Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel.

abstract：:Thrombin induces platelet aggregation and formation of a fibrin clot in platelet-rich plasma; leupeptin, a protease inhibitor, partially inhibits platelet aggregation, but it does not inhibit fibrin clot formation. Indomethacin does not inhibit either thrombin-induced platelet aggregation or fibrin clot formation. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruggiero M,Lapetina EG

更新日期：1986-05-01 00:00:00

abstract：:Tumor hypoxia and the hypoxia-inducible factors (HIFs) play a central role in the development of cancer. To study the relationship between tumor growth, tumor hypoxia, the stabilization of HIF-1alpha, and HIF transcriptional activity, we have established an in vivo imaging tool that allows longitudinal and noninvasive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann S,Stiehl DP,Honer M,Dominietto M,Keist R,Kotevic I,Wollenick K,Ametamey S,Wenger RH,Rudin M

更新日期：2009-08-18 00:00:00

abstract：:OpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and endothelial cells by binding to vitronectin and proteoglycan cell-surface receptors. Here, we report the determination of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prince SM,Achtman M,Derrick JP

更新日期：2002-03-19 00:00:00

abstract：:The bacterial pathogen Shigella flexneri causes bacillary dysentery in humans by invading coloncytes. Upon contact with epithelial cells, S. flexneri elicits localized plasma membrane projections sustained by long actin filaments which engulf the microorganism. The products necessary for Shigella entry include three s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ménard R,Prévost MC,Gounon P,Sansonetti P,Dehio C

更新日期：1996-02-06 00:00:00

abstract：:Somatic crossing-over was used in heterozygous Drosophila melanogaster to effect clonal homozygosity for three mutants (h, Hw, ac). In these mutants, one type of process, chaetae, replaces another type, trichomes, in specific patterns on the adult fly. Heterozygous individuals were irradiated at different larval or pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia-Bellido A,Merriam JR

更新日期：1971-09-01 00:00:00

abstract：:Although in decline after successful anti-HIV therapy, B-cell lymphomas are still elevated in HIV-1-seropositive (HIV+) persons, and the mechanisms are obscure. The HIV-1 matrix protein p17 persists in germinal centers long after HIV-1 drug suppression, and some p17 variants (vp17s) activate Akt signaling and promote ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dolcetti R,Giagulli C,He W,Selleri M,Caccuri F,Eyzaguirre LM,Mazzuca P,Corbellini S,Campilongo F,Marsico S,Giombini E,Muraro E,Rozera G,De Paoli P,Carbone A,Capobianchi MR,Ippolito G,Fiorentini S,Blattner WA,Lu W,

更新日期：2015-11-17 00:00:00

abstract：:The heavy chains of both botulinum neurotoxin type B and tetanus toxin form channels in planar bilayer membranes. These channels have pH-dependent and voltage-dependent properties that are remarkably similar to those previously described for diphtheria toxin. Selectivity experiments with anions and cations show that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoch DH,Romero-Mira M,Ehrlich BE,Finkelstein A,DasGupta BR,Simpson LL

更新日期：1985-03-01 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential to class-switch recombination (CSR) and somatic hypermutation (SHM) in both V region SHM and S region SHM (s-SHM). Uracil DNA glycosylase (UNG), a member of the base excision repair (BER) complex, is required for CSR. Strikingly, however, UNG deficiency causes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yousif AS,Stanlie A,Mondal S,Honjo T,Begum NA

更新日期：2014-03-18 00:00:00

abstract：:Earlier papers demonstrated an extensive genetic exchange among fluorescent Pseudomonads; this one documents for genes specifying enzymes of peripheral dissimilation an extrachromosomal array, segregation, and frequent interstrain transfer. An hypothesis is presented of a general mechanism for the formation and mainte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rheinwald JG,Chakrabarty AM,Gunsalus IC

更新日期：1973-03-01 00:00:00

abstract：:How useful can machine learning be in a quantum laboratory? Here we raise the question of the potential of intelligent machines in the context of scientific research. A major motivation for the present work is the unknown reachability of various entanglement classes in quantum experiments. We investigate this question...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melnikov AA,Poulsen Nautrup H,Krenn M,Dunjko V,Tiersch M,Zeilinger A,Briegel HJ

更新日期：2018-02-06 00:00:00

abstract：:Song syntax, defined as orderly temporal arrangements of acoustic units within a bird song, is a conspicuous feature of the songs of many species of passerine birds. While syntactical features play a role in interspecific song recognition by males of many bird species, syntax variation within species and female respon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balaban E

更新日期：1988-05-01 00:00:00

abstract：:Synthetic 3-phosphocitrate, an extremely potent inhibitor of calcium phosphate crystallization as determined in a nonbiological physical-chemical assay, has many similarities to a mitochondrial factor that inhibits crystallization of nondiffracting amorphous calcium phosphate. In order to determine whether phosphocitr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tew WP,Malis CD,Howard JE,Lehninger AL

更新日期：1981-09-01 00:00:00

abstract：:High-resolution analyses of a late Holocene core from Kettle Lake in North Dakota reveal coeval fluctuations in loss-on-ignition carbonate content, percentage of grass pollen, and charcoal flux. These oscillations are indicative of climate-fuel-fire cycles that have prevailed on the Northern Great Plains (NGP) for mos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown KJ,Clark JS,Grimm EC,Donovan JJ,Mueller PG,Hansen BC,Stefanova I

更新日期：2005-06-21 00:00:00

abstract：:Ribonucleotide reductase provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and repair. The mammalian enzyme consists of a catalytic (R1) and a radical-generating (R2 or p53R2) subunit. During S-phase, a R1/R2 complex is the major provider of deoxynucleotides. p53R2 is induced by p53 after DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pontarin G,Fijolek A,Pizzo P,Ferraro P,Rampazzo C,Pozzan T,Thelander L,Reichard PA,Bianchi V

更新日期：2008-11-18 00:00:00

abstract：:The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larner AC,Jonak G,Cheng YS,Korant B,Knight E,Darnell JE Jr

更新日期：1984-11-01 00:00:00

abstract：:Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. The orphan nuclear re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie W,Yeuh MF,Radominska-Pandya A,Saini SP,Negishi Y,Bottroff BS,Cabrera GY,Tukey RH,Evans RM

更新日期：2003-04-01 00:00:00

abstract：:The distribution of actin stress fibers in normal and regenerating (after endothelial denudation by means of a balloon catheter) rabbit aortic endothelial cells has been studied by means of immunofluorescence with human actin autoantibodies on en face endothelial cell preparations. Our results show that: (i) under nor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gabbiani G,Gabbiani F,Lombardi D,Schwartz SM

更新日期：1983-04-01 00:00:00

abstract：:Many empirical studies throughout the social and biomedical sciences focus only on very narrow outcomes such as income, or a single specific disease state, or a measure of positive affect. Human well-being or flourishing, however, consists in a much broader range of states and outcomes, certainly including mental and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： VanderWeele TJ

更新日期：2017-08-01 00:00:00

abstract：:Molecular adaptation is typically assumed to proceed by sequential fixation of beneficial mutations. In diploids, this picture presupposes that for most adaptive mutations, the homozygotes have a higher fitness than the heterozygotes. Here, we show that contrary to this expectation, a substantial proportion of adaptiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sellis D,Callahan BJ,Petrov DA,Messer PW

更新日期：2011-12-20 00:00:00

abstract：:Are judicial rulings based solely on laws and facts? Legal formalism holds that judges apply legal reasons to the facts of a case in a rational, mechanical, and deliberative manner. In contrast, legal realists argue that the rational application of legal reasons does not sufficiently explain the decisions of judges an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danziger S,Levav J,Avnaim-Pesso L

更新日期：2011-04-26 00:00:00

abstract：:The Schiff base adducts of glyceraldehyde with hemoglobin undergo Amadori rearrangement to form stable ketoamine structures; this reaction is similar to the nonenzymic glucosylation of proteins. In the present studies the analogous rearrangement of the Schiff base adducts of glycolaldehyde with proteins has been demon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acharya AS,Manning JM

更新日期：1983-06-01 00:00:00

abstract：:Dengue virus (DENV) is a global disease threat for which there are no approved antivirals or vaccines. Establishing state-of-the-art screening systems that rely on fluorescent or luminescent reporters may accelerate the development of anti-DENV therapeutics. However, relatively few reporter DENV platforms exist. Here,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoggins JW,Dorner M,Feulner M,Imanaka N,Murphy MY,Ploss A,Rice CM

更新日期：2012-09-04 00:00:00

abstract：:We report here on the isolation and characterization of a serotonin (5HT) transporter from Drosophila melanogaster. A 3.1-kb complementary DNA clone (dSERT) was found to encode a protein of 622 amino acid residues with a predicted molecular mass of approximately 69 kDa and a putative transmembrane topology characteris...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demchyshyn LL,Pristupa ZB,Sugamori KS,Barker EL,Blakely RD,Wolfgang WJ,Forte MA,Niznik HB

更新日期：1994-05-24 00:00:00

abstract：:Telomeric repeat-containing RNA (referred to as TERRA), a noncoding RNA molecule, has recently been found in mammalian cells. The detailed structural features and function of the TERRA RNA at human chromosome ends remain unclear, although this RNA molecule may be a key component of the telomere machinery. In the prese...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Y,Suzuki Y,Ito K,Komiyama M

更新日期：2010-08-17 00:00:00

abstract：:Previous research has implicated a large network of brain regions in the processing of risk during decision making. However, it has not yet been determined if activity in these regions is predictive of choices on future risky decisions. Here, we examined functional MRI data from a large sample of healthy subjects perf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helfinstein SM,Schonberg T,Congdon E,Karlsgodt KH,Mumford JA,Sabb FW,Cannon TD,London ED,Bilder RM,Poldrack RA

更新日期：2014-02-18 00:00:00

abstract：:Normal vision requires the precise control of vascular growth to maintain corneal transparency. Here we provide evidence for a unique mechanism by which the Forkhead box transcription factor FoxC1 regulates corneal vascular development. Murine Foxc1 is essential for development of the ocular anterior segment, and in h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seo S,Singh HP,Lacal PM,Sasman A,Fatima A,Liu T,Schultz KM,Losordo DW,Lehmann OJ,Kume T

更新日期：2012-02-07 00:00:00

abstract：:Cytochrome ba3 from Thermus thermophilus reacts slowly with excess HCN at pH 7.4 to create a form of the enzyme in which CuA, cytochrome b, and CuB remain oxidized, while cytochrome a3 is reduced by one electron, presumably with the formation of cyanogen. We have examined this form of the enzyme by UV-visible, resonan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Surerus KK,Oertling WA,Fan C,Gurbiel RJ,Einarsdóttir O,Antholine WE,Dyer RB,Hoffman BM,Woodruff WH,Fee JA

更新日期：1992-04-15 00:00:00

abstract：:The likelihood with which an action potential elicits neurotransmitter release, the release probability (p(r)), is an important component of synaptic strength. Regulatory mechanisms controlling several steps of synaptic vesicle (SV) exocytosis may affect p(r), yet their relative importance in determining p(r) and elic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matz J,Gilyan A,Kolar A,McCarvill T,Krueger SR

更新日期：2010-05-11 00:00:00

abstract：:Autocatalytic chemical reactions are widely studied as models of biological processes and to better understand the origins of life on Earth. Minimal self-reproducing amphiphiles have been developed in this context and as an approach to de novo "bottom-up" synthetic protocells. How chemicals come together to produce li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortega-Arroyo J,Bissette AJ,Kukura P,Fletcher SP

更新日期：2016-10-04 00:00:00

abstract：:Leucine analogs were tested in the Krebs II ascites cell-free translation system for the ability to inhibit preprotein cleavage by replacing leucine in nascent chains of bovine preprolactin, rat preprolactin, human placental prelactogen (pre-hPL), and pre-alpha subunit of human chorionic gonadotropin (alpha-hCG). In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hortin G,Boime I

更新日期：1980-03-01 00:00:00