Fate of the replisome following arrest by UV-induced DNA damage in Escherichia coli.

abstract：:Fatty liver disease (FLD) is a disorder in which accumulation of triglycerides (TGs) in the liver can lead to inflammation, fibrosis, and cirrhosis. Previously, we identified a variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that is strongly associated with FLD, but the mechanistic b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： BasuRay S,Wang Y,Smagris E,Cohen JC,Hobbs HH

更新日期：2019-05-07 00:00:00

abstract：:We have recently identified a family of rhesus monkeys with members exhibiting a spontaneous hypercholesterolemia associated with a low density lipoprotein receptor (LDLR) deficiency. By using the polymerase chain reaction, we now show that the affected monkeys are heterozygous for a nonsense mutation in exon 6 of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummel M,Li ZG,Pfaffinger D,Neven L,Scanu AM

更新日期：1990-04-01 00:00:00

abstract：:To improve the efficacy of plasminogen activators, we produced a monoclonal antibody (RWR) that inhibits human alpha 2-antiplasmin (alpha 2AP). In addition to inhibiting alpha 2AP in plasma, RWR binds to and inhibits fibrin cross-linked alpha 2AP and reproduces the "spontaneous" clot lysis that is the hallmark of huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed GL 3rd,Matsueda GR,Haber E

更新日期：1990-02-01 00:00:00

abstract：:SsrA/SsrB is a primary two-component system that mediates the survival and replication of Salmonella within host cells. When activated, the SsrB response regulator directly promotes the transcription of multiple genes within Salmonella pathogenicity island 2 (SPI-2). As expression of the SsrB protein is promoted by se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi J,Shin D,Yoon H,Kim J,Lee CR,Kim M,Seok YJ,Ryu S

更新日期：2010-11-23 00:00:00

abstract：:Vertebrates, from zebra fish to humans, have an innate immune recognition of many bacterial flagellins. This involves a conserved eight-amino acid epitope in flagellin recognized by the Toll-like receptor 5 (TLR5). Several important human pathogens, such as Helicobacter pylori and Campylobacter jejuni, have escaped TL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kreutzberger MAB,Ewing C,Poly F,Wang F,Egelman EH

更新日期：2020-07-21 00:00:00

abstract：:Animal foraging and competition are defined by the partitioning of three primary niche axes: space, time, and resources. Human disturbance is rapidly altering the spatial and temporal niches of animals, but the impact of humans on resource consumption and partitioning-arguably the most important niche axis-is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manlick PJ,Pauli JN

更新日期：2020-10-27 00:00:00

abstract：:AK032317 is the GenBank accession no. of a full-length RIKEN mouse cDNA. It encodes a putative variant of the C3-type TRPC (transient receptor potential channel) that differs from the previously cloned murine TRPC3 cDNA in that it has a 5' extension stemming from inclusion of an additional exon (exon 0). The extended ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yildirim E,Kawasaki BT,Birnbaumer L

更新日期：2005-03-01 00:00:00

abstract：:Characteristic classes for the index of the Dirac family [unk](A) are computed in terms of differential forms on the orbit space of vector potentials under gauge transformations. They represent obstructions to the existence of a covariant Dirac propagator. The first obstruction is related to a chiral anomaly. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atiyah MF,Singer IM

更新日期：1984-04-01 00:00:00

abstract：:Chromatin states can be distinguished by differential covalent modifications of histones or by utilization of histone variants. Chromatin associated with transcriptionally active loci becomes enriched for histones with particular lysine modifications and accumulates the H3.3 histone variant, the substrate for replicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKittrick E,Gafken PR,Ahmad K,Henikoff S

更新日期：2004-02-10 00:00:00

abstract：:Two mutants of Balb/c 3T3 cells defective in adhesiveness to substratum have been isolated. After exposure to a mutagen a cell population was treated with prostaglandin E1 and methylisobutylxanthine to elevate the cells 3':5'-cyclic AMP levels and adhesion to the substratum; then, loosley adherent cells were harvested...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pouysségur JM,Pastan I

更新日期：1976-02-01 00:00:00

abstract：:Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, and a detailed understanding of the mechanism of their action is important for the development of improved microtubule-directed therapies. Although there is a large body of data on the interactions of different MTAs with pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohan R,Katrukha EA,Doodhi H,Smal I,Meijering E,Kapitein LC,Steinmetz MO,Akhmanova A

更新日期：2013-05-28 00:00:00

abstract：:The perinuclear localization of myosin-V was investigated in a variety of cultured mammalian cells and in primary cultures of rat hippocampus. In all cells investigated, myosin-V immunoreactivity was associated with the centrosome. In interphase cells, myosin-V was found in pericentriolar material, and in both mother ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Espreafico EM,Coling DE,Tsakraklides V,Krogh K,Wolenski JS,Kalinec G,Kachar B

更新日期：1998-07-21 00:00:00

abstract：:Despite substantial size variations, proportions of the developing body plan are maintained with a remarkable precision. Little is known about the mechanisms that ensure this adaptation (scaling) of pattern with size. Most models of patterning by morphogen gradients do not support scaling. In contrast, we show that sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Zvi D,Barkai N

更新日期：2010-04-13 00:00:00

abstract：:The expression and integration of membrane proteins into vesicle membranes is a critical step in the design of cell-mimetic biosensors, bioreactors, and artificial cells. While membrane proteins have been integrated into a variety of nonnatural membranes, the effects of the chemical and physical properties of these ve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobs ML,Boyd MA,Kamat NP

更新日期：2019-03-05 00:00:00

abstract：:The structural and functional organization of the cell nucleus has been investigated using three-dimensional reconstruction, immunoelectron microscopy, and high-resolution in situ autoradiography. Nuclear regions enriched in small nuclear ribonucleoprotein particles (snRNPs) form a reticular network within the nucleop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spector DL

更新日期：1990-01-01 00:00:00

abstract：:Object recognition is challenging because the same object can produce vastly different images, mixing signals related to its identity with signals due to its image attributes, such as size, position, rotation, etc. Previous studies have shown that both signals are present in high-level visual areas, but precisely how ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratan Murty NA,Arun SP

更新日期：2018-04-03 00:00:00

abstract：:Maximum likelihood estimators and other direct optimization-based estimators dominated statistical estimation and prediction for decades. Yet, the principled foundations supporting their dominance do not apply to the discrete high-dimensional inference problems of the 21st century. As it is well known, statistical dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvalho LE,Lawrence CE

更新日期：2008-03-04 00:00:00

abstract：:The posteromedial barrel subfield of the somatosensory cortex of mice was examined histochemically for cytochrome oxidase activity (cytochrome c oxidase; ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1). In normal mice a high enzymatic activity was found within the barrel hollows, rather than in the sides and sept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong-Riley MT,Welt C

更新日期：1980-04-01 00:00:00

abstract：:We report the discovery of mammalian tribosphenic teeth from the basal Cenomanian of southwestern France that we refer to a new primitive marsupial-like form identified as a basal taxon of Marsupialiformes, a new clade recognized here to include the crown group Marsupialia and primitive stem lineages more closely rela...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vullo R,Gheerbrant E,de Muizon C,Néraudeau D

更新日期：2009-11-24 00:00:00

abstract：:Here we describe a strategy designed to identify RNAs that are actively transported to synapses during learning. Our approach is based on the characterization of RNA transport complexes carried by molecular motor kinesin. Using this strategy in Aplysia, we have identified 5,657 unique sequences consisting of both codi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puthanveettil SV,Antonov I,Kalachikov S,Rajasethupathy P,Choi YB,Kohn AB,Citarella M,Yu F,Karl KA,Kinet M,Morozova I,Russo JJ,Ju J,Moroz LL,Kandel ER

更新日期：2013-04-30 00:00:00

abstract：:The anti-inflammatory activity of intravenous Ig (IVIG) results from a minor population of the pooled IgG molecules that contains terminal alpha2,6-sialic acid linkages on their Fc-linked glycans. These anti-inflammatory properties can be recapitulated with a fully recombinant preparation of appropriately sialylated I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anthony RM,Wermeling F,Karlsson MC,Ravetch JV

更新日期：2008-12-16 00:00:00

abstract：:Hybridomas producing human monoclonal IgM antibodies (mAbs) against bacterial lipopolysaccharide (LPS) were generated by fusion of B lymphocytes from sensitized human spleen with heteromyeloma cells. The splenocytes were from patients undergoing splenectomy during staging for Hodgkin disease after vaccination with the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng NN,Kaplan HS,Hebert JM,Moore C,Douglas H,Wunderlich A,Braude AI

更新日期：1985-03-01 00:00:00

abstract：:New important applications of copper metal, e.g., in the areas of hydrogen production, fuel cell operation, and spent nuclear fuel disposal, require accurate knowledge of the physical and chemical properties of stable and metastable copper compounds. Among the copper(I) compounds with oxygen and hydrogen, cuprous oxid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korzhavyi PA,Soroka IL,Isaev EI,Lilja C,Johansson B

更新日期：2012-01-17 00:00:00

abstract：:Invariant natural killer T cell (NKT) cells (iNKT cells) produce both T-helper 1 (Th1) and T-helper 2 cytokines in response to α-Galactosylceramide (α-GalCer) stimulation and are thought to be the important effectors in the regulation of both innate and adaptive immunity involved in autoimmune disorders, microbial inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TN,Lin KH,Chang YJ,Huang JR,Cheng JY,Yu AL,Wong CH

更新日期：2011-10-18 00:00:00

abstract：:A recently described experimental system for analyzing the mode of action of a morphogen gradient involves the in situ hybridization of sectioned tissue constructs. In these constructs, a source of activin signaling induces the transcription of several mesodermal genes in blastula animal caps, according to the positio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gurdon JB,Mitchell A,Ryan K

更新日期：1996-09-03 00:00:00

abstract：:By selective attachment of a DNA cleavage agent to specific residues in the yeast TATA box binding protein (yTBP), we demonstrate that, in solution, yTBP binds to the TATA boxes of both the adenovirus major late promoter and the yeast CYC1 promoter with only a modest preference in orientation and binds well to several...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox JM,Hayward MM,Sanchez JF,Gegnas LD,van der Zee S,Dennis JH,Sigler PB,Schepartz A

更新日期：1997-12-09 00:00:00

abstract：:After pollen grains germinate on the stigma, pollen tubes traverse the extracellular matrix of the style on their way to the ovules. We previously characterized two pollen-specific, receptor-like kinases, LePRK1 and LePRK2, from tomato (Lycopersicon esculentum). Their structure and immunolocalization pattern and the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wengier D,Valsecchi I,Cabanas ML,Tang WH,McCormick S,Muschietti J

更新日期：2003-05-27 00:00:00

abstract：:While cells within tissues generate and sense 3D states of strain, the current understanding of the mechanics of fibrous extracellular matrices (ECMs) stems mainly from uniaxial, biaxial, and shear tests. Here, we demonstrate that the multiaxial deformations of fiber networks in 3D cannot be inferred solely based on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ban E,Wang H,Franklin JM,Liphardt JT,Janmey PA,Shenoy VB

更新日期：2019-04-02 00:00:00

abstract：:A site has been found that is required for repression of the Escherichia coli araBAD operon. This site was detected by the in vivo properties of deletion mutants. In vitro protection studies with DNase I and dimethylsulfate showed that araC protein can specifically bind in this area to nucleotides lying at position -2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn TM,Hahn S,Ogden S,Schleif RF

更新日期：1984-08-01 00:00:00

abstract：:Cell cycle-controlled human histone genes are coordinately expressed during S phase, and transcriptional regulation involves a series of trans-acting factors (HiNFs). The proliferation-specific factor HiNF-D interacts with multiple recognition motifs in histone H4, H3, and H1 promoters. Using gel shift immunoassays, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Wijnen AJ,Aziz F,Graña X,De Luca A,Desai RK,Jaarsveld K,Last TJ,Soprano K,Giordano A,Lian JB

更新日期：1994-12-20 00:00:00