Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.

abstract：:The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herlocher ML,Maassab HF,Webster RG

更新日期：1993-07-01 00:00:00

abstract：:Social media sites are rapidly becoming one of the most important forums for public deliberation about advocacy issues. However, social scientists have not explained why some advocacy organizations produce social media messages that inspire far-ranging conversation among social media users, whereas the vast majority o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bail CA

更新日期：2016-10-18 00:00:00

abstract：:The emergence of the nematic electronic state that breaks rotational symmetry is one of the most fascinating properties of the iron-based superconductors, and has relevance to cuprates as well. FeSe has a unique ground state in which superconductivity coexists with a nematic order without long-range magnetic ordering,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato Y,Kasahara S,Taniguchi T,Xing X,Kasahara Y,Tokiwa Y,Yamakawa Y,Kontani H,Shibauchi T,Matsuda Y

更新日期：2018-02-06 00:00:00

abstract：:The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2 toxicity in Drosophila is examined through the properties of a mutant strain carrying a cSOD-null mutation, cSODn108. Homozygotes are viable as larvae, which indicates that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips JP,Campbell SD,Michaud D,Charbonneau M,Hilliker AJ

更新日期：1989-04-01 00:00:00

abstract：:Through a process called "bioturbation," burrowing macrofauna have altered the seafloor habitat and modified global carbon cycling since the Cambrian. However, the impact of macrofauna on the community structure of microorganisms is poorly understood. Here, we show that microbial communities across bioturbated, but ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deng L,Bölsterli D,Kristensen E,Meile C,Su CC,Bernasconi SM,Seidenkrantz MS,Glombitza C,Lagostina L,Han X,Jørgensen BB,Røy H,Lever MA

更新日期：2020-07-07 00:00:00

abstract：:Complexin activates Ca(2+)-triggered neurotransmitter release and regulates spontaneous release in the presynaptic terminal by cooperating with the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and the Ca(2+)-sensor synaptotagmin. The N-terminal domain of complexin is importa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Y,Choi UB,Zhang Y,Zhao M,Pfuetzner RA,Wang AL,Diao J,Brunger AT

更新日期：2016-08-09 00:00:00

abstract：:Earlier we have shown that oscillations with a long period ("supercycles") may arise in two-locus systems experiencing cyclical selection with a short period. However, this mode of complex limiting behavior appeared to be possible for narrow ranges of parameters. Here we demonstrate that a multilocus system subjected ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirzhner VM,Korol AB,Nevo E

更新日期：1996-06-25 00:00:00

abstract：:Within the scientific community, much attention has focused on improving communications between scientists, policy makers, and the public. To date, efforts have centered on improving the content, accessibility, and delivery of scientific communications. Here we argue that in the current political and media environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iyengar S,Massey DS

更新日期：2019-04-16 00:00:00

abstract：:Unqualified, the statement that approximately 1.3% of the approximately 10,000 presently known bird species have become extinct since A.D. 1500 yields an estimate of approximately 26 extinctions per million species per year (or 26 E/MSY). This is higher than the benchmark rate of approximately 1 E/MSY before human imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pimm S,Raven P,Peterson A,Sekercioglu CH,Ehrlich PR

更新日期：2006-07-18 00:00:00

abstract：:In response to insect attack, many plants exhibit dynamic biochemical changes, resulting in the induced production of direct and indirect defenses. Elicitors present in herbivore oral secretions are believed to positively regulate many inducible plant defenses; however, little is known about the specificity of elicito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmelz EA,Engelberth J,Alborn HT,Tumlinson JH 3rd,Teal PE

更新日期：2009-01-13 00:00:00

abstract：:Improper function of voltage-gated sodium channels (NaVs), obligatory membrane proteins for bioelectrical signaling, has been linked to a number of human pathologies. Small-molecule agents that target NaVs hold considerable promise for treatment of chronic disease. Absent a comprehensive understanding of channel struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Tran R,Du Bois J

更新日期：2016-05-24 00:00:00

abstract：:Cleavage of the group-specific antigen (Gag) polyprotein by HIV-1 protease represents the critical first step in the conversion of immature noninfectious viral particles to mature infectious virions. Selective pressure exerted by HIV-1 protease inhibitors, a mainstay of current anti-HIV-1 therapies, results in the acc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh L,Louis JM,Ghirlando R,Clore GM

更新日期：2016-11-01 00:00:00

abstract：:Taking advantage of a fluorescent Ca(2+) indicator selectively targeted to the trans-Golgi lumen, we here demonstrate that its Ca(2+) homeostatic mechanisms are distinct from those of the other Golgi subcompartments: (i) Ca(2+) uptake depends exclusively on the activity of the secretory pathway Ca(2+) ATPase1 (SPCA1),...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lissandron V,Podini P,Pizzo P,Pozzan T

更新日期：2010-05-18 00:00:00

abstract：:In this study we compared the cellular concentrations and stability of the mRNA transcribed from the aprE (subtilisin) gene (a gene preferentially expressed in stationary growth phase) with those of a vegetative mRNA, succinate dehydrogenase (SDH) mRNA. The subtilisin transcript was shown to be at least 3 times more s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Resnekov O,Rutberg L,von Gabain A

更新日期：1990-11-01 00:00:00

abstract：:Bacillus thuringiensis subsp. kurstaki produces a proteinaceous crystalline inclusion that is toxic for lepidopteran larvae. There are several size classes of plasmids in this organism and the presence of one or more has been correlated with production of this protein, defined as a protoxin. DNA fragments of B. thurin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Held GA,Bulla LA Jr,Ferrari E,Hoch J,Aronson AI,Minnich SA

更新日期：1982-10-01 00:00:00

abstract：:Many animals employ sex pheromones to find mating partners during their reproductive seasons. However, most sex pheromones of vertebrates remain to be identified. Over the past 20 years, steroids and prostaglandins have been identified as sex pheromones in several fishes. These pheromones are broadly termed "hormonal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yambe H,Kitamura S,Kamio M,Yamada M,Matsunaga S,Fusetani N,Yamazaki F

更新日期：2006-10-17 00:00:00

abstract：:Programmed cell death (apoptosis) is a normal physiological process, which could in principle be manipulated to play an important role in cancer therapy. The key importance of p53 expression in the apoptotic response to DNA-damaging agents has been stressed because mutant or deleted p53 is so common in most kinds of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu C,Meikrantz W,Schlegel R,Sager R

更新日期：1995-08-15 00:00:00

abstract：:Gecko and many insects have adopted nanoscale fibrillar structures on their feet as adhesion devices. Here, we consider adhesion between a single fiber and a substrate by van der Waals or electrostatic interactions. For a given contact area A, the theoretical pull-off force of the fiber is sigma(th)A where sigma(th) i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao H,Yao H

更新日期：2004-05-25 00:00:00

abstract：:Ventriculo-cisternal perfusion of horseradish peroxidase (HRP) in the mouse brain has demonstrated that a brain-blood barrier exists at the microvascular endothelium in brain parenchyma but not in the median eminence of the hypothalamus. The brain-blood barrier is similar to the blood-brain barrier in that: tight junc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broadwell RD,Balin BJ,Salcman M,Kaplan RS

更新日期：1983-12-01 00:00:00

abstract：:Ubiquitin E3 ligases are crucial for eliminating misfolded proteins before they form cytotoxic aggregates that threaten cell fitness and survival. However, it remains unclear how emerging misfolded proteins in the cytoplasm can be selectively recognized and eliminated by E3 ligases in plants. We found that Misfolded P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim JH,Cho SK,Oh TR,Ryu MY,Yang SW,Kim WT

更新日期：2017-11-14 00:00:00

abstract：:We have found that three Escherichia coli heat shock proteins, DnaK (the hsp70 homolog), DnaJ, and GrpE, function in oriP1 DNA replication in vitro solely to activate DNA binding by the replication initiator protein RepA. Activation results from the conversion of P1 or P7 RepA dimers to monomers that bind with high af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wickner S,Skowyra D,Hoskins J,McKenney K

更新日期：1992-11-01 00:00:00

abstract：:The state-to-state transfer of rotational and vibrational energy has been studied for S1 glyoxal (CHOCHO) in collisions with D2, N2, CO and C2H4 using crossed molecular beams. A laser is used to pump glyoxal seeded in He to its S1 zero point level with zero angular momentum about its top axis (K' = 0). The inelastic s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parmenter CS,Clegg SM,Krajnovich DJ,Lu S

更新日期：1997-08-05 00:00:00

abstract：:CD4 can physically associate with the CD3-T-cell receptor complex as visualized in cocapping experiments. This association occurs when the T-cell receptor is cross-linked by certain anti-variable region antibodies that appear to induce a conformational change in the receptor such that it associate with CD4. Similar as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojo JM,Saizawa K,Janeway CA Jr

更新日期：1989-05-01 00:00:00

abstract：:Some spectinomycin-resistant mutants of Escherichia coli are cold-sensitive. They are unable to assemble both 30S and 50S ribosomal subunits at low temperatures. They accumulate two kinds of incomplete particles, related to 30S and 50S subunits respectively. A single mutation, causing an alteration in a 30S ribosomal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nashimoto H,Nomura M

更新日期：1970-11-01 00:00:00

abstract：:The structure and the expression of 11 cellular oncogenes (protooncogenes) were analyzed in primary cells from 20 acute lymphocytic (ALL) and 31 acute myelogenous (AML) leukemia patients. Neoplastic cells, obtained prior to initiation of therapy, were purified and classified, on the basis of both surface antigen patte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mavilio F,Sposi NM,Petrini M,Bottero L,Marinucci M,De Rossi G,Amadori S,Mandelli F,Peschle C

更新日期：1986-06-01 00:00:00

abstract：:Cell type in Saccharomyces yeasts is regulated by two transposable blocks of DNA, the a and alpha cassettes. There are three loci where either cassette can exist. At the HML and HMR loci the cassettes are not expressed. The cassette at the MAT locus is expressed and controls the cell type. Changes of cell type involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strathern JN,Spatola E,McGill C,Hicks JB

更新日期：1980-05-01 00:00:00

abstract：:DNA and protein determinants of nucleosome positioning have been examined after in vitro reconstitutions of native or modified histone octamers onto tandem repeats of 207- and 172-base-pair DNA sequences containing the Lytechinus variegatus 5S rRNA gene and onto monomeric sequences derived from these by digestion with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong F,Hansen JC,van Holde KE

更新日期：1990-08-01 00:00:00

abstract：:Coxsackievirus causes severe disease in adult mice subjected to sustained post-weaning undernutrition (marasmus). Virus-infected marasmic mice have an increased incidence of mortality, severe lesions, and elevated and persistent viral in target organs. Transfer of immune lymphoid cells 30 min or 24 hr after viral chal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woodruff JF,Woodruff JJ

更新日期：1971-09-01 00:00:00

abstract：:We have examined the effect of diphtheria toxin, Pseudomonas aeruginosa exotoxin A, and cycloheximide on the CV-1 cell cytoskeleton. Within a few hours after producing an inhibition of cellular protein synthesis, all these agents specifically disrupted the organization of the vimentin filament system with no discernab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharpe AH,Chen LB,Murphy JR,Fields BN

更新日期：1980-12-01 00:00:00

abstract：:We have developed a coevolutionary method for the computational design of HIV-1 protease inhibitors selected for their ability to retain efficacy in the face of protease mutation. For HIV-1 protease, typical drug design techniques are shown to be ineffective for the design of resistance-evading inhibitors: An inhibito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosin CD,Belew RK,Morris GM,Olson AJ,Goodsell DS

更新日期：1999-02-16 00:00:00