Fire cycles in North American interior grasslands and their relation to prairie drought.

abstract：:The SKW-3 cell line, which was established from the malignant cells of a patient with T-cell chronic lymphocytic leukemia, is characterized by a translocation involving chromosome 8 (band q24) and chromosome 14 (band q11) [t(8;14)(q24;q11)]. To determine the position of the gene encoding the alpha chain of the T-cell ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shima EA,Le Beau MM,McKeithan TW,Minowada J,Showe LC,Mak TW,Minden MD,Rowley JD,Diaz MO

更新日期：1986-05-01 00:00:00

abstract：:The free and membrane-bound ribosomes of hepatic cells were isolated and used to program protein synthesis in cell-free extracts. Immuno-electrophoretic and radioautographic analysis of the products showed that the membrane-bound ribosomes synthesized serum proteins, whereas ribosomes free of endoplasmic reticulum syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ganoza MC,Williams CA

更新日期：1969-08-01 00:00:00

abstract：:The endosperm of cereal grains is one of the most valuable products of modern agriculture. Cereal endosperm development comprises different phases characterized by mitotic cell proliferation, endoreduplication, the accumulation of storage compounds, and programmed cell death. Although manipulation of these processes c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabelli PA,Liu Y,Dante RA,Lizarraga LE,Nguyen HN,Brown SW,Klingler JP,Yu J,LaBrant E,Layton TM,Feldman M,Larkins BA

更新日期：2013-05-07 00:00:00

abstract：:The size of virus-specific RNA synthesized in cultured mouse kidney cells infected with polyoma virus was estimated by electrophoresis and sedimentation analysis of RNA extracts from whole cells. Newly synthesized "late" polyoma-specific RNA appears as "giant" molecules of heterogeneous size, up to several times large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acheson NH,Buetti E,Scherrer K,Weil R

更新日期：1971-09-01 00:00:00

abstract：:Bipedalism is a defining trait of the hominin lineage, associated with a transition from a more arboreal to a more terrestrial environment. While there is debate about when modern human-like bipedalism first appeared in hominins, all known South African hominins show morphological adaptations to bipedalism, suggesting...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Georgiou L,Dunmore CJ,Bardo A,Buck LT,Hublin JJ,Pahr DH,Stratford D,Synek A,Kivell TL,Skinner MM

更新日期：2020-04-14 00:00:00

abstract：:Bone mineralization is an essential step during the embryonic development of vertebrates, and bone serves vital functions in human physiology. To systematically identify unique gene functions essential for osteogenesis, we performed a forward genetic screen in zebrafish and isolated a mutant, no bone (nob), that does ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huitema LF,Apschner A,Logister I,Spoorendonk KM,Bussmann J,Hammond CL,Schulte-Merker S

更新日期：2012-12-26 00:00:00

abstract：:A calix[4]arene was designed to reversibly dimerize and form an egg-shaped enclosure. Adhesive interactions in the assembly were provided by four self-associating ureas, which form a cyclic array containing 16 hydrogen bonds. The synthesis was completed in four steps from the previously described O,O',O",O"'-tetrabenz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu KD,Rebek J Jr

更新日期：1995-12-19 00:00:00

abstract：:The growth or decay of population of a single species interacting with a large number of other species (or environment) according to the Volterra-Lotka model is investigated. When the environment is initially very close to its equilibrium level, the growth of a single species follows a generalized Verhulst law, contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zwanzig R

更新日期：1973-11-01 00:00:00

abstract：:Nicotinic AChRs (nAChRs) represent a paradigm for ligand-gated ion channels. Despite intensive studies over many years, our understanding of the mechanisms of activation and inhibition for nAChRs is still incomplete. Here, we present molecular dynamics (MD) simulations of the alpha7 nAChR ligand-binding domain, both i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yi M,Tjong H,Zhou HX

更新日期：2008-06-17 00:00:00

abstract：:The proteolytic cleavage of sterol regulatory element-binding proteins (SREBPs) is regulated by SREBP cleavage-activating protein (SCAP), which forms complexes with SREBPs in membranes of the endoplasmic reticulum (ER). In sterol-depleted cells, SCAP facilitates cleavage of SREBPs by Site-1 protease, thereby initiatin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nohturfft A,DeBose-Boyd RA,Scheek S,Goldstein JL,Brown MS

更新日期：1999-09-28 00:00:00

abstract：:Reconnections of coherent filamentary structures play a key role in the dynamics of fluids, redistributing energy and helicity among the length scales, triggering dissipative effects, and inducing fine-scale mixing. Unlike ordinary (classical) fluids where vorticity is a continuous field, in superfluid helium and in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galantucci L,Baggaley AW,Parker NG,Barenghi CF

更新日期：2019-06-18 00:00:00

abstract：:Pregnant mothers often report a special awareness of and bonding with their unborn child. Little is known about this relationship although it may offer potential for the assessment of the fetal condition. Recently we found evidence of short epochs of fetal-maternal heart rate synchronization under uncontrolled conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Leeuwen P,Geue D,Thiel M,Cysarz D,Lange S,Romano MC,Wessel N,Kurths J,Grönemeyer DH

更新日期：2009-08-18 00:00:00

abstract：:Calcium oxalate monohydrate (COM), which plays a functional role in plant physiology, is a source of chronic human disease, forming the major inorganic component of kidney stones. Understanding molecular mechanisms of biological control over COM crystallization is central to development of effective stone disease ther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu SR,Wierzbicki A,Orme CA,Cody AM,Hoyer JR,Nancollas GH,Zepeda S,De Yoreo JJ

更新日期：2004-02-17 00:00:00

abstract：:The nonlinearity of the Navier-Stokes equations makes predicting the flow of fluid around rapidly moving small bodies highly resistant to all approaches save careful experiments or brute force computation. Here, we show how a linearization of the Navier-Stokes equations captures the drag-determining features of the fl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roper M,Brenner MP

更新日期：2009-03-03 00:00:00

abstract：:Experimental intramolecular vibrational dephasing transients for several large organic molecules are reanalyzed. Fits to the experimental data, as well as full numerical quantum calculations with a factorized potential surface for all active degrees of freedom of fluorene indicate that power law decays, not exponentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gruebele M

更新日期：1998-05-26 00:00:00

abstract：:An implicit assumption of speciation biology is that population differentiation is an important stage of evolutionary diversification, but its significance as a rate-limiting control on phylogenetic speciation dynamics remains largely untested. If population differentiation within a species is related to its speciatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harvey MG,Seeholzer GF,Smith BT,Rabosky DL,Cuervo AM,Brumfield RT

更新日期：2017-06-13 00:00:00

abstract：:Coxiella burnetti, the etiologic agent of Q fever, is an oligate intracellular parasite of eukaryotes. Unlike the majority of successful bacterial parasites, which escape the bactericidal environment of the phagolysosome by various means, C. burnetii multiplies only in the phagolysosome. In view of the relatively hars...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hackstadt T,Williams JC

更新日期：1981-05-01 00:00:00

abstract：:Using an expression cloning approach, we have isolated a cDNA encoding GD3 synthase (CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase, EC 2.4.99.8), which is a key regulatory enzyme determining the prominence of the ganglioside biosynthesis pathway. The cloned cDNA encodes a 341-amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nara K,Watanabe Y,Maruyama K,Kasahara K,Nagai Y,Sanai Y

更新日期：1994-08-16 00:00:00

abstract：:Although current demands for therapeutic mAbs are growing quickly, production methods to date, including in vitro mammalian tissue culture and transgenic animals, provide only limited quantities at high cost. Several tumor-associated antigens in tumor cells have been identified as targets for therapeutic mAbs. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodzik R,Glogowska M,Bandurska K,Okulicz M,Deka D,Ko K,van der Linden J,Leusen JH,Pogrebnyak N,Golovkin M,Steplewski Z,Koprowski H

更新日期：2006-06-06 00:00:00

abstract：:Forkhead box class O (FoxO) transcription factors are key regulators of growth, metabolism, life span, and stress resistance. FoxOs integrate signals from different pathways and guide the cellular response to varying energy and stress conditions. FoxOs are modulated by several signaling pathways, e.g., the insulin-TOR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mattila J,Kallijärvi J,Puig O

更新日期：2008-09-30 00:00:00

abstract：:In previous work we identified a basilar papilla protein (BPP23) that appears to be one of the most abundant soluble proteins in the basilar papilla of the chick cochlea. Here we report the purification of protein BPP23 from chick cochlea and the generation of a specific antiserum. Immunoblotting and immunoprecipitati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberholtzer JC,Buettger C,Summers MC,Matschinsky FM

更新日期：1988-05-01 00:00:00

abstract：:In both randomly moving Dictyostelium and mammalian cells, phosphatidylinositol (3,4,5)-trisphosphate and F-actin are known to propagate as waves at the membrane and act to push out the protruding edge. To date, however, the relationship between the wave geometry and the patterns of amoeboid shape change remains elusi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taniguchi D,Ishihara S,Oonuki T,Honda-Kitahara M,Kaneko K,Sawai S

更新日期：2013-03-26 00:00:00

abstract：:Using defined oligomers of IgE, our group previously studied the quantitative relationship between the aggregation of the high affinity receptors for IgE (Fc epsilonRI) and the earliest signals initiated by such aggregation: the phosphorylation of tyrosines on the receptor. Notably, at certain doses of the oligomers s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torigoe C,Goldstein B,Wofsy C,Metzger H

更新日期：1997-02-18 00:00:00

abstract：:8-Methylbenz[a]anthracene (8-MeBaA) transdihydrodiol metabolites were isolated by reversed-phase and normal-phase HPLCs from incubations of 8-MeBaA with liver microsomes or a reconstituted system containing purified cytochrome P-448 and epoxide hydrolase. Regardless of the enzyme source, the metabolically formed 8-MeB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SK,Chou MW,Fu PP,Wislocki PG,Lu AH

更新日期：1982-11-01 00:00:00

abstract：:A MODEL OF THE LINEAR HYDROGEN BOND HAS BEEN DEVISED WHICH IS CHARACTERIZED BY THREE PHYSICAL PARAMETERS OF THE ISOLATED ELECTRON DONOR AND PROTON DONOR MOLECULES: mu(A-H), the bond dipole moment; DeltaI, the difference in ionization potential between that of the electron donor and the corresponding noble gas atom; an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Allen LC

更新日期：1975-12-01 00:00:00

abstract：:Chemomechanical coupling in muscle contraction may be due to "swinging crossbridges," such that a change in the angle at which the myosin head binds to the actin filament is tightly coupled to release of products of ATP hydrolysis. This model would limit the step size, the unit displacement of actin produced by a sing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyoshima YY,Kron SJ,Spudich JA

更新日期：1990-09-01 00:00:00

abstract：:In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of HIV-1 infection on vaccination with an Ad5 vaccine. We propose that this was due to activation and expansion of Ad5-specific mucosal-homing memory CD4 T cells. To t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benlahrech A,Harris J,Meiser A,Papagatsias T,Hornig J,Hayes P,Lieber A,Athanasopoulos T,Bachy V,Csomor E,Daniels R,Fisher K,Gotch F,Seymour L,Logan K,Barbagallo R,Klavinskis L,Dickson G,Patterson S

更新日期：2009-11-24 00:00:00

abstract：:Bacteriophage (phage) have attractive advantages as delivery systems compared with mammalian viruses, but have been considered poor vectors because they lack evolved strategies to confront and overcome mammalian cell barriers to infective agents. We reasoned that improved efficacy of delivery might be achieved through...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suwan K,Yata T,Waramit S,Przystal JM,Stoneham CA,Bentayebi K,Asavarut P,Chongchai A,Pothachareon P,Lee KY,Topanurak S,Smith TL,Gelovani JG,Sidman RL,Pasqualini R,Arap W,Hajitou A

更新日期：2019-09-10 00:00:00

abstract：:As a master regulator of functional Ig heavy chain (IgH) expression, the IgH 3' regulatory region (3'RR) controls multiple transcription events at various stages of B-cell ontogeny, from newly formed B cells until the ultimate plasma cell stage. The IgH 3'RR plays a pivotal role in early B-cell receptor expression, ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garot A,Marquet M,Saintamand A,Bender S,Le Noir S,Rouaud P,Carrion C,Oruc Z,Bébin AG,Moreau J,Lebrigand K,Denizot Y,Alt FW,Cogné M,Pinaud E

更新日期：2016-02-09 00:00:00

abstract：:The functions of individual basal transcription factors during the formation of an initiation complex by RNA polymerase II remain largely unknown. Transcription factor IIE (TFIIE) has recently been shown to bind to multiple targets in the initiation complex. To assess the role of zinc binding in basal transcription, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maxon ME,Tjian R

更新日期：1994-09-27 00:00:00