AK

更新日期：1992-01-01 00:00:00

abstract：:A well-known indication that a nucleotide has bound to myosin is the enhancement of the fluorescence of a specific tryptophan in the "subfragment 1" segment of the protein. Empirically the effect has been enormously useful in myosin enzymology. But beyond an early suggestion that it arises from a purine-tryptophan cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bivin DB,Kubota S,Pearlstein R,Morales MF

更新日期：1993-07-15 00:00:00

abstract：:Understanding the origin, nature, and functional significance of complex patterns of neural activity, as recorded by diverse electrophysiological and neuroimaging techniques, is a central challenge in neuroscience. Such patterns include collective oscillations emerging out of neural synchronization as well as highly h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： di Santo S,Villegas P,Burioni R,Muñoz MA

更新日期：2018-02-13 00:00:00

abstract：:The increasing frequency of antibiotic resistance in hospital-acquired infections is a major public health concern that has both biological and economic causes. Here we develop conceptual mathematical models that couple the economic incentives and population biology of hospital infection control (HIC). We show that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DL,Levin SA,Laxminarayan R

更新日期：2005-02-22 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and cause fluid secretion, inflammation, and cell death. Using a gene-trap insertional mutagenesis scre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaFrance ME,Farrow MA,Chandrasekaran R,Sheng J,Rubin DH,Lacy DB

更新日期：2015-06-02 00:00:00

abstract：:Expression of glucokinase in hepatocytes and pancreatic 6-cells is of major physiologic importance to mammalian glucose homeostasis. Liver glucokinase catalyzes the first committed step in the disposal of glucose, and beta-cell glucokinase catalyzes a rate-limiting step required for glucose-regulated insulin release. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heimberg H,De Vos A,Moens K,Quartier E,Bouwens L,Pipeleers D,Van Schaftingen E,Madsen O,Schuit F

更新日期：1996-07-09 00:00:00

abstract：:Gating currents of the cloned delayed-rectifier K+ channel DRK1 expressed in Xenopus oocytes were measured with the open-oocyte Vaseline-gap voltage-clamp technique. DRK1 gating charge had the following salient properties: (i) gating-charge amplitude correlated positively with size of the expressed ionic K+ currents; ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taglialatela M,Stefani E

更新日期：1993-05-15 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery from replication arres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Park SH,Pantazides BG,Karpiuk O,Warren MD,Hardy CW,Duong DM,Park SJ,Kim HS,Vassilopoulos A,Seyfried NT,Johnsen SA,Gius D,Yu DS

更新日期：2013-08-13 00:00:00

abstract：:Precise genome editing is a valuable tool to study gene function in model organisms. Prime editing, a precise editing system developed in mammalian cells, does not require double-strand breaks or donor DNA and has low off-target effects. Here, we applied prime editing for the model organism Drosophila melanogaster and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosch JA,Birchak G,Perrimon N

更新日期：2021-01-05 00:00:00

abstract：:The growth or decay of population of a single species interacting with a large number of other species (or environment) according to the Volterra-Lotka model is investigated. When the environment is initially very close to its equilibrium level, the growth of a single species follows a generalized Verhulst law, contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zwanzig R

更新日期：1973-11-01 00:00:00

abstract：:Pain is a major health concern even though numerous analgesic agents are available. Side effects and lack of wide-spectrum efficacy of current drugs justify efforts to better understand pain mechanisms. Stabilization of natural epoxy-fatty acids (EFAs) through inhibition of the soluble epoxide hydrolase (sEH) reduces ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inceoglu B,Wagner K,Schebb NH,Morisseau C,Jinks SL,Ulu A,Hegedus C,Rose T,Brosnan R,Hammock BD

更新日期：2011-03-22 00:00:00

abstract：:Visual deficits caused by abnormal visual experience during development are hard to recover in adult animals. Removal of chondroitin sulfate proteoglycans from the mature extracellular matrix with chondroitinase ABC promotes plasticity in the adult visual cortex. We tested whether chondroitinase ABC treatment of adult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pizzorusso T,Medini P,Landi S,Baldini S,Berardi N,Maffei L

更新日期：2006-05-30 00:00:00

abstract：:The growth of actin filament networks is a fundamental biological process that drives a variety of cellular and intracellular motions. During motility, eukaryotic cells and intracellular pathogens are propelled by actin networks organized by nucleation-promoting factors that trigger the formation of nascent filaments ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaevitz JW,Fletcher DA

更新日期：2007-10-02 00:00:00

abstract：:Pathologic ocular neovascularization commonly causes blindness. It is critical to identify the factors altered in pathologically proliferating versus normally quiescent vessels to develop effective targeted therapeutics. MicroRNAs regulate both physiological and pathological angiogenesis through modulating expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu CH,Sun Y,Li J,Gong Y,Tian KT,Evans LP,Morss PC,Fredrick TW,Saba NJ,Chen J

更新日期：2015-09-29 00:00:00

abstract：:The effects of three anti-inflammatory drugs, which interfere with arachidonic acid transformation by three different enzymes, have been compared by using a simple model of tissue damage and foreign body rejection. In groups of control rats, subcutaneously implanted polyester sponges were rejected after a mean of 12 d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higgs GA,Mugridge KG,Moncada S,Vane JR

更新日期：1984-05-01 00:00:00