Structure and function of bacterial ribosomes. XI. Dependence of 50S ribosomal assembly on simultaneous assembly of 30S subunits.

abstract：:Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia in humans caused by mutations in the with-no-lysine kinase 4 (WNK4). Several studies have shown that WNK4 modulates the activity of the renal Na(+)Cl(-) cotransporter, NCC. Because the renal consequences of WNK4 carrying pseudoa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castañeda-Bueno M,Cervantes-Pérez LG,Vázquez N,Uribe N,Kantesaria S,Morla L,Bobadilla NA,Doucet A,Alessi DR,Gamba G

更新日期：2012-05-15 00:00:00

abstract：:Many studies have demonstrated that the primary visual cortex contains multiple functional maps of visual properties (e.g., ocular dominance, orientation preference, and spatial-frequency preference), but as yet no consistent picture has emerged as to how these maps are related to one another. Three divergent, prior o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sirovich L,Uglesich R

更新日期：2004-11-30 00:00:00

abstract：:Superficial cells from early amphibian embryos display regional specializations of their cell surfaces. That portion of the plasma membrane facing the perivitelline space (apical surface) is nonadhesive, whereas, in the same cell, the lateral and basal portions of the plasma membrane will adhere to other cells. These ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberson MM,Armstrong PB

更新日期：1980-06-01 00:00:00

abstract：:The nonlinearity of the Navier-Stokes equations makes predicting the flow of fluid around rapidly moving small bodies highly resistant to all approaches save careful experiments or brute force computation. Here, we show how a linearization of the Navier-Stokes equations captures the drag-determining features of the fl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roper M,Brenner MP

更新日期：2009-03-03 00:00:00

abstract：:A survey was performed to estimate the frequency of enterohemorrhagic Escherichia coli O157:H7 or O157:nonmotile (EHEC O157) in feces and on hides within groups of fed cattle from single sources (lots) presented for slaughter at meat processing plants in the Midwestern United States, as well as frequency of carcass co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elder RO,Keen JE,Siragusa GR,Barkocy-Gallagher GA,Koohmaraie M,Laegreid WW

更新日期：2000-03-28 00:00:00

abstract：:The basal ganglia are critical for selecting actions and evaluating their outcome. Although the circuitry for selection is well understood, how these nuclei evaluate the outcome of actions is unknown. Here, we show in lamprey that a separate evaluation circuit, which regulates the habenula-projecting globus pallidus (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephenson-Jones M,Kardamakis AA,Robertson B,Grillner S

更新日期：2013-09-17 00:00:00

abstract：:A dinuclear nickel complex with methyl and thiolate ligands, Ni(dadt(Et))Ni(Me)(SDmp) (2), has been synthesized as a dinuclear Ni(d)-Ni(p)-site model of acetyl-CoA synthase (ACS) (dadt(Et) is N,N'-diethyl-3,7-diazanonane-1,9-dithiolate; Dmp is 2,6-dimesitylphenyl). Complex 2 was prepared via 2 methods: (i) ligand subs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito M,Kotera M,Matsumoto T,Tatsumi K

更新日期：2009-07-21 00:00:00

abstract：:Metal cation homeostasis is essential for plant nutrition and resistance to toxic heavy metals. Many plant metal transporters remain to be identified at the molecular level. In the present study, we have isolated AtNramp cDNAs from Arabidopsis and show that these genes complement the phenotype of a metal uptake defici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomine S,Wang R,Ward JM,Crawford NM,Schroeder JI

更新日期：2000-04-25 00:00:00

abstract：:A virus is associated with a strain of transovarially-transmitted SR-spirochetes, NSR, of Drosophila. This virus, designated spv-1, is able to infect and to multiply in another strain of SR-spirochetes, WSR, thereby eliminating the SR condition from the host flies. Spv-1 contains DNA, has a buoyant density of 1.480 in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oishi K,Poulson DF

更新日期：1970-11-01 00:00:00

abstract：:Melanopsin, the photopigment of the "circadian" receptors that regulate the biological clock and the pupillary reflex in mammals, is homologous to invertebrate rhodopsins. Evidence supporting the involvement of phosphoinositides in light-signaling has been garnered, but the downstream effectors that control the light-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peinado G,Osorno T,Gomez Mdel P,Nasi E

更新日期：2015-06-23 00:00:00

abstract：:It is found that the addition of hexamethylphosphoramide to the solution of an alkyne, Et(2)Zn, and (S)-1,1'-bi-2-naphthol in methylene chloride allows the generation of an alkynylzinc at room temperature and shows highly enantioselective additions to aldehydes. The mild condition for the formation of the alkynylzinc ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao G,Xie RG,Pu L

更新日期：2004-04-13 00:00:00

abstract：:Overexpression of the receptor tyrosine kinase (RTK) erbB2 (also designated neu or HER2) was implicated in causing a variety of human cancers, including mammary and ovarian carcinomas. Ligand-induced receptor dimerization is critical for stimulation of the intrinsic protein tyrosine kinase (PTK) of RTKs. It was theref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleishman SJ,Schlessinger J,Ben-Tal N

更新日期：2002-12-10 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common extranodal lymphoid cell neoplasia; it frequently follows chronic bacteria-induced inflammation in various tissues. MALT lymphomas are characterized genetically by the t(11;18)(q21;q21) translocation, which yields chimeric transcripts encoding struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoffel A,Chaurushiya M,Singh B,Levine AJ

更新日期：2004-06-15 00:00:00

abstract：:Many cyanobacteria alter their phycobilisome composition in response to changes in light wavelength in a process termed complementary chromatic adaptation. Mutant strains FdR1 and FdR2 of the filamentous cyanobacterium Fremyella diplosiphon are characterized by aberrant chromatic adaptation. Instead of adjusting to di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiang GG,Schaefer MR,Grossman AR

更新日期：1992-10-15 00:00:00

abstract：:The basic assumptions of van der Waals theory are contained in two well-known concepts: excluded volume (repulsive forces) and a homogeneous, isotropic field potential (attractive forces). We have superimposed on these, one more well-known concept: the existence of dimers, trimers, etc., at chemical equilibrium. With ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heidemann RA,Prausnitz JM

更新日期：1976-06-01 00:00:00

abstract：:The exquisite NMR spectral sensitivity and negligible reactivity of hyperpolarized xenon-129 (HP(129)Xe) make it attractive for a number of magnetic resonance applications; moreover, HP(129)Xe embodies an alternative to rare and nonrenewable (3)He. However, the ability to reliably and inexpensively produce large quant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikolaou P,Coffey AM,Walkup LL,Gust BM,Whiting N,Newton H,Barcus S,Muradyan I,Dabaghyan M,Moroz GD,Rosen MS,Patz S,Barlow MJ,Chekmenev EY,Goodson BM

更新日期：2013-08-27 00:00:00

abstract：:Circumnutation and winding in plants are universal growth movements that allow plants to survive despite their sessile nature. However, the detailed molecular mechanisms controlling these phenomena remain unclear. We previously found that a gravitropic mutant of Japanese morning glory (Pharbitis nil or Ipomoea nil), S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitazawa D,Hatakeda Y,Kamada M,Fujii N,Miyazawa Y,Hoshino A,Iida S,Fukaki H,Morita MT,Tasaka M,Suge H,Takahashi H

更新日期：2005-12-20 00:00:00

abstract：:The chemical speciation of arsenic in sediments and porewaters of aquifers is the critical factor that determines whether dissolved arsenic accumulates to potentially toxic levels. Sequestration of arsenic in solid phases, which may occur by adsorption or precipitation processes, controls dissolved concentrations. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Day PA,Vlassopoulos D,Root R,Rivera N

更新日期：2004-09-21 00:00:00

abstract：:A full-length cDNA clone encoding a purified augmenter of liver regeneration (ALR) factor prepared from the cytosol of weanling rat livers was isolated. The 1.2-kb cDNA included a 299-bp 5' untranslated region, a 375-bp coding region, and a 550-bp 3' untranslated region. It encoded a protein consisting of 125 amino ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagiya M,Francavilla A,Polimeno L,Ihara I,Sakai H,Seki T,Shimonishi M,Porter KA,Starzl TE

更新日期：1994-08-16 00:00:00

abstract：:FAP48 was identified and cloned thanks to its interaction with FK506-binding proteins (FKBPs) such as FKBP52 and FKBP12, which belong to the large family of immunophilins that bind the macrolide immunosuppressant drugs FK506 and rapamycin. We have previously shown that FAP48-FKBP complexes are dissociated by FK506 and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krummrei U,Baulieu EE,Chambraud B

更新日期：2003-03-04 00:00:00

abstract：:The interplay of human actions and natural processes over varied spatial and temporal scales can result in abrupt transitions between contrasting land surface states. Understanding these transitions is a key goal of sustainability science because they can represent abrupt losses of natural capital. This paper recogniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streeter R,Dugmore AJ

更新日期：2013-04-09 00:00:00

abstract：:Biologists regularly search databases of DNA or protein sequences for evolutionary or functional relationships to a given query sequence. We describe a ranking algorithm that exploits the entire network structure of similarity relationships among proteins in a sequence database by performing a diffusion operation on a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weston J,Elisseeff A,Zhou D,Leslie CS,Noble WS

更新日期：2004-04-27 00:00:00

abstract：:An intense investigation of possible non-Fermi liquid states of matter has been inspired by two of the most intriguing phenomena discovered in the past quarter century, namely, high-temperature superconductivity and the fractional quantum Hall effect. Despite enormous conceptual strides, these two fields have develope...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jain JK,Anderson PW

更新日期：2009-06-09 00:00:00

abstract：:Addition of Na+ to Na+-depleted Swiss 3T3 cells causes a rapid and dramatic increase in intracellular pH, as monitored by uptake of the weak acid 5,5-dimethyloxazolidine-2,4-dione. The effect of Na+ is concentration dependent (half-maximal effect at 38 mM); this cation can be replaced by Li+ but not by K+ or the choli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schuldiner S,Rozengurt E

更新日期：1982-12-01 00:00:00

abstract：:After decades of robust growth, the rise in US life expectancy stalled after 2010. Explanations for the stall have focused on rising drug-related deaths. Here we show that a stagnating decline in cardiovascular disease (CVD) mortality was the main culprit, outpacing and overshadowing the effects of all other causes of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehta NK,Abrams LR,Myrskylä M

更新日期：2020-03-31 00:00:00

abstract：:Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong JW,Hendrix DA,Papatsenko D,Levine MS

更新日期：2008-12-23 00:00:00

abstract：:Antidiuretic hormone (ADH) increases the water permeability of the toad urinary bladder. The increase occurs in the apical plasma membrane of granular cells that line the urinary surface of the bladder and is produced by the insertion of water permeability units that have been identified by freeze-fracture electron mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris HW Jr,Wade JB,Handler JS

更新日期：1988-03-01 00:00:00

abstract：:In all three domains of life, DNA replication begins at specialized loci termed replication origins. In bacteria, replication initiates from a single, clearly defined site. In contrast, eukaryotic organisms exploit a multitude of replication origins, dividing their genomes into an array of short contiguous units. Rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson NP,Bell SD

更新日期：2007-04-03 00:00:00

abstract：:Members of the transforming growth factor-β superfamily play essential roles in various aspects of embryonic development and physiological organ function. Among them, bone morphogenetic protein (BMP) 9 and BMP10 regulate embryonic vascular development by activating their endothelial receptor ALK1 (activin receptor-lik...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Somekawa S,Imagawa K,Hayashi H,Sakabe M,Ioka T,Sato GE,Inada K,Iwamoto T,Mori T,Uemura S,Nakagawa O,Saito Y

更新日期：2012-07-24 00:00:00

abstract：:Mice carrying mutations in either the dominant white-spotting (W) or Steel (Sl) loci exhibit deficits in melanogenesis, gametogenesis, and hematopoiesis. W encodes the Kit receptor tyrosine kinase, while Sl encodes the Kit ligand, Steel factor, and the receptor-ligand pair are contiguously expressed at anatomical site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Motro B,Wojtowicz JM,Bernstein A,van der Kooy D

更新日期：1996-03-05 00:00:00