Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization.

abstract：:Autoimmunity often involves the abnormal targeting of self-antigens by antibodies, leading to tissue destruction and other pathologies. This process could potentially be disrupted by small ligands that bind specifically to autoantibodies and inhibit their interaction with the target antigen. Here we report the identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doudna JA,Cech TR,Sullenger BA

更新日期：1995-03-14 00:00:00

abstract：:A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salerno W,Havlak P,Miller J

更新日期：2006-08-29 00:00:00

abstract：:NMDA receptors are excitatory channels with critical functions in the physiology of central synapses. Their activation reaction proceeds as a series of kinetically distinguishable, reversible steps, whose structural bases are currently under investigation. Very likely, the earliest steps include glutamate binding to g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iacobucci GJ,Wen H,Helou M,Liu B,Zheng W,Popescu GK

更新日期：2021-01-12 00:00:00

abstract：:Quantitative studies of protein abundance rarely span more than a small number of experimental conditions and replicates. In contrast, quantitative studies of transcript abundance often span hundreds of experimental conditions and replicates. This situation exists, in part, because extracting quantitative data from la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan Z,Bloom JS,Garcia BA,Singh M,Kruglyak L

更新日期：2009-09-15 00:00:00

abstract：:The relationship between (187)Os/(186)Os and (143)Nd/(144)Nd in different manganese nodule fields is used to determine the (187)Os/(186)Os ratio of the continental terrains bounding the major ocean basins. The Atlantic Ocean drainages yield (187)Os/(186)Os of about 11; the Pacific Ocean, between 25 and 36; and the wes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turekian KK,Luck JM

更新日期：1984-12-01 00:00:00

abstract：:The pancreatic beta cell can respond in the long term to hyperglycemia both with an increased capacity for insulin production and, in susceptible individuals, with apoptosis. When glucose-induced apoptosis offsets the increasing beta cell capacity, type 2 diabetes results. Here, we tested the idea that the pathway of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu K,Paterson AJ,Chin E,Kudlow JE

更新日期：2000-03-14 00:00:00

abstract：:A combined genetic, biochemical, and immunological approach has clarified structural relationships involving the first three enzymes of de novo pyrimidine biosynthesis. A procedure involving antibody and protein A-Sepharose was used to isolate the enzymes carbamoyl-phosphate synthase [ATP:carbamate phosphotransferase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davidson JN,Patterson D

更新日期：1979-04-01 00:00:00

abstract：:The nucleic acid sequence of the 3' region of human T-cell leukemia virus type II (HTLV-II) proviral DNA was determined using a HTLV-II proviral clone that could be recovered as infectious, transforming virus. The sequence data indicate a region of unknown function of approximately equal to 1.6 kilobase pairs in the 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimotohno K,Wachsman W,Takahashi Y,Golde DW,Miwa M,Sugimura T,Chen IS

更新日期：1984-11-01 00:00:00

abstract：:Transcription in the human immunodeficiency virus type 1 (HIV-1) retrovirus is regulated by binding the viral Tat protein (trans-acting transcriptional activator) to the trans-activation response (TAR) RNA sequence. Here, vacuum UV circular dichroism (VUV-CD) is used to study the structure of TAR and its complex with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loret EP,Georgel P,Johnson WC Jr,Ho PS

更新日期：1992-10-15 00:00:00

abstract：:Recently, surface-sensitive spectroscopy data and molecular dynamics simulations have generated intense interest in the distribution of electrolyte ions between bulk water and the air/water interface. A partitioning model for cations and anions developed for biopolymer surface is extended here to interpret the effects...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pegram LM,Record MT Jr

更新日期：2006-09-26 00:00:00

abstract：:Explaining the variation between human languages and the constraints on that variation is a core goal of linguistics. In the last 20 y, it has been claimed that many striking universals of cross-linguistic variation follow from a hypothetical principle that dependency length--the distance between syntactically related...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Futrell R,Mahowald K,Gibson E

更新日期：2015-08-18 00:00:00

abstract：:Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer biology and targeted treatment have been challenging to reveal, such as the divergence times and genetic clonality of metastatic lineages. To address these challenges, we performed tumor phylogenetics using molecular evolutionary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao ZM,Zhao B,Bai Y,Iamarino A,Gaffney SG,Schlessinger J,Lifton RP,Rimm DL,Townsend JP

更新日期：2016-02-23 00:00:00

abstract：:Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. The orphan nuclear re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie W,Yeuh MF,Radominska-Pandya A,Saini SP,Negishi Y,Bottroff BS,Cabrera GY,Tukey RH,Evans RM

更新日期：2003-04-01 00:00:00

abstract：:The objective of this study has been to determine which Na,K-ATPase isoforms are expressed in red blood cells and whether kinetic differences in the uncoupled sodium efflux mode between the human red blood cell Na,K-ATPase and other preparations can be explained by differences in the underlying subunit composition. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stengelin MK,Hoffman JF

更新日期：1997-05-27 00:00:00

abstract：:The conformation of L-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) has been derived from electron-density maps calculated at 2.8-A resolution with phases obtained from two heavy-atom derivatives and the bound coenzyme, NAD. Like other dehydrogenases, 3-hydroxyacyl-CoA dehydrogenase is a double-domain structure, but t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birktoft JJ,Holden HM,Hamlin R,Xuong NH,Banaszak LJ

更新日期：1987-12-01 00:00:00

abstract：:The science around the use of masks by the public to impede COVID-19 transmission is advancing rapidly. In this narrative review, we develop an analytical framework to examine mask usage, synthesizing the relevant literature to inform multiple areas: population impact, transmission characteristics, source control, wea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howard J,Huang A,Li Z,Tufekci Z,Zdimal V,van der Westhuizen HM,von Delft A,Price A,Fridman L,Tang LH,Tang V,Watson GL,Bax CE,Shaikh R,Questier F,Hernandez D,Chu LF,Ramirez CM,Rimoin AW

更新日期：2021-01-26 00:00:00

abstract：:The discipline-wide effort to database the fossil record at the occurrence level has made it possible to estimate marine invertebrate extinction and origination rates with much greater accuracy. The new data show that two biotic mechanisms have hastened recoveries from mass extinctions and confined diversity to a rela...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alroy J

更新日期：2008-08-12 00:00:00

abstract：:Adrenal chromaffin granules contain at least 10 peptides, ranging in size from 3 to 5 kilodaltons, that yield, upon digestion with trypsin, peptides that show specific binding to opiate receptors. All are distinctly different from beta-endorphin. Two of these peptides have been purified to homogeneity and subjected to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura S,Lewis RV,Stern AS,Rossier J,Stein S,Udenfriend S

更新日期：1980-03-01 00:00:00

abstract：:Unfolded RNase A is known to contain an equilibrium mixture of two forms, a slow-folding form (U(1)) and a fast-folding form (U(2)). If U(1) is produced after unfolding by the slow cis-trans isomerization of proline residues about X-Pro imide bonds, then the formation of U(1) should be catalyzed by strong acids. There...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmid FX,Baldwin RL

更新日期：1978-10-01 00:00:00

abstract：:The basidiomycete Ustilago maydis is the causative agent of the disease corn smut. To be pathogenic, strains of U. maydis must be heterozygous for a locus called "b," which appears to control both pathogenicity and sexual development. Two alleles of the b locus of U. maydis were isolated by complementation and hybridi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronstad JW,Leong SA

更新日期：1989-02-01 00:00:00

abstract：:In 1950, John Nash contributed a remarkable one-page PNAS article that defined and characterized a notion of equilibrium for n- person games. This notion, now called the "Nash equilibrium," has been widely applied and adapted in economics and other behavioral sciences. Indeed, game theory, with the Nash equilibrium as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holt CA,Roth AE

更新日期：2004-03-23 00:00:00

abstract：:Mutagenesis of protein-encoding sequences occurs ubiquitously; it enables evolution, accumulates during aging, and is associated with disease. Many biotechnological methods exploit random mutations to evolve novel proteins. To quantitate protein tolerance to random change, it is vital to understand the probability tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo HH,Choe J,Loeb LA

更新日期：2004-06-22 00:00:00

abstract：:Proper resolution of inflammation is vital for repair and restoration of homeostasis after tissue damage, and its dysregulation underlies various noncommunicable diseases, such as cardiovascular and metabolic diseases. Macrophages play diverse roles throughout initial inflammation, its resolution, and tissue repair. D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama Y,Fujiu K,Yuki R,Oishi Y,Morioka MS,Isagawa T,Matsuda J,Oshima T,Matsubara T,Sugita J,Kudo F,Kaneda A,Endo Y,Nakayama T,Nagai R,Komuro I,Manabe I

更新日期：2020-06-23 00:00:00

abstract：:Chlorarachniophytes are amoeboid algae with unusual chloroplasts. Instead of the usual two membranes that surround the chloroplasts of plants, green algae, and red algae, the chloroplasts of chlorarachniophytes have four bounding membranes. The extra membranes may reflect an unusual origin of chlorarachniophyte chloro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McFadden GI,Gilson PR,Hofmann CJ,Adcock GJ,Maier UG

更新日期：1994-04-26 00:00:00

abstract：:Complement membrane attack complexes (MACs) promote inflammatory functions in endothelial cells (ECs) by stabilizing NF-κB-inducing kinase (NIK) and activating noncanonical NF-κB signaling. Here we report a novel endosome-based signaling complex induced by MACs to stabilize NIK. We found that, in contrast to cytokine-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jane-wit D,Surovtseva YV,Qin L,Li G,Liu R,Clark P,Manes TD,Wang C,Kashgarian M,Kirkiles-Smith NC,Tellides G,Pober JS

更新日期：2015-08-04 00:00:00

abstract：:Mutations in Cu, Zn superoxide dismutase (SOD1) cause the neurodegenerative disease familial amyotrophic lateral sclerosis from an as-yet-unidentified toxic property(ies). Analysis in Saccharomyces cerevisiae of a broad range of human familial amyotrophic lateral sclerosis-linked SOD1 mutants (A4V, G37R, G41D, H46R, H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corson LB,Strain JJ,Culotta VC,Cleveland DW

更新日期：1998-05-26 00:00:00

abstract：:Secretion of extracellular polymeric substances (EPSs) by growing bacteria is an integral part of forming biofilm-like structures. In such dense systems, mechanical interactions among the structural components can be expected to significantly contribute to morphological properties. Here, we use a particle-based modeli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghosh P,Mondal J,Ben-Jacob E,Levine H

更新日期：2015-04-28 00:00:00

abstract：:Physiological and evolutionary adaptations operate at very different time scales. Nevertheless, there are reasons to believe there should be a strong relationship between the two, as together they modify the phenotype. Physiological adaptations change phenotype by altering certain microscopic parameters; evolutionary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milo R,Hou JH,Springer M,Brenner MP,Kirschner MW

更新日期：2007-10-23 00:00:00

abstract：:Individuals homozygous for the C-C chemokine receptor type 5 gene with 32-bp deletions (CCR5Δ32) are resistant to HIV-1 infection. In this study, we generated induced pluripotent stem cells (iPSCs) homozygous for the naturally occurring CCR5Δ32 mutation through genome editing of wild-type iPSCs using a combination of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye L,Wang J,Beyer AI,Teque F,Cradick TJ,Qi Z,Chang JC,Bao G,Muench MO,Yu J,Levy JA,Kan YW

更新日期：2014-07-01 00:00:00

abstract：:After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gais S,Albouy G,Boly M,Dang-Vu TT,Darsaud A,Desseilles M,Rauchs G,Schabus M,Sterpenich V,Vandewalle G,Maquet P,Peigneux P

更新日期：2007-11-20 00:00:00