On the promotion of human flourishing.

abstract：:SIRT6 (sirtuin 6) is a member of sirtuin family of deacetylases involved in diverse processes including genome stability, metabolic homeostasis, and tumorigenesis. However, the role of SIRT6 deacetylase activity in its tumor-suppressor functions is not well understood. Here we report that SIRT6 binds to and deacetylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhardwaj A,Das S

更新日期：2016-02-02 00:00:00

abstract：:Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids can be combined in antiparallel side-by-side dimeric complexes for sequence-specific recognition in the minor groove of DNA. Six polyamides containing three to eight rings bind DNA sites 5-10 bp in length, respectively. Quantitative DNas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly JJ,Baird EE,Dervan PB

更新日期：1996-07-09 00:00:00

abstract：:The calcium, calmodulin-dependent phosphatase calcineurin, regulates growth and gene expression of striated muscles. The activity of calcineurin is modulated by a family of cofactors, referred to as modulatory calcineurin-interacting proteins (MCIPs). In the heart, the MCIP1 gene is activated by calcineurin and has be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bush E,Fielitz J,Melvin L,Martinez-Arnold M,McKinsey TA,Plichta R,Olson EN

更新日期：2004-03-02 00:00:00

abstract：:We induced an essential fatty acid deficiency (EFAD) in human umbilical vein endothelial cells by culture in medium with 20% (vol/vol) delipidated fetal calf serum. EFAD, reflected by decreased cellular linoleic acid (18:2 omega 6) and arachidonic acid (20:4 omega 6) and emergence of the oleic acid derivative 5,8,11-e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerner R,Lindström P,Berg A,Johansson E,Rosendahl K,Palmblad J

更新日期：1995-02-14 00:00:00

abstract：:Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This suggests a key role in disease control for HLA presentation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arora J,McLaren PJ,Chaturvedi N,Carrington M,Fellay J,Lenz TL

更新日期：2019-01-15 00:00:00

abstract：:The ubiquitin ligase Siah2 has been shown to regulate prolyl hydroxylase 3 (PHD3) stability with concomitant effect on HIF-1alpha availability. Because HIF-1alpha is implicated in tumorigenesis and metastasis, we used SW1 mouse melanoma cells, which develop primary tumors with a propensity to metastasize, in a syngene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qi J,Nakayama K,Gaitonde S,Goydos JS,Krajewski S,Eroshkin A,Bar-Sagi D,Bowtell D,Ronai Z

更新日期：2008-10-28 00:00:00

abstract：:Effective gene therapy depends on the efficient transfer of therapeutic genes and their protein products to target cells. Lentiviral vectors appear promising for virus-mediated gene delivery and long-term expression in nondividing cells. The herpes simplex virus type 1 tegument protein VP22 has recently been shown to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Z,Han I,Zirzow G,Brady RO,Reiser J

更新日期：2000-10-10 00:00:00

abstract：:Pathway proteomics strategies measure protein expression changes in specific cellular processes that carry out related functions. Using targeted tandem mass tags-based sample multiplexing, hundreds of proteins can be quantified across 10 or more samples simultaneously. To facilitate these highly complex experiments, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Q,Xiao H,Jedrychowski MP,Schweppe DK,Navarrete-Perea J,Knott J,Rogers J,Chouchani ET,Gygi SP

更新日期：2020-05-05 00:00:00

abstract：:We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moser MB,Moser EI,Forrest E,Andersen P,Morris RG

更新日期：1995-10-10 00:00:00

abstract：:We have isolated, cloned, and expressed a male antennae-specific pheromone-degrading enzyme (PDE) [Antheraea polyphemus PDE (ApolPDE), formerly known as Sensillar Esterase] from the wild silkmoth, A. polyphemus, which seems essential for the rapid inactivation of pheromone during flight. The onset of enzymatic activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida Y,Leal WS

更新日期：2005-09-27 00:00:00

abstract：:Formation of neural circuits depends on stable contacts between neuronal processes, mediated by interaction of cell adhesion molecules, including N-cadherin. In the present study, we found that activity-dependent dendrite arborization specifically requires N-cadherin-mediated extracellular neuron-neuron interaction, b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan ZJ,Peng Y,Song HL,Zheng JJ,Yu X

更新日期：2010-05-25 00:00:00

abstract：:An increasing amount of investment has been devoted to protecting and restoring ecosystem services worldwide. The efficiency of conservation investments, including payments for ecosystem services (PES), has been found to be affected by biological, political, economic, demographic, and social factors, but little is kno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Lupi F,He G,Liu J

更新日期：2009-07-14 00:00:00

abstract：:We performed the biochemical and biophysical characterization of a red fluorescent protein, eqFP611, from the sea anemone Entacmaea quadricolor cloned in Escherichia coli. With an excitation maximum at 559 nm and an emission maximum at 611 nm, the recombinant protein shows the most red-shifted emission and the largest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiedenmann J,Schenk A,Röcker C,Girod A,Spindler KD,Nienhaus GU

更新日期：2002-09-03 00:00:00

abstract：:Aspartate transcarbamoylase (EC 2.1.3.2) from Escherichia coli contains six zinc ions per molecule. Renaturation studies of this allosteric enzyme and its isolated subunits show that the metal binding site is in the regulatory polypeptide chain. Ultraviolet difference spectra of the cadmium and zinc derivatives have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenbusch JP,Weber K

更新日期：1971-05-01 00:00:00

abstract：:Humans speak, monkeys grunt, and ducks quack. How do we come to know which vocalizations animals produce? Here we explore this question by asking whether young infants expect humans, but not other animals, to produce speech, and further, whether infants have similarly restricted expectations about the sources of vocal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vouloumanos A,Druhen MJ,Hauser MD,Huizink AT

更新日期：2009-11-03 00:00:00

abstract：:Components in cerebrospinal fluid that are antigenically related to myelin basic protein have been identified by a technique described recently [Barbarese, E., Braun, P. E. & Carson, J. H. (1977) Proc. Natl. Acad. Sci. USA 74, 3360-3364] involving separating the cerebrospinal fluid proteins by sodium dodecyl sulfate/p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carson JH,Barbarese E,Braun PE,McPherson TA

更新日期：1978-04-01 00:00:00

abstract：:Site-specific recombination is responsible for a broad range of biological phenomena, including DNA inversion, resolution of transposition intermediates, and the integration and excision of bacteriophage genomes. Integration of mycobacteriophage L5 is catalyzed by a phage-encoded integrase with recombination occurring...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peña CE,Kahlenberg JM,Hatfull GF

更新日期：2000-07-05 00:00:00

abstract：:The plasma membrane (PM) is composed of heterogeneous subdomains, characterized by differences in protein and lipid composition. PM receptors can be dynamically sorted into membrane domains to underpin signaling in response to extracellular stimuli. In plants, the plasmodesmal PM is a discrete microdomain that hosts s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheval C,Samwald S,Johnston MG,de Keijzer J,Breakspear A,Liu X,Bellandi A,Kadota Y,Zipfel C,Faulkner C

更新日期：2020-04-28 00:00:00

abstract：:The chief impediment to the precise biochemical identification of transfer factor and its mechanism of action has been the lack of a reproducible in vitro assay. We now report on a method by which dialysates containing transfer factor of proven in vivo potency can convert nonimmune lymphocytes to immune responsiveness...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ascher MS,Schneider WJ,Valentine FT,Lawrence HS

更新日期：1974-04-01 00:00:00

abstract：:Kinetics of growth and decay of triplet states of molecules at known orientation in a magnetic field have been measured. Amplitudes of the zero field eigenstates in each of the eigenstates at finite field were varied by choice of orientation. No interference between the amplitudes of the zero field states was found in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felix CC,Weissman SI

更新日期：1975-11-01 00:00:00

abstract：:Plant litter decomposition is a critical step in the formation of soil organic matter, the mineralization of organic nutrients, and the carbon balance in terrestrial ecosystems. Biotic decomposition in mesic ecosystems is generally negatively correlated with the concentration of lignin, a group of complex aromatic pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austin AT,Ballaré CL

更新日期：2010-03-09 00:00:00

abstract：:(3)H-actinomycin D, a guanine-binding agent, labels fixed human chromosomes nonrandomly. Actinomycin D added in G2 inhibits secondary constrictions and breaks chromosomes. There is some tendency for label to be concentrated at the ends of chromosomes and near the centromere. Labeling with (3)H-thymidine in the late st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles CP

更新日期：1970-03-01 00:00:00

abstract：:A single-nucleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2) gene has recently been identified as associated with insulin resistance in humans. To understand the cellular and molecular mechanisms by which alterations in Nat2 activity might cause insulin resistance, we examined murine ortholog N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Camporez JP,Wang Y,Faarkrog K,Chukijrungroat N,Petersen KF,Shulman GI

更新日期：2017-12-26 00:00:00

abstract：:Destruction of mitotic cyclins by ubiquitin-dependent proteolysis is required for cells to complete mitosis and enter interphase of the next cell cycle. In clam eggs, this process is catalyzed by a cyclin-selective ubiquitin carrier protein, E2-C, and the cyclosome/anaphase promoting complex (APC), a 20S particle cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Townsley FM,Aristarkhov A,Beck S,Hershko A,Ruderman JV

更新日期：1997-03-18 00:00:00

abstract：:Relatively little is known about the biochemical mechanisms through which the Epstein-Barr virus latent infection integral membrane protein 1 (LMP1) transmembrane domains cause constitutive LMP1 aggregation and continuous cytoplasmic C terminus-mediated signal transduction. We now evaluate the role of the three consec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasui T,Luftig M,Soni V,Kieff E

更新日期：2004-01-06 00:00:00

abstract：:Social status motivates much of human behavior. However, status may have been a relatively weak target of selection for much of human evolution if ancestral foragers tended to be more egalitarian. We test the "egalitarianism hypothesis" that status has a significantly smaller effect on reproductive success (RS) in for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Rueden CR,Jaeggi AV

更新日期：2016-09-27 00:00:00

abstract：:The crystal structure of fructose-1,6-bisphosphatase (EC 3.1.3.11) complexed with fructose 6-phosphate, AMP, and Mg2+ has been solved by the molecular replacement method and refined at 2.5-A resolution to a R factor of 0.215, with root-mean-square deviations of 0.013 A and 3.5 degrees for bond lengths and bond angles,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ke HM,Zhang YP,Lipscomb WN

更新日期：1990-07-01 00:00:00

abstract：:Superantigens such as the staphylococcal enterotoxins can play an important role in exacerbation of autoimmune disorders such as experimental allergic encephalomyelitis (EAE) in mice. In fact, superantigens can reactivate EAE in PL/J mice that have been sensitized to rat myelin basic protein (MBP). The T-cell subset p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soos JM,Hobeika AC,Butfiloski EJ,Schiffenbauer J,Johnson HM

更新日期：1995-06-20 00:00:00

abstract：:High genetic diversity of East Asian village dogs has recently been used to argue for an East Asian origin of the domestic dog. However, global village dog genetic diversity and the extent to which semiferal village dogs represent distinct, indigenous populations instead of admixtures of various dog breeds has not bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyko AR,Boyko RH,Boyko CM,Parker HG,Castelhano M,Corey L,Degenhardt JD,Auton A,Hedimbi M,Kityo R,Ostrander EA,Schoenebeck J,Todhunter RJ,Jones P,Bustamante CD

更新日期：2009-08-18 00:00:00

abstract：:Radiation dose rates were evaluated in three areas neighboring a restricted area within a 20- to 50-km radius of the Fukushima Daiichi Nuclear Power Plant in August-September 2012 and projected to 2022 and 2062. Study participants wore personal dosimeters measuring external dose equivalents, almost entirely from depos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada KH,Niisoe T,Imanaka M,Takahashi T,Amako K,Fujii Y,Kanameishi M,Ohse K,Nakai Y,Nishikawa T,Saito Y,Sakamoto H,Ueyama K,Hisaki K,Ohara E,Inoue T,Yamamoto K,Matsuoka Y,Ohata H,Toshima K,Okada A,Sato H,Kuwa

更新日期：2014-03-11 00:00:00